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Items: 1 to 50 of 73

1.

EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential.

Derecka M, Herman JS, Cauchy P, Ramamoorthy S, Lupar E, Grün D, Grosschedl R.

Nat Immunol. 2020 Mar;21(3):261-273. doi: 10.1038/s41590-020-0595-7. Epub 2020 Feb 17.

PMID:
32066955
2.

Myeloid-related protein 8/14 and high-sensitivity cardiac troponin I to differentiate type 2 myocardial infarction.

Bormann J, Psyrakis DA, von Jeinsen B, Grün D, Elsner LK, Wolter JS, Weferling M, Diouf K, Kriechbaum S, Troidl C, Dörr O, Nef H, Hamm CW, Liebetrau C, Keller T.

Int J Cardiol. 2020 Jan 21. pii: S0167-5273(19)34555-3. doi: 10.1016/j.ijcard.2020.01.043. [Epub ahead of print]

PMID:
32008845
3.

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.

Honkoop H, de Bakker DE, Aharonov A, Kruse F, Shakked A, Nguyen PD, de Heus C, Garric L, Muraro MJ, Shoffner A, Tessadori F, Peterson JC, Noort W, Bertozzi A, Weidinger G, Posthuma G, Grün D, van der Laarse WJ, Klumperman J, Jaspers RT, Poss KD, van Oudenaarden A, Tzahor E, Bakkers J.

Elife. 2019 Dec 23;8. pii: e50163. doi: 10.7554/eLife.50163.

4.

DUX is a non-essential synchronizer of zygotic genome activation.

De Iaco A, Verp S, Offner S, Grun D, Trono D.

Development. 2020 Jan 23;147(2). pii: dev177725. doi: 10.1242/dev.177725.

PMID:
31806660
5.

Impact of oral COMT-inhibitors on gut microbiota and short chain fatty acids in Parkinson's disease.

Grün D, Zimmer VC, Kauffmann J, Spiegel J, Dillmann U, Schwiertz A, Faßbender K, Fousse M, Unger MM.

Parkinsonism Relat Disord. 2020 Jan;70:20-22. doi: 10.1016/j.parkreldis.2019.11.020. Epub 2019 Nov 25. No abstract available.

PMID:
31790924
6.

Revealing dynamics of gene expression variability in cell state space.

Grün D.

Nat Methods. 2020 Jan;17(1):45-49. doi: 10.1038/s41592-019-0632-3. Epub 2019 Nov 18.

PMID:
31740822
7.

Mapping microglia states in the human brain through the integration of high-dimensional techniques.

Sankowski R, Böttcher C, Masuda T, Geirsdottir L, Sagar, Sindram E, Seredenina T, Muhs A, Scheiwe C, Shah MJ, Heiland DH, Schnell O, Grün D, Priller J, Prinz M.

Nat Neurosci. 2019 Dec;22(12):2098-2110. doi: 10.1038/s41593-019-0532-y. Epub 2019 Nov 18.

PMID:
31740814
8.

Single-cell RNA-sequencing identifies the developmental trajectory of C-Myc-dependent NK1.1- T-bet+ intraepithelial lymphocyte precursors.

Hummel JF, Zeis P, Ebert K, Fixemer J, Konrad P, Schachtrup C, Arnold SJ, Grün D, Tanriver Y.

Mucosal Immunol. 2020 Mar;13(2):257-270. doi: 10.1038/s41385-019-0220-y. Epub 2019 Nov 11.

PMID:
31712600
9.

Systematic Identification of Cell-Cell Communication Networks in the Developing Brain.

Sheikh BN, Bondareva O, Guhathakurta S, Tsang TH, Sikora K, Aizarani N, Sagar, Holz H, Grün D, Hein L, Akhtar A.

iScience. 2019 Nov 22;21:273-287. doi: 10.1016/j.isci.2019.10.026. Epub 2019 Oct 17.

10.

Prehospital Stroke Management Optimized by Use of Clinical Scoring vs Mobile Stroke Unit for Triage of Patients With Stroke: A Randomized Clinical Trial.

Helwig SA, Ragoschke-Schumm A, Schwindling L, Kettner M, Roumia S, Kulikovski J, Keller I, Manitz M, Martens D, Grün D, Walter S, Lesmeister M, Ewen K, Brand J, Fousse M, Kauffmann J, Zimmer VC, Mathur S, Bertsch T, Guldner J, Magull-Seltenreich A, Binder A, Spüntrup E, Chatzikonstantinou A, Adam O, Kronfeld K, Liu Y, Ruckes C, Schumacher H, Grunwald IQ, Yilmaz U, Schlechtriemen T, Reith W, Fassbender K.

JAMA Neurol. 2019 Sep 3. doi: 10.1001/jamaneurol.2019.2829. [Epub ahead of print]

PMID:
31479116
11.

Prognostic performance of the ESC SCORE and its German recalibrated versions in primary and secondary prevention.

Elsner LK, Jeinsen BV, Grün D, Wolter JS, Weferling M, Diouf K, Kriechbaum S, Troidl C, Dörr O, Nef H, Hamm CW, Liebetrau C, Keller T.

Eur J Prev Cardiol. 2019 Aug 18:2047487319868034. doi: 10.1177/2047487319868034. [Epub ahead of print] No abstract available.

PMID:
31423815
12.

A human liver cell atlas reveals heterogeneity and epithelial progenitors.

Aizarani N, Saviano A, Sagar, Mailly L, Durand S, Herman JS, Pessaux P, Baumert TF, Grün D.

Nature. 2019 Aug;572(7768):199-204. doi: 10.1038/s41586-019-1373-2. Epub 2019 Jul 10.

13.

RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.

Gbenedio OM, Bonnans C, Grun D, Wang CY, Hatch AJ, Mahoney MR, Barras D, Matli M, Miao Y, Garcia KC, Tejpar S, Delorenzi M, Venook AP, Nixon AB, Warren RS, Roose JP, Depeille P.

JCI Insight. 2019 Jun 25;5. pii: 127552. doi: 10.1172/jci.insight.127552.

14.

A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves.

Kolter J, Feuerstein R, Zeis P, Hagemeyer N, Paterson N, d'Errico P, Baasch S, Amann L, Masuda T, Lösslein A, Gharun K, Meyer-Luehmann M, Waskow C, Franzke CW, Grün D, Lämmermann T, Prinz M, Henneke P.

Immunity. 2019 Jun 18;50(6):1482-1497.e7. doi: 10.1016/j.immuni.2019.05.009. Epub 2019 Jun 11.

PMID:
31201094
15.

Lineage Inference and Stem Cell Identity Prediction Using Single-Cell RNA-Sequencing Data.

Sagar, Grün D.

Methods Mol Biol. 2019;1975:277-301. doi: 10.1007/978-1-4939-9224-9_13.

PMID:
31062315
16.

Author Correction: Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.

Masuda T, Sankowski R, Staszewski O, Böttcher C, Amann L, Sagar, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Grün D, Priller J, Stadelmann C, Prinz M.

Nature. 2019 Apr;568(7751):E4. doi: 10.1038/s41586-019-1045-2.

PMID:
30918409
17.

Legionnaire's-disease-associated meningoencephalitis: A case report.

Grün D, Unger MM, Kauffmann J, Zimmer V, Fassbender K, Fousse M.

Pulmonology. 2019 Mar - Apr;25(2):128-130. doi: 10.1016/j.pulmoe.2018.12.006. Epub 2019 Feb 16. No abstract available.

18.

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.

Masuda T, Sankowski R, Staszewski O, Böttcher C, Amann L, Sagar, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Grün D, Priller J, Stadelmann C, Prinz M.

Nature. 2019 Feb;566(7744):388-392. doi: 10.1038/s41586-019-0924-x. Epub 2019 Feb 13. Erratum in: Nature. 2019 Apr;568(7751):E4.

PMID:
30760929
19.

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation.

Jordão MJC, Sankowski R, Brendecke SM, Sagar, Locatelli G, Tai YH, Tay TL, Schramm E, Armbruster S, Hagemeyer N, Groß O, Mai D, Çiçek Ö, Falk T, Kerschensteiner M, Grün D, Prinz M.

Science. 2019 Jan 25;363(6425). pii: eaat7554. doi: 10.1126/science.aat7554.

PMID:
30679343
20.

NRP-1 interacts with GIPC1 and SYX to activate p38 MAPK signaling and cancer stem cell survival.

Grun D, Adhikary G, Eckert RL.

Mol Carcinog. 2019 Apr;58(4):488-499. doi: 10.1002/mc.22943. Epub 2018 Dec 21.

PMID:
30456845
21.

Transglutaminase is a mesothelioma cancer stem cell survival protein that is required for tumor formation.

Adhikary G, Grun D, Alexander HR, Friedberg JS, Xu W, Keillor JW, Kandasamy S, Eckert RL.

Oncotarget. 2018 Oct 2;9(77):34495-34505. doi: 10.18632/oncotarget.26130. eCollection 2018 Oct 2.

22.

GraphDDP: a graph-embedding approach to detect differentiation pathways in single-cell-data using prior class knowledge.

Costa F, Grün D, Backofen R.

Nat Commun. 2018 Sep 11;9(1):3685. doi: 10.1038/s41467-018-05988-7.

23.

Unique microglia recovery population revealed by single-cell RNAseq following neurodegeneration.

Tay TL, Sagar, Dautzenberg J, Grün D, Prinz M.

Acta Neuropathol Commun. 2018 Sep 5;6(1):87. doi: 10.1186/s40478-018-0584-3.

24.

DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.

Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Münke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke MH, Wagner D, Dierks C, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hölscher C, Hauser AE, Lopez-Contreras AJ, Grün D, Gorgoulis V, Diefenbach A, Henneke P, Triantafyllopoulou A.

Cell. 2018 Aug 23;174(5):1325-1326. doi: 10.1016/j.cell.2018.08.015. No abstract available.

25.

Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification.

Roovers EF, Kaaij LJT, Redl S, Bronkhorst AW, Wiebrands K, de Jesus Domingues AM, Huang HY, Han CT, Riemer S, Dosch R, Salvenmoser W, Grün D, Butter F, van Oudenaarden A, Ketting RF.

Dev Cell. 2018 Aug 6;46(3):285-301.e9. doi: 10.1016/j.devcel.2018.07.009.

26.

Mapping the physical network of cellular interactions.

Boisset JC, Vivié J, Grün D, Muraro MJ, Lyubimova A, van Oudenaarden A.

Nat Methods. 2018 Jul;15(7):547-553. doi: 10.1038/s41592-018-0009-z. Epub 2018 May 21.

PMID:
29786092
27.

NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival.

Grun D, Adhikary G, Eckert RL.

Oncogene. 2018 Aug;37(34):4711-4722. doi: 10.1038/s41388-018-0290-4. Epub 2018 May 14.

28.

The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes.

Lu TT, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T, Yang CH, Sagar, Arrigoni L, Dalgaard K, Teperino R, Enders L, Selvaraj M, Ruf M, Raja SJ, Xie H, Boenisch U, Orkin SH, Lynn FC, Hoffman BG, Grün D, Vavouri T, Lempradl AM, Pospisilik JA.

Cell Metab. 2018 Jun 5;27(6):1294-1308.e7. doi: 10.1016/j.cmet.2018.04.013. Epub 2018 May 10.

29.

FateID infers cell fate bias in multipotent progenitors from single-cell RNA-seq data.

Herman JS, Sagar, Grün D.

Nat Methods. 2018 May;15(5):379-386. doi: 10.1038/nmeth.4662. Epub 2018 Apr 9.

PMID:
29630061
30.

High-Throughput Single-Cell RNA Sequencing and Data Analysis.

Sagar, Herman JS, Pospisilik JA, Grün D.

Methods Mol Biol. 2018;1766:257-283. doi: 10.1007/978-1-4939-7768-0_15.

PMID:
29605858
31.

[Severe caffeine poisoning with rhabdomyolysis].

Wolter J, Grün D, Otto S.

Anaesthesist. 2018 Apr;67(4):270-274. doi: 10.1007/s00101-018-0414-9. Epub 2018 Feb 21. German.

PMID:
29468414
32.

Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells.

Fisher ML, Grun D, Adhikary G, Xu W, Eckert RL.

Oncotarget. 2017 Nov 22;8(66):110257-110272. doi: 10.18632/oncotarget.22628. eCollection 2017 Dec 15.

33.

Sulforaphane reduces YAP/∆Np63α signaling to reduce cancer stem cell survival and tumor formation.

Fisher ML, Ciavattone N, Grun D, Adhikary G, Eckert RL.

Oncotarget. 2017 Aug 27;8(43):73407-73418. doi: 10.18632/oncotarget.20562. eCollection 2017 Sep 26.

34.

Zooming in on liver zonation.

Felmlee DJ, Grün D, Baumert TF.

Hepatology. 2018 Feb;67(2):784-787. doi: 10.1002/hep.29554. Epub 2018 Jan 3. No abstract available.

PMID:
28960459
35.

Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation.

Saha K, Fisher ML, Adhikary G, Grun D, Eckert RL.

Carcinogenesis. 2017 Aug 1;38(8):827-836. doi: 10.1093/carcin/bgx044.

36.

Transglutaminase 2 Is a Direct Target Gene of YAP-TAZ-Response.

Fisher ML, Adhikary G, Kerr C, Grun D, Eckert RL.

Cancer Res. 2017 Sep 1;77(17):4736. doi: 10.1158/0008-5472.CAN-17-1255. Epub 2017 Aug 15. No abstract available. Erratum in: Cancer Res. 2018 May 15;78(10 ):2775.

37.

Combination cisplatin and sulforaphane treatment reduces proliferation, invasion, and tumor formation in epidermal squamous cell carcinoma.

Kerr C, Adhikary G, Grun D, George N, Eckert RL.

Mol Carcinog. 2018 Jan;57(1):3-11. doi: 10.1002/mc.22714. Epub 2017 Aug 28.

38.

A new fate mapping system reveals context-dependent random or clonal expansion of microglia.

Tay TL, Mai D, Dautzenberg J, Fernández-Klett F, Lin G, Sagar, Datta M, Drougard A, Stempfl T, Ardura-Fabregat A, Staszewski O, Margineanu A, Sporbert A, Steinmetz LM, Pospisilik JA, Jung S, Priller J, Grün D, Ronneberger O, Prinz M.

Nat Neurosci. 2017 Jun;20(6):793-803. doi: 10.1038/nn.4547. Epub 2017 Apr 17.

PMID:
28414331
39.

DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.

Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Münke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke MH, Wagner D, Dierks C, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hölscher C, Hauser AE, Lopez-Contreras AJ, Grün D, Gorgoulis V, Diefenbach A, Henneke P, Triantafyllopoulou A.

Cell. 2016 Nov 17;167(5):1264-1280.e18. doi: 10.1016/j.cell.2016.09.054. Epub 2016 Oct 27. Erratum in: Cell. 2018 Aug 23;174(5):1325-1326.

40.

A Single-Cell Transcriptome Atlas of the Human Pancreas.

Muraro MJ, Dharmadhikari G, Grün D, Groen N, Dielen T, Jansen E, van Gurp L, Engelse MA, Carlotti F, de Koning EJ, van Oudenaarden A.

Cell Syst. 2016 Oct 26;3(4):385-394.e3. doi: 10.1016/j.cels.2016.09.002. Epub 2016 Sep 29.

41.

Transglutaminase Interaction with α6/β4-Integrin Stimulates YAP1-Dependent ΔNp63α Stabilization and Leads to Enhanced Cancer Stem Cell Survival and Tumor Formation.

Fisher ML, Kerr C, Adhikary G, Grun D, Xu W, Keillor JW, Eckert RL.

Cancer Res. 2016 Dec 15;76(24):7265-7276. Epub 2016 Oct 25.

42.

Response to Letter of the Editor by Tomoyuki Kawada Regarding the Article "Contributory Factors to Caregiver Burden in Parkinson Disease" by Grün et al.

Grün D, Vaillant M, Pieri V, Diederich NJ.

J Am Med Dir Assoc. 2016 Nov 1;17(11):1060-1061. doi: 10.1016/j.jamda.2016.08.011. No abstract available.

PMID:
27780568
43.

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data.

Grün D, Muraro MJ, Boisset JC, Wiebrands K, Lyubimova A, Dharmadhikari G, van den Born M, van Es J, Jansen E, Clevers H, de Koning EJP, van Oudenaarden A.

Cell Stem Cell. 2016 Aug 4;19(2):266-277. doi: 10.1016/j.stem.2016.05.010. Epub 2016 Jun 23.

44.

Contributory Factors to Caregiver Burden in Parkinson Disease.

Grün D, Pieri V, Vaillant M, Diederich NJ.

J Am Med Dir Assoc. 2016 Jul 1;17(7):626-32. doi: 10.1016/j.jamda.2016.03.004. Epub 2016 Apr 30.

45.

Progression-free survival as surrogate end point for overall survival in clinical trials of HER2-targeted agents in HER2-positive metastatic breast cancer.

Michiels S, Pugliano L, Marguet S, Grun D, Barinoff J, Cameron D, Cobleigh M, Di Leo A, Johnston S, Gasparini G, Kaufman B, Marty M, Nekljudova V, Paluch-Shimon S, Penault-Llorca F, Slamon D, Vogel C, von Minckwitz G, Buyse M, Piccart M.

Ann Oncol. 2016 Jun;27(6):1029-34. doi: 10.1093/annonc/mdw132. Epub 2016 Mar 8.

46.

VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors.

Grun D, Adhikary G, Eckert RL.

Oncogene. 2016 Aug 18;35(33):4379-87. doi: 10.1038/onc.2015.507. Epub 2016 Jan 25.

47.

Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration.

Wu CC, Kruse F, Vasudevarao MD, Junker JP, Zebrowski DC, Fischer K, Noël ES, Grün D, Berezikov E, Engel FB, van Oudenaarden A, Weidinger G, Bakkers J.

Dev Cell. 2016 Jan 11;36(1):36-49. doi: 10.1016/j.devcel.2015.12.010. Epub 2015 Dec 31.

48.

The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane.

Fisher ML, Adhikary G, Grun D, Kaetzel DM, Eckert RL.

Mol Carcinog. 2016 Dec;55(12):2024-2036. doi: 10.1002/mc.22448. Epub 2015 Dec 23. Erratum in: Mol Carcinog. 2017 Dec;56(12 ):2718-2720.

49.

Design and Analysis of Single-Cell Sequencing Experiments.

Grün D, van Oudenaarden A.

Cell. 2015 Nov 5;163(4):799-810. doi: 10.1016/j.cell.2015.10.039. Review.

50.

Single-cell messenger RNA sequencing reveals rare intestinal cell types.

Grün D, Lyubimova A, Kester L, Wiebrands K, Basak O, Sasaki N, Clevers H, van Oudenaarden A.

Nature. 2015 Sep 10;525(7568):251-5. doi: 10.1038/nature14966. Epub 2015 Aug 19.

PMID:
26287467

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