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The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5α.

Morger D, Zosel F, Bühlmann M, Züger S, Mittelviefhaus M, Schuler B, Luban J, Grütter MG.

J Virol. 2018 Feb 12;92(5). pii: e01541-17. doi: 10.1128/JVI.01541-17. Print 2018 Mar 1.


Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin.

Kramer L, Renko M, Završnik J, Turk D, Seeger MA, Vasiljeva O, Grütter MG, Turk V, Turk B.

Theranostics. 2017 Jul 8;7(11):2806-2821. doi: 10.7150/thno.19081. eCollection 2017.


NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016 Nov 1;126(11):4388. doi: 10.1172/JCI90897. Epub 2016 Nov 1. No abstract available.


NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016 May 2;126(5):1783-800. doi: 10.1172/JCI83669. Epub 2016 Apr 4.


Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects.

Reichen C, Madhurantakam C, Hansen S, Grütter MG, Plückthun A, Mittl PR.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):168-75. doi: 10.1107/S2059798315023116. Epub 2016 Jan 1.


Altering lamina assembly reveals lamina-dependent and -independent functions for A-type lamins.

Zwerger M, Roschitzki-Voser H, Zbinden R, Denais C, Herrmann H, Lammerding J, Grütter MG, Medalia O.

J Cell Sci. 2015 Oct 1;128(19):3607-20. doi: 10.1242/jcs.171843. Epub 2015 Aug 14.


Crystal structure of TRIM20 C-terminal coiled-coil/B30.2 fragment: implications for the recognition of higher order oligomers.

Weinert C, Morger D, Djekic A, Grütter MG, Mittl PR.

Sci Rep. 2015 Jun 4;5:10819. doi: 10.1038/srep10819.


A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter.

Bukowska MA, Hohl M, Geertsma ER, Hürlimann LM, Grütter MG, Seeger MA.

Biochemistry. 2015 May 19;54(19):3086-99. doi: 10.1021/acs.biochem.5b00188. Epub 2015 May 7.


Specific targeting of human caspases using designed ankyrin repeat proteins.

Flütsch A, Schroeder T, Barandun J, Ackermann R, Bühlmann M, Grütter MG.

Biol Chem. 2014 Oct;395(10):1243-52. doi: 10.1515/hsz-2014-0173.


Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.

Hohl M, Hürlimann LM, Böhm S, Schöppe J, Grütter MG, Bordignon E, Seeger MA.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11025-30. doi: 10.1073/pnas.1400485111. Epub 2014 Jul 16.


Unusual structural features revealed by the solution NMR structure of the NLRC5 caspase recruitment domain.

Gutte PG, Jurt S, Grütter MG, Zerbe O.

Biochemistry. 2014 May 20;53(19):3106-17. doi: 10.1021/bi500177x. Epub 2014 May 9.


Biocrystallography in Switzerland: achievements and future perspectives.

Grütter MG.

Chimia (Aarau). 2014;68(1-2):54-9. doi: 10.2533/chimia.2014.54.


Combined inhibition of caspase 3 and caspase 7 by two highly selective DARPins slows down cellular demise.

Flütsch A, Ackermann R, Schroeder T, Lukarska M, Hausammann GJ, Weinert C, Briand C, Grütter MG.

Biochem J. 2014 Jul 15;461(2):279-90. doi: 10.1042/BJ20131456.


Biocrystallography in Switzerland: Achievements and Future Perspectives.

Grütter MG.

Chimia (Aarau). 2014 Feb 26;68(1):54-59. doi: 10.2533/chimia.2014.54.


Chimeric hERG channels containing a tetramerization domain are functional and stable.

Hausammann GJ, Grütter MG.

Biochemistry. 2013 Dec 23;52(51):9237-45. doi: 10.1021/bi401100a. Epub 2013 Dec 10.


Precision is essential for efficient catalysis in an evolved Kemp eliminase.

Blomberg R, Kries H, Pinkas DM, Mittl PR, Grütter MG, Privett HK, Mayo SL, Hilvert D.

Nature. 2013 Nov 21;503(7476):418-21. doi: 10.1038/nature12623. Epub 2013 Oct 16.


Design, construction, and characterization of a second-generation DARP in library with reduced hydrophobicity.

Seeger MA, Zbinden R, Flütsch A, Gutte PG, Engeler S, Roschitzki-Voser H, Grütter MG.

Protein Sci. 2013 Sep;22(9):1239-57. doi: 10.1002/pro.2312. Epub 2013 Aug 6.


New concepts and aids to facilitate crystallization.

Bukowska MA, Grütter MG.

Curr Opin Struct Biol. 2013 Jun;23(3):409-16. doi: 10.1016/ Epub 2013 Apr 8. Review.


The structure of Bradyrhizobium japonicum transcription factor FixK2 unveils sites of DNA binding and oxidation.

Bonnet M, Kurz M, Mesa S, Briand C, Hennecke H, Grütter MG.

J Biol Chem. 2013 May 17;288(20):14238-46. doi: 10.1074/jbc.M113.465484. Epub 2013 Apr 1.


Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters.

Dreier B, Honegger A, Hess C, Nagy-Davidescu G, Mittl PR, Grütter MG, Belousova N, Mikheeva G, Krasnykh V, Plückthun A.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E869-77. doi: 10.1073/pnas.1213653110. Epub 2013 Feb 19.


Specific inhibition of caspase-3 by a competitive DARPin: molecular mimicry between native and designed inhibitors.

Schroeder T, Barandun J, Flütsch A, Briand C, Mittl PR, Grütter MG.

Structure. 2013 Feb 5;21(2):277-89. doi: 10.1016/j.str.2012.12.011. Epub 2013 Jan 17.


Generation of an antibody toolbox to characterize hERG.

Hausammann GJ, Heitkamp T, Matile H, Gsell B, Thoma R, Schmid G, Frasson D, Sievers M, Hennig M, Grütter MG.

Biochem Biophys Res Commun. 2013 Feb 1;431(1):70-5. doi: 10.1016/j.bbrc.2012.12.089. Epub 2012 Dec 28.


X-Ray Structure of a Heterodimeric ABC Transporter Crystallized in its Inward-Facing Conformation.

Hohl M, Grütter MG, Seeger MA.

Chimia (Aarau). 2012 Oct 31;66(10):802. doi: 10.2533/chimia.2012.802. No abstract available.


Autoproteolytic and catalytic mechanisms for the β-aminopeptidase BapA--a member of the Ntn hydrolase family.

Merz T, Heck T, Geueke B, Mittl PR, Briand C, Seebach D, Kohler HP, Grütter MG.

Structure. 2012 Nov 7;20(11):1850-60. doi: 10.1016/j.str.2012.07.017. Epub 2012 Sep 12.


Crystal structures of BapA complexes with β-lactam-derived inhibitors illustrate substrate specificity and enantioselectivity of β-aminopeptidases.

Heck T, Merz T, Reimer A, Seebach D, Rentsch D, Briand C, Grütter MG, Kohler HP, Geueke B.

Chembiochem. 2012 Sep 24;13(14):2137-45. doi: 10.1002/cbic.201200393. Epub 2012 Sep 7.


Quality control of disulfide bond formation in pilus subunits by the chaperone FimC.

Crespo MD, Puorger C, Schärer MA, Eidam O, Grütter MG, Capitani G, Glockshuber R.

Nat Chem Biol. 2012 Aug;8(8):707-13. doi: 10.1038/nchembio.1019. Epub 2012 Jul 1.


Human caspases in vitro: expression, purification and kinetic characterization.

Roschitzki-Voser H, Schroeder T, Lenherr ED, Frölich F, Schweizer A, Donepudi M, Ganesan R, Mittl PR, Baici A, Grütter MG.

Protein Expr Purif. 2012 Aug;84(2):236-46. doi: 10.1016/j.pep.2012.05.009. Epub 2012 Jun 7.


Tuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin binders.

Seeger MA, Mittal A, Velamakanni S, Hohl M, Schauer S, Salaa I, Grütter MG, van Veen HW.

PLoS One. 2012;7(6):e37845. doi: 10.1371/journal.pone.0037845. Epub 2012 Jun 4.


Structure-based optimization of designed Armadillo-repeat proteins.

Madhurantakam C, Varadamsetty G, Grütter MG, Plückthun A, Mittl PR.

Protein Sci. 2012 Jul;21(7):1015-28. doi: 10.1002/pro.2085. Epub 2012 May 24.


Asymmetry in the homodimeric ABC transporter MsbA recognized by a DARPin.

Mittal A, Böhm S, Grütter MG, Bordignon E, Seeger MA.

J Biol Chem. 2012 Jun 8;287(24):20395-406. doi: 10.1074/jbc.M112.359794. Epub 2012 Apr 20.


TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling.

Grütter MG, Luban J.

Curr Opin Virol. 2012 Apr;2(2):142-50. doi: 10.1016/j.coviro.2012.02.003. Epub 2012 Mar 5. Review.


Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.

Eicher T, Cha HJ, Seeger MA, Brandstätter L, El-Delik J, Bohnert JA, Kern WV, Verrey F, Grütter MG, Diederichs K, Pos KM.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5687-92. doi: 10.1073/pnas.1114944109. Epub 2012 Mar 26.


Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation.

Hohl M, Briand C, Grütter MG, Seeger MA.

Nat Struct Mol Biol. 2012 Mar 25;19(4):395-402. doi: 10.1038/nsmb.2267.


Projection structure of the secondary citrate/sodium symporter CitS at 6 Å resolution by electron crystallography.

Kebbel F, Kurz M, Grütter MG, Stahlberg H.

J Mol Biol. 2012 Apr 20;418(1-2):117-26. doi: 10.1016/j.jmb.2012.02.016. Epub 2012 Feb 17.


A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency.

Chodorge M, Züger S, Stirnimann C, Briand C, Jermutus L, Grütter MG, Minter RR.

Cell Death Differ. 2012 Jul;19(7):1187-95. doi: 10.1038/cdd.2011.208. Epub 2012 Jan 20.


A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders.

Huwiler A, Bourquin F, Kotelevets N, Pastukhov O, Capitani G, Grütter MG, Zangemeister-Wittke U.

PLoS One. 2011;6(8):e22436. doi: 10.1371/journal.pone.0022436. Epub 2011 Aug 1.


In silico identification and crystal structure validation of caspase-3 inhibitors without a P1 aspartic acid moiety.

Ganesan R, Jelakovic S, Mittl PR, Caflisch A, Grütter MG.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):842-50. doi: 10.1107/S1744309111018604. Epub 2011 Jul 13.


PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism.

Bourquin F, Capitani G, Grütter MG.

Protein Sci. 2011 Sep;20(9):1492-508. doi: 10.1002/pro.679. Review.


TRIM5 is an innate immune sensor for the retrovirus capsid lattice.

Pertel T, Hausmann S, Morger D, Züger S, Guerra J, Lascano J, Reinhard C, Santoni FA, Uchil PD, Chatel L, Bisiaux A, Albert ML, Strambio-De-Castillia C, Mothes W, Pizzato M, Grütter MG, Luban J.

Nature. 2011 Apr 21;472(7343):361-5. doi: 10.1038/nature09976.


Designed ankyrin repeat protein binders for the crystallization of AcrB: plasticity of the dominant interface.

Monroe N, Sennhauser G, Seeger MA, Briand C, Grütter MG.

J Struct Biol. 2011 May;174(2):269-81. doi: 10.1016/j.jsb.2011.01.014. Epub 2011 Feb 4.


HIV-1 protease inhibition potential of functionalized polyoxometalates.

Flütsch A, Schroeder T, Grütter MG, Patzke GR.

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1162-6. doi: 10.1016/j.bmcl.2010.12.103. Epub 2010 Dec 25.


Structural basis for reduced activity of 1-aminocyclopropane-1-carboxylate synthase affected by a mutation linked to andromonoecy.

Schärer MA, Eliot AC, Grütter MG, Capitani G.

FEBS Lett. 2011 Jan 3;585(1):111-4. doi: 10.1016/j.febslet.2010.11.013. Epub 2010 Nov 12.


Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe.

Kindermann M, Roschitzki-Voser H, Caglic D, Repnik U, Miniejew C, Mittl PR, Kosec G, Grütter MG, Turk B, Wendt KU.

Chem Biol. 2010 Sep 24;17(9):999-1007. doi: 10.1016/j.chembiol.2010.07.011.


Structural determinants for improved stability of designed ankyrin repeat proteins with a redesigned C-capping module.

Kramer MA, Wetzel SK, Plückthun A, Mittl PR, Grütter MG.

J Mol Biol. 2010 Dec 3;404(3):381-91. doi: 10.1016/j.jmb.2010.09.023. Epub 2010 Sep 17.


Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism.

Bourquin F, Riezman H, Capitani G, Grütter MG.

Structure. 2010 Aug 11;18(8):1054-65. doi: 10.1016/j.str.2010.05.011.


CRK: an evolutionary approach for distinguishing biologically relevant interfaces from crystal contacts.

Schärer MA, Grütter MG, Capitani G.

Proteins. 2010 Sep;78(12):2707-13. doi: 10.1002/prot.22787.


Generation of human TRIM5alpha mutants with high HIV-1 restriction activity.

Pham QT, Bouchard A, Grütter MG, Berthoux L.

Gene Ther. 2010 Jul;17(7):859-71. doi: 10.1038/gt.2010.40. Epub 2010 Apr 1.


Isolation of a small-molecule inhibitor of the antiapoptotic protein Bcl-xL from a DNA-encoded chemical library.

Melkko S, Mannocci L, Dumelin CE, Villa A, Sommavilla R, Zhang Y, Grütter MG, Keller N, Jermutus L, Jackson RH, Scheuermann J, Neri D.

ChemMedChem. 2010 Apr 6;5(4):584-90. doi: 10.1002/cmdc.200900520.


Studies of the molecular mechanism of caspase-8 activation by solution NMR.

Keller N, Grütter MG, Zerbe O.

Cell Death Differ. 2010 Apr;17(4):710-8. doi: 10.1038/cdd.2009.155. Epub 2009 Oct 23.

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