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AKAP6 and phospholamban colocalize and interact in HEK-293T cells and primary murine cardiomyocytes.

Hakem Zadeh F, Teng ACT, Kuzmanov U, Chambers PJ, Tupling AR, Gramolini AO.

Physiol Rep. 2019 Jul;7(14):e14144. doi: 10.14814/phy2.14144.


Nanoscale reorganization of sarcoplasmic reticulum in pressure-overload cardiac hypertrophy visualized by dSTORM.

Hadipour-Lakmehsari S, Driouchi A, Lee SH, Kuzmanov U, Callaghan NI, Heximer SP, Simmons CA, Yip CM, Gramolini AO.

Sci Rep. 2019 May 27;9(1):7867. doi: 10.1038/s41598-019-44331-y.


Modeling cardiac complexity: Advancements in myocardial models and analytical techniques for physiological investigation and therapeutic development in vitro.

Callaghan NI, Hadipour-Lakmehsari S, Lee SH, Gramolini AO, Simmons CA.

APL Bioeng. 2019 Feb 5;3(1):011501. doi: 10.1063/1.5055873. eCollection 2019 Mar. Review.


Next-Generation Approaches to Predicting the Need for Heart Failure Hospitalization.

Afshar M, Lee DS, Epelman S, Gramolini AO, Ross HJ, Lawler PR.

Can J Cardiol. 2019 Apr;35(4):379-381. doi: 10.1016/j.cjca.2019.01.008. Epub 2019 Jan 25. No abstract available.


Limited Endothelial Plasticity of Mesenchymal Stem Cells Revealed by Quantitative Phenotypic Comparisons to Representative Endothelial Cell Controls.

Antonyshyn JA, McFadden MJ, Gramolini AO, Hofer SOP, Santerre JP.

Stem Cells Transl Med. 2019 Jan;8(1):35-45. doi: 10.1002/sctm.18-0127. Epub 2018 Sep 30.


The Dipeptidyl Peptidase 4 Substrate CXCL12 Has Opposing Cardiac Effects in Young Mice and Aged Diabetic Mice Mediated by Ca2+ Flux and Phosphoinositide 3-Kinase γ.

Batchu SN, Thieme K, Zadeh FH, Alghamdi TA, Yerra VG, Hadden MJ, Majumder S, Kabir MG, Bowskill BB, Ladha D, Gramolini AO, Connelly KA, Advani A.

Diabetes. 2018 Nov;67(11):2443-2455. doi: 10.2337/db18-0410. Epub 2018 Aug 27.


Three-dimensional imaging reveals endo(sarco)plasmic reticulum-containing invaginations within the nucleoplasm of muscle.

Lee SH, Hadipour-Lakmehsari S, Miyake T, Gramolini AO.

Am J Physiol Cell Physiol. 2018 Mar 1;314(3):C257-C267. doi: 10.1152/ajpcell.00141.2017. Epub 2017 Nov 22.


Hypoxia-Induced Changes in the Fibroblast Secretome, Exosome, and Whole-Cell Proteome Using Cultured, Cardiac-Derived Cells Isolated from Neonatal Mice.

Cosme J, Guo H, Hadipour-Lakmehsari S, Emili A, Gramolini AO.

J Proteome Res. 2017 Aug 4;16(8):2836-2847. doi: 10.1021/acs.jproteome.7b00144. Epub 2017 Jul 6.


Cardiac Overexpression of S100A6 Attenuates Cardiomyocyte Apoptosis and Reduces Infarct Size After Myocardial Ischemia-Reperfusion.

Mofid A, Newman NS, Lee PJ, Abbasi C, Matkar PN, Rudenko D, Kuliszewski MA, Chen HH, Afrasiabi K, Tsoporis JN, Gramolini AO, Connelly KA, Parker TG, Leong-Poi H.

J Am Heart Assoc. 2017 Feb 7;6(2). pii: e004738. doi: 10.1161/JAHA.116.004738.


Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy.

Kuzmanov U, Guo H, Buchsbaum D, Cosme J, Abbasi C, Isserlin R, Sharma P, Gramolini AO, Emili A.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12592-12597. Epub 2016 Oct 14.


Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer.

Kim Y, Jeon J, Mejia S, Yao CQ, Ignatchenko V, Nyalwidhe JO, Gramolini AO, Lance RS, Troyer DA, Drake RR, Boutros PC, Semmes OJ, Kislinger T.

Nat Commun. 2016 Jun 28;7:11906. doi: 10.1038/ncomms11906.


Self-renewing resident arterial macrophages arise from embryonic CX3CR1(+) precursors and circulating monocytes immediately after birth.

Ensan S, Li A, Besla R, Degousee N, Cosme J, Roufaiel M, Shikatani EA, El-Maklizi M, Williams JW, Robins L, Li C, Lewis B, Yun TJ, Lee JS, Wieghofer P, Khattar R, Farrokhi K, Byrne J, Ouzounian M, Zavitz CC, Levy GA, Bauer CM, Libby P, Husain M, Swirski FK, Cheong C, Prinz M, Hilgendorf I, Randolph GJ, Epelman S, Gramolini AO, Cybulsky MI, Rubin BB, Robbins CS.

Nat Immunol. 2016 Feb;17(2):159-68. doi: 10.1038/ni.3343. Epub 2015 Dec 7.


Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.

Sharma P, Abbasi C, Lazic S, Teng ACT, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann WH, Hamilton R, Sun Y, Liu PP, Keller G, Stagljar I, Scott IC, Kislinger T, Gramolini AO.

Nat Commun. 2015 Sep 25;6:8391. doi: 10.1038/ncomms9391.


Metformin increases degradation of phospholamban via autophagy in cardiomyocytes.

Teng AC, Miyake T, Yokoe S, Zhang L, Rezende LM Jr, Sharma P, MacLennan DH, Liu PP, Gramolini AO.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7165-70. doi: 10.1073/pnas.1508815112. Epub 2015 May 26.


Systems analysis reveals down-regulation of a network of pro-survival miRNAs drives the apoptotic response in dilated cardiomyopathy.

Isserlin R, Merico D, Wang D, Vuckovic D, Bousette N, Gramolini AO, Bader GD, Emili A.

Mol Biosyst. 2015 Jan;11(1):239-51. doi: 10.1039/c4mb00265b. Epub 2014 Oct 31.


Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.

Wang DY, Abbasi C, El-Rass S, Li JY, Dawood F, Naito K, Sharma P, Bousette N, Singh S, Backx PH, Cox B, Wen XY, Liu PP, Gramolini AO.

J Am Heart Assoc. 2014 Oct 20;3(5):e001018. doi: 10.1161/JAHA.114.001018.


Proteomic analysis of human fetal atria and ventricle.

Lu ZQ, Sinha A, Sharma P, Kislinger T, Gramolini AO.

J Proteome Res. 2014 Dec 5;13(12):5869-78. doi: 10.1021/pr5007685. Epub 2014 Oct 31.


Cardiac proteomics.

Burniston JG, Gramolini AO, Solaro RJ.

Biomed Res Int. 2014;2014:903538. doi: 10.1155/2014/903538. Epub 2014 Jun 15. No abstract available.


HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.

Zhang L, Chen X, Sharma P, Moon M, Sheftel AD, Dawood F, Nghiem MP, Wu J, Li RK, Gramolini AO, Sorensen PH, Penninger JM, Brumell JH, Liu PP.

Nat Commun. 2014 Mar 11;5:3430. doi: 10.1038/ncomms4430.


Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers.

Fajardo VA, Bombardier E, Vigna C, Devji T, Bloemberg D, Gamu D, Gramolini AO, Quadrilatero J, Tupling AR.

PLoS One. 2013 Dec 16;8(12):e84304. doi: 10.1371/journal.pone.0084304. eCollection 2013.


Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cells.

Liang W, Huang L, Zhao D, He JZ, Sharma P, Liu J, Gramolini AO, Ward ME, Cho HC, Backx PH.

J Hypertens. 2014 Feb;32(2):318-30. doi: 10.1097/HJH.0000000000000013.


Calnexin silencing in mouse neonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis.

Bousette N, Abbasi C, Chis R, Gramolini AO.

J Cell Physiol. 2014 Mar;229(3):374-83. doi: 10.1002/jcp.24459.


Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure.

Chugh S, Ouzounian M, Lu Z, Mohamed S, Li W, Bousette N, Liu PP, Gramolini AO.

Proteomics. 2013 Aug;13(15):2324-34. doi: 10.1002/pmic.201200455. Epub 2013 Jul 1.


Large-scale characterization of the murine cardiac proteome.

Cosme J, Emili A, Gramolini AO.

Methods Mol Biol. 2013;1005:1-10. doi: 10.1007/978-1-62703-386-2_1. Review.


The cardiovascular exosome: current perspectives and potential.

Cosme J, Liu PP, Gramolini AO.

Proteomics. 2013 May;13(10-11):1654-9. doi: 10.1002/pmic.201200441. Epub 2013 Apr 20. Review.


Recent advances in cardiovascular proteomics.

Sharma P, Cosme J, Gramolini AO.

J Proteomics. 2013 Apr 9;81:3-14. doi: 10.1016/j.jprot.2012.10.026. Epub 2012 Nov 12. Review.


Identification of differentially expressed proteins in direct expressed prostatic secretions of men with organ-confined versus extracapsular prostate cancer.

Kim Y, Ignatchenko V, Yao CQ, Kalatskaya I, Nyalwidhe JO, Lance RS, Gramolini AO, Troyer DA, Stein LD, Boutros PC, Medin JA, Semmes OJ, Drake RR, Kislinger T.

Mol Cell Proteomics. 2012 Dec;11(12):1870-84. doi: 10.1074/mcp.M112.017889. Epub 2012 Sep 17.


Structural determination of the phosphorylation domain of the ryanodine receptor.

Sharma P, Ishiyama N, Nair U, Li W, Dong A, Miyake T, Wilson A, Ryan T, MacLennan DH, Kislinger T, Ikura M, Dhe-Paganon S, Gramolini AO.

FEBS J. 2012 Oct;279(20):3952-64. doi: 10.1111/j.1742-4658.2012.08755.x. Epub 2012 Sep 11.


α-Crystallin B prevents apoptosis after H2O2 exposure in mouse neonatal cardiomyocytes.

Chis R, Sharma P, Bousette N, Miyake T, Wilson A, Backx PH, Gramolini AO.

Am J Physiol Heart Circ Physiol. 2012 Oct 15;303(8):H967-78. doi: 10.1152/ajpheart.00040.2012. Epub 2012 Aug 17.


Clinical proteomics: getting to the heart of the matter.

Chugh S, Sharma P, Kislinger T, Gramolini AO.

Circ Cardiovasc Genet. 2012 Jun;5(3):377. doi: 10.1161/CIRCGENETICS.110.957761. No abstract available.


Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells.

Rugg-Gunn PJ, Cox BJ, Lanner F, Sharma P, Ignatchenko V, McDonald AC, Garner J, Gramolini AO, Rossant J, Kislinger T.

Dev Cell. 2012 Apr 17;22(4):887-901. doi: 10.1016/j.devcel.2012.01.005. Epub 2012 Mar 15.


A proteomic interrogation of Cryptococcus neoformans: interaction networks for calcineurin in a heated environment.

Mulyar OA, Teng AC, Gramolini AO.

Expert Rev Proteomics. 2012;9(1):13-5. doi: 10.1586/epr.11.76.


A method for the direct identification of differentiating muscle cells by a fluorescent mitochondrial dye.

Miyake T, McDermott JC, Gramolini AO.

PLoS One. 2011;6(12):e28628. doi: 10.1371/journal.pone.0028628. Epub 2011 Dec 9.


Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia.

Cox B, Sharma P, Evangelou AI, Whiteley K, Ignatchenko V, Ignatchenko A, Baczyk D, Czikk M, Kingdom J, Rossant J, Gramolini AO, Adamson SL, Kislinger T.

Mol Cell Proteomics. 2011 Dec;10(12):M111.012526. doi: 10.1074/mcp.M111.012526. Epub 2011 Oct 10.


Use of colloidal silica-beads for the isolation of cell-surface proteins for mass spectrometry-based proteomics.

Kim Y, Elschenbroich S, Sharma P, Sepiashvili L, Gramolini AO, Kislinger T.

Methods Mol Biol. 2011;748:227-41. doi: 10.1007/978-1-61779-139-0_16.


Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice.

Tupling AR, Bombardier E, Gupta SC, Hussain D, Vigna C, Bloemberg D, Quadrilatero J, Trivieri MG, Babu GJ, Backx PH, Periasamy M, MacLennan DH, Gramolini AO.

Am J Physiol Cell Physiol. 2011 Oct;301(4):C841-9. doi: 10.1152/ajpcell.00409.2010. Epub 2011 Jun 22.


In-depth proteomics of ovarian cancer ascites: combining shotgun proteomics and selected reaction monitoring mass spectrometry.

Elschenbroich S, Ignatchenko V, Clarke B, Kalloger SE, Boutros PC, Gramolini AO, Shaw P, Jurisica I, Kislinger T.

J Proteome Res. 2011 May 6;10(5):2286-99. doi: 10.1021/pr1011087. Epub 2011 Apr 14.


Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP).

Ryan T, Sharma P, Ignatchenko A, MacLennan DH, Kislinger T, Gramolini AO.

J Biol Chem. 2011 May 13;286(19):17060-8. doi: 10.1074/jbc.M110.197186. Epub 2011 Mar 14.


Identification of an FHL1 protein complex containing ACTN1, ACTN4, and PDLIM1 using affinity purifications and MS-based protein-protein interaction analysis.

Sharma P, Shathasivam T, Ignatchenko V, Kislinger T, Gramolini AO.

Mol Biosyst. 2011 Apr;7(4):1185-96. doi: 10.1039/c0mb00235f. Epub 2011 Jan 18.


Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B.

Bousette N, Chugh S, Fong V, Isserlin R, Kim KH, Volchuk A, Backx PH, Liu P, Kislinger T, MacLennan DH, Emili A, Gramolini AO.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18481-6. doi: 10.1073/pnas.1013555107. Epub 2010 Oct 11.


Genes, proteins and complexes: the multifaceted nature of FHL family proteins in diverse tissues.

Shathasivam T, Kislinger T, Gramolini AO.

J Cell Mol Med. 2010 Dec;14(12):2702-20. doi: 10.1111/j.1582-4934.2010.01176.x. Review.


Endoplasmic reticulum protein targeting of phospholamban: a common role for an N-terminal di-arginine motif in ER retention?

Sharma P, Ignatchenko V, Grace K, Ursprung C, Kislinger T, Gramolini AO.

PLoS One. 2010 Jul 9;5(7):e11496. doi: 10.1371/journal.pone.0011496.


Proteome analysis of mouse model systems: A tool to model human disease and for the investigation of tissue-specific biology.

Kislinger T, Gramolini AO.

J Proteomics. 2010 Oct 10;73(11):2205-18. doi: 10.1016/j.jprot.2010.05.004. Epub 2010 May 15. Review.


Large-scale characterization and analysis of the murine cardiac proteome.

Bousette N, Kislinger T, Fong V, Isserlin R, Hewel JA, Emil A, Gramolini AO.

J Proteome Res. 2009 Apr;8(4):1887-901.


Peptide separations by on-line MudPIT compared to isoelectric focusing in an off-gel format: application to a membrane-enriched fraction from C2C12 mouse skeletal muscle cells.

Elschenbroich S, Ignatchenko V, Sharma P, Schmitt-Ulms G, Gramolini AO, Kislinger T.

J Proteome Res. 2009 Oct;8(10):4860-9. doi: 10.1021/pr900318k.


Characterization of sequences in human TWIST required for nuclear localization.

Singh S, Gramolini AO.

BMC Cell Biol. 2009 Jun 17;10:47. doi: 10.1186/1471-2121-10-47.


Proteomics-based investigations of animal models of disease.

Bousette N, Gramolini AO, Kislinger T.

Proteomics Clin Appl. 2008 May;2(5):638-53. doi: 10.1002/prca.200780043.


Mass spectrometry-based proteomics: a useful tool for biomarker discovery?

Gramolini AO, Peterman SM, Kislinger T.

Clin Pharmacol Ther. 2008 May;83(5):758-60. doi: 10.1038/clpt.2008.18. Epub 2008 Mar 19.


Tbx5-dependent pathway regulating diastolic function in congenital heart disease.

Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Henkelman RM, Backx PH, Redington AN, Maclennan DH, Bruneau BG.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5519-24. doi: 10.1073/pnas.0801779105. Epub 2008 Mar 31.


Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses.

Gramolini AO, Kislinger T, Alikhani-Koopaei R, Fong V, Thompson NJ, Isserlin R, Sharma P, Oudit GY, Trivieri MG, Fagan A, Kannan A, Higgins DG, Huedig H, Hess G, Arab S, Seidman JG, Seidman CE, Frey B, Perry M, Backx PH, Liu PP, MacLennan DH, Emili A.

Mol Cell Proteomics. 2008 Mar;7(3):519-33. Epub 2007 Nov 30.

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