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Items: 1 to 50 of 75

1.

A transcriptomic roadmap to α- and β-cell differentiation in the embryonic pancreas.

van Gurp L, Muraro MJ, Dielen T, Seneby L, Dharmadhikari G, Gradwohl G, van Oudenaarden A, de Koning EJP.

Development. 2019 Jun 24;146(12). pii: dev173716. doi: 10.1242/dev.173716.

PMID:
31160419
2.

Photoplethysmographic assessment of pulse transit time correlates with echocardiographic measurement of stroke volume in preterm infants with patent ductus arteriosus.

Amirtharaj CR, Palmeri LC, Gradwohl G, Adar Y, Nitzan M, Gruber D, Blaufox A, Meyer DB, Kwon EN, Koppel R.

J Perinatol. 2018 Sep;38(9):1220-1226. doi: 10.1038/s41372-018-0165-0. Epub 2018 Jul 2.

PMID:
29961764
3.

Sleep/wake movement velocities, trajectories and micro-arousals during maturation in rats.

Gradwohl G, Olini N, Huber R.

BMC Neurosci. 2017 Feb 7;18(1):24. doi: 10.1186/s12868-017-0343-6.

4.

Photoplethysmographic waveform characteristics of newborns with coarctation of the aorta.

Palmeri L, Gradwohl G, Nitzan M, Hoffman E, Adar Y, Shapir Y, Koppel R.

J Perinatol. 2017 Jan;37(1):77-80. doi: 10.1038/jp.2016.162. Epub 2016 Sep 29.

PMID:
27684424
5.

The Enigma of the Dichotomic Pressure Response of GluN1-4a/b Splice Variants of NMDA Receptor: Experimental and Statistical Analyses.

Bliznyuk A, Gradwohl G, Hollmann M, Grossman Y.

Front Mol Neurosci. 2016 Jun 10;9:40. doi: 10.3389/fnmol.2016.00040. eCollection 2016.

6.

STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage.

De Groef S, Renmans D, Cai Y, Leuckx G, Roels S, Staels W, Gradwohl G, Baeyens L, Heremans Y, Martens GA, De Leu N, Sojoodi M, Van de Casteele M, Heimberg H.

Cell Death Dis. 2016 Jun 23;7(6):e2272. doi: 10.1038/cddis.2016.171.

7.

Selective pressure modulation of synaptic voltage-dependent calcium channels-involvement in HPNS mechanism.

Aviner B, Gradwohl G, Bliznyuk A, Grossman Y.

J Cell Mol Med. 2016 Oct;20(10):1872-88. doi: 10.1111/jcmm.12877. Epub 2016 Jun 8.

8.

Expression and functional studies of the GDNF family receptor alpha 3 in the pancreas.

Nivlet L, Herrmann J, Martin DE, Meunier A, Orvain C, Gradwohl G.

J Mol Endocrinol. 2016 Feb;56(2):77-90. doi: 10.1530/JME-15-0213. Epub 2015 Nov 17.

9.

Differentially Expressed MicroRNA-483 Confers Distinct Functions in Pancreatic β- and α-Cells.

Mohan R, Mao Y, Zhang S, Zhang YW, Xu CR, Gradwohl G, Tang X.

J Biol Chem. 2015 Aug 7;290(32):19955-66. doi: 10.1074/jbc.M115.650705. Epub 2015 Jun 24.

10.

Sleep/Wake Dynamics Changes during Maturation in Rats.

Gradwohl G, Berdugo-Boura N, Segev Y, Tarasiuk A.

PLoS One. 2015 Apr 20;10(4):e0125509. doi: 10.1371/journal.pone.0125509. eCollection 2015.

11.

Pairing-up SOX to kick-start beta cell genesis.

Grapin-Botton A, Seymour PA, Gradwohl G.

Diabetologia. 2015 May;58(5):859-61. doi: 10.1007/s00125-015-3539-2. Epub 2015 Mar 4.

PMID:
25733380
12.

Rfx6 maintains the functional identity of adult pancreatic β cells.

Piccand J, Strasser P, Hodson DJ, Meunier A, Ye T, Keime C, Birling MC, Rutter GA, Gradwohl G.

Cell Rep. 2014 Dec 24;9(6):2219-32. doi: 10.1016/j.celrep.2014.11.033. Epub 2014 Dec 11.

13.

Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure-a suggested HPNS partial mechanism.

Aviner B, Gradwohl G, Mor Aviner M, Levy S, Grossman Y.

Front Cell Neurosci. 2014 May 27;8:136. doi: 10.3389/fncel.2014.00136. eCollection 2014.

14.

Chronic upper airway obstruction induces abnormal sleep/wake dynamics in juvenile rats.

Gradwohl G, Berdugo-Boura N, Segev Y, Tarasiuk A.

PLoS One. 2014 May 13;9(5):e97111. doi: 10.1371/journal.pone.0097111. eCollection 2014.

15.

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.

Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H.

Nat Biotechnol. 2014 Jan;32(1):76-83. doi: 10.1038/nbt.2747. Epub 2013 Nov 17.

16.

Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice.

Piccand J, Meunier A, Merle C, Jia Z, Barnier JV, Gradwohl G.

Diabetes. 2014 Jan;63(1):203-15. doi: 10.2337/db13-0384. Epub 2013 Oct 25.

17.

Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes.

De Leu N, Heremans Y, Coppens V, Van Gassen N, Cai Y, D'Hoker J, Magenheim J, Salpeter S, Swisa A, Khalaileh A, Arnold C, Gradwohl G, Van de Casteele M, Keshet E, Dor Y, Heimberg H.

Diabetologia. 2014 Jan;57(1):140-7.

PMID:
24121626
18.

Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.

Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P.

Dev Cell. 2013 Jul 15;26(1):86-100. doi: 10.1016/j.devcel.2013.05.018. Epub 2013 Jun 27.

19.

Modulation of presynaptic Ca(2+) currents in frog motor nerve terminals by high pressure.

Aviner B, Gradwohl G, Moore HJ, Grossman Y.

Eur J Neurosci. 2013 Sep;38(5):2716-29. doi: 10.1111/ejn.12267. Epub 2013 Jun 5.

PMID:
23738821
20.

Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity.

Anthwal N, Pelling M, Claxton S, Mellitzer G, Collin C, Kessaris N, Richardson WD, Gradwohl G, Ang SL.

Dis Model Mech. 2013 Sep;6(5):1133-45. doi: 10.1242/dmm.011916. Epub 2013 May 2.

21.

Statistical computer model analysis of the reciprocal and recurrent inhibitions of the Ia-EPSP in α-motoneurons.

Gradwohl G, Grossman Y.

Neural Comput. 2013 Jan;25(1):75-100. doi: 10.1162/NECO_a_00375. Epub 2012 Sep 12.

PMID:
22970870
22.

The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice.

Beucher A, Gjernes E, Collin C, Courtney M, Meunier A, Collombat P, Gradwohl G.

PLoS One. 2012;7(5):e36449. doi: 10.1371/journal.pone.0036449. Epub 2012 May 3.

23.

The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation.

Metzger DE, Gasperowicz M, Otto F, Cross JC, Gradwohl G, Zaret KS.

Development. 2012 Apr;139(8):1447-56. doi: 10.1242/dev.072892.

24.

Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development.

Beucher A, Martín M, Spenle C, Poulet M, Collin C, Gradwohl G.

Dev Biol. 2012 Jan 15;361(2):277-85. doi: 10.1016/j.ydbio.2011.10.025. Epub 2011 Oct 26.

25.

Pancreatic islet and progenitor cell surface markers with cell sorting potential.

Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Rønne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD.

Diabetologia. 2012 Jan;55(1):154-65. doi: 10.1007/s00125-011-2295-1. Epub 2011 Sep 23.

PMID:
21947380
26.

Enteroendocrine cells and lipid absorption.

Mellitzer G, Gradwohl G.

Curr Opin Lipidol. 2011 Jun;22(3):171-5. doi: 10.1097/MOL.0b013e32834622a2. Review.

PMID:
21464713
27.

Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus.

Pelling M, Anthwal N, McNay D, Gradwohl G, Leiter AB, Guillemot F, Ang SL.

Dev Biol. 2011 Jan 15;349(2):406-16. doi: 10.1016/j.ydbio.2010.11.007. Epub 2010 Nov 11.

28.

Hyperbaric pressure effects on voltage-dependent Ca+2 channels: relevance to HPNS.

Aviner B, Gnatek Y, Gradwohl G, Grossman Y.

Undersea Hyperb Med. 2010 Sep-Oct;37(5):245-58.

PMID:
20929182
29.

Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival.

Mellitzer G, Beucher A, Lobstein V, Michel P, Robine S, Kedinger M, Gradwohl G.

J Clin Invest. 2010 May;120(5):1708-21. doi: 10.1172/JCI40794. Epub 2010 Apr 1.

30.

Statistical computer model analysis of the reciprocal and recurrent inhibitory postsynaptic potentials in alpha-motoneurons.

Gradwohl G, Grossman Y.

Neural Comput. 2010 Jul;22(7):1764-85. doi: 10.1162/neco.2010.07-09-1054.

PMID:
20235819
31.

Expression of neuropeptide Y and agouti-related peptide in the hypothalamic arcuate nucleus of newborn neurogenin3 null mutant mice.

Arai Y, Gradwohl G, Kameda Y.

Cell Tissue Res. 2010 Apr;340(1):137-45. doi: 10.1007/s00441-009-0925-4. Epub 2010 Feb 3.

PMID:
20127365
32.

Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development.

Soyer J, Flasse L, Raffelsberger W, Beucher A, Orvain C, Peers B, Ravassard P, Vermot J, Voz ML, Mellitzer G, Gradwohl G.

Development. 2010 Jan;137(2):203-12. doi: 10.1242/dev.041673.

33.

GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist.

Quayum N, Kutchma A, Sarkar SA, Juhl K, Gradwohl G, Mellitzer G, Hutton JC, Jensen J.

Exp Diabetes Res. 2008;2008:312060. doi: 10.1155/2008/312060.

34.

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.

Petrova TV, Nykänen A, Norrmén C, Ivanov KI, Andersson LC, Haglund C, Puolakkainen P, Wempe F, von Melchner H, Gradwohl G, Vanharanta S, Aaltonen LA, Saharinen J, Gentile M, Clarke A, Taipale J, Oliver G, Alitalo K.

Cancer Cell. 2008 May;13(5):407-19. doi: 10.1016/j.ccr.2008.02.020.

35.

Characterization of the proneural gene regulatory network during mouse telencephalon development.

Gohlke JM, Armant O, Parham FM, Smith MV, Zimmer C, Castro DS, Nguyen L, Parker JS, Gradwohl G, Portier CJ, Guillemot F.

BMC Biol. 2008 Mar 31;6:15. doi: 10.1186/1741-7007-6-15.

36.
37.

Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas.

Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Scharfmann R, Gradwohl G, Heimberg H.

Cell. 2008 Jan 25;132(2):197-207. doi: 10.1016/j.cell.2007.12.015.

38.

Transcription factors in pancreatic development. Animal models.

Martin M, Hauer V, Messmer M, Orvain C, Gradwohl G.

Endocr Dev. 2007;12:24-32. doi: 10.1159/000109602. Review.

PMID:
17923766
39.

Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation.

Vanhorenbeeck V, Jenny M, Cornut JF, Gradwohl G, Lemaigre FP, Rousseau GG, Jacquemin P.

Dev Biol. 2007 May 15;305(2):685-94. Epub 2007 Feb 28.

40.

Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.

Johansson KA, Dursun U, Jordan N, Gu G, Beermann F, Gradwohl G, Grapin-Botton A.

Dev Cell. 2007 Mar;12(3):457-65.

41.

In vitro models of intestinal epithelial cell differentiation.

Simon-Assmann P, Turck N, Sidhoum-Jenny M, Gradwohl G, Kedinger M.

Cell Biol Toxicol. 2007 Jul;23(4):241-56. Epub 2006 Dec 12. Review.

PMID:
17171431
42.

Development of the endocrine pancreas.

Gradwohl G.

Diabetes Metab. 2006 Dec;32(5 Pt 2):532-3.

PMID:
17130813
43.

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.

Mellitzer G, Bonné S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G, Heimberg H.

EMBO J. 2006 Mar 22;25(6):1344-52. Epub 2006 Mar 2.

44.

Genetic determinants of pancreatic epsilon-cell development.

Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, Serup P.

Dev Biol. 2005 Oct 1;286(1):217-24.

45.

Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice.

Martín M, Gallego-Llamas J, Ribes V, Kedinger M, Niederreither K, Chambon P, Dollé P, Gradwohl G.

Dev Biol. 2005 Aug 15;284(2):399-411.

46.

Lack of TCF2/vHNF1 in mice leads to pancreas agenesis.

Haumaitre C, Barbacci E, Jenny M, Ott MO, Gradwohl G, Cereghini S.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1490-5. Epub 2005 Jan 24.

47.

Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice.

Mellitzer G, Martín M, Sidhoum-Jenny M, Orvain C, Barths J, Seymour PA, Sander M, Gradwohl G.

Mol Endocrinol. 2004 Nov;18(11):2765-76. Epub 2004 Aug 5.

PMID:
15297605
48.

Neurogenesis in hippocampal slice cultures.

Raineteau O, Rietschin L, Gradwohl G, Guillemot F, Gähwiler BH.

Mol Cell Neurosci. 2004 Jun;26(2):241-50.

PMID:
15207849
49.

Opposing actions of Arx and Pax4 in endocrine pancreas development.

Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, Gruss P.

Genes Dev. 2003 Oct 15;17(20):2591-603.

50.

Transcriptional program of the endocrine pancreas in mice and humans.

Kaestner KH, Lee CS, Scearce LM, Brestelli JE, Arsenlis A, Le PP, Lantz KA, Crabtree J, Pizarro A, Mazzarelli J, Pinney D, Fischer S, Manduchi E, Stoeckert CJ Jr, Gradwohl G, Clifton SW, Brown JR, Inoue H, Cras-Méneur C, Permutt MA.

Diabetes. 2003 Jul;52(7):1604-10.

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