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Items: 25


A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier.

Hart EM, Mitchell AM, Konovalova A, Grabowicz M, Sheng J, Han X, Rodriguez-Rivera FP, Schwaid AG, Malinverni JC, Balibar CJ, Bodea S, Si Q, Wang H, Homsher MF, Painter RE, Ogawa AK, Sutterlin H, Roemer T, Black TA, Rothman DM, Walker SS, Silhavy TJ.

Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 201912345. doi: 10.1073/pnas.1912345116. [Epub ahead of print]


Countering Gram-Negative Antibiotic Resistance: Recent Progress in Disrupting the Outer Membrane with Novel Therapeutics.

Lehman KM, Grabowicz M.

Antibiotics (Basel). 2019 Sep 24;8(4). pii: E163. doi: 10.3390/antibiotics8040163. Review.


A Stress Response Monitoring Lipoprotein Trafficking to the Outer Membrane.

May KL, Lehman KM, Mitchell AM, Grabowicz M.

MBio. 2019 May 28;10(3). pii: e00618-19. doi: 10.1128/mBio.00618-19.


Lipoproteins and Their Trafficking to the Outer Membrane.

Grabowicz M.

EcoSal Plus. 2019 Mar;8(2). doi: 10.1128/ecosalplus.ESP-0038-2018. Review.


Fine-Tuning of σE Activation Suppresses Multiple Assembly-Defective Mutations in Escherichia coli.

Hart EM, O'Connell A, Tang K, Wzorek JS, Grabowicz M, Kahne D, Silhavy TJ.

J Bacteriol. 2019 May 8;201(11). pii: e00745-18. doi: 10.1128/JB.00745-18. Print 2019 Jun 1.


Assessment of the Impact of Kinesiology Taping Application Versus Placebo Taping on the Knee Joint Position Sense. Preliminary Report.

Hadamus A, Grabowicz M, Wąsowski P, Mosiołek A, Boguszewski D, Białoszewski D.

Ortop Traumatol Rehabil. 2018 Apr 30;20(2):139-148. doi: 10.5604/01.3001.0012.0425.


The bacterial outer membrane is an evolving antibiotic barrier.

May KL, Grabowicz M.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8852-8854. doi: 10.1073/pnas.1812779115. Epub 2018 Aug 23. No abstract available.


Inhibitor of intramembrane protease RseP blocks the σE response causing lethal accumulation of unfolded outer membrane proteins.

Konovalova A, Grabowicz M, Balibar CJ, Malinverni JC, Painter RE, Riley D, Mann PA, Wang H, Garlisi CG, Sherborne B, Rigel NW, Ricci DP, Black TA, Roemer T, Silhavy TJ, Walker SS.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6614-E6621. doi: 10.1073/pnas.1806107115. Epub 2018 Jun 25.


Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion.

Lee J, Sutterlin HA, Wzorek JS, Mandler MD, Hagan CL, Grabowicz M, Tomasek D, May MD, Hart EM, Silhavy TJ, Kahne D.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2359-2364. doi: 10.1073/pnas.1711727115. Epub 2018 Feb 20.


Redefining the essential trafficking pathway for outer membrane lipoproteins.

Grabowicz M, Silhavy TJ.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4769-4774. doi: 10.1073/pnas.1702248114. Epub 2017 Apr 17.


Envelope Stress Responses: An Interconnected Safety Net.

Grabowicz M, Silhavy TJ.

Trends Biochem Sci. 2017 Mar;42(3):232-242. doi: 10.1016/j.tibs.2016.10.002. Epub 2016 Nov 8. Review.


Characterization of a stalled complex on the β-barrel assembly machine.

Lee J, Xue M, Wzorek JS, Wu T, Grabowicz M, Gronenberg LS, Sutterlin HA, Davis RM, Ruiz N, Silhavy TJ, Kahne DE.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8717-22. doi: 10.1073/pnas.1604100113. Epub 2016 Jul 20.


The CpxQ sRNA Negatively Regulates Skp To Prevent Mistargeting of β-Barrel Outer Membrane Proteins into the Cytoplasmic Membrane.

Grabowicz M, Koren D, Silhavy TJ.

MBio. 2016 Apr 5;7(2):e00312-16. doi: 10.1128/mBio.00312-16.


Mutant Alleles of lptD Increase the Permeability of Pseudomonas aeruginosa and Define Determinants of Intrinsic Resistance to Antibiotics.

Balibar CJ, Grabowicz M.

Antimicrob Agents Chemother. 2015 Nov 23;60(2):845-54. doi: 10.1128/AAC.01747-15. Print 2016 Feb.


A small conserved motif supports polarity augmentation of Shigella flexneri IcsA.

Doyle MT, Grabowicz M, Morona R.

Microbiology. 2015 Nov;161(11):2087-97. doi: 10.1099/mic.0.000165. Epub 2015 Aug 26.


Lipopolysaccharide surface structure does not influence IcsA polarity.

Doyle MT, Grabowicz M, May KL, Morona R.

FEMS Microbiol Lett. 2015 Apr;362(8):fnv042. doi: 10.1093/femsle/fnv042. Epub 2015 Mar 15.


A mutant Escherichia coli that attaches peptidoglycan to lipopolysaccharide and displays cell wall on its surface.

Grabowicz M, Andres D, Lebar MD, Malojčić G, Kahne D, Silhavy TJ.

Elife. 2014 Dec 31;3:e05334. doi: 10.7554/eLife.05334.


LptE binds to and alters the physical state of LPS to catalyze its assembly at the cell surface.

Malojčić G, Andres D, Grabowicz M, George AH, Ruiz N, Silhavy TJ, Kahne D.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9467-72. doi: 10.1073/pnas.1402746111. Epub 2014 Jun 17.


Effect of corn silage and quantitative feed restriction on growth performance, body measurements, and carcass tissue composition in White Kołuda W31 geese.

Kokoszyński D, Bernacki Z, Grabowicz M, Stańczak K.

Poult Sci. 2014 Aug;93(8):1993-9. doi: 10.3382/ps.2013-03833. Epub 2014 Jun 3.


Dominant negative lptE mutation that supports a role for LptE as a plug in the LptD barrel.

Grabowicz M, Yeh J, Silhavy TJ.

J Bacteriol. 2013 Mar;195(6):1327-34. doi: 10.1128/JB.02142-12. Epub 2013 Jan 11.


Self-association of the Shigella flexneri IcsA autotransporter protein.

May KL, Grabowicz M, Polyak SW, Morona R.

Microbiology. 2012 Jul;158(Pt 7):1874-83. doi: 10.1099/mic.0.056465-0. Epub 2012 Apr 19.


Expression of selected tumor suppressor and oncogenes in endometrium of women with endometriosis.

Laudanski P, Szamatowicz J, Kowalczuk O, Kuźmicki M, Grabowicz M, Chyczewski L.

Hum Reprod. 2009 Aug;24(8):1880-90. doi: 10.1093/humrep/dep175. Epub 2009 May 8.


Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H.

Ogunniyi AD, Grabowicz M, Mahdi LK, Cook J, Gordon DL, Sadlon TA, Paton JC.

FASEB J. 2009 Mar;23(3):731-8. doi: 10.1096/fj.08-119537. Epub 2008 Oct 29.


Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae.

Ogunniyi AD, Grabowicz M, Briles DE, Cook J, Paton JC.

Infect Immun. 2007 Jan;75(1):350-7. Epub 2006 Nov 6.

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