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Roles of Extracellular Vesicles in High-Grade Gliomas: Tiny Particles with Outsized Influence.

Graner MW.

Annu Rev Genomics Hum Genet. 2019 Aug 31;20:331-357. doi: 10.1146/annurev-genom-083118-015324. Epub 2019 Apr 12.


The Potential of Exosomes From Cow Milk for Oral Delivery.

Betker JL, Angle BM, Graner MW, Anchordoquy TJ.

J Pharm Sci. 2019 Apr;108(4):1496-1505. doi: 10.1016/j.xphs.2018.11.022. Epub 2018 Nov 20.


Extracellular vesicles in cancer immune responses: roles of purinergic receptors.

Graner MW.

Semin Immunopathol. 2018 Sep;40(5):465-475. doi: 10.1007/s00281-018-0706-9. Epub 2018 Sep 12. Review.


Tumor-derived exosomes, microRNAs, and cancer immune suppression.

Graner MW, Schnell S, Olin MR.

Semin Immunopathol. 2018 Sep;40(5):505-515. doi: 10.1007/s00281-018-0689-6. Epub 2018 Jun 4. Review.


Development of Novel Patient-Derived Xenografts from Breast Cancer Brain Metastases.

Contreras-Zárate MJ, Ormond DR, Gillen AE, Hanna C, Day NL, Serkova NJ, Jacobsen BM, Edgerton SM, Thor AD, Borges VF, Lillehei KO, Graner MW, Kabos P, Cittelly DM.

Front Oncol. 2017 Nov 2;7:252. doi: 10.3389/fonc.2017.00252. eCollection 2017.


Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype.

Oushy S, Hellwinkel JE, Wang M, Nguyen GJ, Gunaydin D, Harland TA, Anchordoquy TJ, Graner MW.

Philos Trans R Soc Lond B Biol Sci. 2018 Jan 5;373(1737). pii: 20160477. doi: 10.1098/rstb.2016.0477.


Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice.

Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaah5360. doi: 10.1126/scitranslmed.aah5360.


A method for extracting and characterizing RNA from urine: For downstream PCR and RNAseq analysis.

Zhou K, Spillman MA, Behbakht K, Komatsu JM, Abrahante JE, Hicks D, Schotl B, Odean E, Jones KL, Graner MW, Bemis LT.

Anal Biochem. 2017 Nov 1;536:8-15. doi: 10.1016/j.ab.2017.08.003. Epub 2017 Aug 10.


HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line.

Graner AN, Hellwinkel JE, Lencioni AM, Madsen HJ, Harland TA, Marchando P, Nguyen GJ, Wang M, Russell LM, Bemis LT, Anchordoquy TJ, Graner MW.

Int J Hyperthermia. 2017 May;33(3):303-317. doi: 10.1080/02656736.2016.1256503. Epub 2016 Dec 20.


Proteomic analyses of brain tumor cell lines amidst the unfolded protein response.

Redzic JS, Gomez JD, Hellwinkel JE, Anchordoquy TJ, Graner MW.

Oncotarget. 2016 Jul 26;7(30):47831-47847. doi: 10.18632/oncotarget.10032.


HSP90 and Immune Modulation in Cancer.

Graner MW.

Adv Cancer Res. 2016;129:191-224. doi: 10.1016/bs.acr.2015.10.001. Epub 2015 Nov 3. Review.


The Dichotomy of Tumor Exosomes (TEX) in Cancer Immunity: Is It All in the ConTEXt?

Kunigelis KE, Graner MW.

Vaccines (Basel). 2015 Dec 17;3(4):1019-51. doi: 10.3390/vaccines3041019. Review.


Glioma-derived extracellular vesicles selectively suppress immune responses.

Hellwinkel JE, Redzic JS, Harland TA, Gunaydin D, Anchordoquy TJ, Graner MW.

Neuro Oncol. 2016 Apr;18(4):497-506. doi: 10.1093/neuonc/nov170. Epub 2015 Sep 18.


The unfolded protein response in glioblastomas: targetable or trouble?

Graner MW.

Future Sci OA. 2015 Sep 1;1(2):FSO45. doi: 10.4155/fso.15.45. eCollection 2015 Sep. Review.


Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccines.

Graner MW, Lillehei KO, Katsanis E.

Front Oncol. 2015 Jan 6;4:379. doi: 10.3389/fonc.2014.00379. eCollection 2014. Review.


Biodistribution and delivery efficiency of unmodified tumor-derived exosomes.

Smyth T, Kullberg M, Malik N, Smith-Jones P, Graner MW, Anchordoquy TJ.

J Control Release. 2015 Feb 10;199:145-55. doi: 10.1016/j.jconrel.2014.12.013. Epub 2014 Dec 16.


Exosome proteomics reveals transcriptional regulator proteins with potential to mediate downstream pathways.

Ung TH, Madsen HJ, Hellwinkel JE, Lencioni AM, Graner MW.

Cancer Sci. 2014 Nov;105(11):1384-92. doi: 10.1111/cas.12534. Epub 2014 Oct 9. Review.


Surface functionalization of exosomes using click chemistry.

Smyth T, Petrova K, Payton NM, Persaud I, Redzic JS, Graner MW, Smith-Jones P, Anchordoquy TJ.

Bioconjug Chem. 2014 Oct 15;25(10):1777-84. doi: 10.1021/bc500291r. Epub 2014 Sep 30.


Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro.

Smyth TJ, Redzic JS, Graner MW, Anchordoquy TJ.

Biochim Biophys Acta. 2014 Nov;1838(11):2954-65. doi: 10.1016/j.bbamem.2014.07.026. Epub 2014 Aug 4.


The unfolded protein response in glioblastomas: passing the stress test.

Graner MW.

CNS Oncol. 2013 Nov;2(6):469-72. doi: 10.2217/cns.13.50. No abstract available.


Glioblastoma extracellular vesicles: reservoirs of potential biomarkers.

Redzic JS, Ung TH, Graner MW.

Pharmgenomics Pers Med. 2014 Feb 13;7:65-77. doi: 10.2147/PGPM.S39768. eCollection 2014. Review.


Gamma interferon immunospot assay of pleural effusion mononuclear cells for diagnosis of tuberculous pleurisy.

Liao M, Yang Q, Zhang J, Zhang M, Deng Q, Liu H, Graner MW, Kornfeld H, Zhou B, Chen X.

Clin Vaccine Immunol. 2014 Mar;21(3):347-53. doi: 10.1128/CVI.00680-13. Epub 2014 Jan 3.


Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells.

Epple LM, Dodd RD, Merz AL, Dechkovskaia AM, Herring M, Winston BA, Lencioni AM, Russell RL, Madsen H, Nega M, Dusto NL, White J, Bigner DD, Nicchitta CV, Serkova NJ, Graner MW.

PLoS One. 2013 Aug 15;8(8):e73267. doi: 10.1371/journal.pone.0073267. eCollection 2013.


Extracellular vesicles secreted from cancer cell lines stimulate secretion of MMP-9, IL-6, TGF-β1 and EMMPRIN.

Redzic JS, Kendrick AA, Bahmed K, Dahl KD, Pearson CG, Robinson WA, Robinson SE, Graner MW, Eisenmesser EZ.

PLoS One. 2013 Aug 1;8(8):e71225. doi: 10.1371/journal.pone.0071225. Print 2013.


Prolonged remission of advanced bronchoalveolar adenocarcinoma in a dog treated with autologous, tumour-derived chaperone-rich cell lysate (CRCL) vaccine.

Epple LM, Bemis LT, Cavanaugh RP, Skope A, Mayer-Sonnenfeld T, Frank C, Olver CS, Lencioni AM, Dusto NL, Tal A, Har-Noy M, Lillehei KO, Katsanis E, Graner MW.

Int J Hyperthermia. 2013 Aug;29(5):390-8. doi: 10.3109/02656736.2013.800997. Epub 2013 Jun 20.


The 'peptidome' of tumour-derived chaperone-rich cell lysate anti-cancer vaccines reveals potential tumour antigens that stimulate tumour immunity.

Graner MW, Romanoski A, Katsanis E.

Int J Hyperthermia. 2013 Aug;29(5):380-9. doi: 10.3109/02656736.2013.793406. Epub 2013 May 31.


Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles.

Epple LM, Griffiths SG, Dechkovskaia AM, Dusto NL, White J, Ouellette RJ, Anchordoquy TJ, Bemis LT, Graner MW.

PLoS One. 2012;7(7):e42064. doi: 10.1371/journal.pone.0042064. Epub 2012 Jul 27.


CD19(+)CD1d(+)CD5(+) B cell frequencies are increased in patients with tuberculosis and suppress Th17 responses.

Zhang M, Zheng X, Zhang J, Zhu Y, Zhu X, Liu H, Zeng M, Graner MW, Zhou B, Chen X.

Cell Immunol. 2012;274(1-2):89-97. doi: 10.1016/j.cellimm.2012.01.007. Epub 2012 Feb 6.


Multifunctional CD4 T cell responses in patients with active tuberculosis.

Qiu Z, Zhang M, Zhu Y, Zheng F, Lu P, Liu H, Graner MW, Zhou B, Chen X.

Sci Rep. 2012;2:216. doi: 10.1038/srep00216. Epub 2012 Jan 10.


Immunotherapy of brain tumors.

Marshall D, Mitchell DA, Graner MW, Bigner DD.

Handb Clin Neurol. 2012;104:309-30. doi: 10.1016/B978-0-444-52138-5.00020-7. Review. No abstract available.


B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis.

Zhang M, Wang Z, Graner MW, Yang L, Liao M, Yang Q, Gou J, Zhu Y, Wu C, Liu H, Zhou B, Chen X.

Cell Immunol. 2011;270(2):217-23. doi: 10.1016/j.cellimm.2011.05.009. Epub 2011 Jun 17.


Reduced Th17 response in patients with tuberculosis correlates with IL-6R expression on CD4+ T Cells.

Chen X, Zhang M, Liao M, Graner MW, Wu C, Yang Q, Liu H, Zhou B.

Am J Respir Crit Care Med. 2010 Apr 1;181(7):734-42. doi: 10.1164/rccm.200909-1463OC. Epub 2009 Dec 17.


Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces.

Graner MW, Raynes DA, Bigner DD, Guerriero V.

Cancer Sci. 2009 Oct;100(10):1870-9. doi: 10.1111/j.1349-7006.2009.01269.x. Epub 2009 Jul 1.


Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy.

Chen X, Zhang M, Zhu X, Deng Q, Liu H, Larmonier N, Graner MW, Zhou B.

J Infect Dis. 2009 Aug 1;200(3):399-408. doi: 10.1086/600075.


Proteomic and immunologic analyses of brain tumor exosomes.

Graner MW, Alzate O, Dechkovskaia AM, Keene JD, Sampson JH, Mitchell DA, Bigner DD.

FASEB J. 2009 May;23(5):1541-57. doi: 10.1096/fj.08-122184. Epub 2008 Dec 24.


Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens.

Bleifuss E, Bendz H, Sirch B, Thompson S, Brandl A, Milani V, Graner MW, Drexler I, Kuppner M, Katsanis E, Noessner E, Issels RD.

Int J Hyperthermia. 2008 Dec;24(8):623-37. doi: 10.1080/02656730802213384.


Combating immunosuppression in glioma.

Vega EA, Graner MW, Sampson JH.

Future Oncol. 2008 Jun;4(3):433-42. doi: 10.2217/14796694.4.3.433. Review.


Immunotherapy against angiogenesis-associated targets: evidence and implications for the treatment of malignant glioma.

Everson RG, Graner MW, Gromeier M, Vredenburgh JJ, Desjardins A, Reardon DA, Friedman HS, Friedman AH, Bigner DD, Sampson JH.

Expert Rev Anticancer Ther. 2008 May;8(5):717-32. doi: 10.1586/14737140.8.5.717. Review.


Human ovarian tumour-derived chaperone-rich cell lysate (CRCL) elicits T cell responses in vitro.

Li G, Zeng Y, Chen X, Larmonier N, Sepassi M, Graner MW, Andreansky S, Brewer MA, Katsanis E.

Clin Exp Immunol. 2007 Apr;148(1):136-45.


Chaperone-rich cell lysate embedded with BCR-ABL peptide demonstrates enhanced anti-tumor activity against a murine BCR-ABL positive leukemia.

Kislin KL, Marron MT, Li G, Graner MW, Katsanis E.

FASEB J. 2007 Jul;21(9):2173-84. Epub 2007 Feb 27.


Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting.

Sok JC, Coppelli FM, Thomas SM, Lango MN, Xi S, Hunt JL, Freilino ML, Graner MW, Wikstrand CJ, Bigner DD, Gooding WE, Furnari FB, Grandis JR.

Clin Cancer Res. 2006 Sep 1;12(17):5064-73.


Therapeutic aspects of chaperones/heat-shock proteins in neuro-oncology.

Graner MW, Bigner DD.

Expert Rev Anticancer Ther. 2006 May;6(5):679-95. Review.


Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme.

Kuan CT, Wakiya K, Dowell JM, Herndon JE 2nd, Reardon DA, Graner MW, Riggins GJ, Wikstrand CJ, Bigner DD.

Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):1970-82.


Peritransplantation vaccination with chaperone-rich cell lysate induces antileukemia immunity.

Chen X, Zeng Y, Li G, Larmonier N, Graner MW, Katsanis E.

Biol Blood Marrow Transplant. 2006 Mar;12(3):275-83.


ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors.

Rich JN, Sathornsumetee S, Keir ST, Kieran MW, Laforme A, Kaipainen A, McLendon RE, Graner MW, Rasheed BK, Wang L, Reardon DA, Ryan AJ, Wheeler C, Dimery I, Bigner DD, Friedman HS.

Clin Cancer Res. 2005 Nov 15;11(22):8145-57.


Chaperone proteins and brain tumors: potential targets and possible therapeutics.

Graner MW, Bigner DD.

Neuro Oncol. 2005 Jul;7(3):260-78. Review.


Vesiculated alpha-tocopheryl succinate enhances the anti-tumor effect of dendritic cell vaccines.

Ramanathapuram LV, Hahn T, Graner MW, Katsanis E, Akporiaye ET.

Cancer Immunol Immunother. 2006 Feb;55(2):166-77. Epub 2005 Jul 23.


Chaperone-rich cell lysates, immune activation and tumor vaccination.

Zeng Y, Graner MW, Katsanis E.

Cancer Immunol Immunother. 2006 Mar;55(3):329-38. Epub 2005 May 11. Review.


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