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Items: 1 to 50 of 116

1.

Cysteine as a Monothiol Reducing Agent to Prevent Copper-Mediated Oxidation of Interferon Beta During PEGylation by CuAAC.

Nairn NW, Bariola PA, Graddis TJ, VanBrunt MP, Wang A, Li G, Grabstein K.

Bioconjug Chem. 2015 Oct 21;26(10):2070-5. doi: 10.1021/acs.bioconjchem.5b00320. Epub 2015 Oct 6.

PMID:
26439457
2.

Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.

Hook G, Jacobsen JS, Grabstein K, Kindy M, Hook V.

Front Neurol. 2015 Sep 2;6:178. doi: 10.3389/fneur.2015.00178. eCollection 2015. Review.

3.

Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody-Drug Conjugates Using Click Cycloaddition Chemistry.

VanBrunt MP, Shanebeck K, Caldwell Z, Johnson J, Thompson P, Martin T, Dong H, Li G, Xu H, D'Hooge F, Masterson L, Bariola P, Tiberghien A, Ezeadi E, Williams DG, Hartley JA, Howard PW, Grabstein KH, Bowen MA, Marelli M.

Bioconjug Chem. 2015 Nov 18;26(11):2249-60. doi: 10.1021/acs.bioconjchem.5b00359. Epub 2015 Sep 11.

PMID:
26332743
4.

AZ17: a new bispecific drug targeting IL-6 and IL-23 with potential clinical use--improves psoriasis in a human xenograft transplantation model.

Stenderup K, Rosada C, Shanebeck K, Brady W, Van Brunt MP, King G, Marelli M, Slagle P, Xu H, Nairn NW, Johnson J, Wang AA, Li G, Thornton KC, Dam TN, Grabstein KH.

Protein Eng Des Sel. 2015 Oct;28(10):467-80. doi: 10.1093/protein/gzv034. Epub 2015 Aug 12.

PMID:
26271488
5.

Development of copper-catalyzed azide-alkyne cycloaddition for increased in vivo efficacy of interferon β-1b by site-specific PEGylation.

Nairn NW, Shanebeck KD, Wang A, Graddis TJ, VanBrunt MP, Thornton KC, Grabstein K.

Bioconjug Chem. 2012 Oct 17;23(10):2087-97. doi: 10.1021/bc300295x. Epub 2012 Sep 28.

PMID:
22988919
6.

Processing of N-terminal unnatural amino acids in recombinant human interferon-beta in Escherichia coli.

Wang A, Winblade Nairn N, Johnson RS, Tirrell DA, Grabstein K.

Chembiochem. 2008 Jan 25;9(2):324-30.

PMID:
18098265
7.

Diversity of the CD8+ T-cell response to herpes simplex virus type 2 proteins among persons with genital herpes.

Hosken N, McGowan P, Meier A, Koelle DM, Sleath P, Wagener F, Elliott M, Grabstein K, Posavad C, Corey L.

J Virol. 2006 Jun;80(11):5509-15.

8.

Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects.

Sylwester AW, Mitchell BL, Edgar JB, Taormina C, Pelte C, Ruchti F, Sleath PR, Grabstein KH, Hosken NA, Kern F, Nelson JA, Picker LJ.

J Exp Med. 2005 Sep 5;202(5):673-85.

9.

Development of a CTL vaccine for Her-2/neu using peptide-microspheres and adjuvants.

Mossman SP, Evans LS, Fang H, Staas J, Tice T, Raychaudhuri S, Grabstein KH, Cheever MA, Johnson ME.

Vaccine. 2005 May 20;23(27):3545-54.

PMID:
15855013
10.

Differential regulation of inflammatory cytokine secretion by human dendritic cells upon Chlamydia trachomatis infection.

Gervassi A, Alderson MR, Suchland R, Maisonneuve JF, Grabstein KH, Probst P.

Infect Immun. 2004 Dec;72(12):7231-9.

11.

Human CD8+ T cells recognize the 60-kDa cysteine-rich outer membrane protein from Chlamydia trachomatis.

Gervassi AL, Grabstein KH, Probst P, Hess B, Alderson MR, Fling SP.

J Immunol. 2004 Dec 1;173(11):6905-13.

12.

Functional characterization of class Ia- and non-class Ia-restricted Chlamydia-reactive CD8+ T cell responses in humans.

Gervassi AL, Probst P, Stamm WE, Marrazzo J, Grabstein KH, Alderson MR.

J Immunol. 2003 Oct 15;171(8):4278-86.

13.

HER2 dendritic cell vaccines.

Morse MA, Clay TM, Colling K, Hobeika A, Grabstein K, Cheever MA, Lyerly HK.

Clin Breast Cancer. 2003 Feb;3 Suppl 4:S164-72.

PMID:
12620155
14.

Induction of antigen-specific CTL responses using antigens conjugated to short peptide vectors.

Day FH, Zhang Y, Clair P, Grabstein KH, Mazel M, Rees AR, Kaczorek M, Temsamani J.

J Immunol. 2003 Feb 1;170(3):1498-503.

15.

Toxicity, immunogenicity, and induction of E75-specific tumor-lytic CTLs by HER-2 peptide E75 (369-377) combined with granulocyte macrophage colony-stimulating factor in HLA-A2+ patients with metastatic breast and ovarian cancer.

Murray JL, Gillogly ME, Przepiorka D, Brewer H, Ibrahim NK, Booser DJ, Hortobagyi GN, Kudelka AP, Grabstein KH, Cheever MA, Ioannides CG.

Clin Cancer Res. 2002 Nov;8(11):3407-18.

16.

Potent stimulation of the innate immune system by a Leishmania brasiliensis recombinant protein.

Borges MM, Campos-Neto A, Sleath P, Grabstein KH, Morrissey PJ, Skeiky YA, Reed SG.

Infect Immun. 2001 Sep;69(9):5270-7.

17.

Vaccination with Her-2/neu DNA or protein subunits protects against growth of a Her-2/neu-expressing murine tumor.

Foy TM, Bannink J, Sutherland RA, McNeill PD, Moulton GG, Smith J, Cheever MA, Grabstein K.

Vaccine. 2001 Mar 21;19(17-19):2598-606.

PMID:
11257398
18.

Classically restricted human CD8+ T lymphocytes derived from Mycobacterium tuberculosis-infected cells: definition of antigenic specificity.

Lewinsohn DM, Zhu L, Madison VJ, Dillon DC, Fling SP, Reed SG, Grabstein KH, Alderson MR.

J Immunol. 2001 Jan 1;166(1):439-46.

19.

Molecular cloning and biological characterization of a novel murine lymphoid growth factor.

Sims JE, Williams DE, Morrissey PJ, Garka K, Foxworthe D, Price V, Friend SL, Farr A, Bedell MA, Jenkins NA, Copeland NG, Grabstein K, Paxton RJ.

J Exp Med. 2000 Sep 4;192(5):671-80.

20.

Mycobacterium tuberculosis-reactive CD8+ T lymphocytes: the relative contribution of classical versus nonclassical HLA restriction.

Lewinsohn DM, Briden AL, Reed SG, Grabstein KH, Alderson MR.

J Immunol. 2000 Jul 15;165(2):925-30.

21.
22.

Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB.

Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T.

Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6879-84.

23.

LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile.

Skeiky YA, Kennedy M, Kaufman D, Borges MM, Guderian JA, Scholler JK, Ovendale PJ, Picha KS, Morrissey PJ, Grabstein KH, Campos-Neto A, Reed SG.

J Immunol. 1998 Dec 1;161(11):6171-9.

24.

Proliferative and cytokine responses to class II HER-2/neu-associated peptides in breast cancer patients.

Tuttle TM, Anderson BW, Thompson WE, Lee JE, Sahin A, Smith TL, Grabstein KH, Wharton JT, Ioannides CG, Murray JL.

Clin Cancer Res. 1998 Aug;4(8):2015-24.

25.

Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells.

Lewinsohn DM, Alderson MR, Briden AL, Riddell SR, Reed SG, Grabstein KH.

J Exp Med. 1998 May 18;187(10):1633-40.

26.

Human purified protein derivative-specific CD4+ T cells use both CD95-dependent and CD95-independent cytolytic mechanisms.

Lewinsohn DM, Bement TT, Xu J, Lynch DH, Grabstein KH, Reed SG, Alderson MR.

J Immunol. 1998 Mar 1;160(5):2374-9.

27.
28.

A functional B cell receptor transgene allows efficient IL-7-independent maturation of B cell precursors.

Melamed D, Kench JA, Grabstein K, Rolink A, Nemazee D.

J Immunol. 1997 Aug 1;159(3):1233-9.

PMID:
9233618
29.

The role of the CD28/B7 interaction in the regulation of NK cell responses during infection with Toxoplasma gondii.

Hunter CA, Ellis-Neyer L, Gabriel KE, Kennedy MK, Grabstein KH, Linsley PS, Remington JS.

J Immunol. 1997 Mar 1;158(5):2285-93.

PMID:
9036976
30.

Structure-function studies of interleukin 15 using site-specific mutagenesis, polyethylene glycol conjugation, and homology modeling.

Pettit DK, Bonnert TP, Eisenman J, Srinivasan S, Paxton R, Beers C, Lynch D, Miller B, Yost J, Grabstein KH, Gombotz WR.

J Biol Chem. 1997 Jan 24;272(4):2312-8.

31.

In vitro immunologic and virologic effects of interleukin 15 on peripheral blood mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients.

Lucey DR, Pinto LA, Bethke FR, Rusnak J, Melcher GP, Hashemi FN, Landay AL, Kessler HA, Paxton RJ, Grabstein K, Shearer GM.

Clin Diagn Lab Immunol. 1997 Jan;4(1):43-8.

32.

Differential expression of CD22 (Lyb8) on murine B cells.

Erickson LD, Tygrett LT, Bhatia SK, Grabstein KH, Waldschmidt TJ.

Int Immunol. 1996 Jul;8(7):1121-9.

33.

CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages.

Kennedy MK, Picha KS, Fanslow WC, Grabstein KH, Alderson MR, Clifford KN, Chin WA, Mohler KM.

Eur J Immunol. 1996 Feb;26(2):370-8.

PMID:
8617306
34.

IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection.

Nishimura H, Hiromatsu K, Kobayashi N, Grabstein KH, Paxton R, Sugamura K, Bluestone JA, Yoshikai Y.

J Immunol. 1996 Jan 15;156(2):663-9.

PMID:
8543818
35.

Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro.

Carson WE, Ross ME, Baiocchi RA, Marien MJ, Boiani N, Grabstein K, Caligiuri MA.

J Clin Invest. 1995 Dec;96(6):2578-82.

36.

Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2.

Munger W, DeJoy SQ, Jeyaseelan R Sr, Torley LW, Grabstein KH, Eisenmann J, Paxton R, Cox T, Wick MM, Kerwar SS.

Cell Immunol. 1995 Oct 15;165(2):289-93.

PMID:
7553894
37.
38.

Regulation of murine B cell growth and differentiation by CD30 ligand.

Shanebeck KD, Maliszewski CR, Kennedy MK, Picha KS, Smith CA, Goodwin RG, Grabstein KH.

Eur J Immunol. 1995 Aug;25(8):2147-53.

PMID:
7664777
39.

Interleukin-15: a novel anabolic cytokine for skeletal muscle.

Quinn LS, Haugk KL, Grabstein KH.

Endocrinology. 1995 Aug;136(8):3669-72.

PMID:
7628408
40.

Activation of B lymphocyte maturation by a human follicular dendritic cell line, FDC-1.

Clark EA, Grabstein KH, Gown AM, Skelly M, Kaisho T, Hirano T, Shu GL.

J Immunol. 1995 Jul 15;155(2):545-55.

PMID:
7608535
41.

IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2.

Giri JG, Anderson DM, Kumaki S, Park LS, Grabstein KH, Cosman D.

J Leukoc Biol. 1995 May;57(5):763-6. Review.

PMID:
7759955
42.

IL-12 enhances Th1-type responses in human Leishmania donovani infections.

Ghalib HW, Whittle JA, Kubin M, Hashim FA, el-Hassan AM, Grabstein KH, Trinchieri G, Reed SG.

J Immunol. 1995 May 1;154(9):4623-9.

PMID:
7722314
43.

The effect of in vivo IL-7 deprivation on T cell maturation.

Bhatia SK, Tygrett LT, Grabstein KH, Waldschmidt TJ.

J Exp Med. 1995 Apr 1;181(4):1399-409.

44.

IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation.

Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH.

J Immunol. 1995 Jan 15;154(2):483-90.

PMID:
7814861
45.

Interleukin 15 and its receptor.

Cosman D, Kumaki S, Ahdieh M, Eisenman J, Grabstein KH, Paxton R, DuBose R, Friend D, Park LS, Anderson D, et al.

Ciba Found Symp. 1995;195:221-9; discussion 229-33. Review.

PMID:
8724840
46.

Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15.

Matthews DJ, Clark PA, Herbert J, Morgan G, Armitage RJ, Kinnon C, Minty A, Grabstein KH, Caput D, Ferrara P, et al.

Blood. 1995 Jan 1;85(1):38-42.

PMID:
7803808
47.

Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses.

Giri JG, Wells J, Dower SK, McCall CE, Guzman RN, Slack J, Bird TA, Shanebeck K, Grabstein KH, Sims JE, et al.

J Immunol. 1994 Dec 15;153(12):5802-9.

PMID:
7989776
48.

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

Peschon JJ, Morrissey PJ, Grabstein KH, Ramsdell FJ, Maraskovsky E, Gliniak BC, Park LS, Ziegler SF, Williams DE, Ware CB, Meyer JD, Davison BL.

J Exp Med. 1994 Nov 1;180(5):1955-60.

49.

IL-10 mediates susceptibility to Trypanosoma cruzi infection.

Reed SG, Brownell CE, Russo DM, Silva JS, Grabstein KH, Morrissey PJ.

J Immunol. 1994 Oct 1;153(7):3135-40.

PMID:
8089491
50.

Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones.

Kennedy MK, Picha KS, Shanebeck KD, Anderson DM, Grabstein KH.

Eur J Immunol. 1994 Oct;24(10):2271-8.

PMID:
7925555

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