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Items: 50


Development of Novel Promiscuous Anti-Chemokine Peptibodies for Treating Autoimmunity and Inflammation.

Abraham M, Wald H, Vaizel-Ohayon D, Grabovsky V, Oren Z, Karni A, Weiss L, Galun E, Peled A, Eizenberg O.

Front Immunol. 2017 Nov 23;8:1432. doi: 10.3389/fimmu.2017.01432. eCollection 2017.


CD151 Regulates T-Cell Migration in Health and Inflammatory Bowel Disease.

Zelman-Toister E, Bakos E, Cohen S, Zigmond E, Shezen E, Grabovsky V, Sagiv A, Hart G, Kaushansky N, Ben-Nun A, Maharshak N, Sonnenberg A, Alon R, Becker-Herman S, Shachar I.

Inflamm Bowel Dis. 2016 Feb;22(2):257-67. doi: 10.1097/MIB.0000000000000621.


Loss of kindlin-3 alters the threshold for NK cell activation in human leukocyte adhesion deficiency-III.

Gruda R, Brown AC, Grabovsky V, Mizrahi S, Gur C, Feigelson SW, Achdout H, Bar-On Y, Alon R, Aker M, Davis DM, Mandelboim O.

Blood. 2012 Nov 8;120(19):3915-24. doi: 10.1182/blood-2012-02-410795. Epub 2012 Sep 14.


Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots.

Shulman Z, Cohen SJ, Roediger B, Kalchenko V, Jain R, Grabovsky V, Klein E, Shinder V, Stoler-Barak L, Feigelson SW, Meshel T, Nurmi SM, Goldstein I, Hartley O, Gahmberg CG, Etzioni A, Weninger W, Ben-Baruch A, Alon R.

Nat Immunol. 2011 Dec 4;13(1):67-76. doi: 10.1038/ni.2173.


Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells.

Feigelson SW, Grabovsky V, Manevich-Mendelson E, Pasvolsky R, Shulman Z, Shinder V, Klein E, Etzioni A, Aker M, Alon R.

Blood. 2011 Jun 30;117(26):7042-52. doi: 10.1182/blood-2010-12-322859. Epub 2011 May 2.


Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state.

Feigelson SW, Pasvolsky R, Cemerski S, Shulman Z, Grabovsky V, Ilani T, Sagiv A, Lemaitre F, Laudanna C, Shaw AS, Alon R.

J Immunol. 2010 Dec 15;185(12):7394-404. doi: 10.4049/jimmunol.1002246. Epub 2010 Nov 15.


Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen.

Manevich-Mendelson E, Grabovsky V, Feigelson SW, Cinamon G, Gore Y, Goverse G, Monkley SJ, Margalit R, Melamed D, Mebius RE, Critchley DR, Shachar I, Alon R.

Blood. 2010 Dec 23;116(26):5907-18. doi: 10.1182/blood-2010-06-293506. Epub 2010 Oct 5.


TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner.

Binsky I, Lantner F, Grabovsky V, Harpaz N, Shvidel L, Berrebi A, Goldenberg DM, Leng L, Bucala R, Alon R, Haran M, Shachar I.

J Immunol. 2010 May 1;184(9):4761-9. doi: 10.4049/jimmunol.0904149. Epub 2010 Mar 31.


Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions.

Manevich-Mendelson E, Feigelson SW, Pasvolsky R, Aker M, Grabovsky V, Shulman Z, Kilic SS, Rosenthal-Allieri MA, Ben-Dor S, Mory A, Bernard A, Moser M, Etzioni A, Alon R.

Blood. 2009 Sep 10;114(11):2344-53. doi: 10.1182/blood-2009-04-218636. Epub 2009 Jul 17.


Beta-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation.

Molteni R, Crespo CL, Feigelson S, Moser C, Fabbri M, Grabovsky V, Krombach F, Laudanna C, Alon R, Pardi R.

Blood. 2009 Jul 30;114(5):1073-82. doi: 10.1182/blood-2008-10-183699. Epub 2009 May 8.


Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow.

Hartmann TN, Grabovsky V, Wang W, Desch P, Rubenzer G, Wollner S, Binsky I, Vallon-Eberhard A, Sapoznikov A, Burger M, Shachar I, Haran M, Honczarenko M, Greil R, Alon R.

Cancer Res. 2009 Apr 1;69(7):3121-30. doi: 10.1158/0008-5472.CAN-08-4136. Epub 2009 Mar 17.


Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin.

Shulman Z, Shinder V, Klein E, Grabovsky V, Yeger O, Geron E, Montresor A, Bolomini-Vittori M, Feigelson SW, Kirchhausen T, Laudanna C, Shakhar G, Alon R.

Immunity. 2009 Mar 20;30(3):384-96. doi: 10.1016/j.immuni.2008.12.020. Epub 2009 Mar 5.


Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions.

Flaishon L, Hart G, Zelman E, Moussion C, Grabovsky V, Lapidot Tal G, Feigelson S, Margalit R, Harmelin A, Avin-Wittenberg T, Shoseyov D, Alon R, Girard JP, Shachar I.

Blood. 2008 Dec 15;112(13):5016-25. doi: 10.1182/blood-2007-12-129122. Epub 2008 Sep 18.


A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells.

Hartmann TN, Grabovsky V, Pasvolsky R, Shulman Z, Buss EC, Spiegel A, Nagler A, Lapidot T, Thelen M, Alon R.

J Leukoc Biol. 2008 Oct;84(4):1130-40. doi: 10.1189/jlb.0208088. Epub 2008 Jul 24.


RhoA is involved in LFA-1 extension triggered by CXCL12 but not in a novel outside-in LFA-1 activation facilitated by CXCL9.

Pasvolsky R, Grabovsky V, Giagulli C, Shulman Z, Shamri R, Feigelson SW, Laudanna C, Alon R.

J Immunol. 2008 Mar 1;180(5):2815-23.


Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces.

Woolf E, Grigorova I, Sagiv A, Grabovsky V, Feigelson SW, Shulman Z, Hartmann T, Sixt M, Cyster JG, Alon R.

Nat Immunol. 2007 Oct;8(10):1076-85. Epub 2007 Aug 26.


Membranal cholesterol is not required for L-selectin adhesiveness in primary lymphocytes but controls a chemokine-induced destabilization of L-selectin rolling adhesions.

Dwir O, Grabovsky V, Pasvolsky R, Manevich E, Shamri R, Gutwein P, Feigelson SW, Altevogt P, Alon R.

J Immunol. 2007 Jul 15;179(2):1030-8.


Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1.

Manevich E, Grabovsky V, Feigelson SW, Alon R.

J Biol Chem. 2007 Aug 31;282(35):25338-48. Epub 2007 Jun 27.


A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets.

Pasvolsky R, Feigelson SW, Kilic SS, Simon AJ, Tal-Lapidot G, Grabovsky V, Crittenden JR, Amariglio N, Safran M, Graybiel AM, Rechavi G, Ben-Dor S, Etzioni A, Alon R.

J Exp Med. 2007 Jul 9;204(7):1571-82. Epub 2007 Jun 18.


Information about a form (on the dynamic laws of morphogenesis).

Beloussov LV, Grabovsky VI.

Biosystems. 2007 Feb;87(2-3):204-14. Epub 2006 Sep 9.


DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration.

Shulman Z, Pasvolsky R, Woolf E, Grabovsky V, Feigelson SW, Erez N, Fukui Y, Alon R.

Blood. 2006 Oct 1;108(7):2150-8. Epub 2006 Jun 13.


Morphomechanics: goals, basic experiments and models.

Beloussov LV, Grabovsky VI.

Int J Dev Biol. 2006;50(2-3):81-92. Review.


A common biomechanical model for the formation of stationary cell domains and propagating waves in the developing organisms.

Beloussov LV, Grabovsky VI.

Comput Methods Biomech Biomed Engin. 2005 Dec;8(6):381-91.


Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11.

Dagan-Berger M, Feniger-Barish R, Avniel S, Wald H, Galun E, Grabovsky V, Alon R, Nagler A, Ben-Baruch A, Peled A.

Blood. 2006 May 15;107(10):3821-31. Epub 2005 Dec 20.


Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain.

Alon R, Feigelson SW, Manevich E, Rose DM, Schmitz J, Overby DR, Winter E, Grabovsky V, Shinder V, Matthews BD, Sokolovsky-Eisenberg M, Ingber DE, Benoit M, Ginsberg MH.

J Cell Biol. 2005 Dec 19;171(6):1073-84.


Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines.

Shamri R, Grabovsky V, Gauguet JM, Feigelson S, Manevich E, Kolanus W, Robinson MK, Staunton DE, von Andrian UH, Alon R.

Nat Immunol. 2005 May;6(5):497-506. Epub 2005 Apr 17.


Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cells.

Franitza S, Grabovsky V, Wald O, Weiss I, Beider K, Dagan M, Darash-Yahana M, Nagler A, Brocke S, Galun E, Alon R, Peled A.

Eur J Immunol. 2004 May;34(5):1333-41.


Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts.

Sotnikov I, Hershkoviz R, Grabovsky V, Ilan N, Cahalon L, Vlodavsky I, Alon R, Lider O.

J Immunol. 2004 May 1;172(9):5185-93.


Formative capacities of mechanically stressed networks: developmental and evolutionary implications.

Beloussov LV, Grabovsky VI.

Riv Biol. 2003 Sep-Dec;96(3):385-98.


Selectin avidity modulation by chemokines at subsecond endothelial contacts: a novel regulatory level of leukocyte trafficking.

Dwir O, Grabovsky V, Alon R.

Ernst Schering Res Found Workshop. 2004;(44):109-35. Review. No abstract available.


LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds.

Kinashi T, Aker M, Sokolovsky-Eisenberg M, Grabovsky V, Tanaka C, Shamri R, Feigelson S, Etzioni A, Alon R.

Blood. 2004 Feb 1;103(3):1033-6. Epub 2003 Oct 9.


The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow.

Feigelson SW, Grabovsky V, Shamri R, Levy S, Alon R.

J Biol Chem. 2003 Dec 19;278(51):51203-12. Epub 2003 Oct 7.


A Geometro-mechanical model for pulsatile morphogenesis.

Beloussov LV, Grabovsky VI.

Comput Methods Biomech Biomed Engin. 2003 Feb;6(1):53-63.


A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow.

Alon R, Aker M, Feigelson S, Sokolovsky-Eisenberg M, Staunton DE, Cinamon G, Grabovsky V, Shamri R, Etzioni A.

Blood. 2003 Jun 1;101(11):4437-45. Epub 2003 Feb 20.


Endothelial chemokines destabilize L-selectin-mediated lymphocyte rolling without inducing selectin shedding.

Grabovsky V, Dwir O, Alon R.

J Biol Chem. 2002 Jun 7;277(23):20640-50. Epub 2002 Mar 21.


Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1.

Peled A, Hardan I, Trakhtenbrot L, Gur E, Magid M, Darash-Yahana M, Cohen N, Grabovsky V, Franitza S, Kollet O, Lider O, Alon R, Rechavi G, Lapidot T.

Stem Cells. 2002;20(3):259-66.


The affinity of integrin alpha(4)beta(1) governs lymphocyte migration.

Rose DM, Grabovsky V, Alon R, Ginsberg MH.

J Immunol. 2001 Sep 1;167(5):2824-30.


Novel chemokine functions in lymphocyte migration through vascular endothelium under shear flow.

Cinamon G, Grabovsky V, Winter E, Franitza S, Feigelson S, Shamri R, Dwir O, Alon R.

J Leukoc Biol. 2001 Jun;69(6):860-6. Review.


DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking.

Geijtenbeek TB, Krooshoop DJ, Bleijs DA, van Vliet SJ, van Duijnhoven GC, Grabovsky V, Alon R, Figdor CG, van Kooyk Y.

Nat Immunol. 2000 Oct;1(4):353-7.


The Src kinase p56(lck) up-regulates VLA-4 integrin affinity. Implications for rapid spontaneous and chemokine-triggered T cell adhesion to VCAM-1 and fibronectin.

Feigelson SW, Grabovsky V, Winter E, Chen LL, Pepinsky RB, Yednock T, Yablonski D, Lobb R, Alon R.

J Biol Chem. 2001 Apr 27;276(17):13891-901. Epub 2000 Dec 1.


Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions.

Grabovsky V, Feigelson S, Chen C, Bleijs DA, Peled A, Cinamon G, Baleux F, Arenzana-Seisdedos F, Lapidot T, van Kooyk Y, Lobb RR, Alon R.

J Exp Med. 2000 Aug 21;192(4):495-506.


The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment.

Sigal A, Bleijs DA, Grabovsky V, van Vliet SJ, Dwir O, Figdor CG, van Kooyk Y, Alon R.

J Immunol. 2000 Jul 1;165(1):442-52.


The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice.

Peled A, Kollet O, Ponomaryov T, Petit I, Franitza S, Grabovsky V, Slav MM, Nagler A, Lider O, Alon R, Zipori D, Lapidot T.

Blood. 2000 Jun 1;95(11):3289-96.


The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow.

Peled A, Grabovsky V, Habler L, Sandbank J, Arenzana-Seisdedos F, Petit I, Ben-Hur H, Lapidot T, Alon R.

J Clin Invest. 1999 Nov;104(9):1199-211.


High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow.

Chen C, Mobley JL, Dwir O, Shimron F, Grabovsky V, Lobb RR, Shimizu Y, Alon R.

J Immunol. 1999 Jan 15;162(2):1084-95.

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