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Adipocyte lipolysis affects Perilipin 5 and cristae organization at the cardiac lipid droplet-mitochondrial interface.

Varghese M, Kimler VA, Ghazi FR, Rathore GK, Perkins GA, Ellisman MH, Granneman JG.

Sci Rep. 2019 Mar 18;9(1):4734. doi: 10.1038/s41598-019-41329-4.


Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop.

Goldberg IJ, Reue K, Abumrad NA, Bickel PE, Cohen S, Fisher EA, Galis ZS, Granneman JG, Lewandowski ED, Murphy R, Olive M, Schaffer JE, Schwartz-Longacre L, Shulman GI, Walther TC, Chen J.

Circulation. 2018 Jul 17;138(3):305-315. doi: 10.1161/CIRCULATIONAHA.118.033704. Review.


Deconstructing Adipogenesis Induced by β3-Adrenergic Receptor Activation with Single-Cell Expression Profiling.

Burl RB, Ramseyer VD, Rondini EA, Pique-Regi R, Lee YH, Granneman JG.

Cell Metab. 2018 Aug 7;28(2):300-309.e4. doi: 10.1016/j.cmet.2018.05.025. Epub 2018 Jun 21.


Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis.

Babaei R, Schuster M, Meln I, Lerch S, Ghandour RA, Pisani DF, Bayindir-Buchhalter I, Marx J, Wu S, Schoiswohl G, Billeter AT, Krunic D, Mauer J, Lee YH, Granneman JG, Fischer L, Müller-Stich BP, Amri EZ, Kershaw EE, Heikenwälder M, Herzig S, Vegiopoulos A.

Sci Signal. 2018 Apr 24;11(527). pii: eaai7838. doi: 10.1126/scisignal.aai7838.


SERCA2b Cycles Its Way to UCP1-Independent Thermogenesis in Beige Fat.

Mottillo EP, Ramseyer VD, Granneman JG.

Cell Metab. 2018 Jan 9;27(1):7-9. doi: 10.1016/j.cmet.2017.12.015.


Vacuolar protein sorting 13C is a novel lipid droplet protein that inhibits lipolysis in brown adipocytes.

Ramseyer VD, Kimler VA, Granneman JG.

Mol Metab. 2018 Jan;7:57-70. doi: 10.1016/j.molmet.2017.10.014. Epub 2017 Nov 12.


Loss of ABHD5 promotes the aggressiveness of prostate cancer cells.

Chen G, Zhou G, Aras S, He Z, Lucas S, Podgorski I, Skar W, Granneman JG, Wang J.

Sci Rep. 2017 Oct 12;7(1):13021. doi: 10.1038/s41598-017-13398-w.


Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes.

Rondini EA, Mladenovic-Lucas L, Roush WR, Halvorsen GT, Green AE, Granneman JG.

J Pharmacol Exp Ther. 2017 Dec;363(3):367-376. doi: 10.1124/jpet.117.243253. Epub 2017 Sep 19.


Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue.

Kim SN, Kwon HJ, Im SW, Son YH, Akindehin S, Jung YS, Lee SJ, Rhyu IJ, Kim IY, Seong JK, Lee J, Yoo HC, Granneman JG, Lee YH.

Sci Rep. 2017 Aug 2;7(1):7159. doi: 10.1038/s41598-017-07658-y.


FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis.

Mottillo EP, Desjardins EM, Fritzen AM, Zou VZ, Crane JD, Yabut JM, Kiens B, Erion DM, Lanba A, Granneman JG, Talukdar S, Steinberg GR.

Mol Metab. 2017 Apr 5;6(6):471-481. doi: 10.1016/j.molmet.2017.04.001. eCollection 2017 Jun.


Lipid droplet biology and evolution illuminated by the characterization of a novel perilipin in teleost fish.

Granneman JG, Kimler VA, Zhang H, Ye X, Luo X, Postlethwait JH, Thummel R.

Elife. 2017 Feb 28;6. pii: e21771. doi: 10.7554/eLife.21771.


Molecular Basis of ABHD5 Lipolysis Activation.

Sanders MA, Zhang H, Mladenovic L, Tseng YY, Granneman JG.

Sci Rep. 2017 Feb 17;7:42589. doi: 10.1038/srep42589.


Metabolic heterogeneity of activated beige/brite adipocytes in inguinal adipose tissue.

Lee YH, Kim SN, Kwon HJ, Granneman JG.

Sci Rep. 2017 Jan 3;7:39794. doi: 10.1038/srep39794.


Sex differences in sympathetic innervation and browning of white adipose tissue of mice.

Kim SN, Jung YS, Kwon HJ, Seong JK, Granneman JG, Lee YH.

Biol Sex Differ. 2016 Dec 9;7:67. doi: 10.1186/s13293-016-0121-7. eCollection 2016.


Sympathetic Innervation of Cold-Activated Brown and White Fat in Lean Young Adults.

Muzik O, Mangner TJ, Leonard WR, Kumar A, Granneman JG.

J Nucl Med. 2017 May;58(5):799-806. doi: 10.2967/jnumed.116.180992. Epub 2016 Oct 27.


Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.

Mottillo EP, Desjardins EM, Crane JD, Smith BK, Green AE, Ducommun S, Henriksen TI, Rebalka IA, Razi A, Sakamoto K, Scheele C, Kemp BE, Hawke TJ, Ortega J, Granneman JG, Steinberg GR.

Cell Metab. 2016 Jul 12;24(1):118-29. doi: 10.1016/j.cmet.2016.06.006.


Adrenergic regulation of cellular plasticity in brown, beige/brite and white adipose tissues.

Ramseyer VD, Granneman JG.

Adipocyte. 2016 Feb 18;5(2):119-29. doi: 10.1080/21623945.2016.1145846. eCollection 2016 Apr-Jun. Review.


Renaissance of brown adipose tissue research: integrating the old and new.

Granneman JG.

Int J Obes Suppl. 2015 Aug;5(Suppl 1):S7-S10. doi: 10.1038/ijosup.2015.3. Epub 2015 Aug 4. Review.


Adipogenic role of alternatively activated macrophages in β-adrenergic remodeling of white adipose tissue.

Lee YH, Kim SN, Kwon HJ, Maddipati KR, Granneman JG.

Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R55-65. doi: 10.1152/ajpregu.00355.2015. Epub 2015 Nov 4.


Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle.

Sanders MA, Madoux F, Mladenovic L, Zhang H, Ye X, Angrish M, Mottillo EP, Caruso JA, Halvorsen G, Roush WR, Chase P, Hodder P, Granneman JG.

Cell Metab. 2015 Nov 3;22(5):851-60. doi: 10.1016/j.cmet.2015.08.023. Epub 2015 Sep 24.


Cellular origins of cold-induced brown adipocytes in adult mice.

Lee YH, Petkova AP, Konkar AA, Granneman JG.

FASEB J. 2015 Jan;29(1):286-99. doi: 10.1096/fj.14-263038. Epub 2014 Nov 12.


Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activity.

Zhang W, Mottillo EP, Zhao J, Gartung A, VanHecke GC, Lee JF, Maddipati KR, Xu H, Ahn YH, Proia RL, Granneman JG, Lee MJ.

J Biol Chem. 2014 Nov 14;289(46):32178-85. doi: 10.1074/jbc.M114.601096. Epub 2014 Sep 24.


Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation.

Mottillo EP, Balasubramanian P, Lee YH, Weng C, Kershaw EE, Granneman JG.

J Lipid Res. 2014 Nov;55(11):2276-86. doi: 10.1194/jlr.M050005. Epub 2014 Sep 5.


Inducible brown adipocytes in subcutaneous inguinal white fat: the role of continuous sympathetic stimulation.

Contreras GA, Lee YH, Mottillo EP, Granneman JG.

Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E793-9. doi: 10.1152/ajpendo.00033.2014. Epub 2014 Sep 2.


Use of fluorescence microscopy to probe intracellular lipolysis.

Mottillo EP, Paul GM, Moore HP, Granneman JG.

Methods Enzymol. 2014;538:263-78. doi: 10.1016/B978-0-12-800280-3.00015-3.


Exploring the activated adipogenic niche: interactions of macrophages and adipocyte progenitors.

Lee YH, Thacker RI, Hall BE, Kong R, Granneman JG.

Cell Cycle. 2014;13(2):184-90. doi: 10.4161/cc.27647. Epub 2014 Jan 6.


Identification of an adipogenic niche for adipose tissue remodeling and restoration.

Lee YH, Petkova AP, Granneman JG.

Cell Metab. 2013 Sep 3;18(3):355-67. doi: 10.1016/j.cmet.2013.08.003.


Analysis and correction of crosstalk effects in pathway analysis.

Donato M, Xu Z, Tomoiaga A, Granneman JG, Mackenzie RG, Bao R, Than NG, Westfall PH, Romero R, Draghici S.

Genome Res. 2013 Nov;23(11):1885-93. doi: 10.1101/gr.153551.112. Epub 2013 Aug 9.


Seeking the source of adipocytes in adult white adipose tissues.

Lee YH, Granneman JG.

Adipocyte. 2012 Oct 1;1(4):230-236.


Adipose tissue plasticity from WAT to BAT and in between.

Lee YH, Mottillo EP, Granneman JG.

Biochim Biophys Acta. 2014 Mar;1842(3):358-69. doi: 10.1016/j.bbadis.2013.05.011. Epub 2013 May 17. Review.


15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat.

Muzik O, Mangner TJ, Leonard WR, Kumar A, Janisse J, Granneman JG.

J Nucl Med. 2013 Apr;54(4):523-31. doi: 10.2967/jnumed.112.111336. Epub 2013 Jan 29.


Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.

Mottillo EP, Bloch AE, Leff T, Granneman JG.

J Biol Chem. 2012 Jul 20;287(30):25038-48. doi: 10.1074/jbc.M112.374041. Epub 2012 Jun 8.


Assessment of oxidative metabolism in brown fat using PET imaging.

Muzik O, Mangner TJ, Granneman JG.

Front Endocrinol (Lausanne). 2012 Feb 8;3:15. doi: 10.3389/fendo.2012.00015. eCollection 2012.


In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding.

Lee YH, Petkova AP, Mottillo EP, Granneman JG.

Cell Metab. 2012 Apr 4;15(4):480-91. doi: 10.1016/j.cmet.2012.03.009.


Intracellular fatty acids suppress β-adrenergic induction of PKA-targeted gene expression in white adipocytes.

Mottillo EP, Granneman JG.

Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E122-31. doi: 10.1152/ajpendo.00039.2011. Epub 2011 Apr 19.


Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase.

Granneman JG, Moore HP, Mottillo EP, Zhu Z, Zhou L.

J Biol Chem. 2011 Feb 18;286(7):5126-35. doi: 10.1074/jbc.M110.180711. Epub 2010 Dec 8.


PER2 controls lipid metabolism by direct regulation of PPARγ.

Grimaldi B, Bellet MM, Katada S, Astarita G, Hirayama J, Amin RH, Granneman JG, Piomelli D, Leff T, Sassone-Corsi P.

Cell Metab. 2010 Nov 3;12(5):509-20. doi: 10.1016/j.cmet.2010.10.005.


Cell Biology Symposium: imaging the organization and trafficking of lipolytic effectors in adipocytes.

Granneman JG, Kimler VA, Moore HP.

J Anim Sci. 2011 Mar;89(3):701-10. doi: 10.2527/jas.2010-3370. Epub 2010 Sep 17. Review.


beta3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK.

Mottillo EP, Shen XJ, Granneman JG.

Biochim Biophys Acta. 2010 Sep;1801(9):1048-55. doi: 10.1016/j.bbalip.2010.04.012. Epub 2010 May 7.


Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl).

Granneman JG, Moore HP, Krishnamoorthy R, Rathod M.

J Biol Chem. 2009 Dec 11;284(50):34538-44. doi: 10.1074/jbc.M109.068478. Epub 2009 Oct 22.


Functional interactions between Mldp (LSDP5) and Abhd5 in the control of intracellular lipid accumulation.

Granneman JG, Moore HP, Mottillo EP, Zhu Z.

J Biol Chem. 2009 Jan 30;284(5):3049-57. doi: 10.1074/jbc.M808251200. Epub 2008 Dec 8.


Delivery of DNA into adipocytes within adipose tissue.

Granneman JG.

Methods Mol Biol. 2008;423:191-5. doi: 10.1007/978-1-59745-194-9_13.


Location, location: protein trafficking and lipolysis in adipocytes.

Granneman JG, Moore HP.

Trends Endocrinol Metab. 2008 Jan;19(1):3-9. Epub 2007 Dec 26. Review.


Role of hormone-sensitive lipase in beta-adrenergic remodeling of white adipose tissue.

Mottillo EP, Shen XJ, Granneman JG.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1188-97. Epub 2007 Aug 21.


Analysis of lipolytic protein trafficking and interactions in adipocytes.

Granneman JG, Moore HP, Granneman RL, Greenberg AS, Obin MS, Zhu Z.

J Biol Chem. 2007 Feb 23;282(8):5726-35. Epub 2006 Dec 21.


Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase.

Moore HP, Silver RB, Mottillo EP, Bernlohr DA, Granneman JG.

J Biol Chem. 2005 Dec 30;280(52):43109-20. Epub 2005 Oct 21.


Metabolic and cellular plasticity in white adipose tissue I: effects of beta3-adrenergic receptor activation.

Granneman JG, Li P, Zhu Z, Lu Y.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E608-16. Epub 2005 Jun 7.


Metabolic and cellular plasticity in white adipose tissue II: role of peroxisome proliferator-activated receptor-alpha.

Li P, Zhu Z, Lu Y, Granneman JG.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E617-26. Epub 2005 Jun 7.


Seeing the trees in the forest: selective electroporation of adipocytes within adipose tissue.

Granneman JG, Li P, Lu Y, Tilak J.

Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E574-82. Epub 2004 May 4.


White adipose tissue contributes to UCP1-independent thermogenesis.

Granneman JG, Burnazi M, Zhu Z, Schwamb LA.

Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1230-6. Epub 2003 Sep 3.

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