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Items: 1 to 50 of 175

1.

Editorial: Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond.

Grandi E, Morotti S, Pueyo E, Rodriguez B.

Front Physiol. 2018 Jun 8;9:678. doi: 10.3389/fphys.2018.00678. eCollection 2018. No abstract available.

2.

Keeping it short and (not so) simple: characterizing hERG kinetics with sinusoidal waves.

Grandi E.

J Physiol. 2018 May 15;596(10):1783-1784. doi: 10.1113/JP276068. Epub 2018 Apr 1. No abstract available.

PMID:
29521425
3.

Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing.

Ortega FA, Grandi E, Krogh-Madsen T, Christini DJ.

Front Physiol. 2018 Jan 4;8:1099. doi: 10.3389/fphys.2017.01099. eCollection 2017. Review.

4.

Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias.

Vaidyanathan R, Van Ert H, Haq KT, Morotti S, Esch S, McCune EC, Grandi E, Eckhardt LL.

Circ Arrhythm Electrophysiol. 2018 Jan;11(1):e005800. doi: 10.1161/CIRCEP.117.005800.

PMID:
29326130
5.

In Silico Assessment of Efficacy and Safety of IKur Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding.

Ellinwood N, Dobrev D, Morotti S, Grandi E.

Front Pharmacol. 2017 Nov 7;8:799. doi: 10.3389/fphar.2017.00799. eCollection 2017.

6.

Erratum: "Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity" [Chaos 27, 093918 (2017)].

Ellinwood N, Dobrev D, Morotti S, Grandi E.

Chaos. 2017 Oct;27(10):109902. doi: 10.1063/1.5007051. No abstract available.

PMID:
29092428
7.

Non-ion channel therapeutics for heart failure and atrial fibrillation: Are CaMKII inhibitors ready for clinical use?

Grandi E, Dobrev D.

J Mol Cell Cardiol. 2017 Oct 25. pii: S0022-2828(17)30334-6. doi: 10.1016/j.yjmcc.2017.10.010. [Epub ahead of print]

PMID:
29079077
8.

Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity.

Ellinwood N, Dobrev D, Morotti S, Grandi E.

Chaos. 2017 Sep;27(9):093918. doi: 10.1063/1.5000226.

PMID:
28964116
9.

Correction: Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step.

Lombardi C, Artuso E, Grandi E, Lolli M, Spyrakis F, Priola E, Prandi C.

Org Biomol Chem. 2017 Oct 4;15(38):8232. doi: 10.1039/c7ob90152f.

PMID:
28932861
10.

Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step.

Lombardi C, Artuso E, Grandi E, Lolli M, Spirakys F, Priola E, Prandi C.

Org Biomol Chem. 2017 Oct 4;15(38):8218-8231. doi: 10.1039/c7ob01917c.

PMID:
28880031
11.

Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia.

Morotti S, Nieves-Cintrón M, Nystoriak MA, Navedo MF, Grandi E.

Channels (Austin). 2017 Jul 4;11(4):340-346. doi: 10.1080/19336950.2017.1293220. Epub 2017 Feb 10.

12.

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.

Surdo NC, Berrera M, Koschinski A, Brescia M, Machado MR, Carr C, Wright P, Gorelik J, Morotti S, Grandi E, Bers DM, Pantano S, Zaccolo M.

Nat Commun. 2017 Apr 20;8:15031. doi: 10.1038/ncomms15031.

13.

Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.

Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF.

Sci Signal. 2017 Jan 24;10(463). pii: eaaf9647. doi: 10.1126/scisignal.aaf9647.

14.

Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk.

Morotti S, Grandi E.

MethodsX. 2016 Dec 23;4:25-34. doi: 10.1016/j.mex.2016.12.002. eCollection 2017.

15.

Quantitative analysis of the Ca2+ -dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes.

Bartos DC, Morotti S, Ginsburg KS, Grandi E, Bers DM.

J Physiol. 2017 Apr 1;595(7):2253-2268. doi: 10.1113/JP273676. Epub 2017 Mar 28.

16.

Size matters, proportion too: coupling of experiments and theory reveals relative roles of K+ channels in action potential stability.

Grandi E.

J Physiol. 2017 Apr 1;595(7):2319-2320. doi: 10.1113/JP273665. Epub 2017 Jan 11. No abstract available.

17.

Potassium channels in the heart: structure, function and regulation.

Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V.

J Physiol. 2017 Apr 1;595(7):2209-2228. doi: 10.1113/JP272864. Epub 2016 Nov 13. Review.

18.

Finite-element modeling of time-dependent sodium exchange across the hollow fiber of a hemodialyzer by coupling with a blood pool model.

Ravagli E, Grandi E, Rovatti P, Severi S.

Int J Artif Organs. 2016 Nov 11;39(9):471-478. doi: 10.5301/ijao.5000528. Epub 2016 Nov 5.

PMID:
27834449
19.

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics.

Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM.

J Physiol. 2017 Apr 1;595(7):2229-2252. doi: 10.1113/JP272883. Epub 2017 Jan 5. Review.

20.

Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization.

Grandi E, Maleckar MM.

Pharmacol Ther. 2016 Dec;168:126-142. doi: 10.1016/j.pharmthera.2016.09.012. Epub 2016 Sep 6. Review.

21.

High serum uric acid is associated to poorly controlled blood pressure and higher arterial stiffness in hypertensive subjects.

Cicero AF, Rosticci M, Fogacci F, Grandi E, D'Addato S, Borghi C; Brisighella Heart Study Group.

Eur J Intern Med. 2017 Jan;37:38-42. doi: 10.1016/j.ejim.2016.07.026. Epub 2016 Aug 3.

PMID:
27498274
22.

Supplementation with Omega-3 Fatty Acids in Psychiatric Disorders: A Review of Literature Data.

Bozzatello P, Brignolo E, De Grandi E, Bellino S.

J Clin Med. 2016 Jul 27;5(8). pii: E67. doi: 10.3390/jcm5080067. Review.

23.
24.

Lipid-lowering and anti-inflammatory effects of omega 3 ethyl esters and krill oil: a randomized, cross-over, clinical trial.

Cicero AF, Rosticci M, Morbini M, Cagnati M, Grandi E, Parini A, Borghi C.

Arch Med Sci. 2016 Jun 1;12(3):507-12. doi: 10.5114/aoms.2016.59923. Epub 2016 May 18.

25.

Middle-Term Dietary Supplementation with Red Yeast Rice Plus Coenzyme Q10 Improves Lipid Pattern, Endothelial Reactivity and Arterial Stiffness in Moderately Hypercholesterolemic Subjects.

Cicero AF, Morbini M, Rosticci M, D''Addato S, Grandi E, Borghi C.

Ann Nutr Metab. 2016;68(3):213-9. doi: 10.1159/000445359. Epub 2016 Apr 8.

PMID:
27055107
26.

Effect of red yeast rice combined with antioxidants on lipid pattern, hs-CRP level, and endothelial function in moderately hypercholesterolemic subjects.

Cicero AF, Morbini M, Parini A, Urso R, Rosticci M, Grandi E, Borghi C.

Ther Clin Risk Manag. 2016 Feb 23;12:281-6. doi: 10.2147/TCRM.S91817. eCollection 2016.

27.

In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia.

Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov SY, Clancy CE.

J Physiol. 2016 Feb 1;594(3):567-93. doi: 10.1113/JP271282. Epub 2015 Dec 30.

28.

Association between self-reported snoring and arterial stiffness: data from the Brisighella Heart Study.

Cicero AF, Morbini M, Urso R, Rosticci M, Parini A, Grandi E, D'Addato S, Borghi C; Brisighella Heart Study Group.

Intern Emerg Med. 2016 Feb;11(1):77-83. doi: 10.1007/s11739-015-1310-9. Epub 2015 Sep 28.

PMID:
26415727
29.

Slow [Na]i Changes and Positive Feedback Between Membrane Potential and [Ca]i Underlie Intermittent Early Afterdepolarizations and Arrhythmias.

Xie Y, Liao Z, Grandi E, Shiferaw Y, Bers DM.

Circ Arrhythm Electrophysiol. 2015 Dec;8(6):1472-80. doi: 10.1161/CIRCEP.115.003085. Epub 2015 Sep 25.

30.

Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes.

Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E.

J Mol Cell Cardiol. 2016 Jul;96:63-71. doi: 10.1016/j.yjmcc.2015.07.030. Epub 2015 Aug 1.

31.

Ion Channels in the Heart.

Bartos DC, Grandi E, Ripplinger CM.

Compr Physiol. 2015 Jul 1;5(3):1423-64. doi: 10.1002/cphy.c140069. Review.

32.

2B.02: SERUM URIC ACID LEVEL, BUT NOT RENAL FUNCTION OR ARTERIAL STIFFNESS, IS ASSOCIATED TO WORSE BLOOD PRESSURE CONTROL IN GENERAL PRACTICE: DATA FROM THE BRISIGHELLA HEART STUDY.

Cicero A, Rosticci M, Tartagni E, Parini A, Grandi E, D'Addato S, Borghi C, Group B.

J Hypertens. 2015 Jun;33 Suppl 1:e22. doi: 10.1097/01.hjh.0000467407.63913.89.

PMID:
26102760
33.

Short-term effects of a combined nutraceutical of insulin-sensitivity, lipid level and indexes of liver steatosis: a double-blind, randomized, cross-over clinical trial.

Cicero AF, Rosticci M, Parini A, Morbini M, Urso R, Grandi E, Borghi C.

Nutr J. 2015 Mar 28;14:30. doi: 10.1186/s12937-015-0019-y.

34.

Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.

35.

β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model.

Negroni JA, Morotti S, Lascano EC, Gomes AV, Grandi E, Puglisi JL, Bers DM.

J Mol Cell Cardiol. 2015 Apr;81:162-75. doi: 10.1016/j.yjmcc.2015.02.014. Epub 2015 Feb 25.

36.

Relationship between serum uric acid and electrocardiographic alterations in a large sample of general population: data from the Brisighella Heart Study.

Cicero AF, Rosticci M, Reggi A, Derosa G, Parini A, Grandi E, D'Addato S, Borghi C.

High Blood Press Cardiovasc Prev. 2015 Jun;22(2):129-34. doi: 10.1007/s40292-014-0077-9. Epub 2014 Dec 16.

PMID:
25512187
37.

Serum uric acid and markers of low-density lipoprotein oxidation in nonsmoking healthy subjects: data from the Brisighella Heart Study.

Cicero AF, Rosticci M, Cagnati M, Urso R, Scapagnini G, Morbini M, Grandi E, D'Addato S, Borghi C; Brisighella Heart Study Group.

Pol Arch Med Wewn. 2014;124(12):661-8. Epub 2014 Oct 10.

38.

Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle.

Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD.

Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1205-13. doi: 10.1161/CIRCEP.113.001666. Epub 2014 Sep 18.

39.

[Interpersonal psychotherapy: a model of intervention for borderline personality disorder].

Bellino S, Bozzatello P, De Grandi E, Bogetto F.

Riv Psichiatr. 2014 Jul-Aug;49(4):158-63. doi: 10.1708/1600.17450. Italian.

PMID:
25174691
40.

Serum LDL cholesterol levels and new onset of arterial hypertension: an 8-year follow-up.

Cicero AF, Rosticci M, Baronio C, Morbini M, Parini A, Grandi E, D'Addato S, Borghi C; Brisighella Heart Study Group.

Eur J Clin Invest. 2014 Oct;44(10):926-32. doi: 10.1111/eci.12325.

PMID:
25124768
41.

CaMKII comes of age in cardiac health and disease.

Grandi E, Edwards AG, Herren AW, Bers DM.

Front Pharmacol. 2014 Jul 3;5:154. doi: 10.3389/fphar.2014.00154. eCollection 2014. No abstract available.

42.

Anatomo-functional study of the temporo-parieto-occipital region: dissection, tractographic and brain mapping evidence from a neurosurgical perspective.

De Benedictis A, Duffau H, Paradiso B, Grandi E, Balbi S, Granieri E, Colarusso E, Chioffi F, Marras CE, Sarubbo S.

J Anat. 2014 Aug;225(2):132-51. doi: 10.1111/joa.12204. Epub 2014 Jun 30.

43.

Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy.

Soukupová M, Binaschi A, Falcicchia C, Zucchini S, Roncon P, Palma E, Magri E, Grandi E, Simonato M.

Exp Neurol. 2014 Jul;257:39-49. doi: 10.1016/j.expneurol.2014.04.014. Epub 2014 Apr 21.

PMID:
24768627
44.

Berberine and monacolin effects on the cardiovascular risk profile of women with oestroprogestin-induced hypercholesterolemia.

Cicero AF, Reggi A, Parini A, Morbini M, Rosticci M, Grandi E, Borghi C.

High Blood Press Cardiovasc Prev. 2014 Sep;21(3):221-6. doi: 10.1007/s40292-014-0052-5. Epub 2014 Apr 12.

PMID:
24728953
45.

CaMKII-dependent regulation of cardiac Na(+) homeostasis.

Grandi E, Herren AW.

Front Pharmacol. 2014 Mar 10;5:41. doi: 10.3389/fphar.2014.00041. eCollection 2014. Review.

46.

How does β-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation?

Xie Y, Grandi E, Bers DM, Sato D.

Europace. 2014 Mar;16(3):452-7. doi: 10.1093/europace/eut412.

47.

A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII.

Morotti S, Edwards AG, McCulloch AD, Bers DM, Grandi E.

J Physiol. 2014 Mar 15;592(6):1181-97. doi: 10.1113/jphysiol.2013.266676. Epub 2014 Jan 13.

48.

Population health needs assessment and healthcare services use in a 3 years follow-up on administrative and clinical data: results from the Brisighella Heart Study.

Cicero AF, Rosticci M, D'Addato S, Baronio C, Grossi G, Grandi E, Borghi C.

High Blood Press Cardiovasc Prev. 2014 Mar;21(1):45-51. doi: 10.1007/s40292-013-0033-0. Epub 2013 Nov 16.

PMID:
24242956
49.

Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening.

Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE.

Circ Res. 2013 Sep 13;113(7):e50-e61. doi: 10.1161/CIRCRESAHA.113.301971. Epub 2013 Jul 29.

50.

Technical, Anatomical, and Functional Study after Removal of a Symptomatic Cavernous Angioma Located in Deep Wernicke's Territories with Cortico-Subcortical Awake Mapping.

Sarubbo S, Basso G, Chioffi F, Cesnik E, Paradiso B, Grandi E, Fainardi E, Tugnoli V, Farneti M, Granieri E.

Case Rep Neurol Med. 2013;2013:835029. doi: 10.1155/2013/835029. Epub 2013 Jun 24.

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