Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 171

1.

Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study.

Ledreux A, Hkansson K, Carlsson R, Kidane M, Columbo L, Terjestam Y, Ryan E, Tusch E, Winblad B, Daffner K, Granholm AC, Mohammed AKH.

J Alzheimers Dis. 2019 Sep 5. doi: 10.3233/JAD-190756. [Epub ahead of print]

PMID:
31498125
2.

Exosome release and cargo in Down syndrome.

Hamlett ED, LaRosa A, Mufson EJ, Fortea J, Ledreux A, Granholm AC.

Dev Neurobiol. 2019 Jul 25. doi: 10.1002/dneu.22712. [Epub ahead of print] Review.

PMID:
31347291
3.

Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy.

Goetzl EJ, Ledreux A, Granholm AC, Elahi FM, Goetzl L, Hiramoto J, Kapogiannis D.

Front Neurosci. 2019 May 8;13:452. doi: 10.3389/fnins.2019.00452. eCollection 2019.

4.

Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury.

Goetzl EJ, Elahi FM, Mustapic M, Kapogiannis D, Pryhoda M, Gilmore A, Gorgens KA, Davidson B, Granholm AC, Ledreux A.

FASEB J. 2019 Apr;33(4):5082-5088. doi: 10.1096/fj.201802319R. Epub 2019 Jan 3.

PMID:
30605353
5.

A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats.

Bharani KL, Derex R, Granholm AC, Ledreux A.

PLoS One. 2017 Dec 19;12(12):e0189821. doi: 10.1371/journal.pone.0189821. eCollection 2017.

6.

Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice.

Buhusi M, Etheredge C, Granholm AC, Buhusi CV.

Front Aging Neurosci. 2017 Aug 31;9:284. doi: 10.3389/fnagi.2017.00284. eCollection 2017.

7.

Exosomal biomarkers in Down syndrome and Alzheimer's disease.

Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC.

Free Radic Biol Med. 2018 Jan;114:110-121. doi: 10.1016/j.freeradbiomed.2017.08.028. Epub 2017 Sep 5. Review.

8.

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome.

Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona-Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, Lott IT, Granholm AC.

Alzheimers Dement. 2017 May;13(5):541-549. doi: 10.1016/j.jalz.2016.08.012. Epub 2016 Oct 15.

9.

BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function.

Håkansson K, Ledreux A, Daffner K, Terjestam Y, Bergman P, Carlsson R, Kivipelto M, Winblad B, Granholm AC, Mohammed AK.

J Alzheimers Dis. 2017;55(2):645-657.

10.

Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats.

Ledreux A, Wang X, Schultzberg M, Granholm AC, Freeman LR.

Behav Brain Res. 2016 Oct 1;312:294-304. doi: 10.1016/j.bbr.2016.06.012. Epub 2016 Jun 22.

PMID:
27343935
11.

Memory and hippocampal architecture following short-term midazolam in western diet-treated rats.

Rosenberger DS, Falangola MF, Ledreux A, Nie X, Suhre WM, Boger HA, Granholm AC.

Neurosci Lett. 2016 May 16;621:68-74. doi: 10.1016/j.neulet.2016.04.021. Epub 2016 Apr 11.

12.

Pilot Study and Review: Physiological Differences in BDNF, a Potential Biomarker in Males and Females with Autistic Disorder.

Spratt EG, Granholm AC, Carpenter LA, Boger HA, Papa CE, Logan S, Chaudhary H, Boatwright SW, Brady KT.

Int Neuropsychiatr Dis J. 2015;3(1):19-26. Epub 2014 Sep 24.

13.

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis.

Zhu M, Wang X, Hjorth E, Colas RA, Schroeder L, Granholm AC, Serhan CN, Schultzberg M.

Mol Neurobiol. 2016 May;53(4):2733-49. doi: 10.1007/s12035-015-9544-0. Epub 2015 Dec 9.

14.

BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson׳s disease.

Ledreux A, Boger HA, Hinson VK, Cantwell K, Granholm AC.

Brain Res. 2016 Jan 15;1631:34-45. doi: 10.1016/j.brainres.2015.11.028. Epub 2015 Nov 19.

PMID:
26607251
15.

Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome.

Hamlett ED, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AC.

Curr Alzheimer Res. 2016;13(1):35-52. Review.

16.

Histologic validation of locus coeruleus MRI contrast in post-mortem tissue.

Keren NI, Taheri S, Vazey EM, Morgan PS, Granholm AC, Aston-Jones GS, Eckert MA.

Neuroimage. 2015 Jun;113:235-45. doi: 10.1016/j.neuroimage.2015.03.020. Epub 2015 Mar 17.

17.

Designer receptors enhance memory in a mouse model of Down syndrome.

Fortress AM, Hamlett ED, Vazey EM, Aston-Jones G, Cass WA, Boger HA, Granholm AC.

J Neurosci. 2015 Jan 28;35(4):1343-53. doi: 10.1523/JNEUROSCI.2658-14.2015.

18.

Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study.

Nie X, Hamlett ED, Granholm AC, Hui ES, Helpern JA, Jensen JH, Boger HA, Collins HR, Falangola MF.

Magn Reson Imaging. 2015 May;33(4):437-47. doi: 10.1016/j.mri.2014.12.008. Epub 2014 Dec 16.

19.

Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus.

Cunningham MA, Wirth JR, Freeman LR, Boger HA, Granholm AC, Gilkeson GS.

J Neuroinflammation. 2014 Dec 16;11:171. doi: 10.1186/s12974-014-0171-x.

20.

Down syndrome and Alzheimer's disease: Common pathways, common goals.

Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, Reeves R, Sabbagh M, Silverman W, Tycko B, Whitten M, Wisniewski T.

Alzheimers Dement. 2015 Jun;11(6):700-9. doi: 10.1016/j.jalz.2014.10.007. Epub 2014 Dec 12.

21.

Intracranial atherosclerosis: correlation between in-vivo 3T high resolution MRI and pathology.

Turan TN, Rumboldt Z, Granholm AC, Columbo L, Welsh CT, Lopes-Virella MF, Spampinato MV, Brown TR.

Atherosclerosis. 2014 Dec;237(2):460-3. doi: 10.1016/j.atherosclerosis.2014.10.007. Epub 2014 Oct 17.

22.

At the interface of sensory and motor dysfunctions and Alzheimer's disease.

Albers MW, Gilmore GC, Kaye J, Murphy C, Wingfield A, Bennett DA, Boxer AL, Buchman AS, Cruickshanks KJ, Devanand DP, Duffy CJ, Gall CM, Gates GA, Granholm AC, Hensch T, Holtzer R, Hyman BT, Lin FR, McKee AC, Morris JC, Petersen RC, Silbert LC, Struble RG, Trojanowski JQ, Verghese J, Wilson DA, Xu S, Zhang LI.

Alzheimers Dement. 2015 Jan;11(1):70-98. doi: 10.1016/j.jalz.2014.04.514. Epub 2014 Jul 9. Review.

23.

Motion capture and associated novel measurement devices for movement function in humans and animal models.

Karakostas T, Granholm AC.

J Neurosci Methods. 2014 Jul 15;231:1-2. doi: 10.1016/j.jneumeth.2014.05.028. No abstract available.

PMID:
24930468
24.

Resolution of inflammation is altered in Alzheimer's disease.

Wang X, Zhu M, Hjorth E, Cortés-Toro V, Eyjolfsdottir H, Graff C, Nennesmo I, Palmblad J, Eriksdotter M, Sambamurti K, Fitzgerald JM, Serhan CN, Granholm AC, Schultzberg M.

Alzheimers Dement. 2015 Jan;11(1):40-50.e1-2. doi: 10.1016/j.jalz.2013.12.024. Epub 2014 Feb 12.

25.

Nerve growth factor metabolic dysfunction in Down's syndrome brains.

Iulita MF, Do Carmo S, Ower AK, Fortress AM, Flores Aguilar L, Hanna M, Wisniewski T, Granholm AC, Buhusi M, Busciglio J, Cuello AC.

Brain. 2014 Mar;137(Pt 3):860-72. doi: 10.1093/brain/awt372. Epub 2014 Feb 11.

26.

Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms.

Freeman LR, Haley-Zitlin V, Rosenberger DS, Granholm AC.

Nutr Neurosci. 2014 Nov;17(6):241-51. doi: 10.1179/1476830513Y.0000000092. Epub 2013 Nov 26. Review.

27.

Three-dimensional rodent motion analysis and neurodegenerative disorders.

Karakostas T, Hsiang S, Boger H, Middaugh L, Granholm AC.

J Neurosci Methods. 2014 Jul 15;231:31-7. doi: 10.1016/j.jneumeth.2013.09.009. Epub 2013 Oct 12.

28.

Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF.

Littrell OM, Granholm AC, Gerhardt GA, Boger HA.

Pharmacol Biochem Behav. 2013 Mar;104:10-9. doi: 10.1016/j.pbb.2012.12.022. Epub 2013 Jan 2.

29.

PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice.

Zhang Y, Granholm AC, Huh K, Shan L, Diaz-Ruiz O, Malik N, Olson L, Hoffer BJ, Lupica CR, Hoffman AF, Bäckman CM.

Brain. 2012 Sep;135(Pt 9):2736-49. doi: 10.1093/brain/aws196.

30.

Age-related neurodegeneration and memory loss in down syndrome.

Lockrow JP, Fortress AM, Granholm AC.

Curr Gerontol Geriatr Res. 2012;2012:463909. doi: 10.1155/2012/463909. Epub 2012 Mar 20.

31.

Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet.

Freeman LR, Granholm AC.

J Cereb Blood Flow Metab. 2012 Apr;32(4):643-53. doi: 10.1038/jcbfm.2011.168. Epub 2011 Nov 23.

32.

Use of seniors as mentors to medical students: a collaboration between the University of South Carolina School of Medicine and the Medical University of South Carolina.

Wiley MK, Granholm AC, Bachman D, Wieland D, Roberts E, Hardin R, Dever-Bumba M, Eleazer GP.

J S C Med Assoc. 2011 Feb;107(1):8-12. No abstract available.

PMID:
22057643
33.

Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats.

Fortress AM, Buhusi M, Helke KL, Granholm AC.

J Aging Res. 2011;2011:460543. doi: 10.4061/2011/460543. Epub 2011 Jul 11.

34.

Diet-induced effects on neuronal and glial elements in the middle-aged rat hippocampus.

Freeman LR, Haley-Zitlin V, Stevens C, Granholm AC.

Nutr Neurosci. 2011 Jan;14(1):32-44. doi: 10.1179/174313211X12966635733358.

35.

A high-fat/high-cholesterol diet inhibits growth of fetal hippocampal transplants via increased inflammation.

Freeman LR, Small BJ, Bickford PC, Umphlet C, Granholm AC.

Cell Transplant. 2011;20(10):1499-514. doi: 10.3727/096368910X557281. Epub 2011 Mar 7.

36.

Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice.

Littrell OM, Pomerleau F, Huettl P, Surgener S, McGinty JF, Middaugh LD, Granholm AC, Gerhardt GA, Boger HA.

Neurobiol Aging. 2012 Feb;33(2):427.e1-14. doi: 10.1016/j.neurobiolaging.2010.10.013. Epub 2010 Dec 8.

37.

A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model.

Lockrow J, Boger H, Gerhardt G, Aston-Jones G, Bachman D, Granholm AC.

J Alzheimers Dis. 2011;23(3):471-89. doi: 10.3233/JAD-2010-101218.

38.

Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice.

Granholm AC, Zaman V, Godbee J, Smith M, Ramadan R, Umphlet C, Randall P, Bhat NR, Rohrer B, Middaugh LD, Boger HA.

Brain Pathol. 2011 May;21(3):330-48. doi: 10.1111/j.1750-3639.2010.00457.x. Epub 2010 Dec 8.

39.

Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging.

Boger HA, Mannangatti P, Samuvel DJ, Saylor AJ, Bender TS, McGinty JF, Fortress AM, Zaman V, Huang P, Middaugh LD, Randall PK, Jayanthi LD, Rohrer B, Helke KL, Granholm AC, Ramamoorthy S.

Genes Brain Behav. 2011 Mar;10(2):186-98. doi: 10.1111/j.1601-183X.2010.00654.x. Epub 2010 Oct 19.

40.

Why do we need to use animal models to study cognition and aging?

Granholm AC.

Neuropsychopharmacology. 2010 Jul;35(8):1621-2. doi: 10.1038/npp.2010.45. No abstract available.

41.

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome.

Lockrow J, Boger H, Bimonte-Nelson H, Granholm AC.

Behav Brain Res. 2011 Aug 10;221(2):610-22. doi: 10.1016/j.bbr.2010.03.036. Epub 2010 Apr 2.

42.

Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts.

Willis LM, Freeman L, Bickford PC, Quintero EM, Umphlet CD, Moore AB, Goetzl L, Granholm AC.

Glia. 2010 Apr 15;58(6):679-90. doi: 10.1002/glia.20954.

43.

A dual-hit animal model for age-related parkinsonism.

Boger HA, Granholm AC, McGinty JF, Middaugh LD.

Prog Neurobiol. 2010 Feb 9;90(2):217-29. doi: 10.1016/j.pneurobio.2009.10.013. Epub 2009 Oct 21. Review.

44.

Chemical signaling in the nervous system in health and disease: Nils-Ake Hillarp's legacy.

Granholm AC, Skirboll L, Schultzberg M.

Prog Neurobiol. 2010 Feb 9;90(2):71-4. doi: 10.1016/j.pneurobio.2009.10.006. Epub 2009 Oct 20. No abstract available.

PMID:
19850101
45.

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

Lockrow J, Prakasam A, Huang P, Bimonte-Nelson H, Sambamurti K, Granholm AC.

Exp Neurol. 2009 Apr;216(2):278-89. doi: 10.1016/j.expneurol.2008.11.021. Epub 2008 Dec 10.

46.

Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice.

Boger HA, Middaugh LD, Granholm AC, McGinty JF.

Neurobiol Dis. 2009 Mar;33(3):459-66. doi: 10.1016/j.nbd.2008.11.013. Epub 2008 Dec 9.

47.

The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior.

Zaman V, Boger HA, Granholm AC, Rohrer B, Moore A, Buhusi M, Gerhardt GA, Hoffer BJ, Middaugh LD.

Eur J Neurosci. 2008 Oct;28(8):1557-68. doi: 10.1111/j.1460-9568.2008.06456.x.

48.

Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene.

Boger HA, Middaugh LD, Zaman V, Hoffer B, Granholm AC.

Brain Res. 2008 Nov 19;1241:18-28. doi: 10.1016/j.brainres.2008.09.011. Epub 2008 Sep 16.

49.

Mood, memory and movement: an age-related neurodegenerative complex?

Granholm AC, Boger H, Emborg ME.

Curr Aging Sci. 2008 Jul;1(2):133-9. Review.

50.

Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat.

Granholm AC, Bimonte-Nelson HA, Moore AB, Nelson ME, Freeman LR, Sambamurti K.

J Alzheimers Dis. 2008 Jun;14(2):133-45.

Supplemental Content

Loading ...
Support Center