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Items: 1 to 50 of 75

1.

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.

Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB.

J Am Soc Nephrol. 2018 Dec 5. pii: ASN.2018070736. doi: 10.1681/ASN.2018070736. [Epub ahead of print]

PMID:
30518531
2.

ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier.

Schell C, Sabass B, Helmstaedter M, Geist F, Abed A, Yasuda-Yamahara M, Sigle A, Maier JI, Grahammer F, Siegerist F, Artelt N, Endlich N, Kerjaschki D, Arnold HH, Dengjel J, Rogg M, Huber TB.

Dev Cell. 2018 Nov 26. pii: S1534-5807(18)30929-8. doi: 10.1016/j.devcel.2018.11.011. [Epub ahead of print]

3.

CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury.

Yakulov TA, Todkar AP, Slanchev K, Wiegel J, Bona A, Groß M, Scholz A, Hess I, Wurditsch A, Grahammer F, Huber TB, Lecaudey V, Bork T, Hochrein J, Boerries M, Leenders J, de Tullio P, Jouret F, Kramer-Zucker A, Walz G.

Nat Commun. 2018 Sep 10;9(1):3660. doi: 10.1038/s41467-018-06094-4.

4.

P2Y2R Signaling Is Involved in the Onset of Glomerulonephritis.

Rennert L, Zschiedrich S, Sandner L, Hartleben B, Cicko S, Ayata CK, Meyer C, Zech A, Zeiser R, Huber TB, Idzko M, Grahammer F.

Front Immunol. 2018 Jul 16;9:1589. doi: 10.3389/fimmu.2018.01589. eCollection 2018.

5.

Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney.

Viau A, Bienaimé F, Lukas K, Todkar AP, Knoll M, Yakulov TA, Hofherr A, Kretz O, Helmstädter M, Reichardt W, Braeg S, Aschman T, Merkle A, Pfeifer D, Dumit VI, Gubler MC, Nitschke R, Huber TB, Terzi F, Dengjel J, Grahammer F, Köttgen M, Busch H, Boerries M, Walz G, Triantafyllopoulou A, Kuehn EW.

EMBO J. 2018 Aug 1;37(15). pii: e98615. doi: 10.15252/embj.201798615. Epub 2018 Jun 19.

6.

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB.

Cell Rep. 2018 May 22;23(8):2495-2508. doi: 10.1016/j.celrep.2018.04.059.

7.

A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury.

Thiele JR, Zeller J, Kiefer J, Braig D, Kreuzaler S, Lenz Y, Potempa LA, Grahammer F, Huber TB, Huber-Lang M, Bannasch H, Stark GB, Peter K, Eisenhardt SU.

Front Immunol. 2018 Apr 16;9:675. doi: 10.3389/fimmu.2018.00675. eCollection 2018.

8.

Single-nephron proteomes connect morphology and function in proteinuric kidney disease.

Höhne M, Frese CK, Grahammer F, Dafinger C, Ciarimboli G, Butt L, Binz J, Hackl MJ, Rahmatollahi M, Kann M, Schneider S, Altintas MM, Schermer B, Reinheckel T, Göbel H, Reiser J, Huber TB, Kramann R, Seeger-Nukpezah T, Liebau MC, Beck BB, Benzing T, Beyer A, Rinschen MM.

Kidney Int. 2018 Jun;93(6):1308-1319. doi: 10.1016/j.kint.2017.12.012. Epub 2018 Mar 9.

PMID:
29530281
9.

Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis.

Henique C, Bollée G, Loyer X, Grahammer F, Dhaun N, Camus M, Vernerey J, Guyonnet L, Gaillard F, Lazareth H, Meyer C, Bensaada I, Legrès L, Satoh T, Akira S, Bruneval P, Dimmeler S, Tedgui A, Karras A, Thervet E, Nochy D, Huber TB, Mesnard L, Lenoir O, Tharaux PL.

Nat Commun. 2017 Nov 28;8(1):1829. doi: 10.1038/s41467-017-01885-7.

10.

The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.

Rogg M, Yasuda-Yamahara M, Abed A, Dinse P, Helmstädter M, Conzelmann AC, Frimmel J, Sellung D, Biniossek ML, Kretz O, Grahammer F, Schilling O, Huber TB, Schell C.

Sci Rep. 2017 Nov 21;7(1):15910. doi: 10.1038/s41598-017-15844-1.

11.

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

Rinschen MM, Hoppe AK, Grahammer F, Kann M, Völker LA, Schurek EM, Binz J, Höhne M, Demir F, Malisic M, Huber TB, Kurschat C, Kizhakkedathu JN, Schermer B, Huesgen PF, Benzing T.

J Am Soc Nephrol. 2017 Oct;28(10):2867-2878. doi: 10.1681/ASN.2016101119. Epub 2017 Jul 19.

12.

The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.

Schell C, Rogg M, Suhm M, Helmstädter M, Sellung D, Yasuda-Yamahara M, Kretz O, Küttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, Huber TB.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4621-E4630. doi: 10.1073/pnas.1617004114. Epub 2017 May 23.

13.

YAP-mediated mechanotransduction determines the podocyte's response to damage.

Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Gandhirajan RK, Krüger M, Brinkkoetter PT, Huber TB, Kann M, Wickström SA, Benzing T, Schermer B.

Sci Signal. 2017 Apr 11;10(474). pii: eaaf8165. doi: 10.1126/scisignal.aaf8165.

PMID:
28400537
14.

New structural insights into podocyte biology.

Grahammer F.

Cell Tissue Res. 2017 Jul;369(1):5-10. doi: 10.1007/s00441-017-2590-3. Epub 2017 Mar 10. Review.

15.

NorUrsodeoxycholic acid ameliorates cholemic nephropathy in bile duct ligated mice.

Krones E, Eller K, Pollheimer MJ, Racedo S, Kirsch AH, Frauscher B, Wahlström A, Ståhlman M, Trauner M, Grahammer F, Huber TB, Wagner K, Rosenkranz AR, Marschall HU, Fickert P.

J Hepatol. 2017 Jul;67(1):110-119. doi: 10.1016/j.jhep.2017.02.019. Epub 2017 Feb 27.

PMID:
28242240
16.

The long journey through renal filtration: new pieces in the puzzle of slit diaphragm architecture.

Conti S, Perico L, Grahammer F, Huber TB.

Curr Opin Nephrol Hypertens. 2017 May;26(3):148-153. doi: 10.1097/MNH.0000000000000322. Review.

PMID:
28212178
17.

Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1.

Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh KH, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J, Gupta V.

J Biol Chem. 2017 Jan 13;292(2):732-747. doi: 10.1074/jbc.M116.753822. Epub 2016 Dec 2.

18.

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.

Kaminski MM, Tosic J, Kresbach C, Engel H, Klockenbusch J, Müller AL, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ, Lienkamp SS.

Nat Cell Biol. 2016 Dec;18(12):1269-1280. doi: 10.1038/ncb3437. Epub 2016 Nov 7.

PMID:
27820600
19.

Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.

Trepiccione F, Gerber SD, Grahammer F, López-Cayuqueo KI, Baudrie V, Păunescu TG, Capen DE, Picard N, Alexander RT, Huber TB, Chambrey R, Brown D, Houillier P, Eladari D, Simons M.

J Am Soc Nephrol. 2016 Nov;27(11):3320-3330. Epub 2016 Apr 4.

20.

MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes.

Ni J, Bao S, Johnson RI, Zhu B, Li J, Vadaparampil J, Smith CM, Campbell KN, Grahammer F, Huber TB, He JC, D'Agati VD, Chan A, Kaufman L.

J Biol Chem. 2016 Nov 18;291(47):24406-24417. Epub 2016 Oct 5.

21.

Roles of mTOR complexes in the kidney: implications for renal disease and transplantation.

Fantus D, Rogers NM, Grahammer F, Huber TB, Thomson AW.

Nat Rev Nephrol. 2016 Oct;12(10):587-609. doi: 10.1038/nrneph.2016.108. Epub 2016 Aug 1. Review.

PMID:
27477490
22.

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes.

Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB.

JCI Insight. 2016 Jun 16;1(9). pii: e86177.

23.

Aberrant podocyte cell cycle in glomerular disease.

Grahammer F, Huber TB.

Cell Cycle. 2016 Sep;15(17):2237-8. doi: 10.1080/15384101.2016.1205413. Epub 2016 Jul 8. No abstract available.

24.

mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells.

Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kühne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F.

J Am Soc Nephrol. 2017 Jan;28(1):230-241. doi: 10.1681/ASN.2015111224. Epub 2016 Jun 13.

25.

mTORC2 critically regulates renal potassium handling.

Grahammer F, Nesterov V, Ahmed A, Steinhardt F, Sandner L, Arnold F, Cordts T, Negrea S, Bertog M, Ruegg MA, Hall MN, Walz G, Korbmacher C, Artunc F, Huber TB.

J Clin Invest. 2016 May 2;126(5):1773-82. doi: 10.1172/JCI80304. Epub 2016 Apr 4.

26.

The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility.

Schell C, Kretz O, Liang W, Kiefer B, Schneider S, Sellung D, Bork T, Leiber C, Rüegg MA, Mallidis C, Schlatt S, Mayerhofer A, Huber TB, Grahammer F.

Am J Pathol. 2016 Feb;186(2):324-36. doi: 10.1016/j.ajpath.2015.10.012. Epub 2015 Dec 10.

PMID:
26683665
27.

Deoxycorticosterone Acetate/Salt-Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood Pressure.

Lother A, Fürst D, Bergemann S, Gilsbach R, Grahammer F, Huber TB, Hilgendorf I, Bode C, Moser M, Hein L.

Hypertension. 2016 Jan;67(1):130-8. doi: 10.1161/HYPERTENSIONAHA.115.06530. Epub 2015 Nov 9.

PMID:
26553231
28.

Microtubule Associated Protein 1b (MAP1B) Is a Marker of the Microtubular Cytoskeleton in Podocytes but Is Not Essential for the Function of the Kidney Filtration Barrier in Mice.

Gödel M, Temerinac D, Grahammer F, Hartleben B, Kretz O, Riederer BM, Propst F, Kohl S, Huber TB.

PLoS One. 2015 Oct 8;10(10):e0140116. doi: 10.1371/journal.pone.0140116. eCollection 2015.

29.

Nephrin Contributes to Insulin Secretion and Affects Mammalian Target of Rapamycin Signaling Independently of Insulin Receptor.

Villarreal R, Mitrofanova A, Maiguel D, Morales X, Jeon J, Grahammer F, Leibiger IB, Guzman J, Fachado A, Yoo TH, Busher Katin A, Gellermann J, Merscher S, Burke GW, Berggren PO, Oh J, Huber TB, Fornoni A.

J Am Soc Nephrol. 2016 Apr;27(4):1029-41. doi: 10.1681/ASN.2015020210. Epub 2015 Sep 23.

30.

Successful immunoadsorption of life-threatening bleeding in factor VIII inhibitor disease, but no long-term remission with anti-CD20 treatment.

Grahammer F, Fischer KG.

BMJ Case Rep. 2015 Aug 30;2015. pii: bcr2015210034. doi: 10.1136/bcr-2015-210034.

31.

Halting renal fibrosis: an unexpected role for mTORC2 signaling.

Grahammer F.

Kidney Int. 2015 Sep;88(3):437-9. doi: 10.1038/ki.2015.137.

PMID:
26323069
32.

Pulmonary infiltrate and painful nodular leg lesions in a patient with membranous glomerulonephritis.

Grahammer F, Fischer KG.

BMJ Case Rep. 2015 Jul 28;2015. pii: bcr2015210032. doi: 10.1136/bcr-2015-210032.

33.

Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response.

Schell C, Kretz O, Bregenzer A, Rogg M, Helmstädter M, Lisewski U, Gotthardt M, Tharaux PL, Huber TB, Grahammer F.

PLoS One. 2015 Jun 15;10(6):e0129424. doi: 10.1371/journal.pone.0129424. eCollection 2015.

34.

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.

Gödel M, Grahammer F, Huber TB.

N Engl J Med. 2015 Mar 12;372(11):1073. doi: 10.1056/NEJMc1500130. No abstract available.

PMID:
25760365
35.

New insights into mechanisms of glomerular injury and repair from the 10th International Podocyte Conference 2014.

Grahammer F, Benzing T, Huber TB.

Kidney Int. 2015 May;87(5):885-93. doi: 10.1038/ki.2015.5. Epub 2015 Feb 25.

PMID:
25715118
36.

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.

Grahammer F, Haenisch N, Steinhardt F, Sandner L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber TB.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):E2817-26. doi: 10.1073/pnas.1402352111. Epub 2014 Jun 23. Erratum in: Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6826. Sander, Lukas [corrected to Sandner, Lukas].

37.

mTOR controls kidney epithelia in health and disease.

Grahammer F, Wanner N, Huber TB.

Nephrol Dial Transplant. 2014 Feb;29 Suppl 1:i9-i18. doi: 10.1093/ndt/gft491. Review.

PMID:
24493874
38.

Unraveling the role of podocyte turnover in glomerular aging and injury.

Wanner N, Hartleben B, Herbach N, Goedel M, Stickel N, Zeiser R, Walz G, Moeller MJ, Grahammer F, Huber TB.

J Am Soc Nephrol. 2014 Apr;25(4):707-16. doi: 10.1681/ASN.2013050452. Epub 2014 Jan 9.

39.

The podocyte slit diaphragm--from a thin grey line to a complex signalling hub.

Grahammer F, Schell C, Huber TB.

Nat Rev Nephrol. 2013 Oct;9(10):587-98. doi: 10.1038/nrneph.2013.169. Epub 2013 Sep 3. Review.

PMID:
23999399
40.

ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3.

Hoff S, Halbritter J, Epting D, Frank V, Nguyen TM, van Reeuwijk J, Boehlke C, Schell C, Yasunaga T, Helmstädter M, Mergen M, Filhol E, Boldt K, Horn N, Ueffing M, Otto EA, Eisenberger T, Elting MW, van Wijk JA, Bockenhauer D, Sebire NJ, Rittig S, Vyberg M, Ring T, Pohl M, Pape L, Neuhaus TJ, Elshakhs NA, Koon SJ, Harris PC, Grahammer F, Huber TB, Kuehn EW, Kramer-Zucker A, Bolz HJ, Roepman R, Saunier S, Walz G, Hildebrandt F, Bergmann C, Lienkamp SS.

Nat Genet. 2013 Aug;45(8):951-6. doi: 10.1038/ng.2681. Epub 2013 Jun 23.

41.

Podocyte regeneration: who can become a podocyte?

Grahammer F, Wanner N, Huber TB.

Am J Pathol. 2013 Aug;183(2):333-5. doi: 10.1016/j.ajpath.2013.04.009. Epub 2013 May 29.

PMID:
23727347
42.

N-wasp is required for stabilization of podocyte foot processes.

Schell C, Baumhakl L, Salou S, Conzelmann AC, Meyer C, Helmstädter M, Wrede C, Grahammer F, Eimer S, Kerjaschki D, Walz G, Snapper S, Huber TB.

J Am Soc Nephrol. 2013 Apr;24(5):713-21. doi: 10.1681/ASN.2012080844. Epub 2013 Mar 7.

43.

Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks.

Boerries M, Grahammer F, Eiselein S, Buck M, Meyer C, Goedel M, Bechtel W, Zschiedrich S, Pfeifer D, Laloë D, Arrondel C, Gonçalves S, Krüger M, Harvey SJ, Busch H, Dengjel J, Huber TB.

Kidney Int. 2013 Jun;83(6):1052-64. doi: 10.1038/ki.2012.487. Epub 2013 Jan 30.

44.

Molecular understanding of the slit diaphragm.

Grahammer F, Schell C, Huber TB.

Pediatr Nephrol. 2013 Oct;28(10):1957-62. doi: 10.1007/s00467-012-2375-6. Epub 2012 Dec 12. Review.

PMID:
23233041
45.

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.

Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, Möller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, Patrakka J, Xiao Z, Grahammer F, Schiffer M, Lohmüller T, Reinheckel T, Gu C, Huber TB, Ju W, Bitzer M, Rastaldi MP, Ruiz P, Tryggvason K, Shaw AS, Faul C, Sever S, Reiser J.

J Clin Invest. 2011 Oct;121(10):3965-80. doi: 10.1172/JCI58552. Epub 2011 Sep 12. Erratum in: J Clin Invest. 2012 Feb 1;122(2):780.

46.

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.

Hartleben B, Gödel M, Meyer-Schwesinger C, Liu S, Ulrich T, Köbler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, Cohen CD, Pavenstädt H, Kerjaschki D, Mizushima N, Shaw AS, Walz G, Huber TB.

J Clin Invest. 2010 Apr;120(4):1084-96. doi: 10.1172/JCI39492.

47.

Role of serum- and glucocorticoid-inducible kinase SGK1 in glucocorticoid regulation of renal electrolyte excretion and blood pressure.

Boini KM, Nammi S, Grahammer F, Osswald H, Kuhl D, Lang F.

Kidney Blood Press Res. 2008;31(4):280-9. doi: 10.1159/000151666. Epub 2008 Aug 28.

48.

Role of the serum and glucocorticoid inducible kinase SGK1 in glucocorticoid stimulation of gastric acid secretion.

Sandu C, Artunc F, Grahammer F, Rotte A, Boini KM, Friedrich B, Sandulache D, Metzger M, Just L, Mack A, Skutella T, Rexhepaj R, Risler T, Wulff P, Kuhl D, Lang F.

Pflugers Arch. 2007 Dec;455(3):493-503. Epub 2007 Jul 6.

PMID:
17618452
49.

Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice.

Rexhepaj R, Grahammer F, Völkl H, Remy C, Wagner CA, Sandulache D, Artunc F, Henke G, Nammi S, Capasso G, Alessi DR, Lang F.

FASEB J. 2006 Nov;20(13):2214-22.

50.

SGK1 is not required for regulation of colonic ENaC activity.

Rexhepaj R, Artunc F, Grahammer F, Nasir O, Sandu C, Friedrich B, Kuhl D, Lang F.

Pflugers Arch. 2006 Oct;453(1):97-105. Epub 2006 Aug 8.

PMID:
16897044

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