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Celebrating 40 Years of Accomplishments.

Dominiczak AF, Kuo D, Bhalla V, Granger JP, Griffin KA.

Hypertension. 2019 Jan;73(1):3-6. doi: 10.1161/HYPERTENSIONAHA.118.12252. No abstract available.


Melanocortin-4 Receptor Deficiency Attenuates Placental Ischemia-Induced Hypertension in Pregnant Rats.

Spradley FT, Palei AC, Anderson CD, Granger JP.

Hypertension. 2019 Jan;73(1):162-170. doi: 10.1161/HYPERTENSIONAHA.118.12028.


Adrenergic receptor blockade attenuates placental ischemia-induced hypertension.

Spradley FT, Ge Y, Haynes BP, Granger JP, Anderson CD.

Physiol Rep. 2018 Sep;6(17):e13814. doi: 10.14814/phy2.13814.


The Endothelin System: A Critical Player in the Pathophysiology of Preeclampsia.

Granger JP, Spradley FT, Bakrania BA.

Curr Hypertens Rep. 2018 Apr 10;20(4):32. doi: 10.1007/s11906-018-0828-4. Review.


Postpartum increases in cerebral edema and inflammation in response to placental ischemia during pregnancy.

Clayton AM, Shao Q, Paauw ND, Giambrone AB, Granger JP, Warrington JP.

Brain Behav Immun. 2018 May;70:376-389. doi: 10.1016/j.bbi.2018.03.028. Epub 2018 Mar 26.


Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells.

Bakrania BA, Spradley FT, Satchell SC, Stec DE, Rimoldi JM, Gadepalli RSV, Granger JP.

Am J Physiol Regul Integr Comp Physiol. 2018 Mar 1;314(3):R427-R432. doi: 10.1152/ajpregu.00370.2017. Epub 2017 Dec 6.


Response to: Using Carbon Monoxide Releasing Molecules in Models of Pre-Eclampsia: When Should We Be Monitoring Vascular Effects?

George EM, Granger JP.

Am J Hypertens. 2017 Oct 1;30(10):e11. doi: 10.1093/ajh/hpx131. No abstract available.


Hypertension: A new genetic clue to unravel the origins of pre-eclampsia.

George EM, Granger JP.

Nat Rev Nephrol. 2017 Oct;13(10):599-600. doi: 10.1038/nrneph.2017.116. Epub 2017 Sep 4. No abstract available.


Carbon Monoxide Releasing Molecules Blunt Placental Ischemia-Induced Hypertension.

George EM, Cockrell K, Arany M, Stec DE, Rimoldi JM, Gadepalli RSV, Granger JP.

Am J Hypertens. 2017 Sep 1;30(9):931-937. doi: 10.1093/ajh/hpx070.


Role of Nitric Oxide Synthase on Blood Pressure Regulation and Vascular Function in Pregnant Rats on a High-Fat Diet.

Palei AC, Spradley FT, Granger JP.

Am J Hypertens. 2017 Mar 1;30(3):240-248. doi: 10.1093/ajh/hpw153.


The Endothelin Type A Receptor as a Potential Therapeutic Target in Preeclampsia.

Bakrania B, Duncan J, Warrington JP, Granger JP.

Int J Mol Sci. 2017 Feb 28;18(3). pii: E522. doi: 10.3390/ijms18030522. Review.


Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats.

Paauw ND, Joles JA, Spradley FT, Bakrania B, Zsengeller ZK, Franx A, Verhaar MC, Granger JP, Lely AT.

Am J Physiol Regul Integr Comp Physiol. 2017 May 1;312(5):R664-R670. doi: 10.1152/ajpregu.00510.2016. Epub 2017 Feb 15.


Nitric oxide synthase-mediated blood pressure regulation in obese melanocortin-4 receptor-deficient pregnant rats.

Spradley FT, Sasser JM, Musall JB, Sullivan JC, Granger JP.

Am J Physiol Regul Integr Comp Physiol. 2016 Nov 1;311(5):R851-R857. doi: 10.1152/ajpregu.00285.2016. Epub 2016 Aug 17.


Methods for the Determination of Rates of Glucose and Fatty Acid Oxidation in the Isolated Working Rat Heart.

Bakrania B, Granger JP, Harmancey R.

J Vis Exp. 2016 Sep 28;(115). doi: 10.3791/54497.


Renal intramedullary infusion of tempol normalizes the blood pressure response to intrarenal blockade of heme oxygenase-1 in angiotensin II-dependent hypertension.

Stec DE, Juncos LA, Granger JP.

J Am Soc Hypertens. 2016 Apr;10(4):346-51. doi: 10.1016/j.jash.2016.01.023. Epub 2016 Jan 30.


Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension.

Spradley FT, Tan AY, Joo WS, Daniels G, Kussie P, Karumanchi SA, Granger JP.

Hypertension. 2016 Apr;67(4):740-7. doi: 10.1161/HYPERTENSIONAHA.115.06783. Epub 2016 Feb 1.


Sildenafil Treatment Ameliorates the Maternal Syndrome of Preeclampsia and Rescues Fetal Growth in the Dahl Salt-Sensitive Rat.

Gillis EE, Mooney JN, Garrett MR, Granger JP, Sasser JM.

Hypertension. 2016 Mar;67(3):647-53. doi: 10.1161/HYPERTENSIONAHA.115.06071. Epub 2016 Jan 4.


Preeclampsia and Pregnancy-Related Hypertensive Disorders.

Karumanchi SA, Granger JP.

Hypertension. 2016 Feb;67(2):238-42. doi: 10.1161/HYPERTENSIONAHA.115.05024. Epub 2015 Dec 22. Review.


Immune Mechanisms Linking Obesity and Preeclampsia.

Spradley FT, Palei AC, Granger JP.

Biomolecules. 2015 Nov 12;5(4):3142-76. doi: 10.3390/biom5043142. Review.


Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms.

Spradley FT, Palei AC, Granger JP.

Am J Physiol Regul Integr Comp Physiol. 2015 Dec 1;309(11):R1326-43. doi: 10.1152/ajpregu.00178.2015. Epub 2015 Oct 7. Review.


Placental ischemia-induced increases in brain water content and cerebrovascular permeability: role of TNF-α.

Warrington JP, Drummond HA, Granger JP, Ryan MJ.

Am J Physiol Regul Integr Comp Physiol. 2015 Dec 1;309(11):R1425-31. doi: 10.1152/ajpregu.00372.2015. Epub 2015 Sep 23.


Heme oxygenase induction attenuates TNF-α-induced hypertension in pregnant rodents.

George EM, Stout JM, Stec DE, Granger JP.

Front Pharmacol. 2015 Aug 17;6:165. doi: 10.3389/fphar.2015.00165. eCollection 2015.


Emerging drugs for preeclampsia--the endothelium as a target.

Sasser JM, Murphy SR, Granger JP.

Expert Opin Emerg Drugs. 2015;20(4):527-30. doi: 10.1517/14728214.2015.1062875. Epub 2015 Jul 3. Review.


Chronic hyperleptinemia results in the development of hypertension in pregnant rats.

Palei AC, Spradley FT, Granger JP.

Am J Physiol Regul Integr Comp Physiol. 2015 May 15;308(10):R855-61. doi: 10.1152/ajpregu.00286.2014. Epub 2015 Mar 11.


Brain-mediated antidiabetic, anorexic, and cardiovascular actions of leptin require melanocortin-4 receptor signaling.

da Silva AA, Spradley FT, Granger JP, Hall JE, do Carmo JM.

J Neurophysiol. 2015 Apr 1;113(7):2786-91. doi: 10.1152/jn.00911.2014. Epub 2015 Feb 25.


Roles for the sympathetic nervous system, renal nerves, and CNS melanocortin-4 receptor in the elevated blood pressure in hyperandrogenemic female rats.

Maranon R, Lima R, Spradley FT, do Carmo JM, Zhang H, Smith AD, Bui E, Thomas RL, Moulana M, Hall JE, Granger JP, Reckelhoff JF.

Am J Physiol Regul Integr Comp Physiol. 2015 Apr 15;308(8):R708-13. doi: 10.1152/ajpregu.00411.2014. Epub 2015 Feb 18.


Reduced uterine perfusion pressure induces hypertension in the pregnant mouse.

Intapad S, Warrington JP, Spradley FT, Palei AC, Drummond HA, Ryan MJ, Granger JP, Alexander BT.

Am J Physiol Regul Integr Comp Physiol. 2014 Dec 1;307(11):R1353-7. doi: 10.1152/ajpregu.00268.2014. Epub 2014 Oct 8.


Placental ischemia in pregnant rats impairs cerebral blood flow autoregulation and increases blood-brain barrier permeability.

Warrington JP, Fan F, Murphy SR, Roman RJ, Drummond HA, Granger JP, Ryan MJ.

Physiol Rep. 2014 Aug 28;2(8). pii: e12134. doi: 10.14814/phy2.12134. Print 2014 Aug 1.


An unusual cause of mineralocorticoid hypertension.

Freel EM, Perry CG, O'Dwyer P, Staessen JA, Jennings GL, Granger JP, De Buyzere M, Schiffrin EL.

Hypertension. 2014 Oct;64(4):689-92. doi: 10.1161/HYPERTENSIONAHA.114.04401. Epub 2014 Aug 25. No abstract available.


Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway.

Rana S, Rajakumar A, Geahchan C, Salahuddin S, Cerdeira AS, Burke SD, George EM, Granger JP, Karumanchi SA.

FASEB J. 2014 Oct;28(10):4324-34. doi: 10.1096/fj.14-252684. Epub 2014 Jun 26.


The heme oxygenases: important regulators of pregnancy and preeclampsia.

George EM, Warrington JP, Spradley FT, Palei AC, Granger JP.

Am J Physiol Regul Integr Comp Physiol. 2014 Oct 1;307(7):R769-77. doi: 10.1152/ajpregu.00132.2014. Epub 2014 Jun 4. Review.


Placental ischemia induces changes in gene expression in chorionic tissue.

George EM, Garrett MR, Granger JP.

Mamm Genome. 2014 Jun;25(5-6):253-61. doi: 10.1007/s00335-014-9505-3. Epub 2014 Mar 26.


Heme oxygenase-1 promotes migration and β-epithelial Na+ channel expression in cytotrophoblasts and ischemic placentas.

Warrington JP, Coleman K, Skaggs C, Hosick PA, George EM, Stec DE, Ryan MJ, Granger JP, Drummond HA.

Am J Physiol Regul Integr Comp Physiol. 2014 May;306(9):R641-6. doi: 10.1152/ajpregu.00566.2013. Epub 2014 Feb 19.


Inhalation of carbon monoxide is ineffective as a long-term therapy to reduce obesity in mice fed a high fat diet.

Hosick PA, Ahmed EK, Gousset MU, Granger JP, Stec DE.

BMC Obes. 2014 Mar 4;1:6. doi: 10.1186/2052-9538-1-6. eCollection 2014.


Euglycemic hyperinsulinemia increases blood pressure in pregnant rats independent of placental antiangiogenic and inflammatory factors.

Palei AC, Spradley FT, Granger JP.

Am J Hypertens. 2013 Dec;26(12):1445-51. doi: 10.1093/ajh/hpt137. Epub 2013 Aug 16.


Recent advances in the understanding of the pathophysiology of preeclampsia.

Warrington JP, George EM, Palei AC, Spradley FT, Granger JP.

Hypertension. 2013 Oct;62(4):666-73. doi: 10.1161/HYPERTENSIONAHA.113.00588. Epub 2013 Jul 29. No abstract available.


Sildenafil attenuates placental ischemia-induced hypertension.

George EM, Palei AC, Dent EA, Granger JP.

Am J Physiol Regul Integr Comp Physiol. 2013 Aug 15;305(4):R397-403. doi: 10.1152/ajpregu.00216.2013. Epub 2013 Jun 19.


Hypertension: physiology and pathophysiology.

Hall JE, Granger JP, do Carmo JM, da Silva AA, Dubinion J, George E, Hamza S, Speed J, Hall ME.

Compr Physiol. 2012 Oct;2(4):2393-442. doi: 10.1002/cphy.c110058. Review.


Pathophysiology of hypertension in pre-eclampsia: a lesson in integrative physiology.

Palei AC, Spradley FT, Warrington JP, George EM, Granger JP.

Acta Physiol (Oxf). 2013 Jul;208(3):224-33. doi: 10.1111/apha.12106. Epub 2013 May 7. Review.


Heme oxygenase inhibition increases blood pressure in pregnant rats.

George EM, Hosick PA, Stec DE, Granger JP.

Am J Hypertens. 2013 Jul;26(7):924-30. doi: 10.1093/ajh/hpt045. Epub 2013 Apr 3.


Heme oxygenase in pregnancy and preeclampsia.

George EM, Granger JP.

Curr Opin Nephrol Hypertens. 2013 Mar;22(2):156-62. doi: 10.1097/MNH.0b013e32835d19f7. Review.


Matrix metalloproteinases as drug targets in preeclampsia.

Palei AC, Granger JP, Tanus-Santos JE.

Curr Drug Targets. 2013 Mar;14(3):325-34. Review.


Physiology's impact: discovering life.

Sieck GC, Granger JP, Miller V, Reckelhoff JF, Wang T, Carey H.

Physiology (Bethesda). 2013 Jan;28(1):4-6. doi: 10.1152/physiol.00050.2012. No abstract available.


Promoting physiology as an essential element in translational research.

Granger JP, Barman SM, Barrett KE.

Physiology (Bethesda). 2012 Dec;27(6):326. doi: 10.1152/physiol.00045.2012. No abstract available.


Control of soluble fms-like tyrosine-1 (sFlt-1) production response to placental ischemia/hypoxia: role of tumor necrosis factor-α.

Murphy SR, LaMarca BB, Parrish M, Cockrell K, Granger JP.

Am J Physiol Regul Integr Comp Physiol. 2013 Jan 15;304(2):R130-5. doi: 10.1152/ajpregu.00069.2012. Epub 2012 Nov 28.


Linking placental ischemia and hypertension in preeclampsia: role of endothelin 1.

George EM, Granger JP.

Hypertension. 2012 Aug;60(2):507-11. doi: 10.1161/HYPERTENSIONAHA.112.194845. Epub 2012 May 7. No abstract available.


Bilirubin, renal hemodynamics, and blood pressure.

Stec DE, Hosick PA, Granger JP.

Front Pharmacol. 2012 Feb 14;3:18. doi: 10.3389/fphar.2012.00018. eCollection 2012.


Endothelin as a final common pathway in the pathophysiology of preeclampsia: therapeutic implications.

George EM, Palei AC, Granger JP.

Curr Opin Nephrol Hypertens. 2012 Mar;21(2):157-62. doi: 10.1097/MNH.0b013e328350094b.

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