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Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.

Zhu C, Kim K, Wang X, Bartolome A, Salomao M, Dongiovanni P, Meroni M, Graham MJ, Yates KP, Diehl AM, Schwabe RF, Tabas I, Valenti L, Lavine JE, Pajvani UB.

Sci Transl Med. 2018 Nov 21;10(468). pii: eaat0344. doi: 10.1126/scitranslmed.aat0344.


Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis.

Puchalska P, Martin SE, Huang X, Lengfeld JE, Daniel B, Graham MJ, Han X, Nagy L, Patti GJ, Crawford PA.

Cell Metab. 2018 Nov 12. pii: S1550-4131(18)30647-8. doi: 10.1016/j.cmet.2018.10.015. [Epub ahead of print]


The Need to Be Sure About CUREs: Discovery and Relevance as Critical Elements of CUREs for Nonmajors.

Corwin LA, Dolan EL, Graham MJ, Hanauer DI, Pelaez N.

J Microbiol Biol Educ. 2018 Oct 31;19(3). pii: 19.3.102. doi: 10.1128/jmbe.v19i3.1683. eCollection 2018. No abstract available.


Faculty Beliefs about Intelligence Are Related to the Adoption of Active-Learning Practices.

Aragón OR, Eddy SL, Graham MJ.

CBE Life Sci Educ. 2018 Sep;17(3):ar47. doi: 10.1187/cbe.17-05-0084.


Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ.

Higgins CB, Zhang Y, Mayer AL, Fujiwara H, Stothard AI, Graham MJ, Swarts BM, DeBosch BJ.

JCI Insight. 2018 Aug 23;3(16). pii: 120794. doi: 10.1172/jci.insight.120794. [Epub ahead of print]


Characterization of the Activity and Distribution of a 2'-O-Methoxyethyl-Modified Antisense Oligonucleotide in Models of Acute and Chronic Kidney Disease.

Donner AJ, Bell TA, Greenlee S, Graham MJ, Crooke RM.

Nucleic Acid Ther. 2018 Oct;28(5):297-306. doi: 10.1089/nat.2018.0723. Epub 2018 Aug 22.


TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose.

Zhang Y, Higgins CB, Mayer AL, Mysorekar IU, Razani B, Graham MJ, Hruz PW, DeBosch BJ.

Autophagy. 2018;14(11):1959-1975. doi: 10.1080/15548627.2018.1493044. Epub 2018 Aug 6.


Drill-Specific Head Impacts in Collegiate Football Practice: Implications for Reducing "Friendly Fire" Exposure.

Asken BM, Brooke ZS, Stevens TC, Silvestri PG, Graham MJ, Jaffee MS, Clugston JR.

Ann Biomed Eng. 2018 Jul 9. doi: 10.1007/s10439-018-2088-5. [Epub ahead of print]


Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome.

d'Avignon DA, Puchalska P, Ercal B, Chang Y, Martin SE, Graham MJ, Patti GJ, Han X, Crawford PA.

JCI Insight. 2018 Jun 21;3(12). pii: 99762. doi: 10.1172/jci.insight.99762. [Epub ahead of print]


γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.

Kim K, Goldberg IJ, Graham MJ, Sundaram M, Bertaggia E, Lee SX, Qiang L, Haeusler RA, Metzger D, Chambon P, Yao Z, Ginsberg HN, Pajvani UB.

Cell Metab. 2018 Apr 3;27(4):816-827.e4. doi: 10.1016/j.cmet.2018.02.010. Epub 2018 Mar 22.


Trust, Growth Mindset, and Student Commitment to Active Learning in a College Science Course.

Cavanagh AJ, Chen X, Bathgate M, Frederick J, Hanauer DI, Graham MJ.

CBE Life Sci Educ. 2018 Spring;17(1). pii: ar10. doi: 10.1187/cbe.17-06-0107.


Novel Reversible Model of Atherosclerosis and Regression Using Oligonucleotide Regulation of the LDL Receptor.

Basu D, Hu Y, Huggins LA, Mullick AE, Graham MJ, Wietecha T, Barnhart S, Mogul A, Pfeiffer K, Zirlik A, Fisher EA, Bornfeldt KE, Willecke F, Goldberg IJ.

Circ Res. 2018 Feb 16;122(4):560-567. doi: 10.1161/CIRCRESAHA.117.311361. Epub 2018 Jan 10.


An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning.

Hanauer DI, Graham MJ; SEA-PHAGES, Betancur L, Bobrownicki A, Cresawn SG, Garlena RA, Jacobs-Sera D, Kaufmann N, Pope WH, Russell DA, Jacobs WR Jr, Sivanathan V, Asai DJ, Hatfull GF.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13531-13536. doi: 10.1073/pnas.1718188115. Epub 2017 Dec 5.


From the Cover: Development and Application of a Dual Rat and Human AHR Activation Assay.

Brown MR, Garside H, Thompson E, Atwal S, Bean C, Goodall T, Sullivan M, Graham MJ.

Toxicol Sci. 2017 Dec 1;160(2):408-419. doi: 10.1093/toxsci/kfx188.


Antisense oligonucleotides targeting translation inhibitory elements in 5' UTRs can selectively increase protein levels.

Liang XH, Sun H, Shen W, Wang S, Yao J, Migawa MT, Bui HH, Damle SS, Riney S, Graham MJ, Crooke RM, Crooke ST.

Nucleic Acids Res. 2017 Sep 19;45(16):9528-9546. doi: 10.1093/nar/gkx632.


Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development.

Kim S, Yang L, Kim S, Lee RG, Graham MJ, Berliner JA, Lusis AJ, Cai L, Temel RE, Rateri DL, Lee S.

PLoS One. 2017 Aug 9;12(8):e0182566. doi: 10.1371/journal.pone.0182566. eCollection 2017.


Blood Pressure Lowering and Safety Improvements With Liver Angiotensinogen Inhibition in Models of Hypertension and Kidney Injury.

Mullick AE, Yeh ST, Graham MJ, Engelhardt JA, Prakash TP, Crooke RM.

Hypertension. 2017 Sep;70(3):566-576. doi: 10.1161/HYPERTENSIONAHA.117.09755. Epub 2017 Jul 17.


The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis AJ, Hazen SL, Brown JM.

Cell Rep. 2017 Jul 5;20(1):279. doi: 10.1016/j.celrep.2017.06.053. No abstract available.


Probing Nuclear Spin Effects on Electronic Spin Coherence via EPR Measurements of Vanadium(IV) Complexes.

Graham MJ, Krzyaniak MD, Wasielewski MR, Freedman DE.

Inorg Chem. 2017 Jul 17;56(14):8106-8113. doi: 10.1021/acs.inorgchem.7b00794. Epub 2017 Jun 28.


The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.

Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis AJ, Hazen SL, Brown JM.

Cell Rep. 2017 Jun 20;19(12):2451-2461. doi: 10.1016/j.celrep.2017.05.077. Erratum in: Cell Rep. 2017 Jul 5;20(1):279.


Student Reflection Papers on a Global Clinical Experience: A Qualitative Study.

Margolis CZ, Rohrbaugh RM, Tsang L, Fleischer J, Graham MJ, Kellett A, Hafler JP.

Ann Glob Health. 2017 Mar - Apr;83(2):333-338. doi: 10.1016/j.aogh.2017.04.006.


Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides.

Graham MJ, Lee RG, Brandt TA, Tai LJ, Fu W, Peralta R, Yu R, Hurh E, Paz E, McEvoy BW, Baker BF, Pham NC, Digenio A, Hughes SG, Geary RS, Witztum JL, Crooke RM, Tsimikas S.

N Engl J Med. 2017 Jul 20;377(3):222-232. doi: 10.1056/NEJMoa1701329. Epub 2017 May 24.


Use of redundant arrays of inexpensive disks in orthodontic practice.

Graham DM, Graham MJ, Mupparapu M.

Am J Orthod Dentofacial Orthop. 2017 Apr;151(4):816-820. doi: 10.1016/j.ajodo.2016.10.022.


Similar metabolic response to lower- versus upper-body interval exercise or endurance exercise.

Francois ME, Graham MJ, Parr EB, Rehrer NJ, Lucas SJE, Stavrianeas S, Cotter JD.

Metabolism. 2017 Mar;68:1-10. doi: 10.1016/j.metabol.2016.11.009. Epub 2016 Nov 26.


Synthetic Approach To Determine the Effect of Nuclear Spin Distance on Electronic Spin Decoherence.

Graham MJ, Yu CJ, Krzyaniak MD, Wasielewski MR, Freedman DE.

J Am Chem Soc. 2017 Mar 1;139(8):3196-3201. doi: 10.1021/jacs.6b13030. Epub 2017 Feb 15.


The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.

Ferguson D, Zhang J, Davis MA, Helsley RN, Vedin LL, Lee RG, Crooke RM, Graham MJ, Allende DS, Parini P, Brown JM.

J Lipid Res. 2017 Feb;58(2):420-432. doi: 10.1194/jlr.M073734. Epub 2016 Dec 10.


Student Buy-In to Active Learning in a College Science Course.

Cavanagh AJ, Aragón OR, Chen X, Couch A, Durham F, Bobrownicki A, Hanauer DI, Graham MJ.

CBE Life Sci Educ. 2016 Winter;15(4). pii: ar76. Erratum in: CBE Life Sci Educ. 2017 Spring;16(1):.


Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in liver fatty acid binding protein null mice.

Newberry EP, Xie Y, Kennedy SM, Graham MJ, Crooke RM, Jiang H, Chen A, Ory DS, Davidson NO.

Hepatology. 2017 Mar;65(3):836-852. doi: 10.1002/hep.28941. Epub 2017 Jan 19.


A Measure of College Student Persistence in the Sciences (PITS).

Hanauer DI, Graham MJ, Hatfull GF.

CBE Life Sci Educ. Winter 2016;15(4). pii: ar54.


Long Coherence Times in Nuclear Spin-Free Vanadyl Qubits.

Yu CJ, Graham MJ, Zadrozny JM, Niklas J, Krzyaniak MD, Wasielewski MR, Poluektov OG, Freedman DE.

J Am Chem Soc. 2016 Nov 9;138(44):14678-14685. Epub 2016 Oct 31.


A One-Hole Cu4S Cluster with N2O Reductase Activity: A Structural and Functional Model for CuZ.

Johnson BJ, Antholine WE, Lindeman SV, Graham MJ, Mankad NP.

J Am Chem Soc. 2016 Oct 3. [Epub ahead of print]


Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials.

Viney NJ, van Capelleveen JC, Geary RS, Xia S, Tami JA, Yu RZ, Marcovina SM, Hughes SG, Graham MJ, Crooke RM, Crooke ST, Witztum JL, Stroes ES, Tsimikas S.

Lancet. 2016 Nov 5;388(10057):2239-2253. doi: 10.1016/S0140-6736(16)31009-1. Epub 2016 Sep 21.


Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys.

Yu RZ, Gunawan R, Post N, Zanardi T, Hall S, Burkey J, Kim TW, Graham MJ, Prakash TP, Seth PP, Swayze EE, Geary RS, Henry SP, Wang Y.

Nucleic Acid Ther. 2016 Dec;26(6):372-380. Epub 2016 Aug 8.


A "Scientific Diversity" Intervention to Reduce Gender Bias in a Sample of Life Scientists.

Moss-Racusin CA, van der Toorn J, Dovidio JF, Brescoll VL, Graham MJ, Handelsman J.

CBE Life Sci Educ. 2016 fall;15(3). pii: ar29. doi: 10.1187/cbe.15-09-0187.


Hypercholesterolemia Induced by a PCSK9 Gain-of-Function Mutation Augments Angiotensin II-Induced Abdominal Aortic Aneurysms in C57BL/6 Mice-Brief Report.

Lu H, Howatt DA, Balakrishnan A, Graham MJ, Mullick AE, Daugherty A.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1753-7. doi: 10.1161/ATVBAHA.116.307613. Epub 2016 Jul 28.


Unexpected suppression of spin-lattice relaxation via high magnetic field in a high-spin iron(iii) complex.

Zadrozny JM, Graham MJ, Krzyaniak MD, Wasielewski MR, Freedman DE.

Chem Commun (Camb). 2016 Aug 9;52(66):10175-8. doi: 10.1039/c6cc05094h.


ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors.

Gordts PL, Nock R, Son NH, Ramms B, Lew I, Gonzales JC, Thacker BE, Basu D, Lee RG, Mullick AE, Graham MJ, Goldberg IJ, Crooke RM, Witztum JL, Esko JD.

J Clin Invest. 2016 Aug 1;126(8):2855-66. doi: 10.1172/JCI86610. Epub 2016 Jul 11.


Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation.

Lord CC, Ferguson D, Thomas G, Brown AL, Schugar RC, Burrows A, Gromovsky AD, Betters J, Neumann C, Sacks J, Marshall S, Watts R, Schweiger M, Lee RG, Crooke RM, Graham MJ, Lathia JD, Sakaguchi TF, Lehner R, Haemmerle G, Zechner R, Brown JM.

Cell Rep. 2016 Jul 26;16(4):939-949. doi: 10.1016/j.celrep.2016.06.049. Epub 2016 Jul 7.


Low-Volume Intense Exercise Elicits Post-exercise Hypotension and Subsequent Hypervolemia, Irrespective of Which Limbs Are Exercised.

Graham MJ, Lucas SJ, Francois ME, Stavrianeas S, Parr EB, Thomas KN, Cotter JD.

Front Physiol. 2016 May 31;7:199. doi: 10.3389/fphys.2016.00199. eCollection 2016.


Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes.

Digenio A, Dunbar RL, Alexander VJ, Hompesch M, Morrow L, Lee RG, Graham MJ, Hughes SG, Yu R, Singleton W, Baker BF, Bhanot S, Crooke RM.

Diabetes Care. 2016 Aug;39(8):1408-15. doi: 10.2337/dc16-0126. Epub 2016 Jun 6.


Synergistic effect of phosphorothioate, 5'-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA.

Prakash TP, Kinberger GA, Murray HM, Chappell A, Riney S, Graham MJ, Lima WF, Swayze EE, Seth PP.

Bioorg Med Chem Lett. 2016 Jun 15;26(12):2817-2820. doi: 10.1016/j.bmcl.2016.04.063. Epub 2016 Apr 27.


Type 1 Deiodinase Regulates ApoA-I Gene Expression and ApoA-I Synthesis Independent of Thyroid Hormone Signaling.

Liu J, Hernandez-Ono A, Graham MJ, Galton VA, Ginsberg HN.

Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1356-66. doi: 10.1161/ATVBAHA.116.307330. Epub 2016 May 5.


Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice.

Yu RZ, Graham MJ, Post N, Riney S, Zanardi T, Hall S, Burkey J, Shemesh CS, Prakash TP, Seth PP, Swayze EE, Geary RS, Wang Y, Henry S.

Mol Ther Nucleic Acids. 2016 May 3;5:e317. doi: 10.1038/mtna.2016.26.


Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.

Prakash TP, Yu J, Migawa MT, Kinberger GA, Wan WB, Østergaard ME, Carty RL, Vasquez G, Low A, Chappell A, Schmidt K, Aghajan M, Crosby J, Murray HM, Booten SL, Hsiao J, Soriano A, Machemer T, Cauntay P, Burel SA, Murray SF, Gaus H, Graham MJ, Swayze EE, Seth PP.

J Med Chem. 2016 Mar 24;59(6):2718-33. doi: 10.1021/acs.jmedchem.5b01948. Epub 2016 Mar 9.


Employing Forbidden Transitions as Qubits in a Nuclear Spin-Free Chromium Complex.

Fataftah MS, Zadrozny JM, Coste SC, Graham MJ, Rogers DM, Freedman DE.

J Am Chem Soc. 2016 Feb 3;138(4):1344-8. doi: 10.1021/jacs.5b11802. Epub 2016 Jan 21.


Angiotensinogen Exerts Effects Independent of Angiotensin II.

Lu H, Wu C, Howatt DA, Balakrishnan A, Moorleghen JJ, Chen X, Zhao M, Graham MJ, Mullick AE, Crooke RM, Feldman DL, Cassis LA, Vander Kooi CW, Daugherty A.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):256-65. doi: 10.1161/ATVBAHA.115.306740. Epub 2015 Dec 17.


CD40 Generation 2.5 Antisense Oligonucleotide Treatment Attenuates Doxorubicin-induced Nephropathy and Kidney Inflammation.

Donner AJ, Yeh ST, Hung G, Graham MJ, Crooke RM, Mullick AE.

Mol Ther Nucleic Acids. 2015 Dec 1;4:e265. doi: 10.1038/mtna.2015.40.


Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans.

Graham MJ, Viney N, Crooke RM, Tsimikas S.

J Lipid Res. 2016 Mar;57(3):340-51. doi: 10.1194/jlr.R052258. Epub 2015 Nov 4. Review. Erratum in: J Lipid Res. 2016 Dec;57(12 ):2235.


Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation.

Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, Pais de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB.

J Biol Chem. 2016 Jan 15;291(3):1115-22. doi: 10.1074/jbc.M115.668269. Epub 2015 Oct 28.


Increased Preclass Preparation Underlies Student Outcome Improvement in the Flipped Classroom.

Gross D, Pietri ES, Anderson G, Moyano-Camihort K, Graham MJ.

CBE Life Sci Educ. 2015 Winter;14(4):ar36. doi: 10.1187/cbe.15-02-0040.

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