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Items: 1 to 50 of 96

1.

Selective and Wash-Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single-Molecule Imaging of μ-Opioid Receptor Dimerization.

Gentzsch C, Seier K, Drakopoulos A, Jobin ML, Lanoiselée Y, Koszegi Z, Maurel D, Sounier R, Hübner H, Gmeiner P, Granier S, Calebiro D, Decker M.

Angew Chem Int Ed Engl. 2019 Dec 6. doi: 10.1002/anie.201912683. [Epub ahead of print]

PMID:
31808251
2.

Phenotypic and Genotypic Antimicrobial Resistance Traits of Vibrio cholerae Non-O1/Non-O139 Isolated From a Large Austrian Lake Frequently Associated With Cases of Human Infection.

Lepuschitz S, Baron S, Larvor E, Granier SA, Pretzer C, Mach RL, Farnleitner AH, Ruppitsch W, Pleininger S, Indra A, Kirschner AKT.

Front Microbiol. 2019 Nov 8;10:2600. doi: 10.3389/fmicb.2019.02600. eCollection 2019.

3.

Occurrence of Third-Generation Cephalosporins-Resistant Klebsiella pneumoniae in Fresh Fruits and Vegetables Purchased at Markets in Algeria.

Mesbah Zekar F, Granier SA, Touati A, Millemann Y.

Microb Drug Resist. 2019 Oct 11. doi: 10.1089/mdr.2019.0249. [Epub ahead of print]

PMID:
31603740
4.

Familial pancreatic adenocarcinoma: A retrospective analysis of germline genetic testing in a French multicentre cohort.

Schwartz M, Korenbaum C, Benfoda M, Mary M, Colas C, Coulet F, Parrin M, Jonveaux P, Ingster O, Granier S, De Mestier L, Cros J, Riffault A, Muller M, Levy P, Rebours V, Greenhalf W, Soufir N, Hammel P.

Clin Genet. 2019 Dec;96(6):579-584. doi: 10.1111/cge.13629. Epub 2019 Sep 3.

PMID:
31432501
5.

Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.

Hawkey J, Le Hello S, Doublet B, Granier SA, Hendriksen RS, Fricke WF, Ceyssens PJ, Gomart C, Billman-Jacobe H, Holt KE, Weill FX.

Microb Genom. 2019 Jul;5(7). doi: 10.1099/mgen.0.000269. Epub 2019 May 20.

6.

7TM proteins are not necessarily GPCRs.

Vasiliauskaité-Brooks I, Healey RD, Granier S.

Mol Cell Endocrinol. 2019 Jul 1;491:110397. doi: 10.1016/j.mce.2019.02.009. Epub 2019 Apr 24. Review.

PMID:
31026477
7.

Genetic Diversity of Salmonella Derby from the Poultry Sector in Europe.

Sévellec Y, Felten A, Radomski N, Granier SA, Le Hello S, Petrovska L, Mistou MY, Cadel-Six S.

Pathogens. 2019 Apr 4;8(2). pii: E46. doi: 10.3390/pathogens8020046.

8.

GNAS: A New Nephrogenic Cause of Inappropriate Antidiuresis.

Bichet DG, Granier S, Bockenhauer D.

J Am Soc Nephrol. 2019 May;30(5):722-725. doi: 10.1681/ASN.2019020143. Epub 2019 Apr 8. No abstract available.

PMID:
30962326
9.

Correction for Sévellec et al., "Complete Genome Sequence of Salmonella enterica subsp. enterica Serotype Derby, Associated with the Pork Sector in France".

Sévellec Y, Granier SA, Radomski N, Felten A, Le Hello S, Feurer C, Mistou MY, Cadel-Six S.

Microbiol Resour Announc. 2019 Jan 3;8(1). pii: e01597-18. doi: 10.1128/MRA.01597-18. eCollection 2019 Jan.

10.

French legal approach to clinical research.

Toulouse E, Masseguin C, Lafont B, McGurk G, Harbonn A, A Roberts J, Granier S, Dupeyron A, Bazin JE.

Anaesth Crit Care Pain Med. 2018 Dec;37(6):607-614. doi: 10.1016/j.accpm.2018.10.013. Epub 2018 Oct 25. Review.

PMID:
30580775
11.

Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy.

Vasiliauskaité-Brooks I, Healey RD, Rochaix P, Saint-Paul J, Sounier R, Grison C, Waltrich-Augusto T, Fortier M, Hoh F, Saied EM, Arenz C, Basu S, Leyrat C, Granier S.

Nat Commun. 2018 Dec 21;9(1):5437. doi: 10.1038/s41467-018-07864-w.

12.

Complete Genome Sequence of Salmonella enterica subsp. enterica Serotype Derby, Associated with the Pork Sector in France.

Sévellec Y, Granier SA, Radomski N, Felten A, Le Hello S, Feurer C, Mistou MY, Cadel-Six S.

Microbiol Resour Announc. 2018 Sep 27;7(12). pii: e01027-18. doi: 10.1128/MRA.01027-18. eCollection 2018 Sep. Erratum in: Microbiol Resour Announc. 2019 Jan 3;8(1):.

13.

Adjuvant chemotherapy with gemcitabine plus erlotinib vs. gemcitabine alone for patients with resected pancreatic ductal adenocarcinoma: is there a role for erlotinib?-review of the open label phase III trial CONKO 005.

Wisniewski M, Placide PA, Granier S, Al Shatti Y, Al Qalaf S, Bouattour M, Lamuraglia M, Hammel P.

Hepatobiliary Surg Nutr. 2018 Oct;7(5):399-402. doi: 10.21037/hbsn.2018.08.03. No abstract available.

14.

Structure of the µ-opioid receptor-Gi protein complex.

Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK.

Nature. 2018 Jun;558(7711):547-552. doi: 10.1038/s41586-018-0219-7. Epub 2018 Jun 13.

15.

Polyphyletic Nature of Salmonella enterica Serotype Derby and Lineage-Specific Host-Association Revealed by Genome-Wide Analysis.

Sévellec Y, Vignaud ML, Granier SA, Lailler R, Feurer C, Le Hello S, Mistou MY, Cadel-Six S.

Front Microbiol. 2018 May 17;9:891. doi: 10.3389/fmicb.2018.00891. eCollection 2018.

16.

NDM-1-producing Vibrio parahaemolyticus isolated from imported seafood.

Briet A, Helsens N, Delannoy S, Debuiche S, Brisabois A, Midelet G, Granier SA.

J Antimicrob Chemother. 2018 Sep 1;73(9):2578-2579. doi: 10.1093/jac/dky200. No abstract available.

PMID:
29796645
17.

Bacillus cereus, a serious cause of nosocomial infections: Epidemiologic and genetic survey.

Glasset B, Herbin S, Granier SA, Cavalié L, Lafeuille E, Guérin C, Ruimy R, Casagrande-Magne F, Levast M, Chautemps N, Decousser JW, Belotti L, Pelloux I, Robert J, Brisabois A, Ramarao N.

PLoS One. 2018 May 23;13(5):e0194346. doi: 10.1371/journal.pone.0194346. eCollection 2018.

18.

Multiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes.

Rebelo AR, Bortolaia V, Kjeldgaard JS, Pedersen SK, Leekitcharoenphon P, Hansen IM, Guerra B, Malorny B, Borowiak M, Hammerl JA, Battisti A, Franco A, Alba P, Perrin-Guyomard A, Granier SA, De Frutos Escobar C, Malhotra-Kumar S, Villa L, Carattoli A, Hendriksen RS.

Euro Surveill. 2018 Feb;23(6). doi: 10.2807/1560-7917.ES.2018.23.6.17-00672. Erratum in: Euro Surveill. 2018 Feb;23(7):.

19.

Illustrative examples of probable transfer of resistance determinants from food animals to humans: Streptothricins, glycopeptides, and colistin.

Webb HE, Angulo FJ, Granier SA, Scott HM, Loneragan GH.

F1000Res. 2017 Oct 5;6:1805. doi: 10.12688/f1000research.12777.1. eCollection 2017. Review.

20.

Salmonella in Peripheral Lymph Nodes of Healthy Cattle at Slaughter.

Webb HE, Brichta-Harhay DM, Brashears MM, Nightingale KK, Arthur TM, Bosilevac JM, Kalchayanand N, Schmidt JW, Wang R, Granier SA, Brown TR, Edrington TS, Shackelford SD, Wheeler TL, Loneragan GH.

Front Microbiol. 2017 Nov 9;8:2214. doi: 10.3389/fmicb.2017.02214. eCollection 2017.

21.

Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering.

Renner M, Paesen GC, Grison CM, Granier S, Grimes JM, Leyrat C.

Sci Rep. 2017 Nov 1;7(1):14865. doi: 10.1038/s41598-017-14448-z.

22.

Antimicrobial Susceptibility among Urban Wastewater and Wild Shellfish Isolates of Non-O1/Non-O139 Vibrio cholerae from La Rance Estuary (Brittany, France).

Baron S, Larvor E, Chevalier S, Jouy E, Kempf I, Granier SA, Lesne J.

Front Microbiol. 2017 Sep 12;8:1637. doi: 10.3389/fmicb.2017.01637. eCollection 2017.

23.

From Farms to Markets: Gram-Negative Bacteria Resistant to Third-Generation Cephalosporins in Fruits and Vegetables in a Region of North Africa.

Mesbah Zekar F, Granier SA, Marault M, Yaici L, Gassilloud B, Manceau C, Touati A, Millemann Y.

Front Microbiol. 2017 Aug 24;8:1569. doi: 10.3389/fmicb.2017.01569. eCollection 2017.

24.

Aeromonas Diversity and Antimicrobial Susceptibility in Freshwater-An Attempt to Set Generic Epidemiological Cut-Off Values.

Baron S, Granier SA, Larvor E, Jouy E, Cineux M, Wilhelm A, Gassilloud B, Le Bouquin S, Kempf I, Chauvin C.

Front Microbiol. 2017 Mar 28;8:503. doi: 10.3389/fmicb.2017.00503. eCollection 2017.

25.

Structural insights into adiponectin receptors suggest ceramidase activity.

Vasiliauskaité-Brooks I, Sounier R, Rochaix P, Bellot G, Fortier M, Hoh F, De Colibus L, Bechara C, Saied EM, Arenz C, Leyrat C, Granier S.

Nature. 2017 Apr 6;544(7648):120-123. doi: 10.1038/nature21714. Epub 2017 Mar 22.

26.

1H, 13C and 15N backbone chemical shift assignments of camelid single-domain antibodies against active state µ-opioid receptor.

Sounier R, Yang Y, Hagelberger J, Granier S, Déméné H.

Biomol NMR Assign. 2017 Apr;11(1):117-121. doi: 10.1007/s12104-017-9733-z. Epub 2017 Feb 26.

27.

MACVIA-LR (Fighting Chronic Diseases for Active and Healthy Ageing in Languedoc-Roussillon): A Success Story of the European Innovation Partnership on Active and Healthy Ageing.

Bousquet J, Bourret R, Camuzat T, Augé P, Bringer J, Noguès M, Jonquet O, de la Coussaye JE, Ankri J, Cesari M, Guérin O, Vellas B, Blain H, Arnavielhe S, Avignon A, Combe B, Canovas G, Daien C, Dray G, Dupeyron A, Jeandel C, Laffont I, Laune D, Marion C, Pastor E, Pélissier JY, Galan B, Reynes J, Reuzeau JC, Bedbrook A, Granier S, Adnet PA, Amouyal M, Alomène B, Bernard PL, Berr C, Caimmi D, Claret PG, Costa DJ, Cristol JP, Fesler P, Hève D, Millot-Keurinck J, Morquin D, Ninot G, Picot MC, Raffort N, Roubille F, Sultan A, Touchon J, Attalin V, Azevedo C, Badin M, Bakhti K, Bardy B, Battesti MP, Bobia X, Boegner C, Boichot S, Bonnin HY, Bouly S, Boubakri C, Bourrain JL, Bourrel G, Bouix V, Bruguière V, Cade S, Camu W, Carre V, Cavalli G, Cayla G, Chiron R, Coignard P, Coroian F, Costa P, Cottalorda J, Coulet B, Coupet AL, Courrouy-Michel MC, Courtet P, Cros V, Cuisinier F, Danko M, Dauenhauer P, Dauzat M, David M, Davy JM, Delignières D, Demoly P, Desplan J, Dujols P, Dupeyron G, Engberink O, Enjalbert M, Fattal C, Fernandes J, Fouletier M, Fraisse P, Gabrion P, Gellerat-Rogier M, Gelis A, Genis C, Giraudeau N, Goucham AY, Gouzi F, Gressard F, Gris JC, Guillot B, Guiraud D, Handweiler V, Hayot M, Hérisson C, Heroum C, Hoa D, Jacquemin S, Jaber S, Jakovenko D, Jorgensen C, Kouyoudjian P, Lamoureux R, Landreau L, Lapierre M, Larrey D, Laurent C, Léglise MS, Lemaitre JM, Le Quellec A, Leclercq F, Lehmann S, Lognos B, Lussert CM, Makinson A, Mandrick K, Mares P, Martin-Gousset P, Matheron A, Mathieu G, Meissonnier M, Mercier G, Messner P, Meunier C, Mondain M, Morales R, Morel J, Mottet D, Nérin P, Nicolas P, Nouvel F, Paccard D, Pandraud G, Pasdelou MP, Pasquié JL, Patte K, Perrey S, Pers YM, Portejoie F, Pujol JL, Quantin X, Quéré I, Ramdani S, Ribstein J, Rédini-Martinez I, Richard S, Ritchie K, Riso JP, Rivier F, Robine JM, Rolland C, Royère E, Sablot D, Savy JL, Schifano L, Senesse P, Sicard R, Stephan Y, Strubel D, Tallon G, Tanfin M, Tassery H, Tavares I, Torre K, Tribout V, Uziel A, Van de Perre P, Venail F, Vergne-Richard C, Vergotte G, Vian L, Vialla F, Viart F, Villain M, Viollet E, Ychou M, Mercier J.

J Frailty Aging. 2016;5(4):233-241.

PMID:
27883170
28.

Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design.

Broad J, Maurel D, Kung VW, Hicks GA, Schemann M, Barnes MR, Kenakin TP, Granier S, Sanger GJ.

Sci Rep. 2016 Aug 5;6:30797. doi: 10.1038/srep30797.

29.

Carbapenem-Resistant Bacteria Recovered from Faeces of Dairy Cattle in the High Plains Region of the USA.

Webb HE, Bugarel M, den Bakker HC, Nightingale KK, Granier SA, Scott HM, Loneragan GH.

PLoS One. 2016 Jan 29;11(1):e0147363. doi: 10.1371/journal.pone.0147363. eCollection 2016.

30.

Dissemination of the mcr-1 colistin resistance gene.

Webb HE, Granier SA, Marault M, Millemann Y, den Bakker HC, Nightingale KK, Bugarel M, Ison SA, Scott HM, Loneragan GH.

Lancet Infect Dis. 2016 Feb;16(2):144-5. doi: 10.1016/S1473-3099(15)00538-1. Epub 2015 Dec 18. No abstract available.

PMID:
26711363
31.

Do endoflip assessments of anal sphincter distensibility provide more information on patients with fecal incontinence than high-resolution anal manometry?

Gourcerol G, Granier S, Bridoux V, Menard JF, Ducrotté P, Leroi AM.

Neurogastroenterol Motil. 2016 Mar;28(3):399-409. doi: 10.1111/nmo.12740. Epub 2015 Dec 15.

PMID:
26670599
32.

Contribution of Avian Salmonella enterica Isolates to Human Salmonellosis Cases in Constantine (Algeria).

Elgroud R, Granier SA, Marault M, Kerouanton A, Lezzar A, Bouzitouna-Bentchouala C, Brisabois A, Millemann Y.

Biomed Res Int. 2015;2015:352029. doi: 10.1155/2015/352029. Epub 2015 Oct 12.

33.

[Living Lab MACVIA-LR. Equilibrium and the prevention of falls].

Blain H, Léglise MS, Bernard PL, Dupeyron A, Pastor E, Strubel D, Akbaraly T, Abecassis F, Adnet PA, Alomène B, Amouyal M, Bardy B, Battesti MP, Baptista G, Boubakri C, Burille J, Calmels MV, Canovas G, Combe B, Delignières D, Dupeyron G, Engberink O, Gressard F, Heve D, Jakovenko D, Jeandel C, Lapierre M, Laffont I, Laurent C, Lognos B, Lussert JM, Mandrick K, Marmelat V, Martin-Gousset P, Matheron A, Mercier G, Meunier C, Morel J, Ninot G, Nouvel F, Pasdelou MP, Pélissier JY, Perrey S, Picot MC, Pinto N, Raffort N, Ramdani S, Radier-Pontal F, Royère E, Rédini-Martinez I, Robine JM, Roux E, Savy JL, Stephan Y, Tallon G, Torre K, Verdier JM, Vergotte G, Viollet E, Bedbrook A, Granier S, Camuzat T, Bourret R, Jonquet O, de la Coussaye JE, Noguès M, Aoustin M, Domy P, Bringer J, Mercier J, Bousquet J.

Presse Med. 2015 Nov;44 Suppl 1:S23-30. doi: 10.1016/j.lpm.2015.07.012. Epub 2015 Oct 21. French. No abstract available.

PMID:
26482487
34.

[Living Lab MACVIA. Chronic diseases].

Avignon A, Fesler P, Daien C, Costa D, Picot MC, Roubille F, Sultan A, Viarouge-Reunier C, Attalin V, Badin M, Boegner C, Demoly P, Dauzat M, David M, Lognos B, Morel J, Pasquié JL, Ribstein J, Granier S, Combe B, Mercier J, Bourret R, Bousquet J.

Presse Med. 2015 Nov;44 Suppl 1:S47-54. doi: 10.1016/j.lpm.2015.07.009. Epub 2015 Oct 23. French. No abstract available.

PMID:
26476755
35.

Are Salmonella-Induced Gastroenteritis Neglected in Developing Countries? Feedback from Microbiological Investigations in N'Djamena Hospitals, Chad.

Tabo DA, Granier SA, Diguimbaye CD, Marault M, Brisabois A, Mama B, Millemann Y.

PLoS One. 2015 Aug 27;10(8):e0136153. doi: 10.1371/journal.pone.0136153. eCollection 2015.

36.

Structural insights into µ-opioid receptor activation.

Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK.

Nature. 2015 Aug 20;524(7565):315-21. doi: 10.1038/nature14886. Epub 2015 Aug 5.

37.

Propagation of conformational changes during μ-opioid receptor activation.

Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S.

Nature. 2015 Aug 20;524(7565):375-8. doi: 10.1038/nature14680. Epub 2015 Aug 5.

38.

Comment on "impact of antibiotic use in the swine industry", by Mary D. Barton [Curr. Opin. Microbiol. 19 (June 2014) 9-15].

Kempf I, Jouy E, Granier SA, Chauvin C, Sanders P, Salvat G, Madec JY.

Curr Opin Microbiol. 2015 Aug;26:137-8. doi: 10.1016/j.mib.2015.06.013. Epub 2015 Jul 10. No abstract available.

PMID:
26165457
39.

Amphipols in G protein-coupled receptor pharmacology: what are they good for?

Mary S, Damian M, Rahmeh R, Mouillac B, Marie J, Granier S, Banères JL.

J Membr Biol. 2014 Oct;247(9-10):853-60. doi: 10.1007/s00232-014-9665-9. Epub 2014 May 7. Review.

PMID:
24801284
40.

The global establishment of a highly-fluoroquinolone resistant Salmonella enterica serotype Kentucky ST198 strain.

Le Hello S, Bekhit A, Granier SA, Barua H, Beutlich J, Zając M, Münch S, Sintchenko V, Bouchrif B, Fashae K, Pinsard JL, Sontag L, Fabre L, Garnier M, Guibert V, Howard P, Hendriksen RS, Christensen JP, Biswas PK, Cloeckaert A, Rabsch W, Wasyl D, Doublet B, Weill FX.

Front Microbiol. 2013 Dec 18;4:395. doi: 10.3389/fmicb.2013.00395. eCollection 2013.

41.

Use of quantitative microbial risk assessment when investigating foodborne illness outbreaks: the example of a monophasic Salmonella Typhimurium 4,5,12:i:- outbreak implicating beef burgers.

Guillier L, Danan C, Bergis H, Delignette-Muller ML, Granier S, Rudelle S, Beaufort A, Brisabois A.

Int J Food Microbiol. 2013 Sep 16;166(3):471-8. doi: 10.1016/j.ijfoodmicro.2013.08.006. Epub 2013 Aug 19.

PMID:
24036262
42.

Genetic diversity and antimicrobial resistance profiles of Salmonella enterica serotype derby isolated from pigs, pork, and humans in France.

Kerouanton A, Rose V, Weill FX, Granier SA, Denis M.

Foodborne Pathog Dis. 2013 Nov;10(11):977-84. doi: 10.1089/fpd.2013.1537. Epub 2013 Aug 14.

PMID:
23944749
43.

Prevalence and antimicrobial resistance of non-typhoidal Salmonella serotypes isolated from laying hens and broiler chicken farms in N'Djamena, Chad.

Tabo DA, Diguimbaye CD, Granier SA, Moury F, Brisabois A, Elgroud R, Millemann Y.

Vet Microbiol. 2013 Sep 27;166(1-2):293-8. doi: 10.1016/j.vetmic.2013.05.010. Epub 2013 Jun 7.

PMID:
23810700
44.

Occurrence of Listeria spp. in retail meat and dairy products in the area of Addis Ababa, Ethiopia.

Derra FA, Karlsmose S, Monga DP, Mache A, Svendsen CA, Félix B, Granier SA, Geyid A, Taye G, Hendriksen RS.

Foodborne Pathog Dis. 2013 Jun;10(6):577-9. doi: 10.1089/fpd.2012.1361. Epub 2013 Jun 6.

PMID:
23742294
45.

Attribution of the French human Salmonellosis cases to the main food-sources according to the type of surveillance data.

David JM, Sanders P, Bemrah N, Granier SA, Denis M, Weill FX, Guillemot D, Watier L.

Prev Vet Med. 2013 May 15;110(1):12-27. doi: 10.1016/j.prevetmed.2013.02.002. Epub 2013 Feb 28.

46.

[Structure of mu and delta opioid receptors].

Granier S.

Med Sci (Paris). 2012 Oct;28(10):870-5. doi: 10.1051/medsci/20122810016. Epub 2012 Oct 12. Review. French.

47.

Salmonella enterica subsp. enterica isolated from chicken carcasses and environment at slaughter in Reunion Island: prevalence, genetic characterization and antibiotic susceptibility.

Henry I, Granier S, Courtillon C, Lalande F, Chemaly M, Salvat G, Cardinale E.

Trop Anim Health Prod. 2013 Jan;45(1):317-26. doi: 10.1007/s11250-012-0221-2. Epub 2012 Jul 19.

PMID:
23011670
48.

Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling.

El Moustaine D, Granier S, Doumazane E, Scholler P, Rahmeh R, Bron P, Mouillac B, Banères JL, Rondard P, Pin JP.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16342-7. doi: 10.1073/pnas.1205838109. Epub 2012 Sep 17.

49.

A new era of GPCR structural and chemical biology.

Granier S, Kobilka B.

Nat Chem Biol. 2012 Jul 18;8(8):670-3. doi: 10.1038/nchembio.1025.

50.

Structure of the δ-opioid receptor bound to naltrindole.

Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK.

Nature. 2012 May 16;485(7398):400-4. doi: 10.1038/nature11111.

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