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Lesion activity and chronic demyelination are the major determinants of brain atrophy in MS.

Wang C, Barnett MH, Yiannikas C, Barton J, Parratt J, You Y, Graham SL, Klistorner A.

Neurol Neuroimmunol Neuroinflamm. 2019 Jul 16;6(5). pii: e593. doi: 10.1212/NXI.0000000000000593. Print 2019 Sep.



You Y, Graham SL, Klistorner A.

Ophthalmology. 2019 Aug;126(8):e64-e65. doi: 10.1016/j.ophtha.2019.03.030. No abstract available.


Irrigation increases forage production of newly established lucerne but enhances net ecosystem carbon losses.

Laubach J, Hunt JE, Graham SL, Buxton RP, Rogers GND, Mudge PL, Carrick S, Whitehead D.

Sci Total Environ. 2019 Nov 1;689:921-936. doi: 10.1016/j.scitotenv.2019.06.407. Epub 2019 Jun 26.


Bilateral Optic Atrophy from a Silent Occipital Lesion.

You Y, Graham SL.

Ophthalmology. 2019 Jul;126(7):979. doi: 10.1016/j.ophtha.2019.04.002. No abstract available.


Macular Ganglion Cell-Inner Plexiform Layer Loss Precedes Peripapillary Retinal Nerve Fiber Layer Loss in Glaucoma with Lower Intraocular Pressure.

Marshall HN, Andrew NH, Hassall M, Qassim A, Souzeau E, Ridge B, Nguyen T, Fitzgerald J, Awadalla MS, Burdon KP, Healey PR, Agar A, Galanopoulos A, Hewitt AW, Graham SL, Landers J, Casson RJ, Craig JE.

Ophthalmology. 2019 Aug;126(8):1119-1130. doi: 10.1016/j.ophtha.2019.03.016. Epub 2019 Mar 22.


Sex-Specific Effect of BDNF Val66Met Genotypes on the Progression of Open-Angle Glaucoma.

Shen T, Gupta VK, Klistorner A, Chitranshi N, Graham SL, You Y.

Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1069-1075. doi: 10.1167/iovs.18-26364.


Amyloid β Induces Early Changes in the Ribosomal Machinery, Cytoskeletal Organization and Oxidative Phosphorylation in Retinal Photoreceptor Cells.

Deng L, Pushpitha K, Joseph C, Gupta V, Rajput R, Chitranshi N, Dheer Y, Amirkhani A, Kamath K, Pascovici D, Wu JX, Salekdeh GH, Haynes PA, Graham SL, Gupta VK, Mirzaei M.

Front Mol Neurosci. 2019 Feb 22;12:24. doi: 10.3389/fnmol.2019.00024. eCollection 2019.


9/11 Residential Exposures: The Impact of World Trade Center Dust on Respiratory Outcomes of Lower Manhattan Residents.

Antao VC, Pallos LL, Graham SL, Shim YK, Sapp JH, Lewis B, Bullard S, Alper HE, Cone JE, Farfel MR, Brackbill RM.

Int J Environ Res Public Health. 2019 Mar 5;16(5). pii: E798. doi: 10.3390/ijerph16050798.


Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand-activated transcription factors, retinoid X receptors.

Chitranshi N, Dheer Y, Kumar S, Graham SL, Gupta V.

J Cell Biochem. 2019 Feb 11. doi: 10.1002/jcb.28455. [Epub ahead of print]


Evidence of Müller Glial Dysfunction in Patients with Aquaporin-4 Immunoglobulin G-Positive Neuromyelitis Optica Spectrum Disorder.

You Y, Zhu L, Zhang T, Shen T, Fontes A, Yiannikas C, Parratt J, Barton J, Schulz A, Gupta V, Barnett MH, Fraser CL, Gillies M, Graham SL, Klistorner A.

Ophthalmology. 2019 Jun;126(6):801-810. doi: 10.1016/j.ophtha.2019.01.016. Epub 2019 Feb 1.


Upregulation of Proteolytic Pathways and Altered Protein Biosynthesis Underlie Retinal Pathology in a Mouse Model of Alzheimer's Disease.

Mirzaei M, Pushpitha K, Deng L, Chitranshi N, Gupta V, Rajput R, Mangani AB, Dheer Y, Godinez A, McKay MJ, Kamath K, Pascovici D, Wu JX, Salekdeh GH, Karl T, Haynes PA, Graham SL, Gupta VK.

Mol Neurobiol. 2019 Sep;56(9):6017-6034. doi: 10.1007/s12035-019-1479-4. Epub 2019 Feb 1.


Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult mice.

Dheer Y, Chitranshi N, Gupta V, Sharma S, Pushpitha K, Abbasi M, Mirzaei M, You Y, Graham SL, Gupta V.

Exp Neurol. 2019 Apr;314:111-125. doi: 10.1016/j.expneurol.2019.01.015. Epub 2019 Jan 28.


Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease.

You Y, Joseph C, Wang C, Gupta V, Liu S, Yiannikas C, Chua BE, Chitranshi N, Shen T, Dheer Y, Invernizzi A, Borotkanics R, Barnett M, Graham SL, Klistorner A.

Brain. 2019 Feb 1;142(2):426-442. doi: 10.1093/brain/awy338.


Pathophysiological basis of low contrast visual acuity loss in multiple sclerosis.

Triplett JD, Yiannikas C, Barnett MH, Parratt J, Barton J, Graham SL, You Y, Klistorner A.

Ann Clin Transl Neurol. 2018 Oct 24;5(12):1505-1512. doi: 10.1002/acn3.659. eCollection 2018 Dec.


Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance.

Awadalla MS, Fitzgerald J, Andrew NH, Zhou T, Marshall H, Qassim A, Hassall M, Casson RJ, Graham SL, Healey PR, Agar A, Galanopoulos A, Phipps S, Chappell A, Landers J, Craig JE.

PLoS One. 2018 Dec 5;13(12):e0206684. doi: 10.1371/journal.pone.0206684. eCollection 2018.


Loss of Shp2 Rescues BDNF/TrkB Signaling and Contributes to Improved Retinal Ganglion Cell Neuroprotection.

Chitranshi N, Dheer Y, Mirzaei M, Wu Y, Salekdeh GH, Abbasi M, Gupta V, Vander Wall R, You Y, Graham SL, Gupta V.

Mol Ther. 2019 Feb 6;27(2):424-441. doi: 10.1016/j.ymthe.2018.09.019. Epub 2018 Oct 4.


Myocilin Gene Gln368Ter Variant Penetrance and Association With Glaucoma in Population-Based and Registry-Based Studies.

Han X, Souzeau E, Ong JS, An J, Siggs OM, Burdon KP, Best S, Goldberg I, Healey PR, Graham SL, Ruddle JB, Mills RA, Landers J, Galanopoulos A, White AJR, Casson R, Mackey DA, Hewitt AW, Gharahkhani P, Craig JE, MacGregor S.

JAMA Ophthalmol. 2019 Jan 1;137(1):28-35. doi: 10.1001/jamaophthalmol.2018.4477.


Differing Structural and Functional Patterns of Optic Nerve Damage in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder.

Shen T, You Y, Arunachalam S, Fontes A, Liu S, Gupta V, Parratt J, Wang C, Barnett M, Barton J, Chitranshi N, Zhu L, Fraser CL, Graham SL, Klistorner A, Yiannikas C.

Ophthalmology. 2019 Mar;126(3):445-453. doi: 10.1016/j.ophtha.2018.06.022. Epub 2018 Jul 27.


Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.

MacGregor S, Ong JS, An J, Han X, Zhou T, Siggs OM, Law MH, Souzeau E, Sharma S, Lynn DJ, Beesley J, Sheldrick B, Mills RA, Landers J, Ruddle JB, Graham SL, Healey PR, White AJR, Casson RJ, Best S, Grigg JR, Goldberg I, Powell JE, Whiteman DC, Radford-Smith GL, Martin NG, Montgomery GW, Burdon KP, Mackey DA, Gharahkhani P, Craig JE, Hewitt AW.

Nat Genet. 2018 Aug;50(8):1067-1071. doi: 10.1038/s41588-018-0176-y. Epub 2018 Jul 27.


BDNF Polymorphism: A Review of Its Diagnostic and Clinical Relevance in Neurodegenerative Disorders.

Shen T, You Y, Joseph C, Mirzaei M, Klistorner A, Graham SL, Gupta V.

Aging Dis. 2018 Jun 1;9(3):523-536. doi: 10.14336/AD.2017.0717. eCollection 2018 Jun. Review.


Carbohydrate ingestion induces differential autonomic dysregulation in normal-tension glaucoma and primary open angle glaucoma.

Cao L, Graham SL, Pilowsky PM.

PLoS One. 2018 Jun 7;13(6):e0198432. doi: 10.1371/journal.pone.0198432. eCollection 2018.


Diffusivity in the core of chronic multiple sclerosis lesions.

Klistorner A, Wang C, Yiannikas C, Parratt J, Barton J, You Y, Graham SL, Barnett MH.

PLoS One. 2018 Apr 25;13(4):e0194142. doi: 10.1371/journal.pone.0194142. eCollection 2018.


Glaucoma Pathogenesis and Neurotrophins: Focus on the Molecular and Genetic Basis for Therapeutic Prospects.

Chitranshi N, Dheer Y, Abbasi M, You Y, Graham SL, Gupta V.

Curr Neuropharmacol. 2018;16(7):1018-1035. doi: 10.2174/1570159X16666180419121247. Review.


Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation.

Dheer Y, Chitranshi N, Gupta V, Abbasi M, Mirzaei M, You Y, Chung R, Graham SL, Gupta V.

Mol Neurobiol. 2018 Dec;55(12):9043-9056. doi: 10.1007/s12035-018-1041-9. Epub 2018 Apr 10.


Regulation of Brain-Derived Neurotrophic Factor and Growth Factor Signaling Pathways by Tyrosine Phosphatase Shp2 in the Retina: A Brief Review.

Abbasi M, Gupta V, Chitranshi N, You Y, Dheer Y, Mirzaei M, Graham SL.

Front Cell Neurosci. 2018 Mar 27;12:85. doi: 10.3389/fncel.2018.00085. eCollection 2018. Review.


Identification of second-generation P2X3 antagonists for treatment of pain.

Ginnetti AT, Paone DV, Stauffer SR, Potteiger CM, Shaw AW, Deng J, Mulhearn JJ, Nguyen DN, Segerdell C, Anquandah J, Calamari A, Cheng G, Leitl MD, Liang A, Moore E, Panigel J, Urban M, Wang J, Fillgrove K, Tang C, Cook S, Kane S, Salvatore CA, Graham SL, Burgey CS.

Bioorg Med Chem Lett. 2018 May 1;28(8):1392-1396. doi: 10.1016/j.bmcl.2018.02.039. Epub 2018 Feb 21.


Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma.

Gharahkhani P, Burdon KP, Cooke Bailey JN, Hewitt AW, Law MH, Pasquale LR, Kang JH, Haines JL, Souzeau E, Zhou T, Siggs OM, Landers J, Awadalla M, Sharma S, Mills RA, Ridge B, Lynn D, Casson R, Graham SL, Goldberg I, White A, Healey PR, Grigg J, Lawlor M, Mitchell P, Ruddle J, Coote M, Walland M, Best S, Vincent A, Gale J, RadfordSmith G, Whiteman DC, Montgomery GW, Martin NG, Mackey DA, Wiggs JL, MacGregor S, Craig JE; NEIGHBORHOOD consortium.

Sci Rep. 2018 Feb 15;8(1):3124. doi: 10.1038/s41598-018-20435-9.


Monitoring of optic nerve function in Neurofibromatosis 2 children with optic nerve sheath meningiomas using multifocal visual evoked potentials.

Jayanetti V, Klistorner AI, Graham SL, Dexter M, Flaherty MP, Jones K, Billson FA, Wilson M, North K, Grigg JR, Fraser CL.

J Clin Neurosci. 2018 Apr;50:262-267. doi: 10.1016/j.jocn.2018.01.012. Epub 2018 Feb 3.


Evidence of progressive tissue loss in the core of chronic MS lesions: A longitudinal DTI study.

Klistorner A, Wang C, Yiannikas C, Parratt J, Dwyer M, Barton J, Graham SL, You Y, Liu S, Barnett MH.

Neuroimage Clin. 2017 Dec 8;17:1028-1035. doi: 10.1016/j.nicl.2017.12.010. eCollection 2018.


DNA methylation at the 9p21 glaucoma susceptibility locus is associated with normal-tension glaucoma.

Burdon KP, Awadalla MS, Mitchell P, Wang JJ, White A, Keane MC, Souzeau E, Graham SL, Goldberg I, Healey PR, Landers J, Mills RAD, Best S, Hewitt AW, Sharma S, Craig JE.

Ophthalmic Genet. 2018 Apr;39(2):221-227. doi: 10.1080/13816810.2017.1413659. Epub 2017 Dec 21.


Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS.

You Y, Graham EC, Shen T, Yiannikas C, Parratt J, Gupta V, Barton J, Dwyer M, Barnett MH, Fraser CL, Graham SL, Klistorner A.

Neurol Neuroimmunol Neuroinflamm. 2017 Dec 15;5(1):e427. doi: 10.1212/NXI.0000000000000427. eCollection 2018 Jan. Erratum in: Neurol Neuroimmunol Neuroinflamm. 2018 Jan 31;5(2):e444.


Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes.

Mirzaei M, Gupta VB, Chick JM, Greco TM, Wu Y, Chitranshi N, Wall RV, Hone E, Deng L, Dheer Y, Abbasi M, Rezaeian M, Braidy N, You Y, Salekdeh GH, Haynes PA, Molloy MP, Martins R, Cristea IM, Gygi SP, Graham SL, Gupta VK.

Sci Rep. 2017 Oct 4;7(1):12685. doi: 10.1038/s41598-017-12858-7.


Performance of iPad-based threshold perimetry in glaucoma and controls.

Schulz AM, Graham EC, You Y, Klistorner A, Graham SL.

Clin Exp Ophthalmol. 2018 May;46(4):346-355. doi: 10.1111/ceo.13082. Epub 2017 Nov 16.


PTPN11 induces endoplasmic stress and apoptosis in SH-SY5Y cells.

Chitranshi N, Dheer Y, Gupta V, Abbasi M, Mirzaei M, You Y, Chung R, Graham SL, Gupta V.

Neuroscience. 2017 Nov 19;364:175-189. doi: 10.1016/j.neuroscience.2017.09.028. Epub 2017 Sep 22.


Progression of retinal ganglion cell loss in multiple sclerosis is associated with new lesions in the optic radiations.

Klistorner A, Graham EC, Yiannikas C, Barnett M, Parratt J, Garrick R, Wang C, You Y, Graham SL.

Eur J Neurol. 2017 Nov;24(11):1392-1398. doi: 10.1111/ene.13404. Epub 2017 Sep 13.


The association between retinal vein pulsation pressure and optic disc haemorrhages in glaucoma.

An D, House P, Barry C, Turpin A, McKendrick AM, Chauhan BC, Manners S, Graham SL, Yu DY, Morgan WH.

PLoS One. 2017 Jul 28;12(7):e0182316. doi: 10.1371/journal.pone.0182316. eCollection 2017.


Quantitative Retinal Vascular Changes in Obstructive Sleep Apnea.

Tong JY, Golzan M, Georgevsky D, Williamson JP, Graham SL, Farah CS, Fraser CL.

Am J Ophthalmol. 2017 Oct;182:72-80. doi: 10.1016/j.ajo.2017.07.012. Epub 2017 Jul 20.


DBA/2J mouse model for experimental glaucoma: pitfalls and problems.

Turner AJ, Vander Wall R, Gupta V, Klistorner A, Graham SL.

Clin Exp Ophthalmol. 2017 Dec;45(9):911-922. doi: 10.1111/ceo.12992. Epub 2017 Jun 13.


High speed in-vivo imaging of retinal hemodynamics in a rodent model of hypertension.

Rezaeian M, Georgevsky D, Golzan SM, Graham SL.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:3243-3246. doi: 10.1109/EMBC.2016.7591420.


Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer's disease.

Golzan SM, Goozee K, Georgevsky D, Avolio A, Chatterjee P, Shen K, Gupta V, Chung R, Savage G, Orr CF, Martins RN, Graham SL.

Alzheimers Res Ther. 2017 Mar 1;9(1):13. doi: 10.1186/s13195-017-0239-9.


Myocilin Predictive Genetic Testing for Primary Open-Angle Glaucoma Leads to Early Identification of At-Risk Individuals.

Souzeau E, Tram KH, Witney M, Ruddle JB, Graham SL, Healey PR, Goldberg I, Mackey DA, Hewitt AW, Burdon KP, Craig JE.

Ophthalmology. 2017 Mar;124(3):303-309. doi: 10.1016/j.ophtha.2016.11.011. Epub 2016 Dec 16.


Diffusivity in multiple sclerosis lesions: At the cutting edge?

Klistorner A, Wang C, Fofanova V, Barnett MH, Yiannikas C, Parratt J, You Y, Graham SL.

Neuroimage Clin. 2016 Jul 5;12:219-26. doi: 10.1016/j.nicl.2016.07.003. eCollection 2016.


Genetic Association at the 9p21 Glaucoma Locus Contributes to Sex Bias in Normal-Tension Glaucoma.

Ng SK, Burdon KP, Fitzgerald JT, Zhou T, Fogarty R, Souzeau E, Landers J, Mills RA, Casson RJ, Ridge B, Graham SL, Hewitt AW, Mackey DA, Healey PR, Wang JJ, Mitchell P, MacGregor S, Craig JE.

Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3416-21. doi: 10.1167/iovs.16-19401.


Carbohydrate ingestion induces sex-specific cardiac vagal inhibition, but not vascular sympathetic modulation, in healthy older women.

Cao L, Graham SL, Pilowsky PM.

Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R49-56. doi: 10.1152/ajpregu.00486.2015. Epub 2016 May 4.


Afferent visual pathways in multiple sclerosis: a review.

Graham SL, Klistorner A.

Clin Exp Ophthalmol. 2017 Jan;45(1):62-72. doi: 10.1111/ceo.12751. Epub 2016 Apr 28. Review.


Progressive Injury in Chronic Multiple Sclerosis Lesions Is Gender-Specific: A DTI Study.

Klistorner A, Wang C, Yiannikas C, Graham SL, Parratt J, Barnett MH.

PLoS One. 2016 Feb 22;11(2):e0149245. doi: 10.1371/journal.pone.0149245. eCollection 2016.


Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins.

Chitranshi N, Gupta V, Kumar S, Graham SL.

Int J Mol Sci. 2015 Sep 3;16(9):21087-108. doi: 10.3390/ijms160921087.


Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination.

You Y, Gupta VK, Chitranshi N, Reedman B, Klistorner A, Graham SL.

J Vis Exp. 2015 Jul 29;(101):e52934. doi: 10.3791/52934.


Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency.

Egbertson M, McGaughey GB, Pitzenberger SM, Stauffer SR, Coburn CA, Stachel SJ, Yang W, Barrow JC, Neilson LA, McWherter M, Perlow D, Fahr B, Munshi S, Allison TJ, Holloway K, Selnick HG, Yang Z, Swestock J, Simon AJ, Sankaranarayanan S, Colussi D, Tugusheva K, Lai MT, Pietrak B, Haugabook S, Jin L, Chen IW, Holahan M, Stranieri-Michener M, Cook JJ, Vacca J, Graham SL.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4812-4819. doi: 10.1016/j.bmcl.2015.06.082. Epub 2015 Jun 29.


Correlation of retinal nerve fibre layer thickness and spontaneous retinal venous pulsations in glaucoma and normal controls.

Golzan SM, Morgan WH, Georgevsky D, Graham SL.

PLoS One. 2015 Jun 4;10(6):e0128433. doi: 10.1371/journal.pone.0128433. eCollection 2015.

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