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Items: 50


Silymarin Prevents Memory Impairments, Anxiety, and Depressive-Like Symptoms in a Rat Model of Post-Traumatic Stress Disorder.

El-Elimat T, Alzoubi KH, AbuAlSamen MM, Al Subeh ZY, Graf TN, Oberlies NH.

Planta Med. 2019 Jan;85(1):32-40. doi: 10.1055/a-0710-5673. Epub 2018 Aug 28.


Delitpyrones: α-Pyrone Derivatives from a Freshwater Delitschia sp.

Rivera-Chávez J, El-Elimat T, Gallagher JM, Graf TN, Fournier J, Panigrahi GK, Deep G, Bunch RL, Raja HA, Oberlies NH.

Planta Med. 2019 Jan;85(1):62-71. doi: 10.1055/a-0654-5850. Epub 2018 Jul 17.


Synthesis of poly(1,2-glycerol carbonate)-paclitaxel conjugates and their utility as a single high-dose replacement for multi-dose treatment regimens in peritoneal cancer.

Ekladious I, Liu R, Zhang H, Foil DH, Todd DA, Graf TN, Padera RF, Oberlies NH, Colson YL, Grinstaff MW.

Chem Sci. 2017 Dec 1;8(12):8443-8450. doi: 10.1039/c7sc03501b. Epub 2017 Oct 20.


Prealamethicin F50 and related peptaibols from Trichoderma arundinaceum: Validation of their authenticity via in situ chemical analysis.

Rivera-Chávez J, Raja HA, Graf TN, Gallagher JM, Metri P, Xue D, Pearce CJ, Oberlies NH.

RSC Adv. 2017;7(72):45733-45751. doi: 10.1039/c7ra09602j. Epub 2017 Sep 25.


Conventional and accelerated-solvent extractions of green tea (camellia sinensis) for metabolomics-based chemometrics.

Kellogg JJ, Wallace ED, Graf TN, Oberlies NH, Cech NB.

J Pharm Biomed Anal. 2017 Oct 25;145:604-610. doi: 10.1016/j.jpba.2017.07.027. Epub 2017 Jul 29.


Biosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach.

Rivera-Chávez J, Raja HA, Graf TN, Burdette JE, Pearce CJ, Oberlies NH.

J Nat Prod. 2017 Jun 23;80(6):1883-1892. doi: 10.1021/acs.jnatprod.7b00189. Epub 2017 Jun 8.


Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study.

Kellogg JJ, Graf TN, Paine MF, McCune JS, Kvalheim OM, Oberlies NH, Cech NB.

J Nat Prod. 2017 May 26;80(5):1457-1466. doi: 10.1021/acs.jnatprod.6b01156. Epub 2017 Apr 28.


A validated UHPLC-tandem mass spectrometry method for quantitative analysis of flavonolignans in milk thistle (Silybum marianum) extracts.

Graf TN, Cech NB, Polyak SJ, Oberlies NH.

J Pharm Biomed Anal. 2016 Jul 15;126:26-33. doi: 10.1016/j.jpba.2016.04.028. Epub 2016 Apr 22.


Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan Glucuronides.

Gufford BT, Graf TN, Paguigan ND, Oberlies NH, Paine MF.

Drug Metab Dispos. 2015 Nov;43(11):1734-43. doi: 10.1124/dmd.115.066076. Epub 2015 Aug 27.


A mass spectrometry-based assay for improved quantitative measurements of efflux pump inhibition.

Brown AR, Ettefagh KA, Todd D, Cole PS, Egan JM, Foil DH, Graf TN, Schindler BD, Kaatz GW, Cech NB.

PLoS One. 2015 May 11;10(5):e0124814. doi: 10.1371/journal.pone.0124814. eCollection 2015.


Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria.

Todd DA, Gulledge TV, Britton ER, Oberhofer M, Leyte-Lugo M, Moody AN, Shymanovich T, Grubbs LF, Juzumaite M, Graf TN, Oberlies NH, Faeth SH, Laster SM, Cech NB.

PLoS One. 2015 May 1;10(5):e0124276. doi: 10.1371/journal.pone.0124276. eCollection 2015.


Comparison of the chemistry and diversity of endophytes isolated from wild-harvested and greenhouse-cultivated yerba mansa (Anemopsis californica).

Bussey RO 3rd, Kaur A, Todd DA, Egan JM, El-Elimat T, Graf TN, Raja HA, Oberlies NH, Cech NB.

Phytochem Lett. 2015 Mar;11:202-208.


Biosynthetically Distinct Cytotoxic Polyketides from Setophoma terrestris.

El-Elimat T, Figueroa M, Raja HA, Graf TN, Swanson SM, Falkinham JO 3rd, Wani MC, Pearce CJ, Oberlies NH.

European J Org Chem. 2015 Jan 1;2015(1):109-121.


Identification of diet-derived constituents as potent inhibitors of intestinal glucuronidation.

Gufford BT, Chen G, Lazarus P, Graf TN, Oberlies NH, Paine MF.

Drug Metab Dispos. 2014 Oct;42(10):1675-83. doi: 10.1124/dmd.114.059451. Epub 2014 Jul 9.


Physiologically based pharmacokinetic modeling framework for quantitative prediction of an herb-drug interaction.

Brantley SJ, Gufford BT, Dua R, Fediuk DJ, Graf TN, Scarlett YV, Frederick KS, Fisher MB, Oberlies NH, Paine MF.

CPT Pharmacometrics Syst Pharmacol. 2014 Mar 26;3:e107. doi: 10.1038/psp.2013.69.


Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum).

El-Elimat T, Raja HA, Graf TN, Faeth SH, Cech NB, Oberlies NH.

J Nat Prod. 2014 Feb 28;77(2):193-9. doi: 10.1021/np400955q. Epub 2014 Jan 23.


A systematic approach to evaluate herb-drug interaction mechanisms: investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors.

Brantley SJ, Graf TN, Oberlies NH, Paine MF.

Drug Metab Dispos. 2013 Sep;41(9):1662-70. doi: 10.1124/dmd.113.052563. Epub 2013 Jun 25.


Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.

Althagafy HS, Graf TN, Sy-Cordero AA, Gufford BT, Paine MF, Wagoner J, Polyak SJ, Croatt MP, Oberlies NH.

Bioorg Med Chem. 2013 Jul 1;21(13):3919-26. doi: 10.1016/j.bmc.2013.04.017. Epub 2013 Apr 16.


Sarothrin from Alkanna orientalis is an antimicrobial agent and efflux pump inhibitor.

Bame JR, Graf TN, Junio HA, Bussey RO 3rd, Jarmusch SA, El-Elimat T, Falkinham JO 3rd, Oberlies NH, Cech RA, Cech NB.

Planta Med. 2013 Mar;79(5):327-9. doi: 10.1055/s-0032-1328259. Epub 2013 Mar 6.


HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case.

Napolitano JG, Lankin DC, Graf TN, Friesen JB, Chen SN, McAlpine JB, Oberlies NH, Pauli GF.

J Org Chem. 2013 Apr 5;78(7):2827-39. doi: 10.1021/jo302720h. Epub 2013 Mar 5.


Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).

El-Elimat T, Figueroa M, Raja HA, Graf TN, Adcock AF, Kroll DJ, Day CS, Wani MC, Pearce CJ, Oberlies NH.

J Nat Prod. 2013 Mar 22;76(3):382-7. doi: 10.1021/np300749w. Epub 2013 Jan 9.


Enhanced bioactivity of silybin B methylation products.

Sy-Cordero AA, Graf TN, Runyon SP, Wani MC, Kroll DJ, Agarwal R, Brantley SJ, Paine MF, Polyak SJ, Oberlies NH.

Bioorg Med Chem. 2013 Feb 1;21(3):742-7. doi: 10.1016/j.bmc.2012.11.035. Epub 2012 Dec 5.


Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae.

Figueroa M, Graf TN, Ayers S, Adcock AF, Kroll DJ, Yang J, Swanson SM, Munoz-Acuna U, Carcache de Blanco EJ, Agrawal R, Wani MC, Darveaux BA, Pearce CJ, Oberlies NH.

J Antibiot (Tokyo). 2012 Nov;65(11):559-64. doi: 10.1038/ja.2012.69. Epub 2012 Sep 12.


Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022).

Ayers S, Graf TN, Adcock AF, Kroll DJ, Shen Q, Swanson SM, Matthew S, Carcache de Blanco EJ, Wani MC, Darveaux BA, Pearce CJ, Oberlies NH.

J Antibiot (Tokyo). 2012 Jan;65(1):3-8. doi: 10.1038/ja.2011.95. Epub 2011 Nov 9.


Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales.

Ayers S, Graf TN, Adcock AF, Kroll DJ, Shen Q, Swanson SM, Wani MC, Darveaux BA, Pearce CJ, Oberlies NH.

Tetrahedron Lett. 2011 Oct 5;52(40):5128-5230.


Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320).

Sy-Cordero AA, Graf TN, Adcock AF, Kroll DJ, Shen Q, Swanson SM, Wani MC, Pearce CJ, Oberlies NH.

J Nat Prod. 2011 Oct 28;74(10):2137-42. doi: 10.1021/np2004243. Epub 2011 Oct 6. Erratum in: J Nat Prod. 2012 Feb 24;75(2):307.


Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis).

Junio HA, Sy-Cordero AA, Ettefagh KA, Burns JT, Micko KT, Graf TN, Richter SJ, Cannon RE, Oberlies NH, Cech NB.

J Nat Prod. 2011 Jul 22;74(7):1621-9. doi: 10.1021/np200336g. Epub 2011 Jun 10.


Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships.

Ayers S, Graf TN, Adcock AF, Kroll DJ, Matthew S, Carcache de Blanco EJ, Shen Q, Swanson SM, Wani MC, Pearce CJ, Oberlies NH.

J Nat Prod. 2011 May 27;74(5):1126-31. doi: 10.1021/np200062x. Epub 2011 Apr 22.


Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation.

Wagoner J, Morishima C, Graf TN, Oberlies NH, Teissier E, Pécheur EI, Tavis JE, Polyak SJ.

PLoS One. 2011 Jan 28;6(1):e16464. doi: 10.1371/journal.pone.0016464.


Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes.

Kim E, Sy-Cordero A, Graf TN, Brantley SJ, Paine MF, Oberlies NH.

Planta Med. 2011 Feb;77(3):265-70. doi: 10.1055/s-0030-1250259. Epub 2010 Aug 17.


Dereplication of macrocyclic trichothecenes from extracts of filamentous fungi through UV and NMR profiles.

Sy-Cordero AA, Graf TN, Wani MC, Kroll DJ, Pearce CJ, Oberlies NH.

J Antibiot (Tokyo). 2010 Sep;63(9):539-44. doi: 10.1038/ja.2010.77. Epub 2010 Jul 21.


Multiple effects of silymarin on the hepatitis C virus lifecycle.

Wagoner J, Negash A, Kane OJ, Martinez LE, Nahmias Y, Bourne N, Owen DM, Grove J, Brimacombe C, McKeating JA, Pécheur EI, Graf TN, Oberlies NH, Lohmann V, Cao F, Tavis JE, Polyak SJ.

Hepatology. 2010 Jun;51(6):1912-21. doi: 10.1002/hep.23587.


Identification of hepatoprotective flavonolignans from silymarin.

Polyak SJ, Morishima C, Lohmann V, Pal S, Lee DY, Liu Y, Graf TN, Oberlies NH.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5995-9. doi: 10.1073/pnas.0914009107. Epub 2010 Mar 15.


Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.

Sy-Cordero A, Graf TN, Nakanishi Y, Wani MC, Agarwal R, Kroll DJ, Oberlies NH.

Planta Med. 2010 Apr;76(6):644-7. doi: 10.1055/s-0029-1240624. Epub 2009 Nov 25.


Bioactive constituents of the stem bark of Mitrephora glabra.

Li C, Lee D, Graf TN, Phifer SS, Nakanishi Y, Riswan S, Setyowati FM, Saribi AM, Soejarto DD, Farnsworth NR, Falkinham JO 3rd, Kroll DJ, Kinghorn AD, Wani MC, Oberlies NH.

J Nat Prod. 2009 Nov;72(11):1949-53. doi: 10.1021/np900572g.


Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection.

Morishima C, Shuhart MC, Wang CC, Paschal DM, Apodaca MC, Liu Y, Sloan DD, Graf TN, Oberlies NH, Lee DY, Jerome KR, Polyak SJ.

Gastroenterology. 2010 Feb;138(2):671-81, 681.e1-2. doi: 10.1053/j.gastro.2009.09.021. Epub 2009 Sep 24.


Identification of a cranberry juice product that inhibits enteric CYP3A-mediated first-pass metabolism in humans.

Ngo N, Yan Z, Graf TN, Carrizosa DR, Kashuba AD, Dees EC, Oberlies NH, Paine MF.

Drug Metab Dispos. 2009 Mar;37(3):514-22. doi: 10.1124/dmd.108.024968. Epub 2008 Dec 29.


Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis.

Phifer SS, Lee D, Seo EK, Kim NC, Graf TN, Kroll DJ, Navarro HA, Izydore RA, Jiménez F, Garcia R, Rose WC, Fairchild CR, Wild R, Soejarto DD, Farnsworth NR, Kinghorn AD, Oberlies NH, Wall ME, Wani MC.

J Nat Prod. 2007 Jun;70(6):954-61. Epub 2007 Jun 7.


Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).

Graf TN, Levine KE, Andrews ME, Perlmutter JM, Nielsen SJ, Davis JM, Wani MC, Oberlies NH.

J Agric Food Chem. 2007 Feb 21;55(4):1205-11. Epub 2007 Jan 25.


A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra.

Li C, Lee D, Graf TN, Phifer SS, Nakanishi Y, Burgess JP, Riswan S, Setyowati FM, Saribi AM, Soejarto DD, Farnsworth NR, Falkinham JO 3rd, Kroll DJ, Kinghorn AD, Wani MC, Oberlies NH.

Org Lett. 2005 Dec 8;7(25):5709-12.


Diterpene glycosides from Egletes viscosa.

Lee D, Li C, Graf TN, Vigo JS, Graham JG, Cabieses F, Farnsworth NR, Cordell GA, Kinghorn AD, Kroll DJ, Wani MC, Oberlies NH.

Planta Med. 2005 Aug;71(8):792-4.


Structural insights into sulfite oxidase deficiency.

Karakas E, Wilson HL, Graf TN, Xiang S, Jaramillo-Busquets S, Rajagopalan KV, Kisker C.

J Biol Chem. 2005 Sep 30;280(39):33506-15. Epub 2005 Jul 27.


Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.

Davis-Searles PR, Nakanishi Y, Kim NC, Graf TN, Oberlies NH, Wani MC, Wall ME, Agarwal R, Kroll DJ.

Cancer Res. 2005 May 15;65(10):4448-57.


Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.

Gu JQ, Graf TN, Lee D, Chai HB, Mi Q, Kardono LB, Setyowati FM, Ismail R, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kroll DJ, Falkinham JO 3rd, Wall ME, Wani MC, Kinghorn AD, Oberlies NH.

J Nat Prod. 2004 Jul;67(7):1156-61.


Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).

Kim NC, Graf TN, Sparacino CM, Wani MC, Wall ME.

Org Biomol Chem. 2003 May 21;1(10):1684-9. Erratum in: Org Biomol Chem. 2003 Oct 7;1(19):3470.


Optimization of expression of human sulfite oxidase and its molybdenum domain.

Temple CA, Graf TN, Rajagopalan KV.

Arch Biochem Biophys. 2000 Nov 15;383(2):281-7.


Isolated sulfite oxidase deficiency: review of two cases in one family.

Edwards MC, Johnson JL, Marriage B, Graf TN, Coyne KE, Rajagopalan KV, MacDonald IM.

Ophthalmology. 1999 Oct;106(10):1957-61.


Human sulfite oxidase R160Q: identification of the mutation in a sulfite oxidase-deficient patient and expression and characterization of the mutant enzyme.

Garrett RM, Johnson JL, Graf TN, Feigenbaum A, Rajagopalan KV.

Proc Natl Acad Sci U S A. 1998 May 26;95(11):6394-8.


Production and purification of N-terminal half-transferrin in Pichia pastoris.

Steinlein LM, Graf TN, Ikeda RA.

Protein Expr Purif. 1995 Oct;6(5):619-24.


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