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Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.

Lee KM, Wilson GJ, Pingen M, Fukuoka A, Hansell CAH, Bartolini R, Medina-Ruiz L, Graham GJ.

PLoS Biol. 2019 May 29;17(5):e3000287. doi: 10.1371/journal.pbio.3000287. eCollection 2019 May.


Leukocyte Adhesion: Reconceptualizing Chemokine Presentation by Glycosaminoglycans.

Graham GJ, Handel TM, Proudfoot AEI.

Trends Immunol. 2019 Jun;40(6):472-481. doi: 10.1016/ Epub 2019 Apr 18. Review.


Chemokine Receptor Redundancy and Specificity Are Context Dependent.

Dyer DP, Medina-Ruiz L, Bartolini R, Schuette F, Hughes CE, Pallas K, Vidler F, Macleod MKL, Kelly CJ, Lee KM, Hansell CAH, Graham GJ.

Immunity. 2019 Feb 19;50(2):378-389.e5. doi: 10.1016/j.immuni.2019.01.009.


The chemokine receptor CXCR2 contributes to murine adipocyte development.

Dyer DP, Nebot JB, Kelly CJ, Medina-Ruiz L, Schuette F, Graham GJ.

J Leukoc Biol. 2019 Mar;105(3):497-506. doi: 10.1002/JLB.1A0618-216RR. Epub 2018 Dec 5.


The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis.

Hansell CAH, Fraser AR, Hayes AJ, Pingen M, Burt CL, Lee KM, Medina-Ruiz L, Brownlie D, Macleod MKL, Burgoyne P, Wilson GJ, Nibbs RJB, Graham GJ.

J Immunol. 2018 Oct 15;201(8):2510-2519. doi: 10.4049/jimmunol.1800131. Epub 2018 Aug 29.


The atypical chemokine receptor-2 does not alter corneal graft survival but regulates early stage of corneal graft-induced lymphangiogenesis.

Yu T, Forrester JV, Graham GJ, Kuffova L.

Graefes Arch Clin Exp Ophthalmol. 2018 Oct;256(10):1875-1882. doi: 10.1007/s00417-018-4070-1. Epub 2018 Jul 27.


The Atypical Chemokine Receptor ACKR2 is Protective Against Sepsis.

Castanheira FVES, Borges V, Sônego F, Kanashiro A, Donate PB, Melo PH, Pallas K, Russo RC, Amaral FA, Teixeira MM, Ramalho FS, Cunha TM, Liew FY, Alves-Filho JC, Graham GJ, Cunha FQ.

Shock. 2018 Jun;49(6):682-689. doi: 10.1097/SHK.0000000000000969.


MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2.

Shams K, Kurowska-Stolarska M, Schütte F, Burden AD, McKimmie CS, Graham GJ.

J Biol Chem. 2018 Feb 23;293(8):3003-3012. doi: 10.1074/jbc.M117.809780. Epub 2017 Dec 26.


Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis.

Leighton SP, Nerurkar L, Krishnadas R, Johnman C, Graham GJ, Cavanagh J.

Mol Psychiatry. 2018 Jan;23(1):48-58. doi: 10.1038/mp.2017.205. Epub 2017 Nov 14. Review.


Elevated ACKR2 expression is a common feature of inflammatory arthropathies.

Baldwin HM, Singh MD, Codullo V, King V, Wilson H, McInnes I, Graham GJ.

Rheumatology (Oxford). 2017 Sep 1;56(9):1607-1617. doi: 10.1093/rheumatology/kex176.


Corrigendum: CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses.

Dyer DP, Pallas K, Medina-Ruiz L, Schuette F, Wilson GJ, Graham GJ.

Sci Rep. 2017 Apr 10;7:45423. doi: 10.1038/srep45423. No abstract available.


CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses.

Dyer DP, Pallas K, Medina-Ruiz L, Schuette F, Wilson GJ, Graham GJ.

Sci Rep. 2017 Feb 16;7:42681. doi: 10.1038/srep42681. Erratum in: Sci Rep. 2017 Apr 10;7:45423.


Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland.

Wilson GJ, Hewit KD, Pallas KJ, Cairney CJ, Lee KM, Hansell CA, Stein T, Graham GJ.

Development. 2017 Jan 1;144(1):74-82. doi: 10.1242/dev.139733. Epub 2016 Nov 25.


Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2.

Shams K, Wilson GJ, Singh M, van den Bogaard EH, Le Brocq ML, Holmes S, Schalkwijk J, Burden AD, McKimmie CS, Graham GJ.

J Invest Dermatol. 2017 Jan;137(1):85-94. doi: 10.1016/j.jid.2016.07.039. Epub 2016 Aug 26.


Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response.

Bonecchi R, Graham GJ.

Front Immunol. 2016 Jun 10;7:224. doi: 10.3389/fimmu.2016.00224. eCollection 2016. Review.


Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection.

Pingen M, Bryden SR, Pondeville E, Schnettler E, Kohl A, Merits A, Fazakerley JK, Graham GJ, McKimmie CS.

Immunity. 2016 Jun 21;44(6):1455-69. doi: 10.1016/j.immuni.2016.06.002.


CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.

Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LE, Kinstrie R, Guitart AV, Dunn K, Abraham SA, Sansom O, Michie AM, Machesky L, Kranc KR, Graham GJ, Pellicano F, Holyoake TL.

Blood. 2016 Jul 21;128(3):371-83. doi: 10.1182/blood-2015-08-661785. Epub 2016 May 24.


TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain.

McColl A, Thomson CA, Nerurkar L, Graham GJ, Cavanagh J.

J Neuroinflammation. 2016 May 9;13(1):102. doi: 10.1186/s12974-016-0562-2.


ACKR4 on Stromal Cells Scavenges CCL19 To Enable CCR7-Dependent Trafficking of APCs from Inflamed Skin to Lymph Nodes.

Bryce SA, Wilson RA, Tiplady EM, Asquith DL, Bromley SK, Luster AD, Graham GJ, Nibbs RJ.

J Immunol. 2016 Apr 15;196(8):3341-53. doi: 10.4049/jimmunol.1501542. Epub 2016 Mar 14.


The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts.

Williams MT, Yousafzai YM, Elder A, Rehe K, Bomken S, Frishman-Levy L, Tavor S, Sinclair P, Dormon K, Masic D, Perry T, Weston VJ, Kearns P, Blair H, Russell LJ, Heidenreich O, Irving JA, Izraeli S, Vormoor J, Graham GJ, Halsey C.

Blood. 2016 Apr 21;127(16):1998-2006. doi: 10.1182/blood-2015-08-665034. Epub 2016 Feb 11.



Graham GJ.

Front Immunol. 2015 Jun 5;6:280. doi: 10.3389/fimmu.2015.00280. eCollection 2015. Review. No abstract available.


An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15.

Bachelerie F, Graham GJ, Locati M, Mantovani A, Murphy PM, Nibbs R, Rot A, Sozzani S, Thelen M.

Br J Pharmacol. 2015 Aug;172(16):3945-9. doi: 10.1111/bph.13182. Epub 2015 Jun 26. Review.


The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density.

Lee KM, Danuser R, Stein JV, Graham D, Nibbs RJ, Graham GJ.

EMBO J. 2014 Nov 3;33(21):2564-80. doi: 10.15252/embj.201488887. Epub 2014 Sep 30.


IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice.

Li D, Guabiraba R, Besnard AG, Komai-Koma M, Jabir MS, Zhang L, Graham GJ, Kurowska-Stolarska M, Liew FY, McSharry C, Xu D.

J Allergy Clin Immunol. 2014 Dec;134(6):1422-1432.e11. doi: 10.1016/j.jaci.2014.05.011. Epub 2014 Jun 27.


Defining the chemokine basis for leukocyte recruitment during viral encephalitis.

Michlmayr D, McKimmie CS, Pingen M, Haxton B, Mansfield K, Johnson N, Fooks AR, Graham GJ.

J Virol. 2014 Sep 1;88(17):9553-67. doi: 10.1128/JVI.03421-13. Epub 2014 Jun 4.


Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes.

Ford LB, Cerovic V, Milling SW, Graham GJ, Hansell CA, Nibbs RJ.

J Immunol. 2014 Jul 1;193(1):400-11. doi: 10.4049/jimmunol.1303236. Epub 2014 Jun 2.


Chemokines as novel and versatile reagents for flow cytometry and cell sorting.

Le Brocq ML, Fraser AR, Cotton G, Woznica K, McCulloch CV, Hewitt KD, McKimmie CS, Nibbs RJB, Campbell JDM, Graham GJ.

J Immunol. 2014 Jun 15;192(12):6120-6130. doi: 10.4049/jimmunol.1303371. Epub 2014 May 21.


Peripheral inflammation is associated with remote global gene expression changes in the brain.

Thomson CA, McColl A, Cavanagh J, Graham GJ.

J Neuroinflammation. 2014 Apr 8;11:73. doi: 10.1186/1742-2094-11-73.


Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia.

Williams MT, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman KE, McAndrew R, Thomas A, Spence A, Gibson B, Graham GJ, Halsey C.

Blood. 2014 May 15;123(20):3116-27. doi: 10.1182/blood-2013-05-499970. Epub 2014 Apr 3.


Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2.

Zakrys L, Ward RJ, Pediani JD, Godin AG, Graham GJ, Milligan G.

Biochem J. 2014 Jul 1;461(1):61-73. doi: 10.1042/BJ20140190.


The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding.

Hewit KD, Fraser A, Nibbs RJ, Graham GJ.

J Biol Chem. 2014 May 2;289(18):12330-42. doi: 10.1074/jbc.M113.534545. Epub 2014 Mar 18.


New nomenclature for atypical chemokine receptors.

Bachelerie F, Graham GJ, Locati M, Mantovani A, Murphy PM, Nibbs R, Rot A, Sozzani S, Thelen M.

Nat Immunol. 2014 Mar;15(3):207-8. doi: 10.1038/ni.2812. No abstract available.


Flow cytometry applications for the analysis of chemokine receptor expression and function.

Anselmo A, Mazzon C, Borroni EM, Bonecchi R, Graham GJ, Locati M.

Cytometry A. 2014 Apr;85(4):292-301. doi: 10.1002/cyto.a.22439. Epub 2014 Jan 24. Review.


IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice.

Guabiraba R, Besnard AG, Menezes GB, Secher T, Jabir MS, Amaral SS, Braun H, Lima-Junior RC, Ribeiro RA, Cunha FQ, Teixeira MM, Beyaert R, Graham GJ, Liew FY.

Mucosal Immunol. 2014 Sep;7(5):1079-93. doi: 10.1038/mi.2013.124. Epub 2014 Jan 15.


Immune regulation by atypical chemokine receptors.

Nibbs RJ, Graham GJ.

Nat Rev Immunol. 2013 Nov;13(11):815-29. Review.


International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.

Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A.

Pharmacol Rev. 2013 Nov 11;66(1):1-79. doi: 10.1124/pr.113.007724. Print 2014. Review. Erratum in: Pharmacol Rev. 2014 Apr;66(2):467.


Microarray analyses demonstrate the involvement of type I interferons in psoriasiform pathology development in D6-deficient mice.

Baldwin HM, Pallas K, King V, Jamieson T, McKimmie CS, Nibbs RJ, Carballido JM, Jaritz M, Rot A, Graham GJ.

J Biol Chem. 2013 Dec 20;288(51):36473-83. doi: 10.1074/jbc.M113.491563. Epub 2013 Nov 5.


Increased number and altered phenotype of lymphatic vessels in peripheral lung compartments of patients with COPD.

Mori M, Andersson CK, Graham GJ, Löfdahl CG, Erjefält JS.

Respir Res. 2013 Jun 11;14:65. doi: 10.1186/1465-9921-14-65.


Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor.

Rot A, McKimmie C, Burt CL, Pallas KJ, Jamieson T, Pruenster M, Horuk R, Nibbs RJB, Graham GJ.

J Immunol. 2013 Jun 15;190(12):6450-6456. doi: 10.4049/jimmunol.1201429. Epub 2013 May 13.


An analysis of the function and expression of D6 on lymphatic endothelial cells.

McKimmie CS, Singh MD, Hewit K, Lopez-Franco O, Le Brocq M, Rose-John S, Lee KM, Baker AH, Wheat R, Blackbourn DJ, Nibbs RJ, Graham GJ.

Blood. 2013 May 2;121(18):3768-77. doi: 10.1182/blood-2012-04-425314. Epub 2013 Mar 11.


Suppression, subversion and escape: the role of regulatory T cells in cancer progression.

Oleinika K, Nibbs RJ, Graham GJ, Fraser AR.

Clin Exp Immunol. 2013 Jan;171(1):36-45. doi: 10.1111/j.1365-2249.2012.04657.x. Review.


Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6.

Graham GJ, Locati M.

J Pathol. 2013 Jan;229(2):168-75. doi: 10.1002/path.4123. Review.


D6: the 'crowd controller' at the immune gateway.

Lee KM, Nibbs RJ, Graham GJ.

Trends Immunol. 2013 Jan;34(1):7-12. doi: 10.1016/ Epub 2012 Aug 24.


Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasis.

Singh MD, King V, Baldwin H, Burden D, Thorrat A, Holmes S, McInnes IB, Nicoll R, Shams K, Pallas K, Jamieson T, Lee KM, Carballido JM, Rot A, Graham GJ.

Am J Pathol. 2012 Oct;181(4):1158-64. doi: 10.1016/j.ajpath.2012.06.042. Epub 2012 Aug 4.


The biochemistry and biology of the atypical chemokine receptors.

Graham GJ, Locati M, Mantovani A, Rot A, Thelen M.

Immunol Lett. 2012 Jul 30;145(1-2):30-8. doi: 10.1016/j.imlet.2012.04.004. Review.


Acute inflammatory response to cobalt chromium orthopaedic wear debris in a rodent air-pouch model.

Akbar M, Fraser AR, Graham GJ, Brewer JM, Grant MH.

J R Soc Interface. 2012 Sep 7;9(74):2109-19. doi: 10.1098/rsif.2012.0006. Epub 2012 Apr 18.


D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion.

Lee KM, McKimmie CS, Gilchrist DS, Pallas KJ, Nibbs RJ, Garside P, McDonald V, Jenkins C, Ransohoff R, Liu L, Milling S, Cerovic V, Graham GJ.

Blood. 2011 Dec 1;118(23):6220-9. doi: 10.1182/blood-2011-03-344044. Epub 2011 Oct 6.


IL-33 induces skin inflammation with mast cell and neutrophil activation.

Hueber AJ, Alves-Filho JC, Asquith DL, Michels C, Millar NL, Reilly JH, Graham GJ, Liew FY, Miller AM, McInnes IB.

Eur J Immunol. 2011 Aug;41(8):2229-37. doi: 10.1002/eji.201041360. Epub 2011 Jun 24.


An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis.

Codullo V, Baldwin HM, Singh MD, Fraser AR, Wilson C, Gilmour A, Hueber AJ, Bonino C, McInnes IB, Montecucco C, Graham GJ.

Ann Rheum Dis. 2011 Jun;70(6):1115-21. doi: 10.1136/ard.2010.137349. Epub 2011 Feb 1.


Astrocytes modulate the chemokine network in a pathogen-specific manner.

McKimmie CS, Graham GJ.

Biochem Biophys Res Commun. 2010 Apr 16;394(4):1006-11. doi: 10.1016/j.bbrc.2010.03.111. Epub 2010 Mar 21.


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