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Items: 46


Valence and patterning of aromatic residues determine the phase behavior of prion-like domains.

Martin EW, Holehouse AS, Peran I, Farag M, Incicco JJ, Bremer A, Grace CR, Soranno A, Pappu RV, Mittag T.

Science. 2020 Feb 7;367(6478):694-699. doi: 10.1126/science.aaw8653.


Allosteric regulation through a switch element in the autophagy E2, Atg3.

Qiu Y, Zheng Y, Grace CRR, Liu X, Klionsky DJ, Schulman BA.

Autophagy. 2020 Jan;16(1):183-184. doi: 10.1080/15548627.2019.1688550. Epub 2019 Nov 9.


A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade.

Zheng Y, Qiu Y, Grace CRR, Liu X, Klionsky DJ, Schulman BA.

Nat Commun. 2019 Aug 9;10(1):3600. doi: 10.1038/s41467-019-11435-y.


Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.

Watson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, Schulman BA.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17280-17289. doi: 10.1073/pnas.1902889116. Epub 2019 Jul 26.


Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.

McNamara DE, Dovey CM, Hale AT, Quarato G, Grace CR, Guibao CD, Diep J, Nourse A, Cai CR, Wu H, Kalathur RC, Green DR, York JD, Carette JE, Moldoveanu T.

Cell Chem Biol. 2019 Jun 20;26(6):863-877.e7. doi: 10.1016/j.chembiol.2019.03.010. Epub 2019 Apr 25.


MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.

Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW Jr, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE.

Mol Cell. 2018 Jun 7;70(5):936-948.e7. doi: 10.1016/j.molcel.2018.05.010. Epub 2018 Jun 7.


Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.

Vanarotti M, Grace CR, Miller DJ, Actis ML, Inoue A, Evison BJ, Vaithiyalingam S, Singh AP, McDonald ET, Fujii N.

J Mol Biol. 2018 Aug 17;430(17):2857-2872. doi: 10.1016/j.jmb.2018.05.042. Epub 2018 Jun 2.


Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis.

Zheng JH, Grace CR, Guibao CD, McNamara DE, Llambi F, Wang YM, Chen T, Moldoveanu T.

Cell Rep. 2018 May 15;23(7):2083-2094.e6. doi: 10.1016/j.celrep.2018.04.060.


Alteration of RNA Splicing by Small-Molecule Inhibitors of the Interaction between NHP2L1 and U4.

Diouf B, Lin W, Goktug A, Grace CRR, Waddell MB, Bao J, Shao Y, Heath RJ, Zheng JJ, Shelat AA, Relling MV, Chen T, Evans WE.

SLAS Discov. 2018 Feb;23(2):164-173. doi: 10.1177/2472555217735035. Epub 2017 Oct 6.


Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation.

Martin EW, Holehouse AS, Grace CR, Hughes A, Pappu RV, Mittag T.

J Am Chem Soc. 2016 Nov 30;138(47):15323-15335. Epub 2016 Nov 17.


Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

Brown NG, VanderLinden R, Watson ER, Weissmann F, Ordureau A, Wu KP, Zhang W, Yu S, Mercredi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, Grace CRR, Miller DJ, Haselbach D, Jarvis MA, Yamaguchi M, Yanishevski D, Petzold G, Sidhu SS, Kuhlman B, Kirschner MW, Harper JW, Peters JM, Stark H, Schulman BA.

Cell. 2016 Jun 2;165(6):1440-1453. doi: 10.1016/j.cell.2016.05.037.


Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis.

Quarato G, Guy CS, Grace CR, Llambi F, Nourse A, Rodriguez DA, Wakefield R, Frase S, Moldoveanu T, Green DR.

Mol Cell. 2016 Feb 18;61(4):589-601. doi: 10.1016/j.molcel.2016.01.011. Epub 2016 Feb 4.


MicroRNAs Form Triplexes with Double Stranded DNA at Sequence-Specific Binding Sites; a Eukaryotic Mechanism via which microRNAs Could Directly Alter Gene Expression.

Paugh SW, Coss DR, Bao J, Laudermilk LT, Grace CR, Ferreira AM, Waddell MB, Ridout G, Naeve D, Leuze M, LoCascio PF, Panetta JC, Wilkinson MR, Pui CH, Naeve CW, Uberbacher EC, Bonten EJ, Evans WE.

PLoS Comput Biol. 2016 Feb 4;12(2):e1004744. doi: 10.1371/journal.pcbi.1004744. eCollection 2016 Feb.


Monitoring Ligand-Induced Protein Ordering in Drug Discovery.

Grace CR, Ban D, Min J, Mayasundari A, Min L, Finch KE, Griffiths L, Bharatham N, Bashford D, Kiplin Guy R, Dyer MA, Kriwacki RW.

J Mol Biol. 2016 Mar 27;428(6):1290-1303. doi: 10.1016/j.jmb.2016.01.016. Epub 2016 Jan 23.


Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.

Pierce WK, Grace CR, Lee J, Nourse A, Marzahn MR, Watson ER, High AA, Peng J, Schulman BA, Mittag T.

J Mol Biol. 2016 Mar 27;428(6):1256-1271. doi: 10.1016/j.jmb.2015.10.002. Epub 2015 Oct 22.


RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.

Brown NG, VanderLinden R, Watson ER, Qiao R, Grace CR, Yamaguchi M, Weissmann F, Frye JJ, Dube P, Ei Cho S, Actis ML, Rodrigues P, Fujii N, Peters JM, Stark H, Schulman BA.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5272-9. doi: 10.1073/pnas.1504161112. Epub 2015 Mar 30.


Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis.

Epling LB, Grace CR, Lowe BR, Partridge JF, Enemark EJ.

J Mol Biol. 2015 May 8;427(9):1779-1796. doi: 10.1016/j.jmb.2015.02.015. Epub 2015 Feb 25.


Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

Brown NG, Watson ER, Weissmann F, Jarvis MA, VanderLinden R, Grace CRR, Frye JJ, Qiao R, Dube P, Petzold G, Cho SE, Alsharif O, Bao J, Davidson IF, Zheng JJ, Nourse A, Kurinov I, Peters JM, Stark H, Schulman BA.

Mol Cell. 2014 Oct 23;56(2):246-260. doi: 10.1016/j.molcel.2014.09.009. Epub 2014 Oct 9.


Structural polymorphism in the N-terminal oligomerization domain of NPM1.

Mitrea DM, Grace CR, Buljan M, Yun MK, Pytel NJ, Satumba J, Nourse A, Park CG, Madan Babu M, White SW, Kriwacki RW.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4466-71. doi: 10.1073/pnas.1321007111. Epub 2014 Mar 10.


Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling.

Rana R, Carroll CE, Lee HJ, Bao J, Marada S, Grace CR, Guibao CD, Ogden SK, Zheng JJ.

Nat Commun. 2013;4:2965. doi: 10.1038/ncomms3965.


Metabolic activation of CaMKII by coenzyme A.

McCoy F, Darbandi R, Lee HC, Bharatham K, Moldoveanu T, Grace CR, Dodd K, Lin W, Chen SI, Tangallapally RP, Kurokawa M, Lee RE, Shelat AA, Chen T, Green DR, Harris RA, Lin SH, Fissore RA, Colbran RJ, Nutt LK.

Mol Cell. 2013 Nov 7;52(3):325-39. doi: 10.1016/j.molcel.2013.08.043. Epub 2013 Oct 3. Erratum in: Mol Cell. 2013 Nov 7;52(3):468.


Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.

Frye JJ, Brown NG, Petzold G, Watson ER, Grace CR, Nourse A, Jarvis MA, Kriwacki RW, Peters JM, Stark H, Schulman BA.

Nat Struct Mol Biol. 2013 Jul;20(7):827-35. doi: 10.1038/nsmb.2593. Epub 2013 May 26.


BID-induced structural changes in BAK promote apoptosis.

Moldoveanu T, Grace CR, Llambi F, Nourse A, Fitzgerald P, Gehring K, Kriwacki RW, Green DR.

Nat Struct Mol Biol. 2013 May;20(5):589-97. doi: 10.1038/nsmb.2563. Epub 2013 Apr 21.


PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.

Follis AV, Chipuk JE, Fisher JC, Yun MK, Grace CR, Nourse A, Baran K, Ou L, Min L, White SW, Green DR, Kriwacki RW.

Nat Chem Biol. 2013 Mar;9(3):163-8. doi: 10.1038/nchembio.1166. Epub 2013 Jan 20.


A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.

Calabrese MF, Scott DC, Duda DM, Grace CR, Kurinov I, Kriwacki RW, Schulman BA.

Nat Struct Mol Biol. 2011 Jul 17;18(8):947-9. doi: 10.1038/nsmb.2086.


The role of the LH subdomain in the function of the Cip/Kip cyclin-dependent kinase regulators.

Otieno S, Grace CR, Kriwacki RW.

Biophys J. 2011 May 18;100(10):2486-94. doi: 10.1016/j.bpj.2011.04.014.


NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist.

Grace CR, Perrin MH, Gulyas J, Rivier JE, Vale WW, Riek R.

J Biol Chem. 2010 Dec 3;285(49):38580-9. doi: 10.1074/jbc.M110.121897. Epub 2010 Sep 15.


A dual E3 mechanism for Rub1 ligation to Cdc53.

Scott DC, Monda JK, Grace CR, Duda DM, Kriwacki RW, Kurz T, Schulman BA.

Mol Cell. 2010 Sep 10;39(5):784-96. doi: 10.1016/j.molcel.2010.08.030.


Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance.

Grace CR, Cowsik SM.

Biopolymers. 2011;96(3):252-9. doi: 10.1002/bip.21519.


Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues.

Erchegyi J, Cescato R, Grace CR, Waser B, Piccand V, Hoyer D, Riek R, Rivier JE, Reubi JC.

J Med Chem. 2009 May 14;52(9):2733-46. doi: 10.1021/jm801314f.


Three-dimensional consensus structure of sst2-selective somatostatin (SRIF) antagonists by NMR.

Grace CR, Erchegyi J, Reubi JC, Rivier JE, Riek R.

Biopolymers. 2008 Dec;89(12):1077-87. doi: 10.1002/bip.21060.


Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity.

Erchegyi J, Grace CR, Samant M, Cescato R, Piccand V, Riek R, Reubi JC, Rivier JE.

J Med Chem. 2008 May 8;51(9):2668-75. doi: 10.1021/jm701444y. Epub 2008 Apr 12.


Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity.

Grace CR, Erchegyi J, Samant M, Cescato R, Piccand V, Riek R, Reubi JC, Rivier JE.

J Med Chem. 2008 May 8;51(9):2676-81. doi: 10.1021/jm701445q. Epub 2008 Apr 12.


Common and divergent structural features of a series of corticotropin releasing factor-related peptides.

Grace CR, Perrin MH, Cantle JP, Vale WW, Rivier JE, Riek R.

J Am Chem Soc. 2007 Dec 26;129(51):16102-14. Epub 2007 Dec 6.


Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled receptors.

Perrin MH, Grace CR, Digruccio MR, Fischer WH, Maji SK, Cantle JP, Smith S, Manning G, Vale WW, Riek R.

J Biol Chem. 2007 Dec 28;282(52):37529-36. Epub 2007 Oct 16.


Astressin-amide and astressin-acid are structurally different in dimethylsulfoxide.

Grace CR, Cervini L, Gulyas J, Rivier J, Riek R.

Biopolymers. 2007 Oct 5-15;87(2-3):196-205.


Unique helical conformation of the fourth cytoplasmic loop of the CB1 cannabinoid receptor in a negatively charged environment.

Grace CR, Cowsik SM, Shim JY, Welsh WJ, Howlett AC.

J Struct Biol. 2007 Sep;159(3):359-68. Epub 2007 Apr 20.


Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand.

Grace CR, Perrin MH, Gulyas J, Digruccio MR, Cantle JP, Rivier JE, Vale WW, Riek R.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4858-63. Epub 2007 Mar 12.


Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR.

Grace CR, Erchegyi J, Koerber SC, Reubi JC, Rivier J, Riek R.

J Med Chem. 2006 Jul 27;49(15):4487-96.


Fast multidimensional NMR spectroscopy by spin-state selective off-resonance decoupling (SITAR).

Keller R, Grace CR, Riek R.

Magn Reson Chem. 2006 Jul;44 Spec No:S196-205.


NMR techniques for very large proteins and rnas in solution.

Tzakos AG, Grace CR, Lukavsky PJ, Riek R.

Annu Rev Biophys Biomol Struct. 2006;35:319-42. Review.


Somatostatin receptor 1 selective analogues: 4. Three-dimensional consensus structure by NMR.

Grace CR, Durrer L, Koerber SC, Erchegyi J, Reubi JC, Rivier JE, Riek R.

J Med Chem. 2005 Jan 27;48(2):523-33.


NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor.

Grace CR, Perrin MH, DiGruccio MR, Miller CL, Rivier JE, Vale WW, Riek R.

Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12836-41. Epub 2004 Aug 23.


Pseudomultidimensional NMR by spin-state selective off-resonance decoupling.

Grace CR, Riek R.

J Am Chem Soc. 2003 Dec 24;125(51):16104-13.


Novel sst(4)-selective somatostatin (SRIF) agonists. 4. Three-dimensional consensus structure by NMR.

Grace CR, Koerber SC, Erchegyi J, Reubi JC, Rivier J, Riek R.

J Med Chem. 2003 Dec 18;46(26):5606-18.


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