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Items: 7


Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus.

Graepel KW, Agostini ML, Lu X, Sexton NR, Denison MR.

J Virol. 2019 Sep 30;93(20). pii: e00711-19. doi: 10.1128/JVI.00711-19. Print 2019 Oct 15.


Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses.

Athmer J, Fehr AR, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M Jr, Denison MR, Perlman S.

MBio. 2018 May 1;9(3). pii: e00272-18. doi: 10.1128/mBio.00272-18.


Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.

Tian D, Battles MB, Moin SM, Chen M, Modjarrad K, Kumar A, Kanekiyo M, Graepel KW, Taher NM, Hotard AL, Moore ML, Zhao M, Zheng ZZ, Xia NS, McLellan JS, Graham BS.

Nat Commun. 2017 Nov 30;8(1):1877. doi: 10.1038/s41467-017-01858-w.


Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations.

Graepel KW, Lu X, Case JB, Sexton NR, Smith EC, Denison MR.

MBio. 2017 Nov 7;8(6). pii: e01503-17. doi: 10.1128/mBio.01503-17.


Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity.

Case JB, Li Y, Elliott R, Lu X, Graepel KW, Sexton NR, Smith EC, Weiss SR, Denison MR.

J Virol. 2017 Dec 14;92(1). pii: e01531-17. doi: 10.1128/JVI.01531-17. Print 2018 Jan 1.


Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.

McLellan JS, Chen M, Joyce MG, Sastry M, Stewart-Jones GB, Yang Y, Zhang B, Chen L, Srivatsan S, Zheng A, Zhou T, Graepel KW, Kumar A, Moin S, Boyington JC, Chuang GY, Soto C, Baxa U, Bakker AQ, Spits H, Beaumont T, Zheng Z, Xia N, Ko SY, Todd JP, Rao S, Graham BS, Kwong PD.

Science. 2013 Nov 1;342(6158):592-8. doi: 10.1126/science.1243283. Erratum in: Science. 2013 Nov 22;342(6161):931.


Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody.

McLellan JS, Chen M, Leung S, Graepel KW, Du X, Yang Y, Zhou T, Baxa U, Yasuda E, Beaumont T, Kumar A, Modjarrad K, Zheng Z, Zhao M, Xia N, Kwong PD, Graham BS.

Science. 2013 May 31;340(6136):1113-7. doi: 10.1126/science.1234914. Epub 2013 Apr 25.

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