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Items: 1 to 50 of 340

1.

Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals.

Leseva MN, Grand RJ, Klett H, Boerries M, Busch H, Binder AM, Michels KB.

Sci Rep. 2018 Apr 4;8(1):5649. doi: 10.1038/s41598-018-23957-4.

2.

Degradation of a novel DNA damage response protein, tankyrase 1 binding protein 1 (Tab182), following adenovirus infection.

Hagkarim NC, Ryan EL, Byrd PJ, Hollingworth R, Shimwell NJ, Agathanggelou A, Vavasseur M, Kolbe V, Speiseder T, Dobner T, Stewart GS, Grand RJ.

J Virol. 2018 Mar 28. pii: JVI.02034-17. doi: 10.1128/JVI.02034-17. [Epub ahead of print]

3.

Risk factors for low bone mineral density in pediatric inflammatory bowel disease: the positive role of physical activity.

Nobile S, Grand RJ, Pappa HM.

Eur J Gastroenterol Hepatol. 2018 Apr;30(4):471-476. doi: 10.1097/MEG.0000000000001076.

PMID:
29438136
4.

Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.

Hollingworth R, Horniblow RD, Forrest C, Stewart GS, Grand RJ.

J Virol. 2017 Oct 27;91(22). pii: e00930-17. doi: 10.1128/JVI.00930-17. Print 2017 Nov 15.

5.

The Utility of the Systemic Inflammatory Respsonse Syndrome Score on Admission in Children With Acute Pancreatitis.

Grover AS, Kadiyala V, Banks PA, Grand RJ, Conwell DL, Lightdale JR.

Pancreas. 2017 Jan;46(1):106-109.

PMID:
27841791
6.

Trends in Pharmacologic Interventions for Preventing Recurrence of Crohn's Disease After Ileocolonic Surgery.

Ong MS, Grand RJ, Mandl KD.

Inflamm Bowel Dis. 2016 Oct;22(10):2432-41. doi: 10.1097/MIB.0000000000000898.

PMID:
27631599
7.

50 Years Ago in TheJournal ofPediatrics: Macroscopic Cysts of the Pancreas in a Case of Cystic Fibrosis.

Leung DH, Grand RJ.

J Pediatr. 2016 Sep;176:133. doi: 10.1016/j.jpeds.2016.03.051. No abstract available.

PMID:
27568251
8.

Activation of the DNA Damage Response by RNA Viruses.

Ryan EL, Hollingworth R, Grand RJ.

Biomolecules. 2016 Jan 6;6(1):2. doi: 10.3390/biom6010002. Review.

9.

Alchemix, p53 and topoisomerase.

Grand RJ, Stewart GS.

Aging (Albany NY). 2015 Sep;7(9):601-2. No abstract available.

10.

Correction: Hollingworth, R.; Grand, R.J. Modulation of DNA Damage and Repair Pathways by Human Tumour Viruses. Viruses 2015, 7, 2542-2591.

Hollingworth R, Grand RJ.

Viruses. 2015 Jun 19;7(6):3201-3. doi: 10.3390/v7062767. No abstract available.

11.

Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.

Hollingworth R, Skalka GL, Stewart GS, Hislop AD, Blackbourn DJ, Grand RJ.

Viruses. 2015 Jun 5;7(6):2908-27. doi: 10.3390/v7062752.

12.

Modulation of DNA damage and repair pathways by human tumour viruses.

Hollingworth R, Grand RJ.

Viruses. 2015 May 22;7(5):2542-91. doi: 10.3390/v7052542. Review. Erratum in: Viruses. 2015 Jun;7(6):3201-3.

13.

Functional significance of single nucleotide polymorphisms in the lactase gene in diverse US patients and evidence for a novel lactase persistence allele at -13909 in those of European ancestry.

Baffour-Awuah NY, Fleet S, Montgomery RK, Baker SS, Butler JL, Campbell C, Tischfield S, Mitchell PD, Allende-Richter S, Moon JE, Fishman L, Bousvaros A, Fox V, Kuokkanen M, Grand RJ, Hirschhorn JN.

J Pediatr Gastroenterol Nutr. 2015 Feb;60(2):182-91. doi: 10.1097/MPG.0000000000000595.

14.

The dual-acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53.

Thomas A, Perry T, Berhane S, Oldreive C, Zlatanou A, Williams LR, Weston VJ, Stankovic T, Kearns P, Pors K, Grand RJ, Stewart GS.

Oncogene. 2015 Jun;34(25):3336-48. doi: 10.1038/onc.2014.266. Epub 2014 Aug 18.

PMID:
25132271
15.

Potential role of IGF-1 z score to predict permanent linear growth impairment in children with IBD.

Lee JJ, Mitchell PD, Hood HC, Grand RJ, Cohen LE.

J Pediatr Gastroenterol Nutr. 2014 Apr;58(4):472-6. doi: 10.1097/MPG.0000000000000234.

PMID:
24663033
16.

ATM activation in hypoxia - causes and consequences.

Olcina MM, Grand RJ, Hammond EM.

Mol Cell Oncol. 2014 Jul 28;1(1):e29903. doi: 10.4161/mco.29903. eCollection 2014. Review.

17.

Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.

Sedgwick GG, Townsend K, Martin A, Shimwell NJ, Grand RJ, Stewart GS, Nilsson J, Turnell AS.

Oncogene. 2013 Sep 26;32(39):4622-33. doi: 10.1038/onc.2012.501. Epub 2012 Nov 19.

18.

Acute cognitive and behavioral effects of systemic corticosteroids in children treated for inflammatory bowel disease.

Mrakotsky C, Forbes PW, Bernstein JH, Grand RJ, Bousvaros A, Szigethy E, Waber DP.

J Int Neuropsychol Soc. 2013 Jan;19(1):96-109. doi: 10.1017/S1355617712001014. Epub 2012 Nov 19.

19.

DNA viruses and the cellular DNA-damage response.

Turnell AS, Grand RJ.

J Gen Virol. 2012 Oct;93(Pt 10):2076-97. doi: 10.1099/vir.0.044412-0. Epub 2012 Aug 1. Review.

PMID:
22855786
20.

Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.

Polo SE, Blackford AN, Chapman JR, Baskcomb L, Gravel S, Rusch A, Thomas A, Blundred R, Smith P, Kzhyshkowska J, Dobner T, Taylor AM, Turnell AS, Stewart GS, Grand RJ, Jackson SP.

Mol Cell. 2012 Feb 24;45(4):505-16. doi: 10.1016/j.molcel.2011.12.035.

21.

Characterization of the 55-residue protein encoded by the 9S E1A mRNA of species C adenovirus.

Miller MS, Pelka P, Fonseca GJ, Cohen MJ, Kelly JN, Barr SD, Grand RJ, Turnell AS, Whyte P, Mymryk JS.

J Virol. 2012 Apr;86(8):4222-33. doi: 10.1128/JVI.06399-11. Epub 2012 Feb 1.

22.

Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection.

Forrester NA, Patel RN, Speiseder T, Groitl P, Sedgwick GG, Shimwell NJ, Seed RI, Catnaigh PÓ, McCabe CJ, Stewart GS, Dobner T, Grand RJ, Martin A, Turnell AS.

J Virol. 2012 Mar;86(6):3167-79. doi: 10.1128/JVI.06583-11. Epub 2011 Dec 28.

23.

Adenovirus E1A interacts directly with, and regulates the level of expression of, the immunoproteasome component MECL1.

Berhane S, Aresté C, Ablack JN, Ryan GB, Blackbourn DJ, Mymryk JS, Turnell AS, Steele JC, Grand RJ.

Virology. 2011 Dec 20;421(2):149-58. doi: 10.1016/j.virol.2011.09.025. Epub 2011 Oct 21.

24.

Prevalence and risk factors for hypovitaminosis D in young patients with inflammatory bowel disease.

Pappa HM, Langereis EJ, Grand RJ, Gordon CM.

J Pediatr Gastroenterol Nutr. 2011 Oct;53(4):361-4. doi: 10.1097/MPG.0b013e3182250b3e.

25.

Efficacy and harms of nasal calcitonin in improving bone density in young patients with inflammatory bowel disease: a randomized, placebo-controlled, double-blind trial.

Pappa HM, Saslowsky TM, Filip-Dhima R, DiFabio D, Hassani Lahsinoui H, Akkad A, Grand RJ, Gordon CM.

Am J Gastroenterol. 2011 Aug;106(8):1527-43. doi: 10.1038/ajg.2011.129. Epub 2011 Apr 26.

26.

Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection.

Forrester NA, Sedgwick GG, Thomas A, Blackford AN, Speiseder T, Dobner T, Byrd PJ, Stewart GS, Turnell AS, Grand RJ.

J Virol. 2011 Mar;85(5):2201-11. doi: 10.1128/JVI.01748-10. Epub 2010 Dec 15.

27.

Characterization of expression in mice of a transgene containing 3.3 kb of the human lactase-phlorizin hydrolase (LPH) 5' flanking sequence.

Baffour-Awuah NY, Delemarre E, Fujiwara Y, Heijmans J, Boerwinkel D, Algra S, Fialkovich JJ, Islam S, Bosse T, Grand RJ, Krasinski SD, Montgomery RK.

Dig Dis Sci. 2011 Jan;56(1):59-69. doi: 10.1007/s10620-010-1480-2. Epub 2010 Nov 18.

28.

Comparison of E1A CR3-dependent transcriptional activation across six different human adenovirus subgroups.

Ablack JN, Pelka P, Yousef AF, Turnell AS, Grand RJ, Mymryk JS.

J Virol. 2010 Dec;84(24):12771-81. doi: 10.1128/JVI.01243-10. Epub 2010 Sep 29.

29.

Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.

Lee JJ, Essers JB, Kugathasan S, Escher JC, Lettre G, Butler JL, Stephens MC, Ramoni MF, Grand RJ, Hirschhorn J.

Ann Hum Genet. 2010 Nov;74(6):489-97. doi: 10.1111/j.1469-1809.2010.00606.x. Epub 2010 Sep 15.

30.

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation.

Blackford AN, Patel RN, Forrester NA, Theil K, Groitl P, Stewart GS, Taylor AM, Morgan IM, Dobner T, Grand RJ, Turnell AS.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12251-6. doi: 10.1073/pnas.0914605107. Epub 2010 Jun 21.

31.

Intestinal ferroportin expression in pediatric Crohn's disease.

Burpee T, Mitchell P, Fishman D, Islam S, Nemeth E, Westerman M, Wessling-Resnick M, Grand RJ.

Inflamm Bowel Dis. 2011 Feb;17(2):524-31. doi: 10.1002/ibd.21367.

32.

Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z-score.

Lee JJ, Escher JC, Shuman MJ, Forbes PW, Delemarre LC, Harr BW, Kruijer M, Moret M, Allende-Richter S, Grand RJ.

Inflamm Bowel Dis. 2010 Oct;16(10):1669-77. doi: 10.1002/ibd.21214.

33.

Developmental expression of Eph and ephrin family genes in mammalian small intestine.

Islam S, Loizides AM, Fialkovich JJ, Grand RJ, Montgomery RK.

Dig Dis Sci. 2010 Sep;55(9):2478-88. doi: 10.1007/s10620-009-1102-z. Epub 2010 Jan 29.

34.

Identification of a second independent binding site for the pCAF acetyltransferase in adenovirus E1A.

Pelka P, Ablack JN, Shuen M, Yousef AF, Rasti M, Grand RJ, Turnell AS, Mymryk JS.

Virology. 2009 Aug 15;391(1):90-8. doi: 10.1016/j.virol.2009.05.024. Epub 2009 Jun 21.

35.

Established genetic risk factors do not distinguish early and later onset Crohn's disease.

Essers JB, Lee JJ, Kugathasan S, Stevens CR, Grand RJ, Daly MJ; NIDDK IBD Genetics Consortium.

Inflamm Bowel Dis. 2009 Oct;15(10):1508-14. doi: 10.1002/ibd.20922.

36.

Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation.

Blackford AN, Grand RJ.

J Virol. 2009 May;83(9):4000-12. doi: 10.1128/JVI.02417-08. Epub 2009 Feb 11. Review. No abstract available.

37.

Immune response to influenza vaccine in children with inflammatory bowel disease.

Lu Y, Jacobson DL, Ashworth LA, Grand RJ, Meyer AL, McNeal MM, Gregas MC, Burchett SK, Bousvaros A.

Am J Gastroenterol. 2009 Feb;104(2):444-53. doi: 10.1038/ajg.2008.120. Epub 2009 Jan 27.

38.

Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP.

Pelka P, Ablack JN, Torchia J, Turnell AS, Grand RJ, Mymryk JS.

Nucleic Acids Res. 2009 Mar;37(4):1095-106. doi: 10.1093/nar/gkn1057. Epub 2009 Jan 7.

39.

Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway.

Shimwell NJ, Martin A, Bruton RK, Blackford AN, Sedgwick GG, Gallimore PH, Turnell AS, Grand RJ.

Oncogene. 2009 Feb 5;28(5):686-97. doi: 10.1038/onc.2008.417. Epub 2008 Nov 24.

PMID:
19029952
40.

Profile of depression in adolescents with inflammatory bowel disease: implications for treatment.

Szigethy E, Craig AE, Iobst EA, Grand RJ, Keljo D, DeMaso D, Noll R.

Inflamm Bowel Dis. 2009 Jan;15(1):69-74. doi: 10.1002/ibd.20693.

41.

Does inflammatory bowel disease develop in infants?

Kappelman MD, Grand RJ.

Inflamm Bowel Dis. 2008 Oct;14 Suppl 2:S6-8. doi: 10.1002/ibd.20544. Review. No abstract available. Erratum in: Inflamm Bowel Dis. 2009 Sep;15(9):1438-47.

42.

GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors.

Beuling E, Bosse T, aan de Kerk DJ, Piaseckyj CM, Fujiwara Y, Katz SG, Orkin SH, Grand RJ, Krasinski SD.

Dev Biol. 2008 Oct 1;322(1):179-89. doi: 10.1016/j.ydbio.2008.07.022. Epub 2008 Jul 26.

43.

Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3.

Bruton RK, Pelka P, Mapp KL, Fonseca GJ, Torchia J, Turnell AS, Mymryk JS, Grand RJ.

J Virol. 2008 Sep;82(17):8476-86. doi: 10.1128/JVI.00248-08. Epub 2008 Jun 4.

44.

A role for E1B-AP5 in ATR signaling pathways during adenovirus infection.

Blackford AN, Bruton RK, Dirlik O, Stewart GS, Taylor AM, Dobner T, Grand RJ, Turnell AS.

J Virol. 2008 Aug;82(15):7640-52. doi: 10.1128/JVI.00170-08. Epub 2008 May 14.

45.

Vitamin D status in gastrointestinal and liver disease.

Pappa HM, Bern E, Kamin D, Grand RJ.

Curr Opin Gastroenterol. 2008 Mar;24(2):176-83. doi: 10.1097/MOG.0b013e3282f4d2f3. Review.

46.

Lactose and lactase--who is lactose intolerant and why?

Montgomery RK, Krasinski SD, Hirschhorn JN, Grand RJ.

J Pediatr Gastroenterol Nutr. 2007 Dec;45 Suppl 2:S131-7. doi: 10.1097/MPG.0b013e31812e68f6. Review.

PMID:
18185074
47.

Lactose malabsorption.

Grand RJ, Montgomery RK.

Curr Treat Options Gastroenterol. 2008 Feb;11(1):19-25. doi: 10.1007/s11938-008-0003-0.

PMID:
21063860
48.

The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States.

Kappelman MD, Rifas-Shiman SL, Kleinman K, Ollendorf D, Bousvaros A, Grand RJ, Finkelstein JA.

Clin Gastroenterol Hepatol. 2007 Dec;5(12):1424-9. Epub 2007 Sep 29.

PMID:
17904915
49.

C-terminal-binding protein interacting protein binds directly to adenovirus early region 1A through its N-terminal region and conserved region 3.

Bruton RK, Rasti M, Mapp KL, Young N, Carter RZ, Abramowicz IA, Sedgwick GG, Onion DF, Shuen M, Mymryk JS, Turnell AS, Grand RJ.

Oncogene. 2007 Nov 22;26(53):7467-79. Epub 2007 Jun 4.

PMID:
17546052
50.

The effect of CtBP1 binding on the structure of the C-terminal region of adenovirus 12 early region 1A.

Molloy DP, Barral PM, Gallimore PH, Grand RJ.

Virology. 2007 Jul 5;363(2):342-56. Epub 2007 Mar 1.

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