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Items: 14

1.

Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder.

Bristow LJ, Gulia J, Weed MR, Srikumar BN, Li YW, Graef JD, Naidu PS, Sanmathi C, Aher J, Bastia T, Paschapur M, Kalidindi N, Kumar KV, Molski T, Pieschl R, Fernandes A, Brown JM, Sivarao DV, Newberry K, Bookbinder M, Polino J, Keavy D, Newton A, Shields E, Simmermacher J, Kempson J, Li J, Zhang H, Mathur A, Kallem RR, Sinha M, Ramarao M, Vikramadithyan RK, Thangathirupathy S, Warrier J, Islam I, Bronson JJ, Olson RE, Macor JE, Albright CF, King D, Thompson LA, Marcin LR, Sinz M.

J Pharmacol Exp Ther. 2017 Dec;363(3):377-393. doi: 10.1124/jpet.117.242784. Epub 2017 Sep 27.

PMID:
28954811
2.

B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor.

Post-Munson DJ, Pieschl RL, Molski TF, Graef JD, Hendricson AW, Knox RJ, McDonald IM, Olson RE, Macor JE, Weed MR, Bristow LJ, Kiss L, Ahlijanian MK, Herrington J.

Eur J Pharmacol. 2017 Mar 15;799:16-25. doi: 10.1016/j.ejphar.2017.01.037. Epub 2017 Jan 26.

PMID:
28132910
3.

Development of a spontaneously active dorsal root ganglia assay using multiwell multielectrode arrays.

Newberry K, Wang S, Hoque N, Kiss L, Ahlijanian MK, Herrington J, Graef JD.

J Neurophysiol. 2016 Jun 1;115(6):3217-28. doi: 10.1152/jn.01122.2015. Epub 2016 Apr 6.

4.

Effect of acute NR2B antagonist treatment on long-term potentiation in the rat hippocampus.

Graef JD, Newberry K, Newton A, Pieschl R, Shields E, Luan FN, Simmermacher J, Luchetti D, Schaeffer E, Li YW, Kiss L, Bristow LJ.

Brain Res. 2015 Jun 3;1609:31-9. doi: 10.1016/j.brainres.2015.03.019. Epub 2015 Mar 19.

PMID:
25796435
5.

TC-8831, a nicotinic acetylcholine receptor agonist, reduces L-DOPA-induced dyskinesia in the MPTP macaque.

Johnston TH, Huot P, Fox SH, Koprich JB, Szeliga KT, James JW, Graef JD, Letchworth SR, Jordan KG, Hill MP, Brotchie JM.

Neuropharmacology. 2013 Oct;73:337-47. doi: 10.1016/j.neuropharm.2013.06.005. Epub 2013 Jun 14.

PMID:
23770260
6.

Slice XVIvo™: a novel electrophysiology system with the capability for 16 independent brain slice recordings.

Graef JD, Wei H, Lippiello PM, Bencherif M, Fedorov N.

J Neurosci Methods. 2013 Jan 30;212(2):228-33. doi: 10.1016/j.jneumeth.2012.10.009. Epub 2012 Oct 23.

PMID:
23099344
7.

Ethosuximide reduces ethanol withdrawal-mediated disruptions in sleep-related EEG patterns.

Wiggins WF, Graef JD, Huitt TW, Godwin DW.

Alcohol Clin Exp Res. 2013 Mar;37(3):372-82. doi: 10.1111/j.1530-0277.2012.01938.x. Epub 2012 Oct 18.

8.

Validation of a high-throughput, automated electrophysiology platform for the screening of nicotinic agonists and antagonists.

Graef JD, Benson LC, Sidach SS, Wei H, Lippiello PM, Bencherif M, Fedorov NB.

J Biomol Screen. 2013 Jan;18(1):116-27. doi: 10.1177/1087057112457414. Epub 2012 Sep 6.

PMID:
22960782
9.

A method for bidirectional solution exchange--"liquid bullet" applications of acetylcholine to α7 nicotinic receptors.

Fedorov N, Benson L, Graef JD, Hyman J, Sollenberger J, Pettersson F, Lippiello PM, Bencherif M.

J Neurosci Methods. 2012 Apr 30;206(1):23-33. doi: 10.1016/j.jneumeth.2012.02.005. Epub 2012 Feb 11.

PMID:
22342972
10.

Disruptions in serotonergic regulation of cortical glutamate release in primate insular cortex in response to chronic ethanol and nursery rearing.

Alexander GM, Graef JD, Hammarback JA, Nordskog BK, Burnett EJ, Daunais JB, Bennett AJ, Friedman DP, Suomi SJ, Godwin DW.

Neuroscience. 2012 Apr 5;207:167-81. doi: 10.1016/j.neuroscience.2012.01.027. Epub 2012 Jan 21.

11.

Disrupted thalamic T-type Ca2+ channel expression and function during ethanol exposure and withdrawal.

Graef JD, Huitt TW, Nordskog BK, Hammarback JH, Godwin DW.

J Neurophysiol. 2011 Feb;105(2):528-40. doi: 10.1152/jn.00424.2010. Epub 2010 Dec 8.

12.

Intrinsic plasticity in acquired epilepsy: too much of a good thing?

Graef JD, Godwin DW.

Neuroscientist. 2010 Oct;16(5):487-95. doi: 10.1177/1073858409358776. Epub 2010 Apr 20.

PMID:
20407126
13.

An acquired channelopathy involving thalamic T-type Ca2+ channels after status epilepticus.

Graef JD, Nordskog BK, Wiggins WF, Godwin DW.

J Neurosci. 2009 Apr 8;29(14):4430-41. doi: 10.1523/JNEUROSCI.0198-09.2009.

14.

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