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Items: 43

1.

Tailoring the properties of (catalytically)-active inclusion bodies.

Jäger VD, Kloss R, Grünberger A, Seide S, Hahn D, Karmainski T, Piqueray M, Embruch J, Longerich S, Mackfeld U, Jaeger KE, Wiechert W, Pohl M, Krauss U.

Microb Cell Fact. 2019 Feb 7;18(1):33. doi: 10.1186/s12934-019-1081-5.

2.

Heterogeneity Studies of Mammalian Cells for Bioproduction: From Tools to Application.

Schmitz J, Noll T, Grünberger A.

Trends Biotechnol. 2019 Jan 11. pii: S0167-7799(18)30317-2. doi: 10.1016/j.tibtech.2018.11.007. [Epub ahead of print] Review.

PMID:
30642642
3.

Germination and Growth Analysis of Streptomyces lividans at the Single-Cell Level Under Varying Medium Compositions.

Koepff J, Sachs CC, Wiechert W, Kohlheyer D, Nöh K, Oldiges M, Grünberger A.

Front Microbiol. 2018 Nov 22;9:2680. doi: 10.3389/fmicb.2018.02680. eCollection 2018.

4.

A microfluidic co-cultivation platform to investigate microbial interactions at defined microenvironments.

Burmeister A, Hilgers F, Langner A, Westerwalbesloh C, Kerkhoff Y, Tenhaef N, Drepper T, Kohlheyer D, von Lieres E, Noack S, Grünberger A.

Lab Chip. 2018 Dec 18;19(1):98-110. doi: 10.1039/c8lc00977e.

PMID:
30488920
5.

Importance of Pyruvate Sensing and Transport for the Resuscitation of Viable but Nonculturable Escherichia coli K-12.

Vilhena C, Kaganovitch E, Grünberger A, Motz M, Forné I, Kohlheyer D, Jung K.

J Bacteriol. 2019 Jan 11;201(3). pii: e00610-18. doi: 10.1128/JB.00610-18. Print 2019 Feb 1.

PMID:
30420452
6.

When a Single Lineage Is Not Enough: Uncertainty-Aware Tracking for Spatio-Temporal Live-Cell Image Analysis.

Theorell A, Seiffarth J, Grünberger A, Nöh K.

Bioinformatics. 2018 Sep 1. doi: 10.1093/bioinformatics/bty776. [Epub ahead of print]

PMID:
30184044
7.

Selective Pressure for Biofilm Formation in Bacillus subtilis: Differential Effect of Mutations in the Master Regulator SinR on Bistability.

Kampf J, Gerwig J, Kruse K, Cleverley R, Dormeyer M, Grünberger A, Kohlheyer D, Commichau FM, Lewis RJ, Stülke J.

MBio. 2018 Sep 4;9(5). pii: e01464-18. doi: 10.1128/mBio.01464-18.

8.

A Synthetic Reaction Cascade Implemented by Colocalization of Two Proteins within Catalytically Active Inclusion Bodies.

Jäger VD, Lamm R, Kloß R, Kaganovitch E, Grünberger A, Pohl M, Büchs J, Jaeger KE, Krauss U.

ACS Synth Biol. 2018 Sep 21;7(9):2282-2295. doi: 10.1021/acssynbio.8b00274. Epub 2018 Aug 20.

PMID:
30053372
9.

Natural biocide cocktails: Combinatorial antibiotic effects of prodigiosin and biosurfactants.

Hage-Hülsmann J, Grünberger A, Thies S, Santiago-Schübel B, Klein AS, Pietruszka J, Binder D, Hilgers F, Domröse A, Drepper T, Kohlheyer D, Jaeger KE, Loeschcke A.

PLoS One. 2018 Jul 19;13(7):e0200940. doi: 10.1371/journal.pone.0200940. eCollection 2018.

10.

Catalytically active inclusion bodies of L-lysine decarboxylase from E. coli for 1,5-diaminopentane production.

Kloss R, Limberg MH, Mackfeld U, Hahn D, Grünberger A, Jäger VD, Krauss U, Oldiges M, Pohl M.

Sci Rep. 2018 Apr 11;8(1):5856. doi: 10.1038/s41598-018-24070-2.

11.

Quantitative modelling of nutrient-limited growth of bacterial colonies in microfluidic cultivation.

Hornung R, Grünberger A, Westerwalbesloh C, Kohlheyer D, Gompper G, Elgeti J.

J R Soc Interface. 2018 Feb;15(139). pii: 20170713. doi: 10.1098/rsif.2017.0713.

12.

Visualization of tandem repeat mutagenesis in Bacillus subtilis.

Dormeyer M, Lentes S, Ballin P, Wilkens M, Klumpp S, Kohlheyer D, Stannek L, Grünberger A, Commichau FM.

DNA Repair (Amst). 2018 Mar;63:10-15. doi: 10.1016/j.dnarep.2018.01.006. Epub 2018 Jan 31.

PMID:
29414049
13.

A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance.

Vilhena C, Kaganovitch E, Shin JY, Grünberger A, Behr S, Kristoficova I, Brameyer S, Kohlheyer D, Jung K.

J Bacteriol. 2017 Dec 5;200(1). pii: e00536-17. doi: 10.1128/JB.00536-17. Print 2018 Jan 1.

14.

Homogenizing bacterial cell factories: Analysis and engineering of phenotypic heterogeneity.

Binder D, Drepper T, Jaeger KE, Delvigne F, Wiechert W, Kohlheyer D, Grünberger A.

Metab Eng. 2017 Jul;42:145-156. doi: 10.1016/j.ymben.2017.06.009. Epub 2017 Jun 20. Review.

PMID:
28645641
15.

Taking control over microbial populations: Current approaches for exploiting biological noise in bioprocesses.

Delvigne F, Baert J, Sassi H, Fickers P, Grünberger A, Dusny C.

Biotechnol J. 2017 Jul;12(7). doi: 10.1002/biot.201600549. Epub 2017 May 24. Review.

PMID:
28544731
16.

Coarse-graining bacteria colonies for modelling critical solute distributions in picolitre bioreactors for bacterial studies on single-cell level.

Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E.

Microb Biotechnol. 2017 Jul;10(4):845-857. doi: 10.1111/1751-7915.12708. Epub 2017 Apr 3.

17.

Enhanced protein and biochemical production using CRISPRi-based growth switches.

Li S, Jendresen CB, Grünberger A, Ronda C, Jensen SI, Noack S, Nielsen AT.

Metab Eng. 2016 Nov;38:274-284. doi: 10.1016/j.ymben.2016.09.003. Epub 2016 Sep 16.

PMID:
27647432
18.

Optogenetic Regulation of Tunable Gene Expression in Yeast Using Photo-Labile Caged Methionine.

Kusen PM, Wandrey G, Probst C, Grünberger A, Holz M, Meyer Zu Berstenhorst S, Kohlheyer D, Büchs J, Pietruszka J.

ACS Chem Biol. 2016 Oct 21;11(10):2915-2922. Epub 2016 Sep 12.

PMID:
27570879
19.

Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments.

Sachs CC, Grünberger A, Helfrich S, Probst C, Wiechert W, Kohlheyer D, Nöh K.

PLoS One. 2016 Sep 23;11(9):e0163453. doi: 10.1371/journal.pone.0163453. eCollection 2016.

20.

Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation.

Binder D, Probst C, Grünberger A, Hilgers F, Loeschcke A, Jaeger KE, Kohlheyer D, Drepper T.

PLoS One. 2016 Aug 15;11(8):e0160711. doi: 10.1371/journal.pone.0160711. eCollection 2016.

21.

Light-Controlled Cell Factories: Employing Photocaged Isopropyl-β-d-Thiogalactopyranoside for Light-Mediated Optimization of lac Promoter-Based Gene Expression and (+)-Valencene Biosynthesis in Corynebacterium glutamicum.

Binder D, Frohwitter J, Mahr R, Bier C, Grünberger A, Loeschcke A, Peters-Wendisch P, Kohlheyer D, Pietruszka J, Frunzke J, Jaeger KE, Wendisch VF, Drepper T.

Appl Environ Microbiol. 2016 Sep 30;82(20):6141-6149. Print 2016 Oct 15.

22.

Photocaged Arabinose: A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression.

Binder D, Bier C, Grünberger A, Drobietz D, Hage-Hülsmann J, Wandrey G, Büchs J, Kohlheyer D, Loeschcke A, Wiechert W, Jaeger KE, Pietruszka J, Drepper T.

Chembiochem. 2016 Feb 15;17(4):296-9. doi: 10.1002/cbic.201500609. Epub 2016 Jan 19.

PMID:
26677142
23.

Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester.

Krämer CE, Singh A, Helfrich S, Grünberger A, Wiechert W, Nöh K, Kohlheyer D.

PLoS One. 2015 Oct 29;10(10):e0141768. doi: 10.1371/journal.pone.0141768. eCollection 2015.

24.

Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform.

Grünberger A, Probst C, Helfrich S, Nanda A, Stute B, Wiechert W, von Lieres E, Nöh K, Frunzke J, Kohlheyer D.

Cytometry A. 2015 Dec;87(12):1101-15. doi: 10.1002/cyto.a.22779. Epub 2015 Sep 8.

25.

Modeling and CFD simulation of nutrient distribution in picoliter bioreactors for bacterial growth studies on single-cell level.

Westerwalbesloh C, Grünberger A, Stute B, Weber S, Wiechert W, Kohlheyer D, von Lieres E.

Lab Chip. 2015 Nov 7;15(21):4177-86. doi: 10.1039/c5lc00646e. Epub 2015 Sep 8.

PMID:
26345659
26.

Vizardous: interactive analysis of microbial populations with single cell resolution.

Helfrich S, Azzouzi CE, Probst C, Seiffarth J, Grünberger A, Wiechert W, Kohlheyer D, Nöh K.

Bioinformatics. 2015 Dec 1;31(23):3875-7. doi: 10.1093/bioinformatics/btv468. Epub 2015 Aug 10.

PMID:
26261223
27.

Technical bias of microcultivation environments on single-cell physiology.

Dusny C, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Schmid A.

Lab Chip. 2015 Apr 21;15(8):1822-34. doi: 10.1039/c4lc01270d.

PMID:
25710324
28.

[Non-cirrhotic portal hypertension presented by acute upper gastrointestinal bleeding 7 years after oxaliplatin-chemotherapy].

Schwarz S, Suppan M, Höbling W, Grünberger A, Nömeyer R, Hubner D, Knoflach P.

Z Gastroenterol. 2014 Jul;52(7):654-6. doi: 10.1055/s-0034-1366415. Epub 2014 Jul 15. German.

PMID:
25026007
29.

Light-responsive control of bacterial gene expression: precise triggering of the lac promoter activity using photocaged IPTG.

Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger KE, Drepper T.

Integr Biol (Camb). 2014 Aug;6(8):755-65. doi: 10.1039/c4ib00027g.

PMID:
24894989
30.

Single-cell microfluidics: opportunity for bioprocess development.

Grünberger A, Wiechert W, Kohlheyer D.

Curr Opin Biotechnol. 2014 Oct;29:15-23. doi: 10.1016/j.copbio.2014.02.008. Epub 2014 Mar 16. Review.

PMID:
24642389
31.

Application of a genetically encoded biosensor for live cell imaging of L-valine production in pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum strains.

Mustafi N, Grünberger A, Mahr R, Helfrich S, Nöh K, Blombach B, Kohlheyer D, Frunzke J.

PLoS One. 2014 Jan 17;9(1):e85731. doi: 10.1371/journal.pone.0085731. eCollection 2014.

32.

Analysis of SOS-induced spontaneous prophage induction in Corynebacterium glutamicum at the single-cell level.

Nanda AM, Heyer A, Krämer C, Grünberger A, Kohlheyer D, Frunzke J.

J Bacteriol. 2014 Jan;196(1):180-8. doi: 10.1128/JB.01018-13. Epub 2013 Oct 25.

33.

Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes.

Probst C, Grünberger A, Wiechert W, Kohlheyer D.

J Microbiol Methods. 2013 Dec;95(3):470-6. doi: 10.1016/j.mimet.2013.09.002. Epub 2013 Sep 13.

PMID:
24041615
34.

Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium.

Unthan S, Grünberger A, van Ooyen J, Gätgens J, Heinrich J, Paczia N, Wiechert W, Kohlheyer D, Noack S.

Biotechnol Bioeng. 2014 Feb;111(2):359-71. doi: 10.1002/bit.25103. Epub 2013 Sep 24.

PMID:
23996851
35.

Visualization of imbalances in sulfur assimilation and synthesis of sulfur-containing amino acids at the single-cell level.

Hoffmann K, Grünberger A, Lausberg F, Bott M, Eggeling L.

Appl Environ Microbiol. 2013 Nov;79(21):6730-6. doi: 10.1128/AEM.01804-13. Epub 2013 Aug 30.

36.

Construction of a prophage-free variant of Corynebacterium glutamicum ATCC 13032 for use as a platform strain for basic research and industrial biotechnology.

Baumgart M, Unthan S, Rückert C, Sivalingam J, Grünberger A, Kalinowski J, Bott M, Noack S, Frunzke J.

Appl Environ Microbiol. 2013 Oct;79(19):6006-15. doi: 10.1128/AEM.01634-13. Epub 2013 Jul 26.

37.

Taking control over control: use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways.

Schendzielorz G, Dippong M, Grünberger A, Kohlheyer D, Yoshida A, Binder S, Nishiyama C, Nishiyama M, Bott M, Eggeling L.

ACS Synth Biol. 2014 Jan 17;3(1):21-9. doi: 10.1021/sb400059y. Epub 2013 Jul 15.

PMID:
23829416
38.

Coarse-grained modeling of protein second osmotic virial coefficients: sterics and short-ranged attractions.

Grünberger A, Lai PK, Blanco MA, Roberts CJ.

J Phys Chem B. 2013 Jan 24;117(3):763-70. doi: 10.1021/jp308234j. Epub 2013 Jan 10.

PMID:
23245189
39.

Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments.

Grünberger A, van Ooyen J, Paczia N, Rohe P, Schiendzielorz G, Eggeling L, Wiechert W, Kohlheyer D, Noack S.

Biotechnol Bioeng. 2013 Jan;110(1):220-8. doi: 10.1002/bit.24616. Epub 2012 Aug 13.

PMID:
22890752
40.

The development and application of a single-cell biosensor for the detection of l-methionine and branched-chain amino acids.

Mustafi N, Grünberger A, Kohlheyer D, Bott M, Frunzke J.

Metab Eng. 2012 Jul;14(4):449-57. doi: 10.1016/j.ymben.2012.02.002. Epub 2012 Feb 15.

PMID:
22583745
41.

Synthesis of chiral cyanohydrins by recombinant Escherichia coli cells in a micro-aqueous reaction system.

Scholz KE, Okrob D, Kopka B, Grünberger A, Pohl M, Jaeger KE, Krauss U.

Appl Environ Microbiol. 2012 Jul;78(14):5025-7. doi: 10.1128/AEM.00582-12. Epub 2012 Apr 27.

42.

A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level.

Grünberger A, Paczia N, Probst C, Schendzielorz G, Eggeling L, Noack S, Wiechert W, Kohlheyer D.

Lab Chip. 2012 May 8;12(11):2060-8. doi: 10.1039/c2lc40156h. Epub 2012 Apr 17.

PMID:
22511122
43.

Midi-level measurement of social anxiety in psychiatric and non-psychiatric samples.

Monti PM, Boice R, Fingeret AL, Zwick WR, Kolko D, Munroe S, Grunberger A.

Behav Res Ther. 1984;22(6):651-60. No abstract available.

PMID:
6517829

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