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Mitochondrial fusion is required for spermatogonial differentiation and meiosis.

Varuzhanyan G, Rojansky R, Sweredoski MJ, Graham RL, Hess S, Ladinsky MS, Chan DC.

Elife. 2019 Oct 9;8. pii: e51601. doi: 10.7554/eLife.51601. [Epub ahead of print]


Diagnosis of epithelial ovarian cancer using a combined protein biomarker panel.

Russell MR, Graham C, D'Amato A, Gentry-Maharaj A, Ryan A, Kalsi JK, Whetton AD, Menon U, Jacobs I, Graham RLJ.

Br J Cancer. 2019 Sep;121(6):483-489. doi: 10.1038/s41416-019-0544-0. Epub 2019 Aug 7.


Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.

Brown AJ, Won JJ, Graham RL, Dinnon KH 3rd, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP.

Antiviral Res. 2019 Sep;169:104541. doi: 10.1016/j.antiviral.2019.104541. Epub 2019 Jun 21.


GII.4 Human Norovirus: Surveying the Antigenic Landscape.

Mallory ML, Lindesmith LC, Graham RL, Baric RS.

Viruses. 2019 Feb 20;11(2). pii: E177. doi: 10.3390/v11020177. Review.


Evaluation of a recombination-resistant coronavirus as a broadly applicable, rapidly implementable vaccine platform.

Graham RL, Deming DJ, Deming ME, Yount BL, Baric RS.

Commun Biol. 2018 Oct 29;1:179. doi: 10.1038/s42003-018-0175-7. eCollection 2018.


Human Norovirus Epitope D Plasticity Allows Escape from Antibody Immunity without Loss of Capacity for Binding Cellular Ligands.

Lindesmith LC, Brewer-Jensen PD, Mallory ML, Yount B, Collins MH, Debbink K, Graham RL, Baric RS.

J Virol. 2019 Jan 4;93(2). pii: e01813-18. doi: 10.1128/JVI.01813-18. Print 2019 Jan 15.


Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPases.

Walkup WG 4th, Sweredoski MJ, Graham RL, Hess S, Kennedy MB.

Biochem Biophys Res Commun. 2018 Sep 10;503(3):1599-1604. doi: 10.1016/j.bbrc.2018.07.087. Epub 2018 Jul 24.


A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques.

Cockrell AS, Johnson JC, Moore IN, Liu DX, Bock KW, Douglas MG, Graham RL, Solomon J, Torzewski L, Bartos C, Hart R, Baric RS, Johnson RF.

Sci Rep. 2018 Jul 16;8(1):10727. doi: 10.1038/s41598-018-28900-1.


Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines.

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, McAnarney ET, Graham RL, Waters KM, Baric RS.

J Virol. 2018 Aug 16;92(17). pii: e00710-18. doi: 10.1128/JVI.00710-18. Print 2018 Sep 1.


Bat Caliciviruses and Human Noroviruses Are Antigenically Similar and Have Overlapping Histo-Blood Group Antigen Binding Profiles.

Kocher JF, Lindesmith LC, Debbink K, Beall A, Mallory ML, Yount BL, Graham RL, Huynh J, Gates JE, Donaldson EF, Baric RS.

MBio. 2018 May 22;9(3). pii: e00869-18. doi: 10.1128/mBio.00869-18.


Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR.

MBio. 2018 Mar 6;9(2). pii: e00221-18. doi: 10.1128/mBio.00221-18.


Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion.

Lindesmith LC, Mallory ML, Debbink K, Donaldson EF, Brewer-Jensen PD, Swann EW, Sheahan TP, Graham RL, Beltramello M, Corti D, Lanzavecchia A, Baric RS.

mSphere. 2018 Feb 7;3(1). pii: e00518-17. doi: 10.1128/mSphere.00518-17. eCollection 2018 Jan-Feb.


Hepatitis B Virus Vaccination in HIV-1-Infected Young Adults: A Tool to Reduce the Size of HIV-1 Reservoirs?

Bekele Y, Graham RL, Soeria-Atmadja S, Nasi A, Zazzi M, Vicenti I, Naver L, Nilsson A, Chiodi F.

Front Immunol. 2018 Jan 10;8:1966. doi: 10.3389/fimmu.2017.01966. eCollection 2017.


Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses.

Johnson BA, Graham RL, Menachery VD.

Virology. 2018 Apr;517:30-37. doi: 10.1016/j.virol.2017.12.009. Epub 2017 Dec 24. Review.


Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis.

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, Graham RL, McAnarney ET, Stratton KG, Cockrell AS, Debbink K, Sims AC, Waters KM, Baric RS.

mSphere. 2017 Nov 15;2(6). pii: e00346-17. doi: 10.1128/mSphere.00346-17. eCollection 2017 Nov-Dec.


Expanded subgenomic mRNA transcriptome and coding capacity of a nidovirus.

Di H, Madden JC Jr, Morantz EK, Tang HY, Graham RL, Baric RS, Brinton MA.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):E8895-E8904. doi: 10.1073/pnas.1706696114. Epub 2017 Oct 4.


MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis.

Menachery VD, Mitchell HD, Cockrell AS, Gralinski LE, Yount BL Jr, Graham RL, McAnarney ET, Douglas MG, Scobey T, Beall A, Dinnon K 3rd, Kocher JF, Hale AE, Stratton KG, Waters KM, Baric RS.

MBio. 2017 Aug 22;8(4). pii: e00665-17. doi: 10.1128/mBio.00665-17.


A combined biomarker panel shows improved sensitivity for the early detection of ovarian cancer allowing the identification of the most aggressive type II tumours.

Russell MR, Graham C, D'Amato A, Gentry-Maharaj A, Ryan A, Kalsi JK, Ainley C, Whetton AD, Menon U, Jacobs I, Graham RLJ.

Br J Cancer. 2017 Aug 22;117(5):666-674. doi: 10.1038/bjc.2017.199. Epub 2017 Jun 29.


Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3653. doi: 10.1126/scitranslmed.aal3653.


Jumping species-a mechanism for coronavirus persistence and survival.

Menachery VD, Graham RL, Baric RS.

Curr Opin Virol. 2017 Apr;23:1-7. doi: 10.1016/j.coviro.2017.01.002. Epub 2017 Mar 31. Review.


Novel risk models for early detection and screening of ovarian cancer.

Russell MR, D'Amato A, Graham C, Crosbie EJ, Gentry-Maharaj A, Ryan A, Kalsi JK, Fourkala EO, Dive C, Walker M, Whetton AD, Menon U, Jacobs I, Graham RL.

Oncotarget. 2017 Jan 3;8(1):785-797. doi: 10.18632/oncotarget.13648.


Corrigendum: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.

Menachery VD, Yount BL Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS.

Nat Med. 2016 Apr;22(4):446. doi: 10.1038/nm0416-446d. No abstract available.


SARS-like WIV1-CoV poised for human emergence.

Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53. doi: 10.1073/pnas.1517719113. Epub 2016 Mar 14.


Protein Z: A putative novel biomarker for early detection of ovarian cancer.

Russell MR, Walker MJ, Williamson AJ, Gentry-Maharaj A, Ryan A, Kalsi J, Skates S, D'Amato A, Dive C, Pernemalm M, Humphryes PC, Fourkala EO, Whetton AD, Menon U, Jacobs I, Graham RL.

Int J Cancer. 2016 Jun 15;138(12):2984-92. doi: 10.1002/ijc.30020. Epub 2016 Feb 19.


A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.

Menachery VD, Yount BL Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS.

Nat Med. 2015 Dec;21(12):1508-13. doi: 10.1038/nm.3985. Epub 2015 Nov 9. Erratum in: Nat Med. 2016 Apr;22(4):446.


Primary follicular lymphoma of the duodenum.

Graham RL, Mardones MA, Krause JR.

Proc (Bayl Univ Med Cent). 2015 Jul;28(3):381-3.


Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.

Hicks JK, Bishop JR, Sangkuhl K, Müller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A; Clinical Pharmacogenetics Implementation Consortium.

Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. Review.


Cell-specific proteomic analysis in Caenorhabditis elegans.

Yuet KP, Doma MK, Ngo JT, Sweredoski MJ, Graham RL, Moradian A, Hess S, Schuman EM, Sternberg PW, Tirrell DA.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2705-10. doi: 10.1073/pnas.1421567112. Epub 2015 Feb 17.


Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases.

Walkup WG 4th, Washburn L, Sweredoski MJ, Carlisle HJ, Graham RL, Hess S, Kennedy MB.

J Biol Chem. 2015 Feb 20;290(8):4908-27. doi: 10.1074/jbc.M114.614420. Epub 2014 Dec 22.


Adult T-cell leukemia/lymphoma.

Graham RL, Burch M, Krause JR.

Proc (Bayl Univ Med Cent). 2014 Jul;27(3):235-8.


Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution.

Tang XC, Agnihothram SS, Jiao Y, Stanhope J, Graham RL, Peterson EC, Avnir Y, Tallarico AS, Sheehan J, Zhu Q, Baric RS, Marasco WA.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):E2018-26. doi: 10.1073/pnas.1402074111. Epub 2014 Apr 28.


A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant.

Agnihothram S, Yount BL Jr, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, Zambon M, Heise M, Denison MR, Baric RS.

MBio. 2014 Mar 25;5(2):e00047-14. doi: 10.1128/mBio.00047-14.


Coronavirus replicase-reporter fusions provide quantitative analysis of replication and replication complex formation.

Freeman MC, Graham RL, Lu X, Peek CT, Denison MR.

J Virol. 2014 May;88(10):5319-27. doi: 10.1128/JVI.00021-14. Epub 2014 Mar 12.


Semiquantitative analysis of clinical heat stress in Clostridium difficile strain 630 using a GeLC/MS workflow with emPAI quantitation.

Ternan NG, Jain S, Graham RL, McMullan G.

PLoS One. 2014 Feb 24;9(2):e88960. doi: 10.1371/journal.pone.0088960. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e97413.


F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.

Honarpour N, Rose CM, Brumbaugh J, Anderson J, Graham RL, Sweredoski MJ, Hess S, Coon JJ, Deshaies RJ.

Mol Cell Proteomics. 2014 Mar;13(3):780-91. doi: 10.1074/mcp.M113.031765. Epub 2014 Jan 5.


Comprehensive proteomic profiling of outer membrane vesicles from Campylobacter jejuni.

Jang KS, Sweredoski MJ, Graham RL, Hess S, Clemons WM Jr.

J Proteomics. 2014 Feb 26;98:90-8. doi: 10.1016/j.jprot.2013.12.014. Epub 2013 Dec 29.


Identification of secreted bacterial proteins by noncanonical amino acid tagging.

Mahdavi A, Szychowski J, Ngo JT, Sweredoski MJ, Graham RL, Hess S, Schneewind O, Mazmanian SK, Tirrell DA.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):433-8. doi: 10.1073/pnas.1301740111. Epub 2013 Dec 17.


Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses.

Agnihothram S, Gopal R, Yount BL Jr, Donaldson EF, Menachery VD, Graham RL, Scobey TD, Gralinski LE, Denison MR, Zambon M, Baric RS.

J Infect Dis. 2014 Apr 1;209(7):995-1006. doi: 10.1093/infdis/jit609. Epub 2013 Nov 18.


A decade after SARS: strategies for controlling emerging coronaviruses.

Graham RL, Donaldson EF, Baric RS.

Nat Rev Microbiol. 2013 Dec;11(12):836-48. doi: 10.1038/nrmicro3143. Epub 2013 Nov 11. Review.


Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus.

Scobey T, Yount BL, Sims AC, Donaldson EF, Agnihothram SS, Menachery VD, Graham RL, Swanstrom J, Bove PF, Kim JD, Grego S, Randell SH, Baric RS.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16157-62. doi: 10.1073/pnas.1311542110. Epub 2013 Sep 16.


Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition.

Kolawa N, Sweredoski MJ, Graham RL, Oania R, Hess S, Deshaies RJ.

Mol Cell Proteomics. 2013 Oct;12(10):2791-803. doi: 10.1074/mcp.M113.030163. Epub 2013 Jun 22.


Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus.

Josset L, Menachery VD, Gralinski LE, Agnihothram S, Sova P, Carter VS, Yount BL, Graham RL, Baric RS, Katze MG.

MBio. 2013 Apr 30;4(3):e00165-13. doi: 10.1128/mBio.00165-13.


Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.

Pierce NW, Lee JE, Liu X, Sweredoski MJ, Graham RL, Larimore EA, Rome M, Zheng N, Clurman BE, Hess S, Shan SO, Deshaies RJ.

Cell. 2013 Mar 28;153(1):206-15. doi: 10.1016/j.cell.2013.02.024. Epub 2013 Feb 28.


Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes.

Eidahl JO, Crowe BL, North JA, McKee CJ, Shkriabai N, Feng L, Plumb M, Graham RL, Gorelick RJ, Hess S, Poirier MG, Foster MP, Kvaratskhelia M.

Nucleic Acids Res. 2013 Apr 1;41(6):3924-36. doi: 10.1093/nar/gkt074. Epub 2013 Feb 8.


T-cell prolymphocytic leukemia.

Graham RL, Cooper B, Krause JR.

Proc (Bayl Univ Med Cent). 2013 Jan;26(1):19-21.


Comprehensive profiling of N-linked glycosylation sites in HeLa cells using hydrazide enrichment.

Malerod H, Graham RL, Sweredoski MJ, Hess S.

J Proteome Res. 2013 Jan 4;12(1):248-59. doi: 10.1021/pr300859k. Epub 2012 Dec 4.


A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.

Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS.

Nat Med. 2012 Dec;18(12):1820-6. doi: 10.1038/nm.2972. Epub 2012 Nov 11.


Designer reagents for mass spectrometry-based proteomics: clickable cross-linkers for elucidation of protein structures and interactions.

Sohn CH, Agnew HD, Lee JE, Sweredoski MJ, Graham RL, Smith GT, Hess S, Czerwieniec G, Loo JA, Heath JR, Deshaies RJ, Beauchamp JL.

Anal Chem. 2012 Mar 20;84(6):2662-9. doi: 10.1021/ac202637n. Epub 2012 Mar 5.


Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.

Haines DS, Lee JE, Beauparlant SL, Kyle DB, den Besten W, Sweredoski MJ, Graham RL, Hess S, Deshaies RJ.

Mol Cell Proteomics. 2012 Jun;11(6):M111.016444. doi: 10.1074/mcp.M111.016444. Epub 2012 Feb 14.


Primary cutaneous angiosarcoma of the breast after breast trauma.

Cao Y, Panos L, Graham RL, Parker TH 3rd, Mennel R.

Proc (Bayl Univ Med Cent). 2012 Jan;25(1):70-2.

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