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Items: 33

1.

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.

Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, Whitmore A, Heise MT, Baric RS.

MBio. 2018 Oct 9;9(5). pii: e01753-18. doi: 10.1128/mBio.01753-18.

2.

Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines.

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, McAnarney ET, Graham RL, Waters KM, Baric RS.

J Virol. 2018 Aug 16;92(17). pii: e00710-18. doi: 10.1128/JVI.00710-18. Print 2018 Sep 1.

3.

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.

Menachery VD, Schäfer A, Burnum-Johnson KE, Mitchell HD, Eisfeld AJ, Walters KB, Nicora CD, Purvine SO, Casey CP, Monroe ME, Weitz KK, Stratton KG, Webb-Robertson BM, Gralinski LE, Metz TO, Smith RD, Waters KM, Sims AC, Kawaoka Y, Baric RS.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E1012-E1021. doi: 10.1073/pnas.1706928115. Epub 2018 Jan 16.

4.

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis.

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, Graham RL, McAnarney ET, Stratton KG, Cockrell AS, Debbink K, Sims AC, Waters KM, Baric RS.

mSphere. 2017 Nov 15;2(6). pii: e00346-17. doi: 10.1128/mSphere.00346-17. eCollection 2017 Nov-Dec.

5.

MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis.

Menachery VD, Mitchell HD, Cockrell AS, Gralinski LE, Yount BL Jr, Graham RL, McAnarney ET, Douglas MG, Scobey T, Beall A, Dinnon K 3rd, Kocher JF, Hale AE, Stratton KG, Waters KM, Baric RS.

MBio. 2017 Aug 22;8(4). pii: e00665-17. doi: 10.1128/mBio.00665-17.

6.

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3653. doi: 10.1126/scitranslmed.aal3653.

7.

Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice.

Gralinski LE, Menachery VD, Morgan AP, Totura AL, Beall A, Kocher J, Plante J, Harrison-Shostak DC, Schäfer A, Pardo-Manuel de Villena F, Ferris MT, Baric RS.

G3 (Bethesda). 2017 Jun 7;7(6):1653-1663. doi: 10.1534/g3.117.041434.

8.

The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus.

McDermott JE, Mitchell HD, Gralinski LE, Eisfeld AJ, Josset L, Bankhead A 3rd, Neumann G, Tilton SC, Schäfer A, Li C, Fan S, McWeeney S, Baric RS, Katze MG, Waters KM.

BMC Syst Biol. 2016 Sep 23;10(1):93.

9.

Corrigendum: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.

Menachery VD, Yount BL Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS.

Nat Med. 2016 Apr;22(4):446. doi: 10.1038/nm0416-446d. No abstract available.

PMID:
27050591
10.

SARS-like WIV1-CoV poised for human emergence.

Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53. doi: 10.1073/pnas.1517719113. Epub 2016 Mar 14.

11.

The Mouse Universal Genotyping Array: From Substrains to Subspecies.

Morgan AP, Fu CP, Kao CY, Welsh CE, Didion JP, Yadgary L, Hyacinth L, Ferris MT, Bell TA, Miller DR, Giusti-Rodriguez P, Nonneman RJ, Cook KD, Whitmire JK, Gralinski LE, Keller M, Attie AD, Churchill GA, Petkov P, Sullivan PF, Brennan JR, McMillan L, Pardo-Manuel de Villena F.

G3 (Bethesda). 2015 Dec 18;6(2):263-79. doi: 10.1534/g3.115.022087.

12.

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.

Menachery VD, Yount BL Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS.

Nat Med. 2015 Dec;21(12):1508-13. doi: 10.1038/nm.3985. Epub 2015 Nov 9. Erratum in: Nat Med. 2016 Apr;22(4):446.

13.

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.

Gralinski LE, Ferris MT, Aylor DL, Whitmore AC, Green R, Frieman MB, Deming D, Menachery VD, Miller DR, Buus RJ, Bell TA, Churchill GA, Threadgill DW, Katze MG, McMillan L, Valdar W, Heise MT, Pardo-Manuel de Villena F, Baric RS.

PLoS Genet. 2015 Oct 9;11(10):e1005504. doi: 10.1371/journal.pgen.1005504. eCollection 2015 Oct.

14.

New Metrics for Evaluating Viral Respiratory Pathogenesis.

Menachery VD, Gralinski LE, Baric RS, Ferris MT.

PLoS One. 2015 Jun 26;10(6):e0131451. doi: 10.1371/journal.pone.0131451. eCollection 2015.

15.

Molecular pathology of emerging coronavirus infections.

Gralinski LE, Baric RS.

J Pathol. 2015 Jan;235(2):185-95. doi: 10.1002/path.4454. Review.

16.

Annotation of long non-coding RNAs expressed in collaborative cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts.

Josset L, Tchitchek N, Gralinski LE, Ferris MT, Eisfeld AJ, Green RR, Thomas MJ, Tisoncik-Go J, Schroth GP, Kawaoka Y, Manuel de Villena FP, Baric RS, Heise MT, Peng X, Katze MG.

RNA Biol. 2014;11(7):875-90. doi: 10.4161/rna.29442. Epub 2014 Jun 12.

17.

Genomic profiling of collaborative cross founder mice infected with respiratory viruses reveals novel transcripts and infection-related strain-specific gene and isoform expression.

Xiong H, Morrison J, Ferris MT, Gralinski LE, Whitmore AC, Green R, Thomas MJ, Tisoncik-Go J, Schroth GP, Pardo-Manuel de Villena F, Baric RS, Heise MT, Peng X, Katze MG.

G3 (Bethesda). 2014 Jun 5;4(8):1429-44. doi: 10.1534/g3.114.011759.

18.

Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

Menachery VD, Eisfeld AJ, Schäfer A, Josset L, Sims AC, Proll S, Fan S, Li C, Neumann G, Tilton SC, Chang J, Gralinski LE, Long C, Green R, Williams CM, Weiss J, Matzke MM, Webb-Robertson BJ, Schepmoes AA, Shukla AK, Metz TO, Smith RD, Waters KM, Katze MG, Kawaoka Y, Baric RS.

MBio. 2014 May 20;5(3):e01174-14. doi: 10.1128/mBio.01174-14.

19.

A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant.

Agnihothram S, Yount BL Jr, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, Zambon M, Heise M, Denison MR, Baric RS.

MBio. 2014 Mar 25;5(2):e00047-14. doi: 10.1128/mBio.00047-14.

20.

Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity.

Menachery VD, Yount BL Jr, Josset L, Gralinski LE, Scobey T, Agnihothram S, Katze MG, Baric RS.

J Virol. 2014 Apr;88(8):4251-64. doi: 10.1128/JVI.03571-13. Epub 2014 Jan 29.

21.

A comprehensive collection of systems biology data characterizing the host response to viral infection.

Aevermann BD, Pickett BE, Kumar S, Klem EB, Agnihothram S, Askovich PS, Bankhead A 3rd, Bolles M, Carter V, Chang J, Clauss TR, Dash P, Diercks AH, Eisfeld AJ, Ellis A, Fan S, Ferris MT, Gralinski LE, Green RR, Gritsenko MA, Hatta M, Heegel RA, Jacobs JM, Jeng S, Josset L, Kaiser SM, Kelly S, Law GL, Li C, Li J, Long C, Luna ML, Matzke M, McDermott J, Menachery V, Metz TO, Mitchell H, Monroe ME, Navarro G, Neumann G, Podyminogin RL, Purvine SO, Rosenberger CM, Sanders CJ, Schepmoes AA, Shukla AK, Sims A, Sova P, Tam VC, Tchitchek N, Thomas PG, Tilton SC, Totura A, Wang J, Webb-Robertson BJ, Wen J, Weiss JM, Yang F, Yount B, Zhang Q, McWeeney S, Smith RD, Waters KM, Kawaoka Y, Baric R, Aderem A, Katze MG, Scheuermann RH.

Sci Data. 2014 Oct 14;1:140033. doi: 10.1038/sdata.2014.33. eCollection 2014.

22.

Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses.

Agnihothram S, Gopal R, Yount BL Jr, Donaldson EF, Menachery VD, Graham RL, Scobey TD, Gralinski LE, Denison MR, Zambon M, Baric RS.

J Infect Dis. 2014 Apr 1;209(7):995-1006. doi: 10.1093/infdis/jit609. Epub 2013 Nov 18.

23.

Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury.

Gralinski LE, Bankhead A 3rd, Jeng S, Menachery VD, Proll S, Belisle SE, Matzke M, Webb-Robertson BJ, Luna ML, Shukla AK, Ferris MT, Bolles M, Chang J, Aicher L, Waters KM, Smith RD, Metz TO, Law GL, Katze MG, McWeeney S, Baric RS.

MBio. 2013 Aug 6;4(4). pii: e00271-13. doi: 10.1128/mBio.00271-13.

24.

Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice.

Tchitchek N, Eisfeld AJ, Tisoncik-Go J, Josset L, Gralinski LE, Bécavin C, Tilton SC, Webb-Robertson BJ, Ferris MT, Totura AL, Li C, Neumann G, Metz TO, Smith RD, Waters KM, Baric R, Kawaoka Y, Katze MG.

BMC Syst Biol. 2013 Jul 29;7:69. doi: 10.1186/1752-0509-7-69.

25.

Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus.

Josset L, Menachery VD, Gralinski LE, Agnihothram S, Sova P, Carter VS, Yount BL, Graham RL, Baric RS, Katze MG.

MBio. 2013 Apr 30;4(3):e00165-13. doi: 10.1128/mBio.00165-13.

26.

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.

Ferris MT, Aylor DL, Bottomly D, Whitmore AC, Aicher LD, Bell TA, Bradel-Tretheway B, Bryan JT, Buus RJ, Gralinski LE, Haagmans BL, McMillan L, Miller DR, Rosenzweig E, Valdar W, Wang J, Churchill GA, Threadgill DW, McWeeney SK, Katze MG, Pardo-Manuel de Villena F, Baric RS, Heise MT.

PLoS Pathog. 2013 Feb;9(2):e1003196. doi: 10.1371/journal.ppat.1003196. Epub 2013 Feb 28.

27.

Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells.

Sims AC, Tilton SC, Menachery VD, Gralinski LE, Schäfer A, Matzke MM, Webb-Robertson BJ, Chang J, Luna ML, Long CE, Shukla AK, Bankhead AR 3rd, Burkett SE, Zornetzer G, Tseng CT, Metz TO, Pickles R, McWeeney S, Smith RD, Katze MG, Waters KM, Baric RS.

J Virol. 2013 Apr;87(7):3885-902. doi: 10.1128/JVI.02520-12. Epub 2013 Jan 30.

28.

Expression quantitative trait Loci for extreme host response to influenza a in pre-collaborative cross mice.

Bottomly D, Ferris MT, Aicher LD, Rosenzweig E, Whitmore A, Aylor DL, Haagmans BL, Gralinski LE, Bradel-Tretheway BG, Bryan JT, Threadgill DW, de Villena FP, Baric RS, Katze MG, Heise M, McWeeney SK.

G3 (Bethesda). 2012 Feb;2(2):213-21. doi: 10.1534/g3.111.001800. Epub 2012 Feb 1.

29.

Genetic analysis of complex traits in the emerging Collaborative Cross.

Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Didion JD, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SN, Collins FS, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill D, de Villena FP, Churchill GA.

Genome Res. 2011 Aug;21(8):1213-22. doi: 10.1101/gr.111310.110. Epub 2011 Mar 15.

30.

Mouse adenovirus type 1-induced breakdown of the blood-brain barrier.

Gralinski LE, Ashley SL, Dixon SD, Spindler KR.

J Virol. 2009 Sep;83(18):9398-410. doi: 10.1128/JVI.00954-09. Epub 2009 Jul 1.

31.

Mouse adenovirus type 1 infection of natural killer cell-deficient mice.

Welton AR, Gralinski LE, Spindler KR.

Virology. 2008 Mar 30;373(1):163-70. Epub 2007 Dec 21.

32.

Contributions of E1A to mouse adenovirus type 1 pathogenesis following intranasal inoculation.

Weinberg JB, Jensen DR, Gralinski LE, Lake AR, Stempfle GS, Spindler KR.

Virology. 2007 Jan 5;357(1):54-67. Epub 2006 Sep 7.

33.

Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes.

Ard PG, Chatterjee C, Kunjibettu S, Adside LR, Gralinski LE, McMahon SB.

Mol Cell Biol. 2002 Aug;22(16):5650-61.

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