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The Disulfide Bond, but Not Zinc or Dimerization, Controls Initiation and Seeded Growth in Amyotrophic Lateral Sclerosis-linked Cu,Zn Superoxide Dismutase (SOD1) Fibrillation.

Chattopadhyay M, Nwadibia E, Strong CD, Gralla EB, Valentine JS, Whitelegge JP.

J Biol Chem. 2015 Dec 18;290(51):30624-36. doi: 10.1074/jbc.M115.666503. Epub 2015 Oct 28.


Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae.

Li AM, Martins J, Tovmasyan A, Valentine JS, Batinic-Haberle I, Spasojevic I, Gralla EB.

Redox Biol. 2014;3:1-6. doi: 10.1016/j.redox.2014.09.003. Epub 2014 Sep 18.


Insights into the role of the unusual disulfide bond in copper-zinc superoxide dismutase.

Sea K, Sohn SH, Durazo A, Sheng Y, Shaw BF, Cao X, Taylor AB, Whitson LJ, Holloway SP, Hart PJ, Cabelli DE, Gralla EB, Valentine JS.

J Biol Chem. 2015 Jan 23;290(4):2405-18. doi: 10.1074/jbc.M114.588798. Epub 2014 Nov 28.


Yeast copper-zinc superoxide dismutase can be activated in the absence of its copper chaperone.

Sea KW, Sheng Y, Lelie HL, Kane Barnese L, Durazo A, Valentine JS, Gralla EB.

J Biol Inorg Chem. 2013 Dec;18(8):985-92. doi: 10.1007/s00775-013-1047-8. Epub 2013 Sep 24.


Structural similarity of wild-type and ALS-mutant superoxide dismutase-1 fibrils using limited proteolysis and atomic force microscopy.

Chan PK, Chattopadhyay M, Sharma S, Souda P, Gralla EB, Borchelt DR, Whitelegge JP, Valentine JS.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10934-9. doi: 10.1073/pnas.1309613110. Epub 2013 Jun 18.


Tetramerization reinforces the dimer interface of MnSOD.

Sheng Y, Durazo A, Schumacher M, Gralla EB, Cascio D, Cabelli DE, Valentine JS.

PLoS One. 2013 May 7;8(5):e62446. doi: 10.1371/journal.pone.0062446. Print 2013.


Biologically relevant mechanism for catalytic superoxide removal by simple manganese compounds.

Barnese K, Gralla EB, Valentine JS, Cabelli DE.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):6892-7. doi: 10.1073/pnas.1203051109. Epub 2012 Apr 13.


A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.

Rajic Z, Tovmasyan A, Spasojevic I, Sheng H, Lu M, Li AM, Gralla EB, Warner DS, Benov L, Batinic-Haberle I.

Free Radic Biol Med. 2012 May 1;52(9):1828-34. doi: 10.1016/j.freeradbiomed.2012.02.006. Epub 2012 Feb 13.


Comparison of two yeast MnSODs: mitochondrial Saccharomyces cerevisiae versus cytosolic Candida albicans.

Sheng Y, Stich TA, Barnese K, Gralla EB, Cascio D, Britt RD, Cabelli DE, Valentine JS.

J Am Chem Soc. 2011 Dec 28;133(51):20878-89. doi: 10.1021/ja2077476. Epub 2011 Nov 30.


Metabolic alterations in yeast lacking copper-zinc superoxide dismutase.

Sehati S, Clement MH, Martins J, Xu L, Longo VD, Valentine JS, Gralla EB.

Free Radic Biol Med. 2011 Jun 1;50(11):1591-8. doi: 10.1016/j.freeradbiomed.2011.03.004. Epub 2011 Mar 10.


Copper and zinc metallation status of copper-zinc superoxide dismutase from amyotrophic lateral sclerosis transgenic mice.

Lelie HL, Liba A, Bourassa MW, Chattopadhyay M, Chan PK, Gralla EB, Miller LM, Borchelt DR, Valentine JS, Whitelegge JP.

J Biol Chem. 2011 Jan 28;286(4):2795-806. doi: 10.1074/jbc.M110.186999. Epub 2010 Nov 10.


Investigation of the highly active manganese superoxide dismutase from Saccharomyces cerevisiae.

Barnese K, Sheng Y, Stich TA, Gralla EB, Britt RD, Cabelli DE, Valentine JS.

J Am Chem Soc. 2010 Sep 15;132(36):12525-7. doi: 10.1021/ja104179r.


Probing in vivo Mn2+ speciation and oxidative stress resistance in yeast cells with electron-nuclear double resonance spectroscopy.

McNaughton RL, Reddi AR, Clement MH, Sharma A, Barnese K, Rosenfeld L, Gralla EB, Valentine JS, Culotta VC, Hoffman BM.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15335-9. doi: 10.1073/pnas.1009648107. Epub 2010 Aug 11.


Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells.

Pollard JM, Reboucas JS, Durazo A, Kos I, Fike F, Panni M, Gralla EB, Valentine JS, Batinic-Haberle I, Gatti RA.

Free Radic Biol Med. 2009 Aug 1;47(3):250-60. doi: 10.1016/j.freeradbiomed.2009.04.018. Epub 2009 Apr 21. Erratum in: Free Radic Biol Med. 2009 Oct 15;47(8):1234.


Initiation and elongation in fibrillation of ALS-linked superoxide dismutase.

Chattopadhyay M, Durazo A, Sohn SH, Strong CD, Gralla EB, Whitelegge JP, Valentine JS.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18663-8. doi: 10.1073/pnas.0807058105. Epub 2008 Nov 20.


Reactive oxygen species special feature.

Valentine JS, Gralla EB.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8178. doi: 10.1073/pnas.0804252105. Epub 2008 Jun 12. No abstract available.


Manganous phosphate acts as a superoxide dismutase.

Barnese K, Gralla EB, Cabelli DE, Valentine JS.

J Am Chem Soc. 2008 Apr 9;130(14):4604-6. doi: 10.1021/ja710162n. Epub 2008 Mar 15.


Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide dismutase-1.

Shaw BF, Lelie HL, Durazo A, Nersissian AM, Xu G, Chan PK, Gralla EB, Tiwari A, Hayward LJ, Borchelt DR, Valentine JS, Whitelegge JP.

J Biol Chem. 2008 Mar 28;283(13):8340-50. doi: 10.1074/jbc.M707751200. Epub 2008 Jan 11.


Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS.

Banci L, Bertini I, Durazo A, Girotto S, Gralla EB, Martinelli M, Valentine JS, Vieru M, Whitelegge JP.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11263-7. Epub 2007 Jun 25.


Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein.

Potter SZ, Zhu H, Shaw BF, Rodriguez JA, Doucette PA, Sohn SH, Durazo A, Faull KF, Gralla EB, Nersissian AM, Valentine JS.

J Am Chem Soc. 2007 Apr 18;129(15):4575-83. Epub 2007 Mar 24.


Time dependence of the frequency and amplitude of the local nanomechanical motion of yeast.

Pelling AE, Sehati S, Gralla EB, Gimzewski JK.

Nanomedicine. 2005 Jun;1(2):178-83.


Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials.

Ferri A, Cozzolino M, Crosio C, Nencini M, Casciati A, Gralla EB, Rotilio G, Valentine JS, Carrì MT.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13860-5. Epub 2006 Aug 30.


Superoxide dismutase 1 modulates expression of transferrin receptor.

Danzeisen R, Achsel T, Bederke U, Cozzolino M, Crosio C, Ferri A, Frenzel M, Gralla EB, Huber L, Ludolph A, Nencini M, Rotilio G, Valentine JS, Carrì MT.

J Biol Inorg Chem. 2006 Jun;11(4):489-98. Epub 2006 Apr 26.


Exogenous manganous ion at millimolar levels rescues all known dioxygen-sensitive phenotypes of yeast lacking CuZnSOD.

Sanchez RJ, Srinivasan C, Munroe WH, Wallace MA, Martins J, Kao TY, Le K, Gralla EB, Valentine JS.

J Biol Inorg Chem. 2005 Dec;10(8):913-23. Epub 2005 Nov 8.


Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae.

Fabrizio P, Battistella L, Vardavas R, Gattazzo C, Liou LL, Diaspro A, Dossen JW, Gralla EB, Longo VD.

J Cell Biol. 2004 Sep 27;166(7):1055-67.


Local nanomechanical motion of the cell wall of Saccharomyces cerevisiae.

Pelling AE, Sehati S, Gralla EB, Valentine JS, Gimzewski JK.

Science. 2004 Aug 20;305(5687):1147-50.


Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase.

Wallace MA, Liou LL, Martins J, Clement MH, Bailey S, Longo VD, Valentine JS, Gralla EB.

J Biol Chem. 2004 Jul 30;279(31):32055-62. Epub 2004 May 27.


SOD2 functions downstream of Sch9 to extend longevity in yeast.

Fabrizio P, Liou LL, Moy VN, Diaspro A, Valentine JS, Gralla EB, Longo VD.

Genetics. 2003 Jan;163(1):35-46.


Measurement of "free" or electron paramagnetic resonance-detectable iron in whole yeast cells as indicator of superoxide stress.

Srinivasan C, Gralla EB.

Methods Enzymol. 2002;349:173-80. No abstract available.


In vivo peroxidative activity of FALS-mutant human CuZnSODs expressed in yeast.

Roe JA, Wiedau-Pazos M, Moy VN, Goto JJ, Gralla EB, Valentine JS.

Free Radic Biol Med. 2002 Jan 15;32(2):169-74.


Evidence for a novel role of copper-zinc superoxide dismutase in zinc metabolism.

Wei JP, Srinivasan C, Han H, Valentine JS, Gralla EB.

J Biol Chem. 2001 Nov 30;276(48):44798-803. Epub 2001 Oct 1.


Copper(2+) binding to the surface residue cysteine 111 of His46Arg human copper-zinc superoxide dismutase, a familial amyotrophic lateral sclerosis mutant.

Liu H, Zhu H, Eggers DK, Nersissian AM, Faull KF, Goto JJ, Ai J, Sanders-Loehr J, Gralla EB, Valentine JS.

Biochemistry. 2000 Jul 18;39(28):8125-32.


Yeast lacking superoxide dismutase(s) show elevated levels of "free iron" as measured by whole cell electron paramagnetic resonance.

Srinivasan C, Liba A, Imlay JA, Valentine JS, Gralla EB.

J Biol Chem. 2000 Sep 22;275(38):29187-92.


Effects of nitric oxide on the copper-responsive transcription factor Ace1 in Saccharomyces cerevisiae: cytotoxic and cytoprotective actions of nitric oxide.

Chiang KT, Shinyashiki M, Switzer CH, Valentine JS, Gralla EB, Thiele DJ, Fukuto JM.

Arch Biochem Biophys. 2000 May 15;377(2):296-303.


Cobalt(2+) binding to human and tomato copper chaperone for superoxide dismutase: implications for the metal ion transfer mechanism.

Zhu H, Shipp E, Sanchez RJ, Liba A, Stine JE, Hart PJ, Gralla EB, Nersissian AM, Valentine JS.

Biochemistry. 2000 May 9;39(18):5413-21.


The metal binding properties of the zinc site of yeast copper-zinc superoxide dismutase: implications for amyotrophic lateral sclerosis.

Lyons TJ, Nersissian A, Huang H, Yeom H, Nishida CR, Graden JA, Gralla EB, Valentine JS.

J Biol Inorg Chem. 2000 Apr;5(2):189-203.


Yeast lacking Cu-Zn superoxide dismutase show altered iron homeostasis. Role of oxidative stress in iron metabolism.

De Freitas JM, Liba A, Meneghini R, Valentine JS, Gralla EB.

J Biol Chem. 2000 Apr 21;275(16):11645-9.


The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism.

Shinyashiki M, Chiang KT, Switzer CH, Gralla EB, Valentine JS, Thiele DJ, Fukuto JM.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2491-6.


Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis.

Goto JJ, Zhu H, Sanchez RJ, Nersissian A, Gralla EB, Valentine JS, Cabelli DE.

J Biol Chem. 2000 Jan 14;275(2):1007-14.


Mitochondrial superoxide decreases yeast survival in stationary phase.

Longo VD, Liou LL, Valentine JS, Gralla EB.

Arch Biochem Biophys. 1999 May 1;365(1):131-42. Erratum in: Arch Biochem Biophys 2000 May 1;377(1):213.


Biological chemistry of copper-zinc superoxide dismutase and its link to amyotrophic lateral sclerosis.

Lyons TJ, Gralla EB, Valentine JS.

Met Ions Biol Syst. 1999;36:125-77. Review. No abstract available.


Copper-zinc superoxide dismutase and ALS.

Valentine JS, Hart PJ, Gralla EB.

Adv Exp Med Biol. 1999;448:193-203. Review. No abstract available.


The dark side of dioxygen biochemistry.

Valentine JS, Wertz DL, Lyons TJ, Liou LL, Goto JJ, Gralla EB.

Curr Opin Chem Biol. 1998 Apr;2(2):253-62. Review.


Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis.

Hart PJ, Liu H, Pellegrini M, Nersissian AM, Gralla EB, Valentine JS, Eisenberg D.

Protein Sci. 1998 Mar;7(3):545-55.


Delivering copper inside yeast and human cells.

Valentine JS, Gralla EB.

Science. 1997 Oct 31;278(5339):817-8. No abstract available.


Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast.

Longo VD, Ellerby LM, Bredesen DE, Valentine JS, Gralla EB.

J Cell Biol. 1997 Jun 30;137(7):1581-8.


Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein.

Lyons TJ, Liu H, Goto JJ, Nersissian A, Roe JA, Graden JA, Café C, Ellerby LM, Bredesen DE, Gralla EB, Valentine JS.

Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12240-4.

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