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The Combination of IFN β and TNF Induces an Antiviral and Immunoregulatory Program via Non-Canonical Pathways Involving STAT2 and IRF9.

Mariani MK, Dasmeh P, Fortin A, Caron E, Kalamujic M, Harrison AN, Hotea DI, Kasumba DM, Cervantes-Ortiz SL, Mukawera E, Serohijos AWR, Grandvaux N.

Cells. 2019 Aug 17;8(8). pii: E919. doi: 10.3390/cells8080919.


CSV2018: The 2nd Symposium of the Canadian Society for Virology.

Grandvaux N, McCormick C.

Viruses. 2019 Jan 18;11(1). pii: E79. doi: 10.3390/v11010079.


Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome.

Kasumba DM, Grandvaux N.

Trends Pharmacol Sci. 2019 Feb;40(2):116-127. doi: 10.1016/ Epub 2018 Dec 31. Review.


Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes.

Petes C, Mariani MK, Yang Y, Grandvaux N, Gee K.

Front Immunol. 2018 Feb 15;9:256. doi: 10.3389/fimmu.2018.00256. eCollection 2018.


Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight.

Zamorano Cuervo N, Osseman Q, Grandvaux N.

Viruses. 2018 Jan 30;10(2). pii: E56. doi: 10.3390/v10020056.


Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function.

Rengachari S, Groiss S, Devos JM, Caron E, Grandvaux N, Panne D.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E601-E609. doi: 10.1073/pnas.1718426115. Epub 2018 Jan 9.


DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection.

Robitaille AC, Caron E, Zucchini N, Mukawera E, Adam D, Mariani MK, Gélinas A, Fortin A, Brochiero E, Grandvaux N.

Sci Rep. 2017 Dec 12;7(1):17388. doi: 10.1038/s41598-017-17689-0.


HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms.

Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P.

JCI Insight. 2017 Aug 3;2(15). pii: 93230. doi: 10.1172/jci.insight.93230. eCollection 2017 Aug 3.


Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.

Williams V, Grosset AA, Zamorano Cuervo N, St-Pierre Y, Sylvestre MP, Gaboury L, Grandvaux N.

BMC Cancer. 2017 May 22;17(1):356. doi: 10.1186/s12885-017-3321-6.


1st Workshop of the Canadian Society for Virology.

McCormick C, Grandvaux N.

Viruses. 2017 Mar 20;9(3). pii: E54. doi: 10.3390/v9030054.


Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology.

Cervantes-Ortiz SL, Zamorano Cuervo N, Grandvaux N.

Viruses. 2016 May 12;8(5). pii: E124. doi: 10.3390/v8050124. Review.


A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3.

Robitaille AC, Mariani MK, Fortin A, Grandvaux N.

J Vis Exp. 2016 Jan 24;(107):e53723. doi: 10.3791/53723.


Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines.

Mukawera E, Chartier S, Williams V, Pagano PJ, Lapointe R, Grandvaux N.

Redox Biol. 2015 Dec;6:9-18. doi: 10.1016/j.redox.2015.06.010. Epub 2015 Jun 23.


Lung epithelial NOX/DUOX and respiratory virus infections.

Grandvaux N, Mariani M, Fink K.

Clin Sci (Lond). 2015 Mar;128(6):337-47. doi: 10.1042/CS20140321. Review.


Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.

Hanafi LA, Gauchat D, Godin-Ethier J, Possamaï D, Duvignaud JB, Leclerc D, Grandvaux N, Lapointe R.

PLoS One. 2014 Jun 9;9(6):e99211. doi: 10.1371/journal.pone.0099211. eCollection 2014.


Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5.

Grandvaux N, Guan X, Yoboua F, Zucchini N, Fink K, Doyon P, Martin L, Servant MJ, Chartier S.

J Innate Immun. 2014;6(5):650-62. doi: 10.1159/000360764. Epub 2014 Apr 30.


STAT2 and IRF9: Beyond ISGF3.

Fink K, Grandvaux N.

JAKSTAT. 2013 Oct 1;2(4):e27521. doi: 10.4161/jkst.27521. Epub 2013 Dec 18. Review.


Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective.

Marr N, Turvey SE, Grandvaux N.

Trends Microbiol. 2013 Nov;21(11):568-74. doi: 10.1016/j.tim.2013.08.006. Epub 2013 Oct 9.


Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses.

Baril M, Es-Saad S, Chatel-Chaix L, Fink K, Pham T, Raymond VA, Audette K, Guenier AS, Duchaine J, Servant M, Bilodeau M, Cohen E, Grandvaux N, Lamarre D.

PLoS Pathog. 2013;9(6):e1003416. doi: 10.1371/journal.ppat.1003416. Epub 2013 Jun 13.


IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH oxidase-mediated airway antiviral response.

Fink K, Martin L, Mukawera E, Chartier S, De Deken X, Brochiero E, Miot F, Grandvaux N.

Cell Res. 2013 May;23(5):673-90. doi: 10.1038/cr.2013.47. Epub 2013 Apr 2. Erratum in: Cell Res. 2014 Apr;24(4):509.


2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV.

Chouinard F, Turcotte C, Guan X, Larose MC, Poirier S, Bouchard L, Provost V, Flamand L, Grandvaux N, Flamand N.

J Leukoc Biol. 2013 Feb;93(2):267-76. doi: 10.1189/jlb.0412200. Epub 2012 Dec 12.


Individual interferon regulatory factor-3 thiol residues are not critical for its activation following virus infection.

Zucchini N, Williams V, Grandvaux N.

J Interferon Cytokine Res. 2012 Sep;32(9):393-400. doi: 10.1089/jir.2012.0010. Epub 2012 Jul 20.


Regulation of normal and cystic fibrosis airway epithelial repair processes by TNF-α after injury.

Maillé E, Trinh NT, Privé A, Bilodeau C, Bissonnette E, Grandvaux N, Brochiero E.

Am J Physiol Lung Cell Mol Physiol. 2011 Dec;301(6):L945-55. doi: 10.1152/ajplung.00149.2011. Epub 2011 Sep 9.


Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients.

Jouan L, Chatel-Chaix L, Melançon P, Rodrigue-Gervais IG, Raymond VA, Selliah S, Bilodeau M, Grandvaux N, Lamarre D.

J Hepatol. 2012 Jan;56(1):70-7. doi: 10.1016/j.jhep.2011.07.017. Epub 2011 Aug 9.


[The IKKε kinase in breast cancer: from oncogenesis to treatment resistance].

Grandvaux N.

Med Sci (Paris). 2011 Jun-Jul;27(6-7):619-25. doi: 10.1051/medsci/2011276014. Epub 2011 Jul 1. French.


The ribonucleotide reductase R1 subunits of herpes simplex virus 1 and 2 protect cells against poly(I · C)-induced apoptosis.

Dufour F, Bertrand L, Pearson A, Grandvaux N, Langelier Y.

J Virol. 2011 Sep;85(17):8689-701. doi: 10.1128/JVI.00362-11. Epub 2011 Jun 22.


Impact of microRNA in normal and pathological respiratory epithelia.

Giovannini-Chami L, Grandvaux N, Zaragosi LE, Robbe-Sermesant K, Marcet B, Cardinaud B, Coraux C, Berthiaume Y, Waldmann R, Mari B, Barbry P.

Methods Mol Biol. 2011;741:171-91. doi: 10.1007/978-1-61779-117-8_12.


Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7.

Monteiro P, Gosselin A, Wacleche VS, El-Far M, Said EA, Kared H, Grandvaux N, Boulassel MR, Routy JP, Ancuta P.

J Immunol. 2011 Apr 15;186(8):4618-30. doi: 10.4049/jimmunol.1004151. Epub 2011 Mar 11.


Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression.

Soucy-Faulkner A, Mukawera E, Fink K, Martel A, Jouan L, Nzengue Y, Lamarre D, Vande Velde C, Grandvaux N.

PLoS Pathog. 2010 Jun 3;6(6):e1000930. doi: 10.1371/journal.ppat.1000930.


Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta.

Yoboua F, Martel A, Duval A, Mukawera E, Grandvaux N.

J Virol. 2010 Jul;84(14):7267-77. doi: 10.1128/JVI.00142-10. Epub 2010 Apr 21.


Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease.

Jouan L, Melançon P, Rodrigue-Gervais IG, Raymond VA, Selliah S, Boucher G, Bilodeau M, Grandvaux N, Lamarre D.

J Hepatol. 2010 Feb;52(2):167-75. doi: 10.1016/j.jhep.2009.11.011. Epub 2009 Nov 27.


Dual role of NOX2 in respiratory syncytial virus- and sendai virus-induced activation of NF-kappaB in airway epithelial cells.

Fink K, Duval A, Martel A, Soucy-Faulkner A, Grandvaux N.

J Immunol. 2008 May 15;180(10):6911-22.


Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association.

Clément JF, Bibeau-Poirier A, Gravel SP, Grandvaux N, Bonneil E, Thibault P, Meloche S, Servant MJ.

J Virol. 2008 Apr;82(8):3984-96. doi: 10.1128/JVI.02526-07. Epub 2008 Feb 13.


Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients.

Lezin A, Gillet N, Olindo S, Signaté A, Grandvaux N, Verlaeten O, Belrose G, de Carvalho Bittencourt M, Hiscott J, Asquith B, Burny A, Smadja D, Césaire R, Willems L.

Blood. 2007 Nov 15;110(10):3722-8. Epub 2007 Aug 23.


Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression.

Lefort S, Soucy-Faulkner A, Grandvaux N, Flamand L.

J Virol. 2007 Oct;81(20):10950-60. Epub 2007 Jul 25.


Innate host defense: Nox and Duox on phox's tail.

Grandvaux N, Soucy-Faulkner A, Fink K.

Biochimie. 2007 Sep;89(9):1113-22. Epub 2007 Apr 21. Review.


Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein.

Jaworska J, Gravel A, Fink K, Grandvaux N, Flamand L.

J Virol. 2007 Jun;81(11):5737-48. Epub 2007 Mar 21.


Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages.

Solis M, Romieu-Mourez R, Goubau D, Grandvaux N, Mesplede T, Julkunen I, Nardin A, Salcedo M, Hiscott J.

Eur J Immunol. 2007 Feb;37(2):528-39.


Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation.

Bibeau-Poirier A, Gravel SP, Clément JF, Rolland S, Rodier G, Coulombe P, Hiscott J, Grandvaux N, Meloche S, Servant MJ.

J Immunol. 2006 Oct 15;177(8):5059-67. Erratum in: J Immunol. 2006 Dec 15;177(12):8878-9.


Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.

Harris J, Olière S, Sharma S, Sun Q, Lin R, Hiscott J, Grandvaux N.

J Immunol. 2006 Aug 15;177(4):2527-35.


Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes.

Bannwarth S, Lainé S, Daher A, Grandvaux N, Clerzius G, Leblanc AC, Hiscott J, Gatignol A.

J Mol Biol. 2006 Feb 3;355(5):898-910. Epub 2005 Nov 28.


Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.

Desfosses Y, Solis M, Sun Q, Grandvaux N, Van Lint C, Burny A, Gatignol A, Wainberg MA, Lin R, Hiscott J.

J Virol. 2005 Jul;79(14):9180-91.


Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response.

Grandvaux N, Gaboriau F, Harris J, tenOever BR, Lin R, Hiscott J.

FEBS J. 2005 Jun;272(12):3120-31.


Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.

Breiman A, Grandvaux N, Lin R, Ottone C, Akira S, Yoneyama M, Fujita T, Hiscott J, Meurs EF.

J Virol. 2005 Apr;79(7):3969-78.


Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.

tenOever BR, Sharma S, Zou W, Sun Q, Grandvaux N, Julkunen I, Hemmi H, Yamamoto M, Akira S, Yeh WC, Lin R, Hiscott J.

J Virol. 2004 Oct;78(19):10636-49.


Cryptic O2- -generating NADPH oxidase in dendritic cells.

Elsen S, Doussière J, Villiers CL, Faure M, Berthier R, Papaioannou A, Grandvaux N, Marche PN, Vignais PV.

J Cell Sci. 2004 May 1;117(Pt 11):2215-26.


Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis.

Hiscott J, Grandvaux N, Sharma S, Tenoever BR, Servant MJ, Lin R.

Ann N Y Acad Sci. 2003 Dec;1010:237-48. Review.


Triggering the interferon antiviral response through an IKK-related pathway.

Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, Hiscott J.

Science. 2003 May 16;300(5622):1148-51. Epub 2003 Apr 17.


Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.

Servant MJ, Grandvaux N, tenOever BR, Duguay D, Lin R, Hiscott J.

J Biol Chem. 2003 Mar 14;278(11):9441-7. Epub 2003 Jan 10.

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