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Items: 42


Pillars Article: Molecular Cloning of cDNA Encoding a Murine Haematopoietic Growth Regulator, Granulocyte-Macrophage Colony Stimulating Factor. Nature. 1984. 309: 763-767.

Gough NM, Gough J, Metcalf D, Kelso A, Grail D, Nicola NA, Burgess AW, Dunn AR.

J Immunol. 2017 Apr 1;198(7):2522-2526. No abstract available.


IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.

Fielding CA, McLoughlin RM, McLeod L, Colmont CS, Najdovska M, Grail D, Ernst M, Jones SA, Topley N, Jenkins BJ.

J Immunol. 2008 Aug 1;181(3):2189-95.


STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

Ernst M, Najdovska M, Grail D, Lundgren-May T, Buchert M, Tye H, Matthews VB, Armes J, Bhathal PS, Hughes NR, Marcusson EG, Karras JG, Na S, Sedgwick JD, Hertzog PJ, Jenkins BJ.

J Clin Invest. 2008 May;118(5):1727-38. doi: 10.1172/JCI34944.


Mice lacking both G-CSF and IL-6 are more susceptible to Candida albicans infection: critical role of neutrophils in defense against Candida albicans.

Basu S, Quilici C, Zhang HH, Grail D, Dunn AR.

Growth Factors. 2008 Feb;26(1):23-34. doi: 10.1080/08977190801987513.


Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation.

Yeoh GC, Ernst M, Rose-John S, Akhurst B, Payne C, Long S, Alexander W, Croker B, Grail D, Matthews VB.

Hepatology. 2007 Feb;45(2):486-94.


Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis.

Jenkins BJ, Roberts AW, Greenhill CJ, Najdovska M, Lundgren-May T, Robb L, Grail D, Ernst M.

Blood. 2007 Mar 15;109(6):2380-8. Epub 2006 Nov 2.


Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130.

Howlett M, Judd LM, Jenkins B, La Gruta NL, Grail D, Ernst M, Giraud AS.

Gastroenterology. 2005 Sep;129(3):1005-18.


Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P, Inglese M, McLoughlin RM, Jones SA, Topley N, Baumann H, Judd LM, Giraud AS, Boussioutas A, Zhu HJ, Ernst M.

Nat Med. 2005 Aug;11(8):845-52. Epub 2005 Jul 24.


IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.

McLoughlin RM, Jenkins BJ, Grail D, Williams AS, Fielding CA, Parker CR, Ernst M, Topley N, Jones SA.

Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9589-94. Epub 2005 Jun 23.


Vascular endothelial growth factor D is dispensable for development of the lymphatic system.

Baldwin ME, Halford MM, Roufail S, Williams RA, Hibbs ML, Grail D, Kubo H, Stacker SA, Achen MG.

Mol Cell Biol. 2005 Mar;25(6):2441-9.


The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis.

Jenkins BJ, Roberts AW, Najdovska M, Grail D, Ernst M.

Blood. 2005 May 1;105(9):3512-20. Epub 2005 Jan 13.


Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression.

Jenkins BJ, Grail D, Inglese M, Quilici C, Bozinovski S, Wong P, Ernst M.

Mol Cell Biol. 2004 Feb;24(4):1453-63.


Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130.

Judd LM, Alderman BM, Howlett M, Shulkes A, Dow C, Moverley J, Grail D, Jenkins BJ, Ernst M, Giraud AS.

Gastroenterology. 2004 Jan;126(1):196-207.


Threshold effects of glucose transporter-4 (GLUT4) deficiency on cardiac glucose uptake and development of hypertrophy.

Kaczmarczyk SJ, Andrikopoulos S, Favaloro J, Domenighetti AA, Dunn A, Ernst M, Grail D, Fodero-Tavoletti M, Huggins CE, Delbridge LM, Zajac JD, Proietto J.

J Mol Endocrinol. 2003 Dec;31(3):449-59.


Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos.

Stenvers KL, Tursky ML, Harder KW, Kountouri N, Amatayakul-Chantler S, Grail D, Small C, Weinberg RA, Sizeland AM, Zhu HJ.

Mol Cell Biol. 2003 Jun;23(12):4371-85.


Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling.

Jenkins BJ, Quilici C, Roberts AW, Grail D, Dunn AR, Ernst M.

Exp Hematol. 2002 Nov;30(11):1248-56.


Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice.

Tebbutt NC, Giraud AS, Inglese M, Jenkins B, Waring P, Clay FJ, Malki S, Alderman BM, Grail D, Hollande F, Heath JK, Ernst M.

Nat Med. 2002 Oct;8(10):1089-97. Epub 2002 Sep 9.


Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites.

Gugasyan R, Quilici C, I ST, Grail D, Verhagen AM, Roberts A, Kitamura T, Dunn AR, Lock P.

J Cell Biol. 2002 Jul 8;158(1):115-25. Epub 2002 Jul 1.


Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.

Harder KW, Parsons LM, Armes J, Evans N, Kountouri N, Clark R, Quilici C, Grail D, Hodgson GS, Dunn AR, Hibbs ML.

Immunity. 2001 Oct;15(4):603-15.


Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk.

Halford MM, Armes J, Buchert M, Meskenaite V, Grail D, Hibbs ML, Wilks AF, Farlie PG, Newgreen DF, Hovens CM, Stacker SA.

Nat Genet. 2000 Aug;25(4):414-8.


Functional deficiencies of peritoneal cells from gene-targeted mice lacking G-CSF or GM-CSF.

Zhan Y, Basu S, Lieschke GJ, Grail D, Dunn AR, Cheers C.

J Leukoc Biol. 1999 Feb;65(2):256-64.


Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice.

Campbell IK, Rich MJ, Bischof RJ, Dunn AR, Grail D, Hamilton JA.

J Immunol. 1998 Oct 1;161(7):3639-44.


Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor.

Horwood NJ, Udagawa N, Elliott J, Grail D, Okamura H, Kurimoto M, Dunn AR, Martin T, Gillespie MT.

J Clin Invest. 1998 Feb 1;101(3):595-603.


TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination.

Liu J, Marino MW, Wong G, Grail D, Dunn A, Bettadapura J, Slavin AJ, Old L, Bernard CC.

Nat Med. 1998 Jan;4(1):78-83.


Characterization of tumor necrosis factor-deficient mice.

Marino MW, Dunn A, Grail D, Inglese M, Noguchi Y, Richards E, Jungbluth A, Wada H, Moore M, Williamson B, Basu S, Old LJ.

Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8093-8.


Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease.

Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, Stacker SA, Dunn AR.

Cell. 1995 Oct 20;83(2):301-11.


Granulocyte-macrophage colony-stimulating factor is not responsible for the correction of hematopoietic deficiencies in the maturing op/op mouse.

Nilsson SK, Lieschke GJ, Garcia-Wijnen CC, Williams B, Tzelepis D, Hodgson G, Grail D, Dunn AR, Bertoncello I.

Blood. 1995 Jul 1;86(1):66-72.


Insertional mutagenesis inducing hypomyelination in transgenic mice.

Orian JM, Mitchell AW, Marshman WE, Webb GC, Ayers MM, Grail D, Ford JH, Kaye AH, Gonzales MF.

J Neurosci Res. 1994 Dec 1;39(5):604-12.


Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization.

Lieschke GJ, Grail D, Hodgson G, Metcalf D, Stanley E, Cheers C, Fowler KJ, Basu S, Zhan YF, Dunn AR.

Blood. 1994 Sep 15;84(6):1737-46.


Mice lacking both macrophage- and granulocyte-macrophage colony-stimulating factor have macrophages and coexistent osteopetrosis and severe lung disease.

Lieschke GJ, Stanley E, Grail D, Hodgson G, Sinickas V, Gall JA, Sinclair RA, Dunn AR.

Blood. 1994 Jul 1;84(1):27-35.


Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology.

Stanley E, Lieschke GJ, Grail D, Metcalf D, Hodgson G, Gall JA, Maher DW, Cebon J, Sinickas V, Dunn AR.

Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5592-6.


Insights into the physiology of TGF alpha and signaling through the EGF receptor revealed by gene targeting and acts of nature.

Dunn AR, Mann GB, Fowler KJ, Grail D, Hibbs ML, Alexander WS, Walker F, Burgess AW.

Princess Takamatsu Symp. 1994;24:276-89. Review.


Identification of germ-line chimaeras by polymerase chain reaction and isoenzyme analysis of mouse spermatozoa.

Mann GB, Fowler KJ, Grail D, Dunn AR.

J Reprod Fertil. 1993 Nov;99(2):505-12.


Isolation of embryonic stem (ES) cells in media supplemented with recombinant leukemia inhibitory factor (LIF).

Pease S, Braghetta P, Gearing D, Grail D, Williams RL.

Dev Biol. 1990 Oct;141(2):344-52.


Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor.

Gough NM, Metcalf D, Gough J, Grail D, Dunn AR.

EMBO J. 1985 Mar;4(3):645-53.


Cloning and expression of the gene for murine granulocyte-macrophage colony-stimulating factor.

Gough NM, Gough J, Metcalf D, Kelso A, Grail D, Nicola NA, Dunn AR.

Haematol Blood Transfus. 1985;29:380-4. No abstract available.


Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor.

Gough NM, Gough J, Metcalf D, Kelso A, Grail D, Nicola NA, Burgess AW, Dunn AR.

Nature. 1984 Jun 28-Jul 4;309(5971):763-7.


Natural cytotoxicity of haemopoietic cell populations against murine lymphoid tumours.

Burton RC, Grail D, Warner NL.

Br J Cancer. 1978 May;37(5):806-17.

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