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Items: 17

1.

Atypical signaling of metabotropic glutamate receptor 1 in human melanoma cells.

Gelb T, Pshenichkin S, Hathaway HA, Grajkowska E, Dalley CB, Wolfe BB, Wroblewski JT.

Biochem Pharmacol. 2015 Nov 1;98(1):182-9. doi: 10.1016/j.bcp.2015.08.091. Epub 2015 Aug 17.

PMID:
26291396
2.

Chloride is an Agonist of Group II and III Metabotropic Glutamate Receptors.

DiRaddo JO, Miller EJ, Bowman-Dalley C, Wroblewska B, Javidnia M, Grajkowska E, Wolfe BB, Liotta DC, Wroblewski JT.

Mol Pharmacol. 2015 Sep;88(3):450-9. doi: 10.1124/mol.114.096420. Epub 2015 Jun 18.

PMID:
26089372
3.

Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism.

Hathaway HA, Pshenichkin S, Grajkowska E, Gelb T, Emery AC, Wolfe BB, Wroblewski JT.

Neuropharmacology. 2015 Jun;93:199-208. doi: 10.1016/j.neuropharm.2015.02.007. Epub 2015 Feb 17.

4.

Metabotropic glutamate receptor 1 acts as a dependence receptor creating a requirement for glutamate to sustain the viability and growth of human melanomas.

Gelb T, Pshenichkin S, Rodriguez OC, Hathaway HA, Grajkowska E, DiRaddo JO, Wroblewska B, Yasuda RP, Albanese C, Wolfe BB, Wroblewski JT.

Oncogene. 2015 May 21;34(21):2711-20. doi: 10.1038/onc.2014.231. Epub 2014 Jul 28.

5.

A real-time method for measuring cAMP production modulated by Gαi/o-coupled metabotropic glutamate receptors.

DiRaddo JO, Miller EJ, Hathaway HA, Grajkowska E, Wroblewska B, Wolfe BB, Liotta DC, Wroblewski JT.

J Pharmacol Exp Ther. 2014 Jun;349(3):373-82. doi: 10.1124/jpet.113.211532. Epub 2014 Mar 21.

PMID:
24659805
6.

Ligand bias at metabotropic glutamate 1a receptors: molecular determinants that distinguish β-arrestin-mediated from G protein-mediated signaling.

Emery AC, DiRaddo JO, Miller E, Hathaway HA, Pshenichkin S, Takoudjou GR, Grajkowska E, Yasuda RP, Wolfe BB, Wroblewski JT.

Mol Pharmacol. 2012 Aug;82(2):291-301. doi: 10.1124/mol.112.078444. Epub 2012 May 14.

7.

Heat shock enhances CMV-IE promoter-driven metabotropic glutamate receptor expression and toxicity in transfected cells.

Pshenichkin S, Surin A, Surina E, Klauzińska M, Grajkowska E, Luchenko V, Dolińska M, Wroblewska B, Wroblewski JT.

Neuropharmacology. 2011 Jun;60(7-8):1292-300. doi: 10.1016/j.neuropharm.2011.01.010. Epub 2011 Jan 15.

8.

The protective signaling of metabotropic glutamate receptor 1 Is mediated by sustained, beta-arrestin-1-dependent ERK phosphorylation.

Emery AC, Pshenichkin S, Takoudjou GR, Grajkowska E, Wolfe BB, Wroblewski JT.

J Biol Chem. 2010 Aug 20;285(34):26041-8. doi: 10.1074/jbc.M110.139899. Epub 2010 Jun 21.

9.

Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation - possible role as a dependence receptor.

Pshenichkin S, Dolińska M, Klauzińska M, Luchenko V, Grajkowska E, Wroblewski JT.

Neuropharmacology. 2008 Sep;55(4):500-8. doi: 10.1016/j.neuropharm.2008.06.039. Epub 2008 Jun 27.

10.

Cyclothiazide selectively inhibits mGluR1 receptors interacting with a common allosteric site for non-competitive antagonists.

Surin A, Pshenichkin S, Grajkowska E, Surina E, Wroblewski JT.

Neuropharmacology. 2007 Mar;52(3):744-54. Epub 2006 Nov 7.

11.

Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.

Iso Y, Grajkowska E, Wroblewski JT, Davis J, Goeders NE, Johnson KM, Sanker S, Roth BL, Tueckmantel W, Kozikowski AP.

J Med Chem. 2006 Feb 9;49(3):1080-100.

PMID:
16451073
12.

Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive antagonists MPEP.

Alagille D, Baldwin RM, Roth BL, Wroblewski JT, Grajkowska E, Tamagnan GD.

Bioorg Med Chem Lett. 2005 Feb 15;15(4):945-9.

PMID:
15686891
13.

Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity.

Alagille D, Baldwin RM, Roth BL, Wroblewski JT, Grajkowska E, Tamagnan GD.

Bioorg Med Chem. 2005 Jan 3;13(1):197-209.

PMID:
15582465
14.

Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model.

Yamamoto T, Hirasawa S, Wroblewska B, Grajkowska E, Zhou J, Kozikowski A, Wroblewski J, Neale JH.

Eur J Neurosci. 2004 Jul;20(2):483-94.

PMID:
15233757
15.

Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.

Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH.

J Med Chem. 2004 Mar 25;47(7):1729-38.

PMID:
15027864
16.

L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.

Shi Q, Savage JE, Hufeisen SJ, Rauser L, Grajkowska E, Ernsberger P, Wroblewski JT, Nadeau JH, Roth BL.

J Pharmacol Exp Ther. 2003 Apr;305(1):131-42.

PMID:
12649361
17.

Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors.

Mukhopadhyaya JK, Kozikowski AP, Grajkowska E, Pshenichkin S, Wroblewski JT.

Bioorg Med Chem Lett. 2001 Jul 23;11(14):1919-24.

PMID:
11459661

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