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Items: 1 to 50 of 165

1.

Antihypertensive effect of etamicastat in dopamine D2 receptor-deficient mice.

Armando I, Asico LD, Wang X, Jones JE, Serrão MP, Cuevas S, Grandy DK, Soares-da-Silva P, Jose PA.

Hypertens Res. 2018 Jul;41(7):489-498. doi: 10.1038/s41440-018-0041-5. Epub 2018 Apr 13.

2.

Efficacy of Hybrid Tetrahydrobenzo[d]thiazole Based Aryl Piperazines D-264 and D-301 at D₂ and D₃ Receptors.

Zhen J, Antonio T, Jacob JC, Grandy DK, Reith MEA, Dutta AK, Selley DE.

Neurochem Res. 2016 Feb;41(1-2):328-339. doi: 10.1007/s11064-015-1808-6. Epub 2015 Dec 31.

3.

"TAARgeting Addiction"--The Alamo Bears Witness to Another Revolution: An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference.

Grandy DK, Miller GM, Li JX.

Drug Alcohol Depend. 2016 Feb 1;159:9-16. doi: 10.1016/j.drugalcdep.2015.11.014. Epub 2015 Nov 22.

4.

Trace Amine-Associated Receptor 1 Localization at the Apical Plasma Membrane Domain of Fisher Rat Thyroid Epithelial Cells Is Confined to Cilia.

Szumska J, Qatato M, Rehders M, Führer D, Biebermann H, Grandy DK, Köhrle J, Brix K.

Eur Thyroid J. 2015 Sep;4(Suppl 1):30-41. doi: 10.1159/000434717. Epub 2015 Jun 10.

5.

Dopamine D₂-Like Receptors and Behavioral Economics of Food Reinforcement.

Soto PL, Hiranita T, Xu M, Hursh SR, Grandy DK, Katz JL.

Neuropsychopharmacology. 2016 Mar;41(4):971-8. doi: 10.1038/npp.2015.223. Epub 2015 Jul 24.

6.

Regulation of ethanol intake under chronic mild stress: roles of dopamine receptors and transporters.

Delis F, Rombola C, Bellezza R, Rosko L, Grandy DK, Volkow ND, Thanos PK.

Front Behav Neurosci. 2015 May 12;9:118. doi: 10.3389/fnbeh.2015.00118. eCollection 2015.

7.

The effect of dopamine D4 receptor density on novelty seeking, activity, social interaction, and alcohol binge drinking in adult mice.

Thanos PK, Roushdy K, Sarwar Z, Rice O, Ashby CR Jr, Grandy DK.

Synapse. 2015 Jul;69(7):356-64. doi: 10.1002/syn.21822. Epub 2015 May 20.

PMID:
25914336
8.

Erratum to: behavioral economics of food reinforcement and the effects of prefeeding, extinction, and eticlopride in dopamine D₂ receptor mutant mice.

Soto PL, Grandy DK, Hursh SR, Katz JL.

Psychopharmacology (Berl). 2015 May;232(9):1669. doi: 10.1007/s00213-015-3918-x. No abstract available.

PMID:
25814138
9.

TAAR1 transforms thinking about a plant alkaloid that transformed the practice of medicine.

Grandy DK.

Int J Neuropsychopharmacol. 2014 Oct;17(10):1545-7. doi: 10.1017/S1461145714000911. Epub 2014 Jun 5. No abstract available.

PMID:
24901712
10.

Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1.

Liu X, Grandy DK, Janowsky A.

J Pharmacol Exp Ther. 2014 Jul;350(1):124-9. doi: 10.1124/jpet.114.213116. Epub 2014 May 5.

11.

Choice for response alternatives differing in reinforcement frequency in dopamine D2 receptor mutant and Swiss-Webster mice.

Soto PL, Hiranita T, Grandy DK, Katz JL.

Psychopharmacology (Berl). 2014 Aug;231(16):3169-77. doi: 10.1007/s00213-014-3495-4. Epub 2014 Feb 28.

PMID:
24682471
12.

Dopamine D4 receptors in psychostimulant addiction.

Di Ciano P, Grandy DK, Le Foll B.

Adv Pharmacol. 2014;69:301-21. doi: 10.1016/B978-0-12-420118-7.00008-1. Review.

13.

Exploring the determinants of trace amine-associated receptor 1's functional selectivity for the stereoisomers of amphetamine and methamphetamine.

Reese EA, Norimatsu Y, Grandy MS, Suchland KL, Bunzow JR, Grandy DK.

J Med Chem. 2014 Jan 23;57(2):378-90. doi: 10.1021/jm401316v. Epub 2014 Jan 7.

PMID:
24354319
14.

Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist.

Desai RI, Grandy DK, Lupica CR, Katz JL.

J Pharmacol Exp Ther. 2014 Jan;348(1):106-15. doi: 10.1124/jpet.113.208538. Epub 2013 Nov 5.

15.

Normalizing dopamine D2 receptor-mediated responses in D2 null mutant mice by virus-mediated receptor restoration: comparing D2L and D2S.

Neve KA, Ford CP, Buck DC, Grandy DK, Neve RL, Phillips TJ.

Neuroscience. 2013 Sep 17;248:479-87. doi: 10.1016/j.neuroscience.2013.06.035. Epub 2013 Jun 27.

16.

Dopamine D4 receptor deficiency in mice alters behavioral responses to anxiogenic stimuli and the psychostimulant methylphenidate.

Keck TM, Suchland KL, Jimenez CC, Grandy DK.

Pharmacol Biochem Behav. 2013 Feb;103(4):831-41. doi: 10.1016/j.pbb.2012.12.006. Epub 2012 Dec 19.

PMID:
23262298
17.

A decade of pharma discovery delivers new tools targeting trace amine-associated receptor 1.

Tallman KR, Grandy DK.

Neuropsychopharmacology. 2012 Nov;37(12):2553-4. doi: 10.1038/npp.2012.148. No abstract available.

18.

Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of NADPH oxidase.

Yang Y, Zhang Y, Cuevas S, Villar VA, Escano C, D Asico L, Yu P, Grandy DK, Felder RA, Armando I, Jose PA.

Free Radic Biol Med. 2012 Aug 1;53(3):437-46. doi: 10.1016/j.freeradbiomed.2012.05.015. Epub 2012 May 23.

19.

Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes.

Maison SF, Liu XP, Eatock RA, Sibley DR, Grandy DK, Liberman MC.

J Neurosci. 2012 Jan 4;32(1):344-55. doi: 10.1523/JNEUROSCI.4720-11.2012.

20.

Behavioral economics of food reinforcement and the effects of prefeeding, extinction, and eticlopride in dopamine D2 receptor mutant mice.

Soto PL, Grandy DK, Hursh SR, Katz JL.

Psychopharmacology (Berl). 2011 Jun;215(4):775-84. doi: 10.1007/s00213-011-2173-z. Epub 2011 Feb 2. Erratum in: Psychopharmacology (Berl). 2015 May;232(9):1669.

21.

Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption.

Thanos PK, Gopez V, Delis F, Michaelides M, Grandy DK, Wang GJ, Kunos G, Volkow ND.

Alcohol Clin Exp Res. 2011 Jan;35(1):19-27. doi: 10.1111/j.1530-0277.2010.01318.x. Epub 2010 Oct 19.

22.

Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate.

Michaelides M, Pascau J, Gispert JD, Delis F, Grandy DK, Wang GJ, Desco M, Rubinstein M, Volkow ND, Thanos PK.

Eur J Neurosci. 2010 Aug;32(4):668-76. doi: 10.1111/j.1460-9568.2010.07319.x. Epub 2010 Jul 16.

23.

Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats.

Li SM, Collins GT, Paul NM, Grundt P, Newman AH, Xu M, Grandy DK, Woods JH, Katz JL.

Behav Pharmacol. 2010 May;21(3):171-81. doi: 10.1097/FBP.0b013e32833a5c68.

24.

Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine.

Thanos PK, Habibi R, Michaelides M, Patel UB, Suchland K, Anderson BJ, Robinson JK, Wang GJ, Grandy DK, Volkow ND.

Behav Brain Res. 2010 Mar 5;207(2):508-11. doi: 10.1016/j.bbr.2009.10.020. Epub 2009 Oct 22.

25.

Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice.

Wang HD, Stanwood GD, Grandy DK, Deutch AY.

Brain Res. 2009 Dec 1;1300:58-64. doi: 10.1016/j.brainres.2009.09.008. Epub 2009 Sep 10.

26.

Modulation of cardiac ionic homeostasis by 3-iodothyronamine.

Ghelardoni S, Suffredini S, Frascarelli S, Brogioni S, Chiellini G, Ronca-Testoni S, Grandy DK, Scanlan TS, Cerbai E, Zucchi R.

J Cell Mol Med. 2009 Sep;13(9B):3082-90. doi: 10.1111/j.1582-4934.2009.00728.x. Epub 2009 Feb 27.

27.

Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors.

Thanos PK, Bermeo C, Rubinstein M, Suchland KL, Wang GJ, Grandy DK, Volkow ND.

J Psychopharmacol. 2010 Jun;24(6):897-904. doi: 10.1177/0269881109102613. Epub 2009 Mar 12.

28.

Central effects of thyronamines on glucose metabolism in rats.

Klieverik LP, Foppen E, Ackermans MT, Serlie MJ, Sauerwein HP, Scanlan TS, Grandy DK, Fliers E, Kalsbeek A.

J Endocrinol. 2009 Jun;201(3):377-86. doi: 10.1677/JOE-09-0043. Epub 2009 Mar 9.

PMID:
19273499
29.

The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)).

Tan ES, Naylor JC, Groban ES, Bunzow JR, Jacobson MP, Grandy DK, Scanlan TS.

ACS Chem Biol. 2009 Mar 20;4(3):209-20. doi: 10.1021/cb800304d.

30.

Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice.

Collins GT, Truccone A, Haji-Abdi F, Newman AH, Grundt P, Rice KC, Husbands SM, Greedy BM, Enguehard-Gueiffier C, Gueiffier A, Chen J, Wang S, Katz JL, Grandy DK, Sunahara RK, Woods JH.

J Pharmacol Exp Ther. 2009 Apr;329(1):210-7. doi: 10.1124/jpet.108.144048. Epub 2009 Jan 9.

31.

Decreased dopamine D4 receptor expression increases extracellular glutamate and alters its regulation in mouse striatum.

Thomas TC, Grandy DK, Gerhardt GA, Glaser PE.

Neuropsychopharmacology. 2009 Jan;34(2):436-45. doi: 10.1038/npp.2008.74. Epub 2008 Jun 4.

32.

Cardiac effects of trace amines: pharmacological characterization of trace amine-associated receptors.

Frascarelli S, Ghelardoni S, Chiellini G, Vargiu R, Ronca-Testoni S, Scanlan TS, Grandy DK, Zucchi R.

Eur J Pharmacol. 2008 Jun 10;587(1-3):231-6. doi: 10.1016/j.ejphar.2008.03.055. Epub 2008 Apr 7.

PMID:
18486124
33.

D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking.

Helms CM, Gubner NR, Wilhelm CJ, Mitchell SH, Grandy DK.

Pharmacol Biochem Behav. 2008 Sep;90(3):387-93. doi: 10.1016/j.pbb.2008.03.013. Epub 2008 Mar 28.

34.

PCR cloning of neural gene products.

Grandy DK, Bunzow JR, Dorit RL.

Curr Protoc Neurosci. 2001 May;Chapter 4:Unit 4.2. doi: 10.1002/0471142301.ns0402s08.

PMID:
18428481
35.

3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation.

Braulke LJ, Klingenspor M, DeBarber A, Tobias SC, Grandy DK, Scanlan TS, Heldmaier G.

J Comp Physiol B. 2008 Feb;178(2):167-77. Epub 2007 Oct 3.

PMID:
17912534
36.

Trace amine-associated receptor 1-Family archetype or iconoclast?

Grandy DK.

Pharmacol Ther. 2007 Dec;116(3):355-90. Epub 2007 Jul 17. Review.

37.

Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury.

Doyle KP, Suchland KL, Ciesielski TM, Lessov NS, Grandy DK, Scanlan TS, Stenzel-Poore MP.

Stroke. 2007 Sep;38(9):2569-76. Epub 2007 Aug 9.

PMID:
17690312
38.

Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1.

Tan ES, Miyakawa M, Bunzow JR, Grandy DK, Scanlan TS.

J Med Chem. 2007 Jun 14;50(12):2787-98. Epub 2007 May 12.

PMID:
17497842
39.

Dopamine D4 receptor knockout mice exhibit neurochemical changes consistent with decreased dopamine release.

Thomas TC, Kruzich PJ, Joyce BM, Gash CR, Suchland K, Surgener SP, Rutherford EC, Grandy DK, Gerhardt GA, Glaser PE.

J Neurosci Methods. 2007 Nov 30;166(2):306-14. Epub 2007 Mar 18.

40.

Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function.

Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, DeBarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R.

FASEB J. 2007 May;21(7):1597-608. Epub 2007 Feb 6.

PMID:
17284482
41.

Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine.

Reese EA, Bunzow JR, Arttamangkul S, Sonders MS, Grandy DK.

J Pharmacol Exp Ther. 2007 Apr;321(1):178-86. Epub 2007 Jan 11.

PMID:
17218486
42.

Trace amine-associated receptors and their ligands.

Zucchi R, Chiellini G, Scanlan TS, Grandy DK.

Br J Pharmacol. 2006 Dec;149(8):967-78. Epub 2006 Nov 6. Review.

43.

Dopamine D2 receptors mediate reversal learning in male C57BL/6J mice.

Kruzich PJ, Mitchell SH, Younkin A, Grandy DK.

Cogn Affect Behav Neurosci. 2006 Mar;6(1):86-90.

PMID:
16869233
44.

Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues.

Hart ME, Suchland KL, Miyakawa M, Bunzow JR, Grandy DK, Scanlan TS.

J Med Chem. 2006 Feb 9;49(3):1101-12.

PMID:
16451074
45.

Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'.

Tomiyama K, Makihara Y, Yamamoto H, O'Sullivan G, Nally RE, Tighe O, Kinsella A, Fienberg AA, Grandy DK, Sibley DR, Croke DT, Koshikawa N, Waddington JL.

Eur Neuropsychopharmacol. 2006 Aug;16(6):437-45. Epub 2006 Jan 18.

PMID:
16413758
46.

Angiotensin-II type 1 receptor-mediated hypertension in D4 dopamine receptor-deficient mice.

Bek MJ, Wang X, Asico LD, Jones JE, Zheng S, Li X, Eisner GM, Grandy DK, Carey RM, Soares-da-Silva P, Jose PA.

Hypertension. 2006 Feb;47(2):288-95. Epub 2005 Dec 27. Erratum in: Hypertension. 2006 May;47(5):e23.

PMID:
16380537
47.
48.

Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice.

Kachroo A, Orlando LR, Grandy DK, Chen JF, Young AB, Schwarzschild MA.

J Neurosci. 2005 Nov 9;25(45):10414-9.

49.

Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice.

Elmer GI, Pieper JO, Levy J, Rubinstein M, Low MJ, Grandy DK, Wise RA.

Psychopharmacology (Berl). 2005 Oct;182(1):33-44. Epub 2005 Sep 29.

PMID:
16136297
50.

Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking.

Thanos PK, Rivera SN, Weaver K, Grandy DK, Rubinstein M, Umegaki H, Wang GJ, Hitzemann R, Volkow ND.

Life Sci. 2005 May 27;77(2):130-9. Epub 2005 Feb 9.

PMID:
15862598

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