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Items: 1 to 50 of 93

1.

Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity.

Achour A, Broggini L, Han X, Sun R, Santambrogio C, Buratto J, Visentin C, Barbiroli A, De Luca CMG, Sormanni P, Moda F, De Simone A, Sandalova T, Grandori R, Camilloni C, Ricagno S.

FEBS J. 2019 Aug 17. doi: 10.1111/febs.15046. [Epub ahead of print]

PMID:
31420997
2.

An arsenal of methods for the experimental characterization of intrinsically disordered proteins - How to choose and combine them?

Schramm A, Bignon C, Brocca S, Grandori R, Santambrogio C, Longhi S.

Arch Biochem Biophys. 2019 Jul 26. pii: S0003-9861(19)30452-7. doi: 10.1016/j.abb.2019.07.020. [Epub ahead of print] Review.

PMID:
31356778
3.

Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity.

Daniels MJ, Nourse JB Jr, Kim H, Sainati V, Schiavina M, Murrali MG, Pan B, Ferrie JJ, Haney CM, Moons R, Gould NS, Natalello A, Grandori R, Sobott F, Petersson EJ, Rhoades E, Pierattelli R, Felli I, Uversky VN, Caldwell KA, Caldwell GA, Krol ES, Ischiropoulos H.

Sci Rep. 2019 Feb 27;9(1):2937. doi: 10.1038/s41598-019-39480-z.

4.

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity.

Carija A, Pinheiro F, Pujols J, Brás IC, Lázaro DF, Santambrogio C, Grandori R, Outeiro TF, Navarro S, Ventura S.

Redox Biol. 2019 Apr;22:101135. doi: 10.1016/j.redox.2019.101135. Epub 2019 Feb 5.

5.

Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure.

Ponzini E, De Palma A, Cerboni L, Natalello A, Rossi R, Moons R, Konijnenberg A, Narkiewicz J, Legname G, Sobott F, Mauri P, Santambrogio C, Grandori R.

J Biol Chem. 2019 Apr 5;294(14):5657-5665. doi: 10.1074/jbc.RA118.001907. Epub 2019 Feb 12.

6.

Structural characterization of aerogels derived from enzymatically oxidized galactomannans of fenugreek, sesbania and guar gums.

Ponzini E, Natalello A, Usai F, Bechmann M, Peri F, Müller N, Grandori R.

Carbohydr Polym. 2019 Mar 1;207:510-520. doi: 10.1016/j.carbpol.2018.11.100. Epub 2018 Dec 3.

PMID:
30600034
7.

Conformational Characterization and Classification of Intrinsically Disordered Proteins by Native Mass Spectrometry and Charge-State Distribution Analysis.

Santambrogio C, Natalello A, Brocca S, Ponzini E, Grandori R.

Proteomics. 2019 Mar;19(6):e1800060. doi: 10.1002/pmic.201800060. Epub 2018 Nov 29. Review.

PMID:
30365227
8.

Conformational response to charge clustering in synthetic intrinsically disordered proteins.

Tedeschi G, Salladini E, Santambrogio C, Grandori R, Longhi S, Brocca S.

Biochim Biophys Acta Gen Subj. 2018 Oct;1862(10):2204-2214. doi: 10.1016/j.bbagen.2018.07.011. Epub 2018 Jul 17.

PMID:
30025858
9.

Conformational properties of intrinsically disordered proteins bound to the surface of silica nanoparticles.

Vitali M, Rigamonti V, Natalello A, Colzani B, Avvakumova S, Brocca S, Santambrogio C, Narkiewicz J, Legname G, Colombo M, Prosperi D, Grandori R.

Biochim Biophys Acta Gen Subj. 2018 Jul;1862(7):1556-1564. doi: 10.1016/j.bbagen.2018.03.026. Epub 2018 Apr 2.

PMID:
29621630
10.

Disulfide driven folding for a conditionally disordered protein.

Fraga H, Pujols J, Gil-Garcia M, Roque A, Bernardo-Seisdedos G, Santambrogio C, Bech-Serra JJ, Canals F, Bernadó P, Grandori R, Millet O, Ventura S.

Sci Rep. 2017 Dec 5;7(1):16994. doi: 10.1038/s41598-017-17259-4.

11.

Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System.

Barbero F, Russo L, Vitali M, Piella J, Salvo I, Borrajo ML, Busquets-Fité M, Grandori R, Bastús NG, Casals E, Puntes V.

Semin Immunol. 2017 Dec;34:52-60. doi: 10.1016/j.smim.2017.10.001. Epub 2017 Oct 21. Review.

PMID:
29066063
12.

Terbium chelation, a specific fluorescent tagging of human transferrin. Optimization of conditions in view of its application to the HPLC analysis of carbohydrate-deficient transferrin (CDT).

Nicotra S, Sorio D, Filippi G, De Gioia L, Paterlini V, De Palo EF, Grandori R, Tagliaro F, Santambrogio C.

Anal Bioanal Chem. 2017 Nov;409(28):6605-6612. doi: 10.1007/s00216-017-0616-z. Epub 2017 Sep 29.

PMID:
28971232
13.

Proton Dynamics in Protein Mass Spectrometry.

Li J, Lyu W, Rossetti G, Konijnenberg A, Natalello A, Ippoliti E, Orozco M, Sobott F, Grandori R, Carloni P.

J Phys Chem Lett. 2017 Mar 16;8(6):1105-1112. doi: 10.1021/acs.jpclett.7b00127. Epub 2017 Feb 22.

14.

"Aerogels of enzymatically oxidized galactomannans from leguminous plants: Versatile delivery systems of antimicrobial peptides and enzymes".

Campia P, Ponzini E, Rossi B, Farris S, Silvetti T, Merlini L, Brasca M, Grandori R, Galante YM.

Carbohydr Polym. 2017 Feb 20;158:102-111. doi: 10.1016/j.carbpol.2016.11.089. Epub 2016 Dec 2.

15.

Correction: In Silico Generation of Peptides by Replica Exchange Monte Carlo: Docking-Based Optimization of Maltose-Binding-Protein Ligands.

Russo A, Scognamiglio PL, Hong Enriquez RP, Santambrogio C, Grandori R, Marasco D, Giordano A, Scoles G, Fortuna S.

PLoS One. 2016 Oct 18;11(10):e0165349. doi: 10.1371/journal.pone.0165349. eCollection 2016.

16.

Are Charge-State Distributions a Reliable Tool Describing Molecular Ensembles of Intrinsically Disordered Proteins by Native MS?

Natalello A, Santambrogio C, Grandori R.

J Am Soc Mass Spectrom. 2017 Jan;28(1):21-28. doi: 10.1007/s13361-016-1490-1. Epub 2016 Oct 11. Review.

PMID:
27730522
17.

α-Synuclein is a Novel Microtubule Dynamase.

Cartelli D, Aliverti A, Barbiroli A, Santambrogio C, Ragg EM, Casagrande FV, Cantele F, Beltramone S, Marangon J, De Gregorio C, Pandini V, Emanuele M, Chieregatti E, Pieraccini S, Holmqvist S, Bubacco L, Roybon L, Pezzoli G, Grandori R, Arnal I, Cappelletti G.

Sci Rep. 2016 Sep 15;6:33289. doi: 10.1038/srep33289.

18.

Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein.

Konijnenberg A, Ranica S, Narkiewicz J, Legname G, Grandori R, Sobott F, Natalello A.

Anal Chem. 2016 Sep 6;88(17):8468-75. doi: 10.1021/acs.analchem.6b00731. Epub 2016 Aug 12.

19.

Burkholderia cepacia lipase is a promising biocatalyst for biofuel production.

Sasso F, Natalello A, Castoldi S, Lotti M, Santambrogio C, Grandori R.

Biotechnol J. 2016 Jul;11(7):954-60. doi: 10.1002/biot.201500305. Epub 2016 Apr 29.

PMID:
27067648
20.

Embelin binds to human neuroserpin and impairs its polymerisation.

Saga G, Sessa F, Barbiroli A, Santambrogio C, Russo R, Sala M, Raccosta S, Martorana V, Caccia S, Noto R, Moriconi C, Miranda E, Grandori R, Manno M, Bolognesi M, Ricagno S.

Sci Rep. 2016 Jan 6;6:18769. doi: 10.1038/srep18769.

21.

In Silico Generation of Peptides by Replica Exchange Monte Carlo: Docking-Based Optimization of Maltose-Binding-Protein Ligands.

Russo A, Scognamiglio PL, Hong Enriquez RP, Santambrogio C, Grandori R, Marasco D, Giordano A, Scoles G, Fortuna S.

PLoS One. 2015 Aug 7;10(8):e0133571. doi: 10.1371/journal.pone.0133571. eCollection 2015. Erratum in: PLoS One. 2016 Oct 18;11(10 ):e0165349.

22.

An induced folding process characterizes the partial-loss of function mutant LptAI36D in its interactions with ligands.

Santambrogio C, Sperandeo P, Barbieri F, Martorana AM, Polissi A, Grandori R.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1451-7. doi: 10.1016/j.bbapap.2015.06.013. Epub 2015 Jun 27.

PMID:
26123264
23.

Conformational effects in protein electrospray-ionization mass spectrometry.

Li J, Santambrogio C, Brocca S, Rossetti G, Carloni P, Grandori R.

Mass Spectrom Rev. 2016 Jan-Feb;35(1):111-22. doi: 10.1002/mas.21465. Epub 2015 May 7. Review.

PMID:
25952139
24.

Bile salt recognition by human liver fatty acid binding protein.

Favretto F, Santambrogio C, D'Onofrio M, Molinari H, Grandori R, Assfalg M.

FEBS J. 2015 Apr;282(7):1271-88. doi: 10.1111/febs.13218. Epub 2015 Feb 18.

25.

Molecular basis for structural heterogeneity of an intrinsically disordered protein bound to a partner by combined ESI-IM-MS and modeling.

D'Urzo A, Konijnenberg A, Rossetti G, Habchi J, Li J, Carloni P, Sobott F, Longhi S, Grandori R.

J Am Soc Mass Spectrom. 2015 Mar;26(3):472-81. doi: 10.1007/s13361-014-1048-z. Epub 2014 Dec 16.

PMID:
25510932
26.

Structural investigation of the cold-adapted acylaminoacyl peptidase from Sporosarcina psychrophila by atomistic simulations and biophysical methods.

Papaleo E, Parravicini F, Grandori R, De Gioia L, Brocca S.

Biochim Biophys Acta. 2014 Dec;1844(12):2203-13. doi: 10.1016/j.bbapap.2014.09.018. Epub 2014 Oct 1.

PMID:
25280393
27.

The conformational response to Zn(II) and Ni(II) binding of Sporosarcina pasteurii UreG, an intrinsically disordered GTPase.

D'Urzo A, Santambrogio C, Grandori R, Ciurli S, Zambelli B.

J Biol Inorg Chem. 2014 Dec;19(8):1341-54. doi: 10.1007/s00775-014-1191-9. Epub 2014 Sep 9.

PMID:
25200810
28.

Functional characterization of E. coli LptC: interaction with LPS and a synthetic ligand.

Sestito SE, Sperandeo P, Santambrogio C, Ciaramelli C, Calabrese V, Rovati GE, Zambelloni L, Grandori R, Polissi A, Peri F.

Chembiochem. 2014 Mar 21;15(5):734-42.

PMID:
24677607
29.

Class I major histocompatibility complex, the trojan horse for secretion of amyloidogenic β2-microglobulin.

Halabelian L, Ricagno S, Giorgetti S, Santambrogio C, Barbiroli A, Pellegrino S, Achour A, Grandori R, Marchese L, Raimondi S, Mangione PP, Esposito G, Al-Shawi R, Simons JP, Speck I, Stoppini M, Bolognesi M, Bellotti V.

J Biol Chem. 2014 Feb 7;289(6):3318-27. doi: 10.1074/jbc.M113.524157. Epub 2013 Dec 13.

30.

LptA assembles into rod-like oligomers involving disorder-to-order transitions.

Santambrogio C, Sperandeo P, Villa R, Sobott F, Polissi A, Grandori R.

J Am Soc Mass Spectrom. 2013 Oct;24(10):1593-602. doi: 10.1007/s13361-013-0687-9. Epub 2013 Jul 30.

PMID:
23897621
31.

Mass spectrometry and NMR analysis of ligand binding by human liver fatty acid binding protein.

Santambrogio C, Favretto F, D'Onofrio M, Assfalg M, Grandori R, Molinari H.

J Mass Spectrom. 2013 Aug;48(8):895-903. doi: 10.1002/jms.3237.

PMID:
23893635
32.

Characterization of the genome of the dairy Lactobacillus helveticus bacteriophage {Phi}AQ113.

Zago M, Scaltriti E, Rossetti L, Guffanti A, Armiento A, Fornasari ME, Grolli S, Carminati D, Brini E, Pavan P, Felsani A, D'Urzo A, Moles A, Claude JB, Grandori R, Ramoni R, Giraffa G.

Appl Environ Microbiol. 2013 Aug;79(15):4712-8. doi: 10.1128/AEM.00620-13. Epub 2013 May 31.

33.

Extracting structural information from charge-state distributions of intrinsically disordered proteins by non-denaturing electrospray-ionization mass spectrometry.

Testa L, Brocca S, Santambrogio C, D'Urzo A, Habchi J, Longhi S, Uversky VN, Grandori R.

Intrinsically Disord Proteins. 2013 Apr 1;1(1):e25068. doi: 10.4161/idp.25068. eCollection 2013 Jan-Dec. Review.

34.

Effects of methanol on a methanol-tolerant bacterial lipase.

Santambrogio C, Sasso F, Natalello A, Brocca S, Grandori R, Doglia SM, Lotti M.

Appl Microbiol Biotechnol. 2013 Oct;97(19):8609-18. doi: 10.1007/s00253-013-4712-5. Epub 2013 Feb 1.

PMID:
23371296
35.

Intramolecular interactions stabilizing compact conformations of the intrinsically disordered kinase-inhibitor domain of Sic1: a molecular dynamics investigation.

Lambrughi M, Papaleo E, Testa L, Brocca S, De Gioia L, Grandori R.

Front Physiol. 2012 Nov 22;3:435. doi: 10.3389/fphys.2012.00435. eCollection 2012.

36.

A computational model for protein ionization by electrospray based on gas-phase basicity.

Marchese R, Grandori R, Carloni P, Raugei S.

J Am Soc Mass Spectrom. 2012 Nov;23(11):1903-10. doi: 10.1007/s13361-012-0449-0. Epub 2012 Sep 20.

PMID:
22993040
37.

Length-dependent compaction of intrinsically disordered proteins.

Uversky VN, Santambrogio C, Brocca S, Grandori R.

FEBS Lett. 2012 Jan 2;586(1):70-3. doi: 10.1016/j.febslet.2011.11.026. Epub 2011 Nov 28.

38.

The role of the central flexible region on the aggregation and conformational properties of human ataxin-3.

Santambrogio C, Frana AM, Natalello A, Papaleo E, Regonesi ME, Doglia SM, Tortora P, Invernizzi G, Grandori R.

FEBS J. 2012 Feb;279(3):451-63. doi: 10.1111/j.1742-4658.2011.08438.x. Epub 2012 Jan 9.

39.

Charge-surface correlation in electrospray ionization of folded and unfolded proteins.

Testa L, Brocca S, Grandori R.

Anal Chem. 2011 Sep 1;83(17):6459-63. doi: 10.1021/ac201740z. Epub 2011 Aug 5.

PMID:
21800882
40.

Characterization of β2-microglobulin conformational intermediates associated to different fibrillation conditions.

Santambrogio C, Ricagno S, Sobott F, Colombo M, Bolognesi M, Grandori R.

J Mass Spectrom. 2011 Aug;46(8):734-41. doi: 10.1002/jms.1946.

PMID:
21766392
41.

Novel RasGRF1-derived Tat-fused peptides inhibiting Ras-dependent proliferation and migration in mouse and human cancer cells.

Sacco E, Metalli D, Spinelli M, Manzoni R, Samalikova M, Grandori R, Morrione A, Traversa S, Alberghina L, Vanoni M.

Biotechnol Adv. 2012 Jan-Feb;30(1):233-43. doi: 10.1016/j.biotechadv.2011.05.011. Epub 2011 May 18.

PMID:
21620943
42.

D-strand perturbation and amyloid propensity in beta-2 microglobulin.

Azinas S, Colombo M, Barbiroli A, Santambrogio C, Giorgetti S, Raimondi S, Bonomi F, Grandori R, Bellotti V, Ricagno S, Bolognesi M.

FEBS J. 2011 Jul;278(13):2349-58. doi: 10.1111/j.1742-4658.2011.08157.x. Epub 2011 May 31.

43.

Compaction properties of an intrinsically disordered protein: Sic1 and its kinase-inhibitor domain.

Brocca S, Testa L, Sobott F, Samalikova M, Natalello A, Papaleo E, Lotti M, De Gioia L, Doglia SM, Alberghina L, Grandori R.

Biophys J. 2011 May 4;100(9):2243-52. doi: 10.1016/j.bpj.2011.02.055.

44.

The effects of an ideal beta-turn on beta-2 microglobulin fold stability.

Colombo M, Ricagno S, Barbiroli A, Santambrogio C, Giorgetti S, Raimondi S, Bonomi F, Grandori R, Bellotti V, Bolognesi M.

J Biochem. 2011 Jul;150(1):39-47. doi: 10.1093/jb/mvr034. Epub 2011 Mar 11.

PMID:
21398368
45.

New insights into the Lpt machinery for lipopolysaccharide transport to the cell surface: LptA-LptC interaction and LptA stability as sensors of a properly assembled transenvelope complex.

Sperandeo P, Villa R, Martorana AM, Samalikova M, Grandori R, Dehò G, Polissi A.

J Bacteriol. 2011 Mar;193(5):1042-53. doi: 10.1128/JB.01037-10. Epub 2010 Dec 17.

46.

Compact conformations of α-synuclein induced by alcohols and copper.

Natalello A, Benetti F, Doglia SM, Legname G, Grandori R.

Proteins. 2011 Feb;79(2):611-21. doi: 10.1002/prot.22909.

PMID:
21120859
47.

Electrospray ionization-mass spectrometry conformational analysis of isolated domains of an intrinsically disordered protein.

Testa L, Brocca S, Samalikova M, Santambrogio C, Alberghina L, Grandori R.

Biotechnol J. 2011 Jan;6(1):96-100. doi: 10.1002/biot.201000253.

PMID:
21053335
48.

Defining structural domains of an intrinsically disordered protein: Sic1, the cyclin-dependent kinase inhibitor of Saccharomyces cerevisiae.

Brocca S, Testa L, Samalikova M, Grandori R, Lotti M.

Mol Biotechnol. 2011 Jan;47(1):34-42. doi: 10.1007/s12033-010-9309-y.

PMID:
20589454
49.

DE-loop mutations affect beta2 microglobulin stability, oligomerization, and the low-pH unfolded form.

Santambrogio C, Ricagno S, Colombo M, Barbiroli A, Bonomi F, Bellotti V, Bolognesi M, Grandori R.

Protein Sci. 2010 Jul;19(7):1386-94. doi: 10.1002/pro.419.

50.

On the zwitterionic nature of gas-phase peptides and protein ions.

Marchese R, Grandori R, Carloni P, Raugei S.

PLoS Comput Biol. 2010 May 6;6(5):e1000775. doi: 10.1371/journal.pcbi.1000775.

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