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Items: 1 to 50 of 218

1.

Expression of Human ACE2 in Lactobacillus and Beneficial Effects in Diabetic Retinopathy in Mice.

Verma A, Xu K, Du T, Zhu P, Liang Z, Liao S, Zhang J, Raizada MK, Grant MB, Li Q.

Mol Ther Methods Clin Dev. 2019 Jul 10;14:161-170. doi: 10.1016/j.omtm.2019.06.007. eCollection 2019 Sep 13.

2.

CCN1-Yes-Associated Protein Feedback Loop Regulates Physiological and Pathological Angiogenesis.

Lee S, Ahad A, Luu M, Moon S, Caesar J, Cardoso WV, Grant MB, Chaqour B.

Mol Cell Biol. 2019 Aug 27;39(18). pii: e00107-19. doi: 10.1128/MCB.00107-19. Print 2019 Sep 15.

PMID:
31262999
3.

Peripheral blood-derived mesenchymal stem cells demonstrate immunomodulatory potential for therapeutic use in horses.

Longhini ALF, Salazar TE, Vieira C, Trinh T, Duan Y, Pay LM, Li Calzi S, Losh M, Johnston NA, Xie H, Kim M, Hunt RJ, Yoder MC, Santoro D, McCarrel TM, Grant MB.

PLoS One. 2019 Mar 14;14(3):e0212642. doi: 10.1371/journal.pone.0212642. eCollection 2019.

4.

Antiarrhythmic and proarrhythmic effects of subcutaneous nerve stimulation in ambulatory dogs.

Wan J, Chen M, Yuan Y, Wang Z, Shen C, Fishbein MC, Chen Z, Wong J, Grant MB, Everett TH 4th, Chen PS.

Heart Rhythm. 2019 Aug;16(8):1251-1260. doi: 10.1016/j.hrthm.2019.02.027. Epub 2019 Feb 25.

PMID:
30818091
5.

Long-Term Diabetic Microenvironment Augments the Decay Rate of Capsaicin-Induced Currents in Mouse Dorsal Root Ganglion Neurons.

Chen X, Duan Y, Riley AM, Welch MA, White FA, Grant MB, Obukhov AG.

Molecules. 2019 Feb 21;24(4):775. doi: 10.3390/molecules24040775.

6.

Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1-Mediated Cholesterol Removal.

Saadane A, Mast N, Trichonas G, Chakraborty D, Hammer S, Busik JV, Grant MB, Pikuleva IA.

Am J Pathol. 2019 Feb;189(2):405-425. doi: 10.1016/j.ajpath.2018.10.013. Epub 2018 Nov 16.

PMID:
30448403
7.

Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization.

McAnally D, Siddiquee K, Gomaa A, Szabo A, Vasile S, Maloney PR, Divlianska DB, Peddibhotla S, Morfa CJ, Hershberger P, Falter R, Williamson R, Terry DB, Farjo R, Pinkerton AB, Qi X, Quigley J, Boulton ME, Grant MB, Smith LH.

PLoS One. 2018 Sep 12;13(9):e0202436. doi: 10.1371/journal.pone.0202436. eCollection 2018.

8.

Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction.

Duan Y, Beli E, Li Calzi S, Quigley JL, Miller RC, Moldovan L, Feng D, Salazar TE, Hazra S, Al-Sabah J, Chalam KV, Phuong Trinh TL, Meroueh M, Markel TA, Murray MC, Vyas RJ, Boulton ME, Parsons-Wingerter P, Oudit GY, Obukhov AG, Grant MB.

Stem Cells. 2018 Sep;36(9):1430-1440. doi: 10.1002/stem.2848. Epub 2018 Jul 15.

9.

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice.

Beli E, Yan Y, Moldovan L, Vieira CP, Gao R, Duan Y, Prasad R, Bhatwadekar A, White FA, Townsend SD, Chan L, Ryan CN, Morton D, Moldovan EG, Chu FI, Oudit GY, Derendorf H, Adorini L, Wang XX, Evans-Molina C, Mirmira RG, Boulton ME, Yoder MC, Li Q, Levi M, Busik JV, Grant MB.

Diabetes. 2018 Sep;67(9):1867-1879. doi: 10.2337/db18-0158. Epub 2018 Apr 30.

10.

Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity.

Shaw LC, Li Calzi S, Li N, Moldovan L, Sengupta-Caballero N, Quigley JL, Ivan M, Jun B, Bazan NG, Boulton ME, Busik J, Neu J, Grant MB.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):858-869. doi: 10.1167/iovs.17-23034.

11.

Models of retinal diseases and their applicability in drug discovery.

Malek G, Busik J, Grant MB, Choudhary M.

Expert Opin Drug Discov. 2018 Apr;13(4):359-377. doi: 10.1080/17460441.2018.1430136. Epub 2018 Jan 30. Review.

12.

Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier.

Lakshmikanthan S, Sobczak M, Li Calzi S, Shaw L, Grant MB, Chrzanowska-Wodnicka M.

J Cell Sci. 2018 Jan 10;131(1). pii: jcs207605. doi: 10.1242/jcs.207605.

13.

Improving the Transduction of Bone Marrow-Derived Cells with an Integrase-Defective Lentiviral Vector.

Pay SL, Qi X, Willard JF, Godoy J, Sankhavaram K, Horton R, Mitter SK, Quigley JL, Chang LJ, Grant MB, Boulton ME.

Hum Gene Ther Methods. 2018 Feb;29(1):44-59. doi: 10.1089/hgtb.2017.082. Epub 2017 Dec 18.

14.

Beneficial Effects of Angiotensin-(1-7) on CD34+ Cells From Patients With Heart Failure.

Cole-Jeffrey CT, Pepine CJ, Katovich MJ, Grant MB, Raizada MK, Hazra S.

J Cardiovasc Pharmacol. 2018 Mar;71(3):155-159. doi: 10.1097/FJC.0000000000000556.

15.

Bone Marrow-Derived Cell Recruitment to the Neurosensory Retina and Retinal Pigment Epithelial Cell Layer Following Subthreshold Retinal Phototherapy.

Caballero S, Kent DL, Sengupta N, Li Calzi S, Shaw L, Beli E, Moldovan L, Dominguez JM 2nd, Moorthy RS, Grant MB.

Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5164-5176. doi: 10.1167/iovs.16-20736.

16.

Hematopoietic stem/progenitor involvement in retinal microvascular repair during diabetes: Implications for bone marrow rejuvenation.

Bhatwadekar AD, Duan Y, Korah M, Thinschmidt JS, Hu P, Leley SP, Caballero S, Shaw L, Busik J, Grant MB.

Vision Res. 2017 Oct;139:211-220. doi: 10.1016/j.visres.2017.06.016. Epub 2017 Oct 31. Review.

17.

iPSC-Derived Vascular Cell Spheroids as Building Blocks for Scaffold-Free Biofabrication.

Moldovan L, Barnard A, Gil CH, Lin Y, Grant MB, Yoder MC, Prasain N, Moldovan NI.

Biotechnol J. 2017 Dec;12(12). doi: 10.1002/biot.201700444. Epub 2017 Nov 14.

PMID:
29030959
18.

Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina.

Hu P, Hunt NH, Arfuso F, Shaw LC, Uddin MN, Zhu M, Devasahayam R, Adamson SJ, Benson VL, Chan-Ling T, Grant MB.

Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5043-5055. doi: 10.1167/iovs.17-21654.

19.

The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor.

Hammer SS, Beli E, Kady N, Wang Q, Wood K, Lydic TA, Malek G, Saban DR, Wang XX, Hazra S, Levi M, Busik JV, Grant MB.

EBioMedicine. 2017 Aug;22:181-190. doi: 10.1016/j.ebiom.2017.07.008. Epub 2017 Jul 11.

20.

Long-term spironolactone treatment reduces coronary TRPC expression, vasoconstriction, and atherosclerosis in metabolic syndrome pigs.

Li W, Chen X, Riley AM, Hiett SC, Temm CJ, Beli E, Long X, Chakraborty S, Alloosh M, White FA, Grant MB, Sturek M, Obukhov AG.

Basic Res Cardiol. 2017 Sep;112(5):54. doi: 10.1007/s00395-017-0643-0. Epub 2017 Jul 29.

21.

Immunodeficiency in Pancreatic Adenocarcinoma with Diabetes Revealed by Comparative Genomics.

Yan Y, Gao R, Trinh TLP, Grant MB.

Clin Cancer Res. 2017 Oct 15;23(20):6363-6373. doi: 10.1158/1078-0432.CCR-17-0250. Epub 2017 Jul 6.

22.

Promoting vascular repair in the retina: can stem/progenitor cells help?

Trinh TLP, Li Calzi S, Shaw LC, Yoder MC, Grant MB.

Eye Brain. 2016 May 26;8:113-122. doi: 10.2147/EB.S94451. eCollection 2016. Review.

23.

Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy.

Lee S, Elaskandrany M, Lau LF, Lazzaro D, Grant MB, Chaqour B.

Sci Rep. 2017 May 3;7(1):1405. doi: 10.1038/s41598-017-01585-8.

24.

Conditional Deletion of Bmal1 Accentuates Microvascular and Macrovascular Injury.

Bhatwadekar AD, Beli E, Diao Y, Chen J, Luo Q, Alex A, Caballero S, Dominguez JM 2nd, Salazar TE, Busik JV, Segal MS, Grant MB.

Am J Pathol. 2017 Jun;187(6):1426-1435. doi: 10.1016/j.ajpath.2017.02.014. Epub 2017 Apr 19.

25.

Erratum to: CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes.

Beli E, Dominguez JM 2nd, Hu P, Thinschmidt JS, Caballero S, Calzi SL, Luo D, Shanmugam S, Salazar TE, Duan Y, Boulton ME, Mohr S, Abcouwer SF, Saban DR, Harrison JK, Grant MB.

J Mol Med (Berl). 2017 May;95(5):565-566. doi: 10.1007/s00109-017-1530-8. No abstract available.

PMID:
28421250
26.

Ferrochelatase is a therapeutic target for ocular neovascularization.

Basavarajappa HD, Sulaiman RS, Qi X, Shetty T, Sheik Pran Babu S, Sishtla KL, Lee B, Quigley J, Alkhairy S, Briggs CM, Gupta K, Tang B, Shadmand M, Grant MB, Boulton ME, Seo SY, Corson TW.

EMBO Mol Med. 2017 Jun;9(6):786-801. doi: 10.15252/emmm.201606561.

27.

Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem Cells.

Salazar TE, Richardson MR, Beli E, Ripsch MS, George J, Kim Y, Duan Y, Moldovan L, Yan Y, Bhatwadekar A, Jadhav V, Smith JA, McGorray S, Bertone AL, Traktuev DO, March KL, Colon-Perez LM, Avin KG, Sims E, Mund JA, Case J, Deng X, Kim MS, McDavitt B, Boulton ME, Thinschmidt J, Li Calzi S, Fitz SD, Fuchs RK, Warden SJ, McKinley T, Shekhar A, Febo M, Johnson PL, Chang LJ, Gao Z, Kolonin MG, Lai S, Ma J, Dong X, White FA, Xie H, Yoder MC, Grant MB.

Stem Cells. 2017 May;35(5):1303-1315. doi: 10.1002/stem.2613.

28.

Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy.

Song C, Mitter SK, Qi X, Beli E, Rao HV, Ding J, Ip CS, Gu H, Akin D, Dunn WA Jr, Bowes Rickman C, Lewin AS, Grant MB, Boulton ME.

PLoS One. 2017 Feb 21;12(2):e0171940. doi: 10.1371/journal.pone.0171940. eCollection 2017.

29.

Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration.

Qi X, Pay SL, Yan Y, Thomas J Jr, Lewin AS, Chang LJ, Grant MB, Boulton ME.

Mol Ther. 2017 Apr 5;25(4):917-927. doi: 10.1016/j.ymthe.2017.01.015. Epub 2017 Feb 13.

30.

Advances in bone marrow stem cell therapy for retinal dysfunction.

Park SS, Moisseiev E, Bauer G, Anderson JD, Grant MB, Zam A, Zawadzki RJ, Werner JS, Nolta JA.

Prog Retin Eye Res. 2017 Jan;56:148-165. doi: 10.1016/j.preteyeres.2016.10.002. Epub 2016 Oct 23. Review.

31.

CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes.

Beli E, Dominguez JM 2nd, Hu P, Thinschmidt JS, Caballero S, Li Calzi S, Luo D, Shanmugam S, Salazar TE, Duan Y, Boulton ME, Mohr S, Abcouwer SF, Saban DR, Harrison JK, Grant MB.

J Mol Med (Berl). 2016 Nov;94(11):1255-1265. doi: 10.1007/s00109-016-1433-0. Epub 2016 Jun 25. Erratum in: J Mol Med (Berl). 2017 May;95(5):565-566.

32.

Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF).

Jadhav V, Luo Q, M Dominguez J 2nd, Al-Sabah J, Chaqour B, Grant MB, Bhatwadekar AD.

PLoS One. 2016 Sep 23;11(9):e0163367. doi: 10.1371/journal.pone.0163367. eCollection 2016.

33.

Dual Anti-Inflammatory and Anti-Angiogenic Action of miR-15a in Diabetic Retinopathy.

Wang Q, Navitskaya S, Chakravarthy H, Huang C, Kady N, Lydic TA, Chen YE, Yin KJ, Powell FL, Martin PM, Grant MB, Busik JV.

EBioMedicine. 2016 Sep;11:138-150. doi: 10.1016/j.ebiom.2016.08.013. Epub 2016 Aug 8.

34.

Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy.

Wert KJ, Mahajan VB, Zhang L, Yan Y, Li Y, Tosi J, Hsu CW, Nagasaki T, Janisch KM, Grant MB, Mahajan M, Bassuk AG, Tsang SH.

Signal Transduct Target Ther. 2016;1. pii: 16005. Epub 2016 Apr 22.

35.

Adeno-Associated Virus Overexpression of Angiotensin-Converting Enzyme-2 Reverses Diabetic Retinopathy in Type 1 Diabetes in Mice.

Dominguez JM 2nd, Hu P, Caballero S, Moldovan L, Verma A, Oudit GY, Li Q, Grant MB.

Am J Pathol. 2016 Jun;186(6):1688-700. doi: 10.1016/j.ajpath.2016.01.023. Epub 2016 May 10.

36.

Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure.

Patel VB, Zhong JC, Grant MB, Oudit GY.

Circ Res. 2016 Apr 15;118(8):1313-26. doi: 10.1161/CIRCRESAHA.116.307708. Review.

37.

Depressed basal hypothalamic neuronal activity in type-1 diabetic mice is correlated with proinflammatory secretion of HMBG1.

Thinschmidt JS, Colon-Perez LM, Febo M, Caballero S, King MA, White FA, Grant MB.

Neurosci Lett. 2016 Feb 26;615:21-7. doi: 10.1016/j.neulet.2016.01.014. Epub 2016 Jan 14.

38.

Imbalances in Mobilization and Activation of Pro-Inflammatory and Vascular Reparative Bone Marrow-Derived Cells in Diabetic Retinopathy.

Chakravarthy H, Beli E, Navitskaya S, O'Reilly S, Wang Q, Kady N, Huang C, Grant MB, Busik JV.

PLoS One. 2016 Jan 13;11(1):e0146829. doi: 10.1371/journal.pone.0146829. eCollection 2016.

39.

Role of Acid Sphingomyelinase in Shifting the Balance Between Proinflammatory and Reparative Bone Marrow Cells in Diabetic Retinopathy.

Chakravarthy H, Navitskaya S, O'Reilly S, Gallimore J, Mize H, Beli E, Wang Q, Kady N, Huang C, Blanchard GJ, Grant MB, Busik JV.

Stem Cells. 2016 Apr;34(4):972-83. doi: 10.1002/stem.2259. Epub 2016 Jan 4.

40.

Identification of Bone Marrow Cell Subpopulations Associated With Improved Functional Outcomes in Patients With Chronic Left Ventricular Dysfunction: An Embedded Cohort Evaluation of the FOCUS-CCTRN Trial.

Taylor DA, Perin EC, Willerson JT, Zierold C, Resende M, Carlson M, Nestor B, Wise E, Orozco A, Pepine CJ, Henry TD, Ellis SG, Zhao DX, Traverse JH, Cooke JP, Schutt RC, Bhatnagar A, Grant MB, Lai D, Johnstone BH, Sayre SL, Moyé L, Ebert RF, Bolli R, Simari RD, Cogle CR; Cardiovascular Cell Therapy Research Network (CCTRN).

Cell Transplant. 2016;25(9):1675-1687. Epub 2015 Nov 19.

41.

Ataxia Telangiectasia Mutated Dysregulation Results in Diabetic Retinopathy.

Bhatwadekar AD, Duan Y, Chakravarthy H, Korah M, Caballero S, Busik JV, Grant MB.

Stem Cells. 2016 Feb;34(2):405-17. doi: 10.1002/stem.2235. Epub 2015 Nov 17.

42.

A Non-Canonical Role for β-Secretase in the Retina.

Qian Q, Mitter SK, Pay SL, Qi X, Rickman CB, Grant MB, Boulton ME.

Adv Exp Med Biol. 2016;854:333-9. doi: 10.1007/978-3-319-17121-0_44. Review.

PMID:
26427429
43.

miR-92a Corrects CD34+ Cell Dysfunction in Diabetes by Modulating Core Circadian Genes Involved in Progenitor Differentiation.

Bhatwadekar AD, Yan Y, Stepps V, Hazra S, Korah M, Bartelmez S, Chaqour B, Grant MB.

Diabetes. 2015 Dec;64(12):4226-37. doi: 10.2337/db15-0521. Epub 2015 Aug 17.

44.

Single and Compound Knock-outs of MicroRNA (miRNA)-155 and Its Angiogenic Gene Target CCN1 in Mice Alter Vascular and Neovascular Growth in the Retina via Resident Microglia.

Yan L, Lee S, Lazzaro DR, Aranda J, Grant MB, Chaqour B.

J Biol Chem. 2015 Sep 18;290(38):23264-81. doi: 10.1074/jbc.M115.646950. Epub 2015 Aug 4.

45.

ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity.

Patel VB, Mori J, McLean BA, Basu R, Das SK, Ramprasath T, Parajuli N, Penninger JM, Grant MB, Lopaschuk GD, Oudit GY.

Diabetes. 2016 Jan;65(1):85-95. doi: 10.2337/db15-0399. Epub 2015 Jul 29.

46.

A Simple Optical Coherence Tomography Quantification Method for Choroidal Neovascularization.

Sulaiman RS, Quigley J, Qi X, O'Hare MN, Grant MB, Boulton ME, Corson TW.

J Ocul Pharmacol Ther. 2015 Oct;31(8):447-54. doi: 10.1089/jop.2015.0049. Epub 2015 Jun 10.

47.

Central neural activation following contact sensitivity peripheral immune challenge: evidence of brain-immune regulation through C fibres.

Thinschmidt JS, King MA, Korah M, Perez PD, Febo M, Miyan J, Grant MB.

Immunology. 2015 Oct;146(2):206-16. doi: 10.1111/imm.12479. Epub 2015 Aug 24.

48.

Wnting out ocular neovascularization: using nanoparticle delivery of very-low density lipoprotein receptor extracellular domain as Wnt pathway inhibitor in the retina.

Busik JV, Grant MB.

Arterioscler Thromb Vasc Biol. 2015 May;35(5):1046-7. doi: 10.1161/ATVBAHA.115.305395. No abstract available.

49.

Antagonism of angiotensin 1-7 prevents the therapeutic effects of recombinant human ACE2.

Patel VB, Takawale A, Ramprasath T, Das SK, Basu R, Grant MB, Hall DA, Kassiri Z, Oudit GY.

J Mol Med (Berl). 2015 Sep;93(9):1003-13. doi: 10.1007/s00109-015-1285-z. Epub 2015 Apr 15.

50.

Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice.

Hu P, Thinschmidt JS, Caballero S, Adamson S, Cole L, Chan-Ling T, Grant MB.

Am J Physiol Endocrinol Metab. 2015 Apr 15;308(8):E688-98. doi: 10.1152/ajpendo.00504.2014. Epub 2015 Feb 24.

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