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Items: 50

1.

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.

Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen O, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ.

Cell. 2018 Nov 15;175(5):1307-1320.e22. doi: 10.1016/j.cell.2018.10.008. Epub 2018 Nov 1.

PMID:
30392957
2.

Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets.

Uniken Venema WT, Voskuil MD, Vila AV, van der Vries G, Jansen BH, Jabri B, Faber KN, Dijkstra G, Xavier RJ, Wijmenga C, Graham DB, Weersma RK, Festen EA.

Gastroenterology. 2019 Feb;156(3):812-815.e22. doi: 10.1053/j.gastro.2018.10.046. Epub 2018 Nov 2. No abstract available.

PMID:
30391472
3.

Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes.

Graham DB, Luo C, O'Connell DJ, Lefkovith A, Brown EM, Yassour M, Varma M, Abelin JG, Conway KL, Jasso GJ, Matar CG, Carr SA, Xavier RJ.

Nat Med. 2018 Nov;24(11):1762-1772. doi: 10.1038/s41591-018-0203-7. Epub 2018 Oct 22.

PMID:
30349087
4.

A rare case of Aerococcus urinae infective endocarditis in an atypically young male: case report and review of the literature.

Yabes JM, Perdikis S, Graham DB, Markelz A.

BMC Infect Dis. 2018 Oct 17;18(1):522. doi: 10.1186/s12879-018-3414-0. Review.

5.

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.

Graham DB, Jasso GJ, Mok A, Goel G, Ng ACY, Kolde R, Varma M, Doench JG, Root DE, Clish CB, Carr SA, Xavier RJ.

Cell Rep. 2018 Jul 24;24(4):838-850. doi: 10.1016/j.celrep.2018.06.081.

6.

Wave Phenomena and Beam-Plasma Interactions at the Magnetopause Reconnection Region.

Burch JL, Webster JM, Genestreti KJ, Torbert RB, Giles BL, Fuselier SA, Dorelli JC, Rager AC, Phan TD, Allen RC, Chen LJ, Wang S, Le Contel O, Russell CT, Strangeway RJ, Ergun RE, Jaynes AN, Lindqvist PA, Graham DB, Wilder FD, Hwang KJ, Goldstein J.

J Geophys Res Space Phys. 2018 Feb;123(2):1118-1133. doi: 10.1002/2017JA024789. Epub 2018 Feb 3.

7.

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease.

Leshchiner ES, Rush JS, Durney MA, Cao Z, Dančík V, Chittick B, Wu H, Petrone A, Bittker JA, Phillips A, Perez JR, Shamji AF, Kaushik VK, Daly MJ, Graham DB, Schreiber SL, Xavier RJ.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11392-11397. doi: 10.1073/pnas.1705748114. Epub 2017 Oct 9.

8.

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.

Johannessen L, Sundberg TB, O'Connell DJ, Kolde R, Berstler J, Billings KJ, Khor B, Seashore-Ludlow B, Fassl A, Russell CN, Latorre IJ, Jiang B, Graham DB, Perez JR, Sicinski P, Phillips AJ, Schreiber SL, Gray NS, Shamji AF, Xavier RJ.

Nat Chem Biol. 2017 Oct;13(10):1102-1108. doi: 10.1038/nchembio.2458. Epub 2017 Aug 14.

9.

Instability of Agyrotropic Electron Beams near the Electron Diffusion Region.

Graham DB, Khotyaintsev YV, Vaivads A, Norgren C, André M, Webster JM, Burch JL, Lindqvist PA, Ergun RE, Torbert RB, Paterson WR, Gershman DJ, Giles BL, Magnes W, Russell CT.

Phys Rev Lett. 2017 Jul 14;119(2):025101. doi: 10.1103/PhysRevLett.119.025101. Epub 2017 Jul 13.

PMID:
28753352
10.

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.

Graham DB, Lefkovith A, Deelen P, de Klein N, Varma M, Boroughs A, Desch AN, Ng ACY, Guzman G, Schenone M, Petersen CP, Bhan AK, Rivas MA, Daly MJ, Carr SA, Wijmenga C, Xavier RJ.

Cell Rep. 2016 Dec 13;17(11):2955-2965. doi: 10.1016/j.celrep.2016.11.042.

11.

Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo.

Sundberg TB, Liang Y, Wu H, Choi HG, Kim ND, Sim T, Johannessen L, Petrone A, Khor B, Graham DB, Latorre IJ, Phillips AJ, Schreiber SL, Perez J, Shamji AF, Gray NS, Xavier RJ.

ACS Chem Biol. 2016 Aug 19;11(8):2105-11. doi: 10.1021/acschembio.6b00217. Epub 2016 Jun 6.

12.

Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing.

O'Connell DJ, Kolde R, Sooknah M, Graham DB, Sundberg TB, Latorre I, Mikkelsen TS, Xavier RJ.

Cell Syst. 2016 May 25;2(5):323-334. doi: 10.1016/j.cels.2016.04.011. Epub 2016 May 19.

13.

Resources for the design of CRISPR gene editing experiments.

Graham DB, Root DE.

Genome Biol. 2015 Nov 27;16:260. doi: 10.1186/s13059-015-0823-x. Review.

14.

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.

Graham DB, Becker CE, Doan A, Goel G, Villablanca EJ, Knights D, Mok A, Ng AC, Doench JG, Root DE, Clish CB, Xavier RJ.

Nat Commun. 2015 Jul 21;6:7838. doi: 10.1038/ncomms8838.

15.

CRISPR-Cas9 knockin mice for genome editing and cancer modeling.

Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F.

Cell. 2014 Oct 9;159(2):440-55. doi: 10.1016/j.cell.2014.09.014. Epub 2014 Sep 25.

16.

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE.

Nat Biotechnol. 2014 Dec;32(12):1262-7. doi: 10.1038/nbt.3026. Epub 2014 Sep 3.

17.

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.

Sundberg TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B, Gagnon J, O'Connell DJ, Narayan K, Dančík V, Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, Shamji AF.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12468-73. doi: 10.1073/pnas.1412308111. Epub 2014 Aug 11.

18.

Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming.

Graham DB, Osborne DG, Piotrowski JT, Gomez TS, Gmyrek GB, Akilesh HM, Dani A, Billadeau DD, Swat W.

PLoS One. 2014 Jun 2;9(6):e98606. doi: 10.1371/journal.pone.0098606. eCollection 2014.

19.

Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.

Sandoval GJ, Graham DB, Gmyrek GB, Akilesh HM, Fujikawa K, Sammut B, Bhattacharya D, Srivatsan S, Kim A, Shaw AS, Yang-Iott K, Bassing CH, Duncavage E, Xavier RJ, Swat W.

Cancer Immunol Res. 2013 Dec;1(6):426-37. doi: 10.1158/2326-6066.CIR-13-0065. Epub 2013 Oct 7.

20.

Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.

Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ.

ACS Chem Biol. 2013 Dec 20;8(12):2724-2733. doi: 10.1021/cb400352d. Epub 2013 Oct 29.

21.

Loss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs.

Gmyrek GB, Akilesh HM, Graham DB, Fuchs A, Yang L, Miller MJ, Sandoval GJ, Sheehan KC, Schreiber RD, Diamond MS, Swat W.

PLoS One. 2013 Oct 14;8(10):e76145. doi: 10.1371/journal.pone.0076145. eCollection 2013.

22.

Constraints on the formation and structure of Langmuir eigenmodes in the solar wind.

Graham DB, Cairns IH.

Phys Rev Lett. 2013 Sep 20;111(12):121101. Epub 2013 Sep 17.

PMID:
24093240
23.

From genetics of inflammatory bowel disease towards mechanistic insights.

Graham DB, Xavier RJ.

Trends Immunol. 2013 Aug;34(8):371-8. doi: 10.1016/j.it.2013.04.001. Epub 2013 Apr 30. Review.

24.

Polarity gene discs large homolog 1 regulates the generation of memory T cells.

Gmyrek GB, Graham DB, Sandoval GJ, Blaufuss GS, Akilesh HM, Fujikawa K, Xavier RJ, Swat W.

Eur J Immunol. 2013 May;43(5):1185-94. doi: 10.1002/eji.201142362. Epub 2013 Apr 9.

25.

Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells.

Sandoval GJ, Graham DB, Bhattacharya D, Sleckman BP, Xavier RJ, Swat W.

J Immunol. 2013 Mar 15;190(6):2485-9. doi: 10.4049/jimmunol.1203208. Epub 2013 Feb 18.

26.

Quality in orthopaedic surgery--an international perspective: AOA critical issues.

Saleh KJ, Bozic KJ, Graham DB, Shaha SH, Swiontkowski MF, Wright JG, Robinson BS, Novicoff WM.

J Bone Joint Surg Am. 2013 Jan 2;95(1):e3. doi: 10.2106/JBJS.L.00093.

PMID:
23283380
27.

Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.

Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ.

Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9.

28.

Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts.

Cremasco V, Decker CE, Stumpo D, Blackshear PJ, Nakayama KI, Nakayama K, Lupu TS, Graham DB, Novack DV, Faccio R.

J Bone Miner Res. 2012 Dec;27(12):2452-63. doi: 10.1002/jbmr.1701.

29.

Outcomes and long term follow-up after emergent cricothyroidotomy: is routine conversion to tracheostomy necessary?

Graham DB, Eastman AL, Aldy KN, Carroll EA, Minei JP, Brakenridge SC, Phelan HA.

Am Surg. 2011 Dec;77(12):1707-11.

PMID:
22273235
30.

ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling.

Graham DB, Akilesh HM, Gmyrek GB, Piccio L, Gilfillan S, Sim J, Belizaire R, Carrero JA, Wang Y, Blaufuss GS, Sandoval G, Fujikawa K, Cross AH, Russell JH, Cella M, Swat W.

Blood. 2010 Oct 28;116(17):3208-18. doi: 10.1182/blood-2009-10-250415. Epub 2010 Jul 15.

31.

Probiotic therapy for irritable bowel syndrome.

Aragon G, Graham DB, Borum M, Doman DB.

Gastroenterol Hepatol (N Y). 2010 Jan;6(1):39-44.

32.

A rare case of synchronous invasive ductal carcinoma of the breast and follicular lymphoma.

Laudenschlager MD, Tyler KL, Geis MC, Koch MR, Graham DB.

S D Med. 2010 Apr;63(4):123-5.

PMID:
20397374
33.

Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity.

Miletic AV, Graham DB, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Cemerski S, Kloeppel T, Billadeau DD, Kanagawa O, Tokunaga M, Swat W.

PLoS One. 2009 Aug 12;4(8):e6599. doi: 10.1371/journal.pone.0006599.

34.

Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.

Stephenson LM, Miller BC, Ng A, Eisenberg J, Zhao Z, Cadwell K, Graham DB, Mizushima NN, Xavier R, Virgin HW, Swat W.

Autophagy. 2009 Jul;5(5):625-35. Epub 2009 Jul 10.

35.

ITAM signaling by Vav family Rho guanine nucleotide exchange factors regulates interstitial transit rates of neutrophils in vivo.

Graham DB, Zinselmeyer BH, Mascarenhas F, Delgado R, Miller MJ, Swat W.

PLoS One. 2009;4(2):e4652. doi: 10.1371/journal.pone.0004652. Epub 2009 Feb 27.

36.

Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis.

Cremasco V, Graham DB, Novack DV, Swat W, Faccio R.

Arthritis Rheum. 2008 Sep;58(9):2712-22. doi: 10.1002/art.23757.

37.

An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells.

Graham DB, Stephenson LM, Lam SK, Brim K, Lee HM, Bautista J, Gilfillan S, Akilesh S, Fujikawa K, Swat W.

J Exp Med. 2007 Nov 26;204(12):2889-97. Epub 2007 Nov 5.

38.

Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice.

Graham DB, Robertson CM, Bautista J, Mascarenhas F, Diacovo MJ, Montgrain V, Lam SK, Cremasco V, Dunne WM, Faccio R, Coopersmith CM, Swat W.

J Clin Invest. 2007 Nov;117(11):3445-52.

39.

An evaluation of vaginal symptoms in women with Crohn's disease.

Graham DB, Tishon JR, Borum ML.

Dig Dis Sci. 2008 Mar;53(3):765-6. Epub 2007 Sep 1.

PMID:
17764029
40.

DLGH1 is a negative regulator of T-lymphocyte proliferation.

Stephenson LM, Sammut B, Graham DB, Chan-Wang J, Brim KL, Huett AS, Miletic AV, Kloeppel T, Landry A, Xavier R, Swat W.

Mol Cell Biol. 2007 Nov;27(21):7574-81. Epub 2007 Aug 27.

41.

Vav proteins control MyD88-dependent oxidative burst.

Miletic AV, Graham DB, Montgrain V, Fujikawa K, Kloeppel T, Brim K, Weaver B, Schreiber R, Xavier R, Swat W.

Blood. 2007 Apr 15;109(8):3360-8. Epub 2006 Dec 7.

42.

CD28 ligation costimulates cell death but not maturation of double-positive thymocytes due to defective ERK MAPK signaling.

Graham DB, Bell MP, Huntoon CJ, Griffin MD, Tai X, Singer A, McKean DJ.

J Immunol. 2006 Nov 1;177(9):6098-107.

43.

Metastatic Crohn's disease of the face.

Graham DB, Jager DL, Borum ML.

Dig Dis Sci. 2006 Nov;51(11):2062-3. Epub 2006 Sep 29. No abstract available.

PMID:
17009111
44.

Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics.

Graham DB, Cella M, Giurisato E, Fujikawa K, Miletic AV, Kloeppel T, Brim K, Takai T, Shaw AS, Colonna M, Swat W.

J Immunol. 2006 Aug 15;177(4):2349-55.

45.

Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice.

Graham DB, Bell MP, McCausland MM, Huntoon CJ, van Deursen J, Faubion WA, Crotty S, McKean DJ.

J Immunol. 2006 Jan 1;176(1):291-300. Erratum in: J Immunol. 2006 Mar 15;176(6):3841.

46.

Increased thymic output in HIV-negative patients after antiretroviral therapy.

Graham DB, Bell MP, Huntoon CJ, Weaver JG, Hawley N, Badley AD, McKean DJ.

AIDS. 2005 Sep 23;19(14):1467-72.

PMID:
16135899
47.

Pediatric emergency room visits for nontraumatic dental disease.

Graham DB, Webb MD, Seale NS.

Pediatr Dent. 2000 Mar-Apr;22(2):134-40.

PMID:
10769858
48.

Splenic abscess: two case reports.

Gisi P, Graham DB.

S D J Med. 1992 Feb;45(2):37-40.

PMID:
1557631
49.

Two ships in the night. Physician usage of community drug and alcohol treatment centers.

Phelps GL, Graham DB, Johnson NP, Mulcahey CP.

J S C Med Assoc. 1990 Jan;86(1):22-3. No abstract available.

PMID:
2308275
50.

Eighteen-year-old Caucasian female with left upper quadrant mass.

Hogue ME, Graham DB, Jaqua RA, Barlow JF.

S D J Med. 1984 Jul;37(7):5-8. No abstract available.

PMID:
6591428

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