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n-Butanol production in S. cerevisiae: co-ordinate use of endogenous and exogenous pathways.

Swidah R, Ogunlabi O, Grant CM, Ashe MP.

Appl Microbiol Biotechnol. 2018 Nov;102(22):9857-9866. doi: 10.1007/s00253-018-9305-x. Epub 2018 Sep 1.


Endoplasmic reticulum (ER) stress-induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant.

Kritsiligkou P, Rand JD, Weids AJ, Wang X, Kershaw CJ, Grant CM.

J Biol Chem. 2018 Aug 3;293(31):11984-11995. doi: 10.1074/jbc.RA118.001824. Epub 2018 Jun 5.


Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions.

Talavera D, Kershaw CJ, Costello JL, Castelli LM, Rowe W, Sims PFG, Ashe MP, Grant CM, Pavitt GD, Hubbard SJ.

Sci Rep. 2018 May 21;8(1):7949. doi: 10.1038/s41598-018-26170-5.


A quantitative and temporal map of proteostasis during heat shock in Saccharomyces cerevisiae.

Jarnuczak AF, Albornoz MG, Eyers CE, Grant CM, Hubbard SJ.

Mol Omics. 2018 Feb 1;14(1):37-52. doi: 10.1039/c7mo00050b. Epub 2018 Jan 16.


Loss of mRNA surveillance pathways results in widespread protein aggregation.

Jamar NH, Kritsiligkou P, Grant CM.

Sci Rep. 2018 Mar 1;8(1):3894. doi: 10.1038/s41598-018-22183-2.


Guidelines and recommendations on yeast cell death nomenclature.

Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte-Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F.

Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review.


Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses.

Costello JL, Kershaw CJ, Castelli LM, Talavera D, Rowe W, Sims PFG, Ashe MP, Grant CM, Hubbard SJ, Pavitt GD.

Genome Biol. 2017 Oct 27;18(1):201. doi: 10.1186/s13059-017-1338-4.


ER stress causes widespread protein aggregation and prion formation.

Hamdan N, Kritsiligkou P, Grant CM.

J Cell Biol. 2017 Aug 7;216(8):2295-2304. doi: 10.1083/jcb.201612165. Epub 2017 Jun 19.


The non-stop decay mRNA surveillance pathway is required for oxidative stress tolerance.

Jamar NH, Kritsiligkou P, Grant CM.

Nucleic Acids Res. 2017 Jun 20;45(11):6881-6893. doi: 10.1093/nar/gkx306.


The frequency of yeast [PSI+] prion formation is increased during chronological ageing.

Speldewinde SH, Grant CM.

Microb Cell. 2017 Mar 27;4(4):127-132. doi: 10.15698/mic2017.04.568.


Disrupting the cortical actin cytoskeleton points to two distinct mechanisms of yeast [PSI+] prion formation.

Speldewinde SH, Doronina VA, Tuite MF, Grant CM.

PLoS Genet. 2017 Apr 3;13(4):e1006708. doi: 10.1371/journal.pgen.1006708. eCollection 2017 Apr.


Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding.

Kritsiligkou P, Chatzi A, Charalampous G, Mironov A Jr, Grant CM, Tokatlidis K.

Cell Rep. 2017 Mar 14;18(11):2729-2741. doi: 10.1016/j.celrep.2017.02.053.


Absolute protein quantification of the yeast chaperome under conditions of heat shock.

Mackenzie RJ, Lawless C, Holman SW, Lanthaler K, Beynon RJ, Grant CM, Hubbard SJ, Eyers CE.

Proteomics. 2016 Aug;16(15-16):2128-40. doi: 10.1002/pmic.201500503. Epub 2016 Jul 22.


Distinct stress conditions result in aggregation of proteins with similar properties.

Weids AJ, Ibstedt S, Tamás MJ, Grant CM.

Sci Rep. 2016 Apr 18;6:24554. doi: 10.1038/srep24554.


Yeast mitochondrial glutathione is an essential antioxidant with mitochondrial thioredoxin providing a back-up system.

Gostimskaya I, Grant CM.

Free Radic Biol Med. 2016 May;94:55-65. doi: 10.1016/j.freeradbiomed.2016.02.015. Epub 2016 Feb 17.


Direct and Absolute Quantification of over 1800 Yeast Proteins via Selected Reaction Monitoring.

Lawless C, Holman SW, Brownridge P, Lanthaler K, Harman VM, Watkins R, Hammond DE, Miller RL, Sims PF, Grant CM, Eyers CE, Beynon RJ, Hubbard SJ.

Mol Cell Proteomics. 2016 Apr;15(4):1309-22. doi: 10.1074/mcp.M115.054288. Epub 2016 Jan 10.


Spermidine cures yeast of prions.

Speldewinde SH, Grant CM.

Microb Cell. 2015 Dec 25;3(1):46-48. doi: 10.15698/mic2016.01.474.


Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p.

Kershaw CJ, Costello JL, Talavera D, Rowe W, Castelli LM, Sims PF, Grant CM, Ashe MP, Hubbard SJ, Pavitt GD.

Sci Rep. 2015 Oct 23;5:15518. doi: 10.1038/srep15518.


Autophagy protects against de novo formation of the [PSI+] prion in yeast.

Speldewinde SH, Doronina VA, Grant CM.

Mol Biol Cell. 2015 Dec 15;26(25):4541-51. doi: 10.1091/mbc.E15-08-0548. Epub 2015 Oct 21.


Sup35 methionine oxidation is a trigger for de novo [PSI(+)] prion formation.

Grant CM.

Prion. 2015;9(4):257-65. doi: 10.1080/19336896.2015.1065372. Review.


Butanol production in S. cerevisiae via a synthetic ABE pathway is enhanced by specific metabolic engineering and butanol resistance.

Swidah R, Wang H, Reid PJ, Ahmed HZ, Pisanelli AM, Persaud KC, Grant CM, Ashe MP.

Biotechnol Biofuels. 2015 Jul 8;8:97. doi: 10.1186/s13068-015-0281-4. eCollection 2015.


The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation.

Castelli LM, Talavera D, Kershaw CJ, Mohammad-Qureshi SS, Costello JL, Rowe W, Sims PF, Grant CM, Hubbard SJ, Ashe MP, Pavitt GD.

PLoS Genet. 2015 May 14;11(5):e1005233. doi: 10.1371/journal.pgen.1005233. eCollection 2015 May.


Quantitative proteomics and network analysis of SSA1 and SSB1 deletion mutants reveals robustness of chaperone HSP70 network in Saccharomyces cerevisiae.

Jarnuczak AF, Eyers CE, Schwartz JM, Grant CM, Hubbard SJ.

Proteomics. 2015 Sep;15(18):3126-39. doi: 10.1002/pmic.201400527. Epub 2015 Apr 10.


Elevated interleukin-10: a new cause of dyslipidemia leading to severe HDL deficiency.

Moraitis AG, Freeman LA, Shamburek RD, Wesley R, Wilson W, Grant CM, Price S, Demosky S, Thacker SG, Zarzour A, Hornung RL, Pucino F, Csako G, Yarboro C, McInnes IB, Kuroiwa T, Boumpas D, Rao VK, Illei GG, Remaley AT.

J Clin Lipidol. 2015 Jan-Feb;9(1):81-90. doi: 10.1016/j.jacl.2014.09.014. Epub 2014 Oct 5.


Global mRNA selection mechanisms for translation initiation.

Costello J, Castelli LM, Rowe W, Kershaw CJ, Talavera D, Mohammad-Qureshi SS, Sims PF, Grant CM, Pavitt GD, Hubbard SJ, Ashe MP.

Genome Biol. 2015 Jan 5;16:10. doi: 10.1186/s13059-014-0559-z.


Oxidative stress conditions increase the frequency of de novo formation of the yeast [PSI+] prion.

Doronina VA, Staniforth GL, Speldewinde SH, Tuite MF, Grant CM.

Mol Microbiol. 2015 Apr;96(1):163-74. doi: 10.1111/mmi.12930. Epub 2015 Feb 11.


The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response.

Kershaw CJ, Costello JL, Castelli LM, Talavera D, Rowe W, Sims PF, Ashe MP, Hubbard SJ, Pavitt GD, Grant CM.

PLoS Genet. 2015 Jan 8;11(1):e1004903. doi: 10.1371/journal.pgen.1004903. eCollection 2015 Jan.


Epithelial mesenchymal transition (EMT) in prostate growth and tumor progression.

Grant CM, Kyprianou N.

Transl Androl Urol. 2013 Sep 1;2(3):202-211.


Large mass on base of tongue. Diagnosis: lingual thyroid.

Reed JT, Grant CM.

J Fam Pract. 2014 Oct;63(10):603-5.


Global analysis of protein aggregation in yeast during physiological conditions and arsenite stress.

Ibstedt S, Sideri TC, Grant CM, Tamás MJ.

Biol Open. 2014 Sep 12;3(10):913-23. doi: 10.1242/bio.20148938.


Oxidant-specific regulation of protein synthesis in Candida albicans.

Sundaram A, Grant CM.

Fungal Genet Biol. 2014 Jun;67:15-23. doi: 10.1016/j.fgb.2014.03.005. Epub 2014 Apr 1.


The yeast peroxiredoxin Tsa1 protects against protein-aggregate-induced oxidative stress.

Weids AJ, Grant CM.

J Cell Sci. 2014 Mar 15;127(Pt 6):1327-35. doi: 10.1242/jcs.144022. Epub 2014 Jan 14.


Puf3p induces translational repression of genes linked to oxidative stress.

Rowe W, Kershaw CJ, Castelli LM, Costello JL, Ashe MP, Grant CM, Sims PF, Pavitt GD, Hubbard SJ.

Nucleic Acids Res. 2014 Jan;42(2):1026-41. doi: 10.1093/nar/gkt948. Epub 2013 Oct 25.


Calling, courtship, and condition in the fall field cricket, Gryllus pennsylvanicus.

Harrison SJ, Thomson IR, Grant CM, Bertram SM.

PLoS One. 2013;8(3):e60356. doi: 10.1371/journal.pone.0060356. Epub 2013 Mar 20.


Quantitative analysis of chaperone network throughput in budding yeast.

Brownridge P, Lawless C, Payapilly AB, Lanthaler K, Holman SW, Harman VM, Grant CM, Beynon RJ, Hubbard SJ.

Proteomics. 2013 Apr;13(8):1276-91. doi: 10.1002/pmic.201200412. Epub 2013 Mar 15.


The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome.

Zhai C, Li Y, Mascarenhas C, Lin Q, Li K, Vyrides I, Grant CM, Panaretou B.

Oncogene. 2014 Jan 23;33(4):484-94. doi: 10.1038/onc.2012.604. Epub 2013 Jan 14.


Arsenite interferes with protein folding and triggers formation of protein aggregates in yeast.

Jacobson T, Navarrete C, Sharma SK, Sideri TC, Ibstedt S, Priya S, Grant CM, Christen P, Goloubinoff P, Tamás MJ.

J Cell Sci. 2012 Nov 1;125(Pt 21):5073-83. doi: 10.1242/jcs.107029. Epub 2012 Sep 3.


Cytosolic thioredoxin system facilitates the import of mitochondrial small Tim proteins.

Durigon R, Wang Q, Ceh Pavia E, Grant CM, Lu H.

EMBO Rep. 2012 Oct;13(10):916-22. doi: 10.1038/embor.2012.116. Epub 2012 Aug 10.


Oxidation of the yeast mitochondrial thioredoxin promotes cell death.

Greetham D, Kritsiligkou P, Watkins RH, Carter Z, Parkin J, Grant CM.

Antioxid Redox Signal. 2013 Feb 1;18(4):376-85. doi: 10.1089/ars.2012.4597. Epub 2012 Aug 27.


Public health and biosecurity. Adaptations of avian flu virus are a cause for concern.

Berns KI, Casadevall A, Cohen ML, Ehrlich SA, Enquist LW, Fitch JP, Franz DR, Fraser-Liggett CM, Grant CM, Imperiale MJ, Kanabrocki J, Keim PS, Lemon SM, Levy SB, Lumpkin JR, Miller JF, Murch R, Nance ME, Osterholm MT, Relman DA, Roth JA, Vidaver AK.

Science. 2012 Feb 10;335(6069):660-1. doi: 10.1126/science.1217994. Epub 2012 Jan 31. No abstract available.


Policy: Adaptations of avian flu virus are a cause for concern.

Berns KI, Casadevall A, Cohen ML, Ehrlich SA, Enquist LW, Fitch JP, Franz DR, Fraser-Liggett CM, Grant CM, Imperiale MJ, Kanabrocki J, Keim PS, Lemon SM, Levy SB, Lumpkin JR, Miller JF, Murch R, Nance ME, Osterholm MT, Relman DA, Roth JA, Vidaver AK.

Nature. 2012 Jan 31;482(7384):153-4. doi: 10.1038/482153a. No abstract available.


The response to heat shock and oxidative stress in Saccharomyces cerevisiae.

Morano KA, Grant CM, Moye-Rowley WS.

Genetics. 2012 Apr;190(4):1157-95. doi: 10.1534/genetics.111.128033. Epub 2011 Dec 29. Review.


Methionine oxidation of Sup35 protein induces formation of the [PSI+] prion in a yeast peroxiredoxin mutant.

Sideri TC, Koloteva-Levine N, Tuite MF, Grant CM.

J Biol Chem. 2011 Nov 11;286(45):38924-31. doi: 10.1074/jbc.M111.272419. Epub 2011 Aug 9.


Global absolute quantification of a proteome: Challenges in the deployment of a QconCAT strategy.

Brownridge P, Holman SW, Gaskell SJ, Grant CM, Harman VM, Hubbard SJ, Lanthaler K, Lawless C, O'Cualain R, Sims P, Watkins R, Beynon RJ.

Proteomics. 2011 Aug;11(15):2957-70. doi: 10.1002/pmic.201100039. Epub 2011 Jun 28. Review.


Regulation of translation by hydrogen peroxide.

Grant CM.

Antioxid Redox Signal. 2011 Jul 1;15(1):191-203. doi: 10.1089/ars.2010.3699. Epub 2011 Apr 10. Review.


The critical role of glutathione in maintenance of the mitochondrial genome.

Ayer A, Tan SX, Grant CM, Meyer AJ, Dawes IW, Perrone GG.

Free Radic Biol Med. 2010 Dec 15;49(12):1956-68. doi: 10.1016/j.freeradbiomed.2010.09.023. Epub 2010 Sep 29.


Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins.

Cridge AG, Castelli LM, Smirnova JB, Selley JN, Rowe W, Hubbard SJ, McCarthy JE, Ashe MP, Grant CM, Pavitt GD.

Nucleic Acids Res. 2010 Dec;38(22):8039-50. doi: 10.1093/nar/gkq686. Epub 2010 Aug 12.


Ribosome-associated peroxiredoxins suppress oxidative stress-induced de novo formation of the [PSI+] prion in yeast.

Sideri TC, Stojanovski K, Tuite MF, Grant CM.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6394-9. doi: 10.1073/pnas.1000347107. Epub 2010 Mar 22.


Thioredoxins function as deglutathionylase enzymes in the yeast Saccharomyces cerevisiae.

Greetham D, Vickerstaff J, Shenton D, Perrone GG, Dawes IW, Grant CM.

BMC Biochem. 2010 Jan 14;11:3. doi: 10.1186/1471-2091-11-3.

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