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Rapid homeostatic downregulation of LTP by extrasynaptic GluN2B receptors.

Delgado JY, Fink AE, Grant SGN, O'Dell TJ, Opazo P.

J Neurophysiol. 2018 Aug 15. doi: 10.1152/jn.00421.2018. [Epub ahead of print]


Robust nanoscopy of a synaptic protein in living mice by organic-fluorophore labeling.

Masch JM, Steffens H, Fischer J, Engelhardt J, Hubrich J, Keller-Findeisen J, D'Este E, Urban NT, Grant SGN, Sahl SJ, Kamin D, Hell SW.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8047-E8056. doi: 10.1073/pnas.1807104115. Epub 2018 Aug 6.


Architecture of the Mouse Brain Synaptome.

Zhu F, Cizeron M, Qiu Z, Benavides-Piccione R, Kopanitsa MV, Skene NG, Koniaris B, DeFelipe J, Fransén E, Komiyama NH, Grant SGN.

Neuron. 2018 Aug 22;99(4):781-799.e10. doi: 10.1016/j.neuron.2018.07.007. Epub 2018 Aug 2.


Regional Diversity in the Postsynaptic Proteome of the Mouse Brain.

Roy M, Sorokina O, McLean C, Tapia-González S, DeFelipe J, Armstrong JD, Grant SGN.

Proteomes. 2018 Aug 1;6(3). pii: E31. doi: 10.3390/proteomes6030031.


Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1+/- mice.

Kopanitsa MV, Gou G, Afinowi NO, Bayés À, Grant SGN, Komiyama NH.

Pharmacol Rep. 2018 Aug;70(4):777-783. doi: 10.1016/j.pharep.2018.02.021. Epub 2018 Jun 23.


Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability.

Coba MP, Ramaker MJ, Ho EV, Thompson SL, Komiyama NH, Grant SGN, Knowles JA, Dulawa SC.

Sci Rep. 2018 Feb 2;8(1):2281. doi: 10.1038/s41598-018-20610-y.


In vivo STED microscopy visualizes PSD95 sub-structures and morphological changes over several hours in the mouse visual cortex.

Wegner W, Mott AC, Grant SGN, Steffens H, Willig KI.

Sci Rep. 2018 Jan 9;8(1):219. doi: 10.1038/s41598-017-18640-z.


Enhanced cognition and dysregulated hippocampal synaptic physiology in mice with a heterozygous deletion of PSD-95.

Horner AE, McLaughlin CL, Afinowi NO, Bussey TJ, Saksida LM, Komiyama NH, Grant SGN, Kopanitsa MV.

Eur J Neurosci. 2018 Jan;47(2):164-176. doi: 10.1111/ejn.13792. Epub 2018 Jan 10.


Proteomic analysis of postsynaptic proteins in regions of the human neocortex.

Roy M, Sorokina O, Skene N, Simonnet C, Mazzo F, Zwart R, Sher E, Smith C, Armstrong JD, Grant SGN.

Nat Neurosci. 2018 Jan;21(1):130-138. doi: 10.1038/s41593-017-0025-9. Epub 2017 Dec 4.


Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence.

Fernández E, Collins MO, Frank RAW, Zhu F, Kopanitsa MV, Nithianantharajah J, Lemprière SA, Fricker D, Elsegood KA, McLaughlin CL, Croning MDR, Mclean C, Armstrong JD, Hill WD, Deary IJ, Cencelli G, Bagni C, Fromer M, Purcell SM, Pocklington AJ, Choudhary JS, Komiyama NH, Grant SGN.

Cell Rep. 2017 Oct 17;21(3):679-691. doi: 10.1016/j.celrep.2017.09.045.


A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia.

Skene NG, Roy M, Grant SG.

Elife. 2017 Sep 12;6. pii: e17915. doi: 10.7554/eLife.17915.


Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

McQueen J, Ryan TJ, McKay S, Marwick K, Baxter P, Carpanini SM, Wishart TM, Gillingwater TH, Manson JC, Wyllie DJA, Grant SGN, McColl BW, Komiyama NH, Hardingham GE.

Elife. 2017 Jul 21;6. pii: e17161. doi: 10.7554/eLife.17161.


Supramolecular organization of NMDA receptors and the postsynaptic density.

Frank RA, Grant SG.

Curr Opin Neurobiol. 2017 Aug;45:139-147. doi: 10.1016/j.conb.2017.05.019. Epub 2017 May 31. Review.


Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes.

Frank RAW, Zhu F, Komiyama NH, Grant SGN.

J Neurochem. 2017 Aug;142(4):504-511. doi: 10.1111/jnc.14056. Epub 2017 Jul 25.


Evolution of complexity in the zebrafish synapse proteome.

Bayés À, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG.

Nat Commun. 2017 Mar 2;8:14613. doi: 10.1038/ncomms14613.


Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference.

Shukla A, Beroun A, Panopoulou M, Neumann PA, Grant SG, Olive MF, Dong Y, Schlüter OM.

EMBO J. 2017 Feb 15;36(4):458-474. doi: 10.15252/embj.201695465. Epub 2017 Jan 11.


Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation.

Benevento M, Oomen CA, Horner AE, Amiri H, Jacobs T, Pauwels C, Frega M, Kleefstra T, Kopanitsa MV, Grant SG, Bussey TJ, Saksida LM, Van der Zee CE, van Bokhoven H, Glennon JC, Kasri NN.

Sci Rep. 2017 Jan 10;7:40284. doi: 10.1038/srep40284.


Standardized experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds.

van de Lagemaat LN, Stanford LE, Pettit CM, Strathdee DJ, Strathdee KE, Elsegood KA, Fricker DG, Croning MD, Komiyama NH, Grant SG.

Genes Brain Behav. 2017 Apr;16(4):409-418. doi: 10.1111/gbb.12364. Epub 2017 Jan 20.


ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex.

Lalo U, Palygin O, Verkhratsky A, Grant SG, Pankratov Y.

Sci Rep. 2016 Sep 19;6:33609. doi: 10.1038/srep33609.


Altered thalamocortical development in the SAP102 knockout model of intellectual disability.

Crocker-Buque A, Currie SP, Luz LL, Grant SG, Duffy KR, Kind PC, Daw MI.

Hum Mol Genet. 2016 Sep 15;25(18):4052-4061. doi: 10.1093/hmg/ddw244. Epub 2016 Jul 27.


NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation.

Frank RA, Komiyama NH, Ryan TJ, Zhu F, O'Dell TJ, Grant SG.

Nat Commun. 2016 Apr 27;7:11264. doi: 10.1038/ncomms11264.


PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits.

Broadhead MJ, Horrocks MH, Zhu F, Muresan L, Benavides-Piccione R, DeFelipe J, Fricker D, Kopanitsa MV, Duncan RR, Klenerman D, Komiyama NH, Lee SF, Grant SG.

Sci Rep. 2016 Apr 25;6:24626. doi: 10.1038/srep24626.


Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment.

Skene NG, Grant SG.

Front Neurosci. 2016 Jan 27;10:16. doi: 10.3389/fnins.2016.00016. eCollection 2016.


The molecular evolution of the vertebrate behavioural repertoire.

Grant SG.

Philos Trans R Soc Lond B Biol Sci. 2016 Jan 5;371(1685):20150051. doi: 10.1098/rstb.2015.0051. Review.


Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice.

Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nägerl UV, Kind PC, Wyllie DJ.

J Neurosci. 2015 Nov 11;35(45):15073-81. doi: 10.1523/JNEUROSCI.1087-15.2015.


Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene.

Nithianantharajah J, McKechanie AG, Stewart TJ, Johnstone M, Blackwood DH, St Clair D, Grant SG, Bussey TJ, Saksida LM.

Sci Rep. 2015 Oct 1;5:14613. doi: 10.1038/srep14613.


Synaptopathy--From Biology to Therapy.

Grant SG, Bagni C, O'Dell TJ.

Neuropharmacology. 2016 Jan;100:1. doi: 10.1016/j.neuropharm.2015.08.022. Epub 2015 Aug 17. No abstract available.


Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns.

Charlesworth P, Morton A, Eglen SJ, Komiyama NH, Grant SG.

Neuropharmacology. 2016 Jan;100:47-55. doi: 10.1016/j.neuropharm.2015.07.027. Epub 2015 Jul 26.


Are Molecules Involved in Neuritogenesis and Axon Guidance Related to Autism Pathogenesis?

Bakos J, Bacova Z, Grant SG, Castejon AM, Ostatnikova D.

Neuromolecular Med. 2015 Sep;17(3):297-304. doi: 10.1007/s12017-015-8357-7. Epub 2015 May 20. Review.


Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways.

Farzana F, Zalm R, Chen N, Li KW, Grant SG, Smit AB, Toonen RF, Verhage M.

Mol Neurobiol. 2016 May;53(4):2112-23. doi: 10.1007/s12035-015-9164-8. Epub 2015 May 2.


Durable fear memories require PSD-95.

Fitzgerald PJ, Pinard CR, Camp MC, Feyder M, Sah A, Bergstrom HC, Graybeal C, Liu Y, Schlüter OM, Grant SG, Singewald N, Xu W, Holmes A.

Mol Psychiatry. 2015 Jul;20(7):913. doi: 10.1038/mp.2015.44. Epub 2015 Mar 31. No abstract available.


NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism.

Kiselycznyk C, Jury NJ, Halladay LR, Nakazawa K, Mishina M, Sprengel R, Grant SG, Svenningsson P, Holmes A.

Behav Brain Res. 2015;287:89-95. doi: 10.1016/j.bbr.2015.03.023. Epub 2015 Mar 21.


Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures.

Charlesworth P, Cotterill E, Morton A, Grant SG, Eglen SJ.

Neural Dev. 2015 Jan 28;10:1. doi: 10.1186/s13064-014-0028-0.


Durable fear memories require PSD-95.

Fitzgerald PJ, Pinard CR, Camp MC, Feyder M, Sah A, Bergstrom HC, Graybeal C, Liu Y, Schlüter OM, Grant SG, Singewald N, Xu W, Holmes A.

Mol Psychiatry. 2015 Jul;20(7):901-12. doi: 10.1038/mp.2014.161. Epub 2014 Dec 16. Erratum in: Mol Psychiatry. 2015 Jul;20(7):913.


Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes.

Bayés À, Collins MO, Galtrey CM, Simonnet C, Roy M, Croning MD, Gou G, van de Lagemaat LN, Milward D, Whittle IR, Smith C, Choudhary JS, Grant SG.

Mol Brain. 2014 Nov 28;7:88. doi: 10.1186/s13041-014-0088-4.


Regulation and disregulation of mammalian nucleotide excision repair: a pathway to nongermline breast carcinogenesis.

Latimer JJ, Majekwana VJ, Pabón-Padín YR, Pimpley MR, Grant SG.

Photochem Photobiol. 2015 Mar-Apr;91(2):493-500. doi: 10.1111/php.12387. Epub 2014 Dec 19.


Flattop regulates basal body docking and positioning in mono- and multiciliated cells.

Gegg M, Böttcher A, Burtscher I, Hasenoeder S, Van Campenhout C, Aichler M, Walch A, Grant SG, Lickert H.

Elife. 2014 Oct 8;3. doi: 10.7554/eLife.03842.


Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95.

Zhang J, Saur T, Duke AN, Grant SG, Platt DM, Rowlett JK, Isacson O, Yao WD.

J Neurogenet. 2014 Mar-Jun;28(1-2):98-111. doi: 10.3109/01677063.2014.892486. Epub 2014 Apr 22.


Molecular analysis of mutations in the human HPRT gene.

Keohavong P, Xi L, Grant SG.

Methods Mol Biol. 2014;1105:291-301. doi: 10.1007/978-1-62703-739-6_23.


The blood-based glycophorin A (GPA) human in vivo somatic mutation assay.

Myers NT, Grant SG.

Methods Mol Biol. 2014;1105:223-44. doi: 10.1007/978-1-62703-739-6_18.


Pulsed-field gel electrophoresis analysis of multicellular DNA double-strand break damage and repair.

Joshi N, Grant SG.

Methods Mol Biol. 2014;1105:193-202. doi: 10.1007/978-1-62703-739-6_16.


A polygenic burden of rare disruptive mutations in schizophrenia.

Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O'Dushlaine C, Chambert K, Bergen SE, Kähler A, Duncan L, Stahl E, Genovese G, Fernández E, Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E, Shakir K, Garimella K, Fennell T, DePristo M, Grant SG, Haggarty SJ, Gabriel S, Scolnick EM, Lander ES, Hultman CM, Sullivan PF, McCarroll SA, Sklar P.

Nature. 2014 Feb 13;506(7487):185-90. doi: 10.1038/nature12975. Epub 2014 Jan 22.


De novo mutations in schizophrenia implicate synaptic networks.

Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon E, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar P, Owen MJ, Purcell SM, O'Donovan MC.

Nature. 2014 Feb 13;506(7487):179-84. doi: 10.1038/nature12929. Epub 2014 Jan 22.


Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins.

Hill WD, Davies G, van de Lagemaat LN, Christoforou A, Marioni RE, Fernandes CP, Liewald DC, Croning MD, Payton A, Craig LC, Whalley LJ, Horan M, Ollier W, Hansell NK, Wright MJ, Martin NG, Montgomery GW, Steen VM, Le Hellard S, Espeseth T, Lundervold AJ, Reinvang I, Starr JM, Pendleton N, Grant SG, Bates TC, Deary IJ.

Transl Psychiatry. 2014 Jan 7;4:e341. doi: 10.1038/tp.2013.114.


Tolerance to ethanol intoxication after chronic ethanol: role of GluN2A and PSD-95.

Daut RA, Busch EF, Ihne J, Fisher D, Mishina M, Grant SG, Camp M, Holmes A.

Addict Biol. 2015 Mar;20(2):259-62. doi: 10.1111/adb.12110. Epub 2014 Jan 7.


SnapShot: Organizational principles of the postsynaptic proteome.

Grant SG.

Neuron. 2013 Oct 16;80(2):534.e1. doi: 10.1016/j.neuron.2013.10.014. No abstract available.


Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption.

Milner LC, Shirley RL, Kozell LB, Walter NA, Kruse LC, Komiyama NH, Grant SG, Buck KJ.

Addict Biol. 2015 Jan;20(1):143-7. doi: 10.1111/adb.12087. Epub 2013 Oct 10.


CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.

De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, Ostroff LE, Klann E, Zwartkruis FJ, Komiyama NH, Grant SG, Poujol C, Choquet D, Achsel T, Posthuma D, Smit AB, Bagni C.

Neuron. 2013 Sep 18;79(6):1169-82. doi: 10.1016/j.neuron.2013.06.039.


Cognitive components in mice and humans: combining genetics and touchscreens for medical translation.

Nithianantharajah J, Grant SG.

Neurobiol Learn Mem. 2013 Oct;105:13-9. doi: 10.1016/j.nlm.2013.06.006. Epub 2013 Jun 22. Review.


WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer.

Wend P, Runke S, Wend K, Anchondo B, Yesayan M, Jardon M, Hardie N, Loddenkemper C, Ulasov I, Lesniak MS, Wolsky R, Bentolila LA, Grant SG, Elashoff D, Lehr S, Latimer JJ, Bose S, Sattar H, Krum SA, Miranda-Carboni GA.

EMBO Mol Med. 2013 Feb;5(2):264-79. doi: 10.1002/emmm.201201320. Epub 2013 Jan 11.

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