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Items: 20

1.

CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1.

Silverman JM, Christy D, Shyu CC, Moon KM, Fernando S, Gidden Z, Cowan CM, Ban Y, Stacey RG, Grad LI, McAlary L, Mackenzie IR, Foster LJ, Cashman NR.

J Biol Chem. 2019 Mar 8;294(10):3744-3759. doi: 10.1074/jbc.RA118.004825. Epub 2019 Jan 11.

PMID:
30635404
2.

Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites.

Bean BDM, Dziurdzik SK, Kolehmainen KL, Fowler CMS, Kwong WK, Grad LI, Davey M, Schluter C, Conibear E.

J Cell Biol. 2018 Oct 1;217(10):3593-3607. doi: 10.1083/jcb.201804111. Epub 2018 Jul 17.

3.

Intercellular Prion-Like Conversion and Transmission of Cu/Zn Superoxide Dismutase (SOD1) in Cell Culture.

Grad LI, Pokrishevsky E, Cashman NR.

Methods Mol Biol. 2017;1658:357-367. doi: 10.1007/978-1-4939-7244-9_24.

PMID:
28861801
4.

Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS).

Grad LI, Rouleau GA, Ravits J, Cashman NR.

Cold Spring Harb Perspect Med. 2017 Aug 1;7(8). pii: a024117. doi: 10.1101/cshperspect.a024117. Review.

5.

TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion.

Pokrishevsky E, Grad LI, Cashman NR.

Sci Rep. 2016 Mar 1;6:22155. doi: 10.1038/srep22155.

6.

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.

Silverman JM, Fernando SM, Grad LI, Hill AF, Turner BJ, Yerbury JJ, Cashman NR.

Cell Mol Neurobiol. 2016 Apr;36(3):377-81. doi: 10.1007/s10571-015-0294-3. Epub 2016 Feb 23. Review.

PMID:
26908139
7.

From molecule to molecule and cell to cell: prion-like mechanisms in amyotrophic lateral sclerosis.

Grad LI, Fernando SM, Cashman NR.

Neurobiol Dis. 2015 May;77:257-65. doi: 10.1016/j.nbd.2015.02.009. Epub 2015 Feb 17. Review.

PMID:
25701498
8.

Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding.

Grad LI, Pokrishevsky E, Silverman JM, Cashman NR.

Prion. 2014;8(5):331-5. doi: 10.4161/19336896.2014.983398.

9.

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms.

Grad LI, Yerbury JJ, Turner BJ, Guest WC, Pokrishevsky E, O'Neill MA, Yanai A, Silverman JM, Zeineddine R, Corcoran L, Kumita JR, Luheshi LM, Yousefi M, Coleman BM, Hill AF, Plotkin SS, Mackenzie IR, Cashman NR.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3620-5. doi: 10.1073/pnas.1312245111. Epub 2014 Feb 18.

10.
11.

Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.

Pokrishevsky E, Grad LI, Yousefi M, Wang J, Mackenzie IR, Cashman NR.

PLoS One. 2012;7(4):e35050. doi: 10.1371/journal.pone.0035050. Epub 2012 Apr 6.

12.

Generalization of the prion hypothesis to other neurodegenerative diseases: an imperfect fit.

Guest WC, Silverman JM, Pokrishevsky E, O'Neill MA, Grad LI, Cashman NR.

J Toxicol Environ Health A. 2011;74(22-24):1433-59. doi: 10.1080/15287394.2011.618967. Review.

PMID:
22043906
13.

Intermolecular transmission of superoxide dismutase 1 misfolding in living cells.

Grad LI, Guest WC, Yanai A, Pokrishevsky E, O'Neill MA, Gibbs E, Semenchenko V, Yousefi M, Wishart DS, Plotkin SS, Cashman NR.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16398-403. doi: 10.1073/pnas.1102645108. Epub 2011 Sep 19.

14.

Isolation and functional analysis of mitochondria from the nematode Caenorhabditis elegans.

Grad LI, Sayles LC, Lemire BD.

Methods Mol Biol. 2007;372:51-66. doi: 10.1007/978-1-59745-365-3_4.

PMID:
18314717
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18.

Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span.

Tsang WY, Sayles LC, Grad LI, Pilgrim DB, Lemire BD.

J Biol Chem. 2001 Aug 24;276(34):32240-6. Epub 2001 Jun 15.

19.

Locally released retinoic acid repatterns the first branchial arch cartilages in vivo.

Plant MR, MacDonald ME, Grad LI, Ritchie SJ, Richman JM.

Dev Biol. 2000 Jun 1;222(1):12-26.

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