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Best matches for Graña X[au]:

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. Zhang H et al. Cell. (2018)

PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues. Kurimchak A et al. Cell Cycle. (2015)

Monographs editor. Graña X et al. Genes Cancer. (2012)

Search results

Items: 1 to 50 of 62

1.

Invadopodia-mediated ECM degradation is enhanced in the G1 phase of the cell cycle.

Bayarmagnai B, Perrin L, Esmaeili Pourfarhangi K, Graña X, Tüzel E, Gligorijevic B.

J Cell Sci. 2019 Oct 18;132(20). pii: jcs227116. doi: 10.1242/jcs.227116.

PMID:
31533971
2.

PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer.

Fowle H, Zhao Z, Graña X.

Adv Cancer Res. 2019;144:55-93. doi: 10.1016/bs.acr.2019.03.009. Epub 2019 Apr 12.

PMID:
31349904
3.

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer.

Zhang H, Pandey S, Travers M, Sun H, Morton G, Madzo J, Chung W, Khowsathit J, Perez-Leal O, Barrero CA, Merali C, Okamoto Y, Sato T, Pan J, Garriga J, Bhanu NV, Simithy J, Patel B, Huang J, Raynal NJ, Garcia BA, Jacobson MA, Kadoch C, Merali S, Zhang Y, Childers W, Abou-Gharbia M, Karanicolas J, Baylin SB, Zahnow CA, Jelinek J, Graña X, Issa JJ.

Cell. 2018 Nov 15;175(5):1244-1258.e26. doi: 10.1016/j.cell.2018.09.051. Epub 2018 Oct 25.

PMID:
30454645
4.

PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.

Kurimchak A, Graña X.

Cell Cycle. 2015;14(1):18-30. doi: 10.4161/15384101.2014.985069. Review.

5.

CDK9 inhibition strategy defines distinct sets of target genes.

Garriga J, Graña X.

BMC Res Notes. 2014 May 16;7:301. doi: 10.1186/1756-0500-7-301.

6.

CTIP2 is a negative regulator of P-TEFb.

Cherrier T, Le Douce V, Eilebrecht S, Riclet R, Marban C, Dequiedt F, Goumon Y, Paillart JC, Mericskay M, Parlakian A, Bausero P, Abbas W, Herbein G, Kurdistani SK, Grana X, Van Driessche B, Schwartz C, Candolfi E, Benecke AG, Van Lint C, Rohr O.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12655-60. doi: 10.1073/pnas.1220136110. Epub 2013 Jul 12.

7.

Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme.

Kurimchak A, Haines DS, Garriga J, Wu S, De Luca F, Sweredoski MJ, Deshaies RJ, Hess S, Graña X.

Mol Cell Biol. 2013 Aug;33(16):3330-42. doi: 10.1128/MCB.00082-13. Epub 2013 Jun 17.

8.
9.

Monographs editor.

Graña X.

Genes Cancer. 2012 Nov;3(11-12):611. doi: 10.1177/1947601912473480. No abstract available.

10.

Complex effects of flavopiridol on the expression of primary response genes.

Keskin H, Garriga J, Georlette D, Graña X.

Cell Div. 2012 Mar 29;7:11. doi: 10.1186/1747-1028-7-11.

11.

PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substrates.

Kurimchak A, Graña X.

Gene. 2012 May 10;499(1):1-7. doi: 10.1016/j.gene.2012.02.015. Epub 2012 Feb 22. Review.

PMID:
22387205
12.

B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation.

Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis AJ, Haines DS, Mumby M, Graña X.

J Biol Chem. 2010 Sep 24;285(39):29863-73. doi: 10.1074/jbc.M110.162354. Epub 2010 Jul 27.

13.

Requirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C Mutation.

Reddy HK, Graña X, Dhanasekaran DN, Litvin J, Reddy EP.

Genes Cancer. 2010 Jan;1(1):69-80. doi: 10.1177/1947601909358105.

14.

Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.

Rivadeneira DB, Mayhew CN, Thangavel C, Sotillo E, Reed CA, Graña X, Knudsen ES.

Gastroenterology. 2010 May;138(5):1920-30. doi: 10.1053/j.gastro.2010.01.007. Epub 2010 Jan 25.

15.

Selective control of gene expression by CDK9 in human cells.

Garriga J, Xie H, Obradovic Z, Graña X.

J Cell Physiol. 2010 Jan;222(1):200-8. doi: 10.1002/jcp.21938.

16.

Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E.

Sotillo E, Garriga J, Padgaonkar A, Kurimchak A, Cook JG, Graña X.

J Biol Chem. 2009 May 22;284(21):14126-35. doi: 10.1074/jbc.M900687200. Epub 2009 Mar 25.

17.
18.

Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts.

Sotillo E, Garriga J, Kurimchak A, Graña X.

J Biol Chem. 2008 Apr 25;283(17):11280-92. doi: 10.1074/jbc.M709055200. Epub 2008 Feb 14.

19.

Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes.

Salerno D, Hasham MG, Marshall R, Garriga J, Tsygankov AY, Graña X.

Gene. 2007 Dec 15;405(1-2):65-78. Epub 2007 Sep 19.

21.

Mechanisms controlling CDK9 activity.

Marshall RM, Grana X.

Front Biosci. 2006 Sep 1;11:2598-613. Review.

PMID:
16720337
22.

Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis.

Reddy HK, Mettus RV, Rane SG, Graña X, Litvin J, Reddy EP.

Cancer Res. 2005 Nov 15;65(22):10174-8.

23.
24.

A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130.

Garriga J, Jayaraman AL, Limón A, Jayadeva G, Sotillo E, Truongcao M, Patsialou A, Wadzinski BE, Graña X.

Cell Cycle. 2004 Oct;3(10):1320-30. Epub 2004 Oct 15. Erratum in: Cell Cycle. 2005 Mar;4(3):e45.

PMID:
15467457
25.

The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity.

Calbó J, Serna C, Garriga J, Graña X, Mazo A.

Cell Death Differ. 2004 Oct;11(10):1055-65.

26.

Cellular control of gene expression by T-type cyclin/CDK9 complexes.

Garriga J, Graña X.

Gene. 2004 Aug 4;337:15-23. Review.

PMID:
15276198
27.

CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2.

Garriga J, Bhattacharya S, Calbó J, Marshall RM, Truongcao M, Haines DS, Graña X.

Mol Cell Biol. 2003 Aug;23(15):5165-73.

28.

SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells.

Bhattacharya S, Garriga J, Calbó J, Yong T, Haines DS, Graña X.

Oncogene. 2003 Apr 24;22(16):2443-51.

PMID:
12717421
29.

G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression.

Calbó J, Parreño M, Sotillo E, Yong T, Mazo A, Garriga J, Grana X.

J Biol Chem. 2002 Dec 27;277(52):50263-74. Epub 2002 Oct 24.

30.

Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells.

Rane SG, Mangan JK, Amanullah A, Wong BC, Vora RK, Liebermann DA, Hoffman B, Graña X, Reddy EP.

Blood. 2002 Oct 15;100(8):2753-62.

PMID:
12351382
31.

E1A modulates phosphorylation of p130 and p107 by differentially regulating the activity of G1/S cyclin/CDK complexes.

Parreño M, Garriga J, Limón A, Albrecht JH, Graña X.

Oncogene. 2001 Aug 9;20(35):4793-806.

32.

E1A blocks hyperphosphorylation of p130 and p107 without affecting the phosphorylation status of the retinoblastoma protein.

Parreño M, Garriga J, Limón A, Mayol X, Beck GR Jr, Moran E, Graña X.

J Virol. 2000 Apr;74(7):3166-76.

33.

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth.

Graña X, Garriga J, Mayol X.

Oncogene. 1998 Dec 24;17(25):3365-83. Review.

34.

Upregulation of cyclin T1/CDK9 complexes during T cell activation.

Garriga J, Peng J, Parreño M, Price DH, Henderson EE, Graña X.

Oncogene. 1998 Dec 17;17(24):3093-102.

35.
36.

Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation.

Garriga J, Limón A, Mayol X, Rane SG, Albrecht JH, Reddy EP, Andrés V, Graña X.

Biochem J. 1998 Aug 1;333 ( Pt 3):645-54.

37.

The cell cycle inhibitor p21CIP is phosphorylated by cyclin A-CDK2 complexes.

Jaumot M, Estañol JM, Casanovas O, Graña X, Agell N, Bachs O.

Biochem Biophys Res Commun. 1997 Dec 18;241(2):434-8.

PMID:
9425288
38.

The p130 pocket protein: keeping order at cell cycle exit/re-entrance transitions.

Mayol X, Grana X.

Front Biosci. 1998 Jan 1;3:d11-24. Review.

PMID:
9405335
39.

pRB, p107 and p130 as transcriptional regulators: role in cell growth and differentiation.

Mayol X, Graña X.

Prog Cell Cycle Res. 1997;3:157-69. Review.

PMID:
9580269
40.

Phosphorylation site specificity of the CDC2-related kinase PITALRE.

Garriga J, Segura E, Mayol X, Grubmeyer C, Graña X.

Biochem J. 1996 Dec 15;320 ( Pt 3):983-9.

41.
43.

Cytokine induction of proliferation and expression of CDC2 and cyclin A in FDC-P1 myeloid hematopoietic progenitor cells: regulation of ubiquitous and cell cycle-dependent histone gene transcription factors.

Shakoori AR, van Wijnen AJ, Cooper C, Aziz F, Birnbaum M, Reddy GP, Grana X, De Luca A, Giordano A, Lian JB, et al.

J Cell Biochem. 1995 Nov;59(3):291-302.

PMID:
8567748
44.

2,3-Bisphosphoglycerate-independent phosphoglycerate mutase is conserved among different phylogenic kingdoms.

Graña X, Pérez de la Ossa P, Broceño C, Stöcker M, Garriga J, Puigdomènech P, Climent F.

Comp Biochem Physiol B Biochem Mol Biol. 1995 Oct;112(2):287-93.

PMID:
7584858
45.

Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130.

Mayol X, Garriga J, Graña X.

Oncogene. 1995 Aug 17;11(4):801-8.

PMID:
7651744
47.

Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest.

Guillouf C, Graña X, Selvakumaran M, De Luca A, Giordano A, Hoffman B, Liebermann DA.

Blood. 1995 May 15;85(10):2691-8.

PMID:
7742528
48.

Transcription of histone H4, H3, and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-related protein.

van Wijnen AJ, Aziz F, Graña X, De Luca A, Desai RK, Jaarsveld K, Last TJ, Soprano K, Giordano A, Lian JB, et al.

Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12882-6.

49.

Cyclin/cdk2 complexes in the nucleus of HeLa cells.

Jaumot M, Graña X, Giordano A, Reddy PV, Agell N, Bachs O.

Biochem Biophys Res Commun. 1994 Sep 30;203(3):1527-34.

PMID:
7945302
50.

Isolation and characterization of cofactor-independent phosphoglycerate mutase gene from maize.

Pérez de la Ossa P, Graña X, Ruiz-Lozano P, Climent F.

Biochem Biophys Res Commun. 1994 Sep 15;203(2):1204-9.

PMID:
8093040

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