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Items: 1 to 50 of 95

1.

Toxic and Genomic Influences of Inhaled Nanomaterials as a Basis for Predicting Adverse Outcome.

Nymark P, Kohonen P, Hongisto V, Grafström RC.

Ann Am Thorac Soc. 2018 Apr;15(Suppl 2):S91-S97. doi: 10.1513/AnnalsATS.201706-478MG.

PMID:
29676641
2.

A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions.

Nymark P, Rieswijk L, Ehrhart F, Jeliazkova N, Tsiliki G, Sarimveis H, Evelo CT, Hongisto V, Kohonen P, Willighagen E, Grafström RC.

Toxicol Sci. 2018 Mar 1;162(1):264-275. doi: 10.1093/toxsci/kfx252.

PMID:
29149350
3.

A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury.

Kohonen P, Parkkinen JA, Willighagen EL, Ceder R, Wennerberg K, Kaski S, Grafström RC.

Nat Commun. 2017 Jul 3;8:15932. doi: 10.1038/ncomms15932.

4.

Toward the Replacement of Animal Experiments through the Bioinformatics-driven Analysis of 'Omics' Data from Human Cell Cultures.

Grafström RC, Nymark P, Hongisto V, Spjuth O, Ceder R, Willighagen E, Hardy B, Kaski S, Kohonen P.

Altern Lab Anim. 2015 Nov;43(5):325-32.

PMID:
26551289
5.

YAP1 is a potential biomarker for cetuximab resistance in head and neck cancer.

Jerhammar F, Johansson AC, Ceder R, Welander J, Jansson A, Grafström RC, Söderkvist P, Roberg K.

Oral Oncol. 2014 Sep;50(9):832-9. doi: 10.1016/j.oraloncology.2014.06.003. Epub 2014 Jun 30.

PMID:
24993889
6.

The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing.

Kohonen P, Benfenati E, Bower D, Ceder R, Crump M, Cross K, Grafström RC, Healy L, Helma C, Jeliazkova N, Jeliazkov V, Maggioni S, Miller S, Myatt G, Rautenberg M, Stacey G, Willighagen E, Wiseman J, Hardy B.

Mol Inform. 2013 Jan;32(1):47-63. doi: 10.1002/minf.201200114. Epub 2013 Jan 17.

PMID:
27481023
7.

Requirement of apoptotic protease-activating factor-1 for bortezomib-induced apoptosis but not for Fas-mediated apoptosis in human leukemic cells.

Ottosson-Wadlund A, Ceder R, Preta G, Pokrovskaja K, Grafström RC, Heyman M, Söderhäll S, Grandér D, Hedenfalk I, Robertson JD, Fadeel B.

Mol Pharmacol. 2013 Jan;83(1):245-55. doi: 10.1124/mol.112.080788. Epub 2012 Oct 23.

PMID:
23093495
8.

MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters: implications for nephrogenesis and the development of renal cancer.

Hansson ML, Behmer S, Ceder R, Mohammadi S, Preta G, Grafström RC, Fadeel B, Wallberg AE.

PLoS One. 2012;7(9):e46001. doi: 10.1371/journal.pone.0046001. Epub 2012 Sep 27.

9.

CD44 expression in oro-pharyngeal carcinoma tissues and cell lines.

Rajarajan A, Stokes A, Bloor BK, Ceder R, Desai H, Grafström RC, Odell EW.

PLoS One. 2012;7(1):e28776. doi: 10.1371/journal.pone.0028776. Epub 2012 Jan 5.

10.

Differentiation-promoting culture of competent and noncompetent keratinocytes identifies biomarkers for head and neck cancer.

Ceder R, Haig Y, Merne M, Hansson A, Zheng X, Roberg K, Nees M, Iljin K, Bloor BK, Morgan PR, Fadeel B, Grafström RC.

Am J Pathol. 2012 Feb;180(2):457-72. doi: 10.1016/j.ajpath.2011.10.016. Epub 2011 Dec 3.

PMID:
22142811
11.

Computational toxicology using the OpenTox application programming interface and Bioclipse.

Willighagen EL, Jeliazkova N, Hardy B, Grafström RC, Spjuth O.

BMC Res Notes. 2011 Nov 10;4:487. doi: 10.1186/1756-0500-4-487.

12.

Combining factors on protein and gene level to predict radioresponse in head and neck cancer cell lines.

Farnebo L, Jerhammar F, Ceder R, Grafström RC, Vainikka L, Thunell L, Grénman R, Johansson AC, Roberg K.

J Oral Pathol Med. 2011 Nov;40(10):739-46. doi: 10.1111/j.1600-0714.2011.01036.x. Epub 2011 Apr 11.

PMID:
21481002
13.

HAX-1 expression in human B lymphoma.

Kwiecinska A, Ottosson-Wadlund A, Ceder R, Grafström RC, Björck E, Nordenskjöld M, Porwit A, Fadeel B.

Leukemia. 2011 May;25(5):868-72. doi: 10.1038/leu.2010.321. Epub 2011 Jan 28. No abstract available.

PMID:
21274001
14.

Considerations for the implausibility of leukemia induction by formaldehyde.

Thompson CM, Grafström RC.

Toxicol Sci. 2011 Mar;120(1):230-2; author reply 233. doi: 10.1093/toxsci/kfq340. Epub 2010 Nov 8. No abstract available.

PMID:
21059796
15.

Fibronectin 1 is a potential biomarker for radioresistance in head and neck squamous cell carcinoma.

Jerhammar F, Ceder R, Garvin S, Grénman R, Grafström RC, Roberg K.

Cancer Biol Ther. 2010 Dec 15;10(12):1244-51. Epub 2010 Dec 15.

PMID:
20930522
16.

Intrinsic differences in cisplatin sensitivity of head and neck cancer cell lines: Correlation to lysosomal pH.

Nilsson C, Roberg K, Grafström RC, Ollinger K.

Head Neck. 2010 Sep;32(9):1185-94. doi: 10.1002/hed.21317.

PMID:
20029982
17.

Formaldehyde dehydrogenase: beyond phase I metabolism.

Thompson CM, Ceder R, Grafström RC.

Toxicol Lett. 2010 Mar 1;193(1):1-3. doi: 10.1016/j.toxlet.2009.11.023. Epub 2009 Dec 4.

PMID:
19963048
18.

Commentary: mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma.

Thompson CM, Grafström RC.

Environ Health. 2009 Nov 25;8:53. doi: 10.1186/1476-069X-8-53.

19.

High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth.

Iljin K, Ketola K, Vainio P, Halonen P, Kohonen P, Fey V, Grafström RC, Perälä M, Kallioniemi O.

Clin Cancer Res. 2009 Oct 1;15(19):6070-8. doi: 10.1158/1078-0432.CCR-09-1035. Epub 2009 Sep 29.

20.

The ontogeny, distribution, and regulation of alcohol dehydrogenase 3: implications for pulmonary physiology.

Thompson CM, Sonawane B, Grafström RC.

Drug Metab Dispos. 2009 Aug;37(8):1565-71. doi: 10.1124/dmd.109.027904. Epub 2009 May 21. Review.

PMID:
19460944
21.

Medium-chain fatty acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol dehydrogenase 3.

Staab CA, Hellgren M, Grafström RC, Höög JO.

Chem Biol Interact. 2009 Jun 15;180(1):113-8. doi: 10.1016/j.cbi.2009.01.008. Epub 2009 Jan 29.

PMID:
19428350
22.

The Janus face of alcohol dehydrogenase 3.

Staab CA, Alander J, Morgenstern R, Grafström RC, Höög JO.

Chem Biol Interact. 2009 Mar 16;178(1-3):29-35. doi: 10.1016/j.cbi.2008.10.050. Epub 2008 Nov 6.

PMID:
19038239
23.

Serum-responsive expression of carbonyl-metabolizing enzymes in normal and transformed human buccal keratinocytes.

Staab CA, Ceder R, Roberg K, Grafström RC, Höög JO.

Cell Mol Life Sci. 2008 Nov;65(22):3653-63. doi: 10.1007/s00018-008-8554-8.

PMID:
18854940
24.

Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde.

Thompson CM, Subramaniam RP, Grafström RC.

Toxicol Appl Pharmacol. 2008 Dec 15;233(3):355-9. doi: 10.1016/j.taap.2008.09.011. Epub 2008 Sep 25.

PMID:
18851987
25.

Multiple genotypic aberrances associate to terminal differentiation-deficiency of an oral squamous cell carcinoma in serum-free culture.

Roberg K, Ceder R, Farnebo L, Norberg-Spaak L, Grafström RC.

Differentiation. 2008 Oct;76(8):868-80. doi: 10.1111/j.1432-0436.2008.00267.x. Epub 2008 Apr 29.

PMID:
18452551
26.

Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors.

Staab CA, Alander J, Brandt M, Lengqvist J, Morgenstern R, Grafström RC, Höög JO.

Biochem J. 2008 Aug 1;413(3):493-504. doi: 10.1042/BJ20071666.

PMID:
18412547
27.
28.

Mechanistic considerations for formaldehyde-induced bronchoconstriction involving S-nitrosoglutathione reductase.

Thompson CM, Grafström RC.

J Toxicol Environ Health A. 2008;71(3):244-8. Review.

PMID:
18097950
29.

Bioinformatics processing of protein and transcript profiles of normal and transformed cell lines indicates functional impairment of transcriptional regulators in buccal carcinoma.

Staab CA, Ceder R, Jägerbrink T, Nilsson JA, Roberg K, Jörnvall H, Höög JO, Grafström RC.

J Proteome Res. 2007 Sep;6(9):3705-17. Epub 2007 Aug 15.

PMID:
17696463
30.

Modelling of normal and premalignant oral tissue by using the immortalised cell line, SVpgC2a: a review of the value of the model.

Staab CA, Vondracek M, Custodio H, Johansson K, Nilsson JA, Morgan P, Höög JO, Cotgreave I, Grafström RC.

Altern Lab Anim. 2004 Oct;32(4):401-5. Review.

PMID:
15651925
31.

Alcohol dehydrogenase 3 transcription associates with proliferation of human oral keratinocytes.

Nilsson JA, Hedberg JJ, Vondracek M, Staab CA, Hansson A, Höög JO, Grafström RC.

Cell Mol Life Sci. 2004 Mar;61(5):610-617. doi: 10.1007/s00018-003-3433-9.

PMID:
15004699
32.

Analysis of proliferation, apoptosis and keratin expression in cultured normal and immortalized human buccal keratinocytes.

Hansson A, Bloor BK, Sarang Z, Haig Y, Morgan PR, Stark HJ, Fusenig NE, Ekstrand J, Grafström RC.

Eur J Oral Sci. 2003 Feb;111(1):34-41.

PMID:
12558806
33.

Transcript profiling of enzymes involved in detoxification of xenobiotics and reactive oxygen in human normal and simian virus 40 T antigen-immortalized oral keratinocytes.

Vondracek M, Weaver DA, Sarang Z, Hedberg JJ, Willey JC, Wärngård L, Grafström RC.

Int J Cancer. 2002 Jun 20;99(6):776-82.

34.

Expression of retinoid-related genes in serum-free cultures of normal, immortalized and malignant human oral keratinocytes.

Dressler D, Sarang Z, Szondy Z, Engelhart K, Grafström RC.

Int J Oncol. 2002 May;20(5):897-903.

PMID:
11956581
35.

Reproducible gene expression measurement among multiple laboratories obtained in a blinded study using standardized RT (StaRT)-PCR.

Crawford EL, Peters GJ, Noordhuis P, Rots MG, Vondracek M, Grafström RC, Lieuallen K, Lennon G, Zahorchak RJ, Georgeson MJ, Wali A, Lechner JF, Fan PS, Kahaleh MB, Khuder SA, Warner KA, Weaver DA, Willey JC.

Mol Diagn. 2001 Dec;6(4):217-25.

PMID:
11774186
36.

Micro-array chip analysis of carbonyl-metabolising enzymes in normal, immortalised and malignant human oral keratinocytes.

Hedberg JJ, Grafström RC, Vondracek M, Sarang Z, Wärngård L, Höög JO.

Cell Mol Life Sci. 2001 Oct;58(11):1719-26.

PMID:
11706998
37.

Uniform expression of alcohol dehydrogenase 3 in epithelia regenerated with cultured normal, immortalised and malignant human oral keratinocytes.

Hedberg JJ, Hansson A, Nilsson JA, Höög JO, Grafström RC.

Altern Lab Anim. 2001 May-Jun;29(3):325-33.

PMID:
11387027
38.

Expression of keratins in normal, immortalized and malignant oral epithelia in organotypic culture.

Hansson A, Bloor BK, Haig Y, Morgan PR, Ekstrand J, Grafström RC.

Oral Oncol. 2001 Jul;37(5):419-30.

PMID:
11377230
39.

Cytochrome P450 expression and related metabolism in human buccal mucosa.

Vondracek M, Xi Z, Larsson P, Baker V, Mace K, Pfeifer A, Tjälve H, Donato MT, Gomez-Lechon MJ, Grafström RC.

Carcinogenesis. 2001 Mar;22(3):481-8.

PMID:
11238190
40.

Expression of alcohol dehydrogenase 3 in tissue and cultured cells from human oral mucosa.

Hedberg JJ, Höög JO, Nilsson JA, Xi Z, Elfwing A, Grafström RC.

Am J Pathol. 2000 Nov;157(5):1745-55.

41.

Toxicity of formaldehyde to human oral fibroblasts and epithelial cells: influences of culture conditions and role of thiol status.

Nilsson JA, Zheng X, Sundqvist K, Liu Y, Atzori L, Elfwing A, Arvidson K, Grafström RC.

J Dent Res. 1998 Nov;77(11):1896-903.

PMID:
9823728
42.

Formation of DNA adducts in human buccal epithelial cells exposed to acetaldehyde and methylglyoxal in vitro.

Vaca CE, Nilsson JA, Fang JL, Grafström RC.

Chem Biol Interact. 1998 Jan 30;108(3):197-208.

PMID:
9528690
43.
44.

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain.

Selivanova G, Iotsova V, Okan I, Fritsche M, Ström M, Groner B, Grafström RC, Wiman KG.

Nat Med. 1997 Jun;3(6):632-8.

PMID:
9176489
45.

Growth and transformation of human oral epithelium in vitro.

Grafström RC, Norén UG, Zheng X, Elfwing A, Sundqvist K.

Recent Results Cancer Res. 1997;143:275-306. Review. No abstract available.

PMID:
8912427
46.

The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.

Selivanova G, Iotsova V, Kiseleva E, Ström M, Bakalkin G, Grafström RC, Wiman KG.

Nucleic Acids Res. 1996 Sep 15;24(18):3560-7.

47.

Non-tumorigenic SV40T immortalized human buccal epithelial cells show aneuploidy and genetic instability.

Kulkarni Schmidt-Kastner PS, Heiden T, Tribukait B, Grafström RC.

Anticancer Res. 1996 Sep-Oct;16(5A):2681-6.

PMID:
8917370
48.

Characterization of human buccal epithelial cells transfected with the simian virus 40 T-antigen gene.

Kulkarni PS, Sundqvist K, Betsholtz C, Höglund P, Wiman KG, Zhivotovsky B, Bertolero F, Liu Y, Grafström RC.

Carcinogenesis. 1995 Oct;16(10):2515-21.

PMID:
7586160
49.
50.

Pathobiological effects of acetaldehyde in cultured human epithelial cells and fibroblasts.

Grafström RC, Dypbukt JM, Sundqvist K, Atzori L, Nielsen I, Curren RD, Harris CC.

Carcinogenesis. 1994 May;15(5):985-90.

PMID:
8200105

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