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Items: 43

1.

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity.

Castillo-Quan JI, Tain LS, Kinghorn KJ, Li L, Grönke S, Hinze Y, Blackwell TK, Bjedov I, Partridge L.

Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20817-20819. doi: 10.1073/pnas.1913212116. Epub 2019 Sep 30.

2.

Branched-chain amino acids have equivalent effects to other essential amino acids on lifespan and ageing-related traits in Drosophila.

Juricic P, Grönke S, Partridge L.

J Gerontol A Biol Sci Med Sci. 2019 Mar 20. pii: glz080. doi: 10.1093/gerona/glz080. [Epub ahead of print]

PMID:
30891588
3.

Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster.

Weigelt CM, Hahn O, Arlt K, Gruhn M, Jahn AJ, Eßer J, Werner JA, Klein C, Büschges A, Grönke S, Partridge L.

Life Sci Alliance. 2019 Jan 22;2(1). pii: e201800149. doi: 10.26508/lsa.201800149. Print 2019 Feb.

4.

Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity.

Hahn O, Stubbs TM, Reik W, Grönke S, Beyer A, Partridge L.

PLoS Genet. 2018 Nov 21;14(11):e1007766. doi: 10.1371/journal.pgen.1007766. eCollection 2018 Nov.

5.

Mutations of mitochondrial DNA are not major contributors to aging of fruit flies.

Kauppila TES, Bratic A, Jensen MB, Baggio F, Partridge L, Jasper H, Grönke S, Larsson NG.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9620-E9629. doi: 10.1073/pnas.1721683115. Epub 2018 Sep 24.

6.

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.

Moens TG, Mizielinska S, Niccoli T, Mitchell JS, Thoeng A, Ridler CE, Grönke S, Esser J, Heslegrave A, Zetterberg H, Partridge L, Isaacs AM.

Acta Neuropathol. 2018 Mar;135(3):445-457. doi: 10.1007/s00401-017-1798-3. Epub 2018 Jan 29.

7.

A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance.

Tain LS, Sehlke R, Jain C, Chokkalingam M, Nagaraj N, Essers P, Rassner M, Grönke S, Froelich J, Dieterich C, Mann M, Alic N, Beyer A, Partridge L.

Mol Syst Biol. 2017 Sep 15;13(9):939. doi: 10.15252/msb.20177663.

8.

Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity.

Gorsky MK, Burnouf S, Sofola-Adesakin O, Dols J, Augustin H, Weigelt CM, Grönke S, Partridge L.

Sci Rep. 2017 Aug 30;7(1):9984. doi: 10.1038/s41598-017-10225-0.

9.

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.

Hahn O, Grönke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, Andrews S, Zhang Q, Wakelam MJ, Beyer A, Reik W, Partridge L.

Genome Biol. 2017 Mar 28;18(1):56. doi: 10.1186/s13059-017-1187-1.

10.

A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin.

Kinghorn KJ, Grönke S, Castillo-Quan JI, Woodling NS, Li L, Sirka E, Gegg M, Mills K, Hardy J, Bjedov I, Partridge L.

J Neurosci. 2016 Nov 16;36(46):11654-11670.

11.

Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing.

Kakanj P, Moussian B, Grönke S, Bustos V, Eming SA, Partridge L, Leptin M.

Nat Commun. 2016 Oct 7;7:12972. doi: 10.1038/ncomms12972.

12.

Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila.

Niccoli T, Cabecinha M, Tillmann A, Kerr F, Wong CT, Cardenes D, Vincent AJ, Bettedi L, Li L, Grönke S, Dols J, Partridge L.

Curr Biol. 2016 Sep 26;26(18):2550. doi: 10.1016/j.cub.2016.09.018. Epub 2016 Sep 26. No abstract available.

13.

Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila.

Niccoli T, Cabecinha M, Tillmann A, Kerr F, Wong CT, Cardenes D, Vincent AJ, Bettedi L, Li L, Grönke S, Dols J, Partridge L.

Curr Biol. 2016 Sep 12;26(17):2291-300. doi: 10.1016/j.cub.2016.07.017. Epub 2016 Aug 11. Erratum in: Curr Biol. 2016 Sep 26;26(18):2550.

14.

Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster.

Iyer J, Wang Q, Le T, Pizzo L, Grönke S, Ambegaokar SS, Imai Y, Srivastava A, Troisí BL, Mardon G, Artero R, Jackson GR, Isaacs AM, Partridge L, Lu B, Kumar JP, Girirajan S.

G3 (Bethesda). 2016 May 3;6(5):1427-37. doi: 10.1534/g3.116.027060.

15.

Deletion of endogenous Tau proteins is not detrimental in Drosophila.

Burnouf S, Grönke S, Augustin H, Dols J, Gorsky MK, Werner J, Kerr F, Alic N, Martinez P, Partridge L.

Sci Rep. 2016 Mar 15;6:23102. doi: 10.1038/srep23102.

16.

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies.

Bratic A, Kauppila TE, Macao B, Grönke S, Siibak T, Stewart JB, Baggio F, Dols J, Partridge L, Falkenberg M, Wredenberg A, Larsson NG.

Nat Commun. 2015 Nov 10;6:8808. doi: 10.1038/ncomms9808.

17.

Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo.

Burnouf S, Gorsky MK, Dols J, Grönke S, Partridge L.

Acta Neuropathol. 2015 Jul;130(1):35-47. doi: 10.1007/s00401-015-1419-y. Epub 2015 Apr 11.

18.

Our 2015 approach to invasive pulmonary aspergillosis.

Liss B, Vehreschild JJ, Bangard C, Maintz D, Frank K, Grönke S, Michels G, Hamprecht A, Wisplinghoff H, Markiefka B, Hekmat K, Vehreschild MJ, Cornely OA.

Mycoses. 2015 Jun;58(6):375-82. doi: 10.1111/myc.12319. Epub 2015 Mar 24. Review.

PMID:
25808916
19.

[Surgical therapy for pulmonary metastases from malignant melanoma].

Macherey S, Schlaak M, Doerr F, Grönke S, Heldwein M, Quaas A, Zander T, Hekmat K.

Hautarzt. 2015 Jan;66(1):65-73. doi: 10.1007/s00105-014-3555-z. Review. German.

PMID:
25576143
20.

[Surgical therapy of lung metastases from head and neck cancer].

Macherey S, Preuss SF, Doerr F, Grönke S, Heldwein M, Quaas A, Zander T, Hekmat K.

HNO. 2014 Dec;62(12):893-901; quiz 902-3. doi: 10.1007/s00106-014-2933-2. German.

PMID:
25294229
21.

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.

Mizielinska S, Grönke S, Niccoli T, Ridler CE, Clayton EL, Devoy A, Moens T, Norona FE, Woollacott IOC, Pietrzyk J, Cleverley K, Nicoll AJ, Pickering-Brown S, Dols J, Cabecinha M, Hendrich O, Fratta P, Fisher EMC, Partridge L, Isaacs AM.

Science. 2014 Sep 5;345(6201):1192-1194. doi: 10.1126/science.1256800. Epub 2014 Aug 7.

22.

Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.

Metaxakis A, Tain LS, Grönke S, Hendrich O, Hinze Y, Birras U, Partridge L.

PLoS Biol. 2014 Apr 1;12(4):e1001824. doi: 10.1371/journal.pbio.1001824. eCollection 2014 Apr.

23.

MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals.

Wredenberg A, Lagouge M, Bratic A, Metodiev MD, Spåhr H, Mourier A, Freyer C, Ruzzenente B, Tain L, Grönke S, Baggio F, Kukat C, Kremmer E, Wibom R, Polosa PL, Habermann B, Partridge L, Park CB, Larsson NG.

PLoS Genet. 2013;9(1):e1003178. doi: 10.1371/journal.pgen.1003178. Epub 2013 Jan 3.

24.

The G protein Gα11 is essential for hypertrophic signalling in diabetic myocardium.

Reuter H, Seuthe K, Korkmaz Y, Grönke S, Hoyer DP, Rottlaender D, Zobel C, Addicks K, Hoyer J, Grimminger P, Brabender J, Wilkie TM, Erdmann E.

Int J Cardiol. 2013 Aug 20;167(4):1476-85. doi: 10.1016/j.ijcard.2012.04.039. Epub 2012 May 3.

PMID:
22560942
25.

Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization.

Bi J, Xiang Y, Chen H, Liu Z, Grönke S, Kühnlein RP, Huang X.

J Cell Sci. 2012 Aug 1;125(Pt 15):3568-77. Epub 2012 Apr 14.

26.

The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster.

Bratic A, Wredenberg A, Grönke S, Stewart JB, Mourier A, Ruzzenente B, Kukat C, Wibom R, Habermann B, Partridge L, Larsson NG.

PLoS Genet. 2011 Oct;7(10):e1002324. doi: 10.1371/journal.pgen.1002324. Epub 2011 Oct 13.

27.

Differential effects of childhood abuse and neglect: mediation by posttraumatic distress in neurotic disorder and negative symptoms in schizophrenia?

Vogel M, Meier J, Grönke S, Waage M, Schneider W, Freyberger HJ, Klauer T.

Psychiatry Res. 2011 Aug 30;189(1):121-7. doi: 10.1016/j.psychres.2011.01.008. Epub 2011 Feb 3.

PMID:
21295351
28.

Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Gα11.

Hoyer DP, Korkmaz Y, Grönke S, Addicks K, Wettschureck N, Offermanns S, Reuter H.

Cardiovasc Diabetol. 2010 Dec 29;9:93. doi: 10.1186/1475-2840-9-93.

29.

Insulin signalling regulates remating in female Drosophila.

Wigby S, Slack C, Grönke S, Martinez P, Calboli FC, Chapman T, Partridge L.

Proc Biol Sci. 2011 Feb 7;278(1704):424-31. doi: 10.1098/rspb.2010.1390. Epub 2010 Aug 25.

30.

Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes.

Hoyer DP, Grönke S, Frank KF, Addicks K, Wettschureck N, Offermanns S, Erdmann E, Reuter H.

Mol Cell Biochem. 2010 Aug;341(1-2):235-44. doi: 10.1007/s11010-010-0454-1. Epub 2010 Apr 7.

PMID:
20372981
31.

Molecular evolution and functional characterization of Drosophila insulin-like peptides.

Grönke S, Clarke DF, Broughton S, Andrews TD, Partridge L.

PLoS Genet. 2010 Feb 26;6(2):e1000857. doi: 10.1371/journal.pgen.1000857.

32.

A Drosophila insulin-like peptide promotes growth during nonfeeding states.

Slaidina M, Delanoue R, Gronke S, Partridge L, Léopold P.

Dev Cell. 2009 Dec;17(6):874-84. doi: 10.1016/j.devcel.2009.10.009.

33.

Curled encodes the Drosophila homolog of the vertebrate circadian deadenylase Nocturnin.

Grönke S, Bickmeyer I, Wunderlich R, Jäckle H, Kühnlein RP.

Genetics. 2009 Sep;183(1):219-32. doi: 10.1534/genetics.109.105601. Epub 2009 Jul 6.

34.

Sarcoplasmic Ca2+ release is prolonged in nonfailing myocardium of diabetic patients.

Reuter H, Grönke S, Adam C, Ribati M, Brabender J, Zobel C, Frank KF, Wippermann J, Schwinger RH, Brixius K, Müller-Ehmsen J.

Mol Cell Biochem. 2008 Jan;308(1-2):141-9. Epub 2007 Oct 20.

PMID:
17952561
35.

Coronary artery ectasia.

Grönke S, Erdmann E.

Clin Res Cardiol. 2007 Nov;96(11):831, author reply 832. No abstract available.

PMID:
17874034
36.

Dual lipolytic control of body fat storage and mobilization in Drosophila.

Grönke S, Müller G, Hirsch J, Fellert S, Andreou A, Haase T, Jäckle H, Kühnlein RP.

PLoS Biol. 2007 Jun;5(6):e137.

37.

The increased angiotensin II (type 1) receptor density in myocardium of type 2 diabetic patients is prevented by blockade of the renin-angiotensin system.

Reuter H, Adam C, Grönke S, Zobel C, Frank KF, Müller-Ehmsen J, Brabender J, Schwinger RH.

Diabetologia. 2006 Dec;49(12):3067-74. Epub 2006 Oct 19.

PMID:
17051401
38.

[Characteristics of patients with coronary ectasias with and without stenotic coronary artery disease].

Grönke S, Diet F, Kilter H, Böhm M, Erdmann E.

Dtsch Med Wochenschr. 2005 Oct 21;130(42):2375-9. German.

PMID:
16235144
39.

Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila.

Grönke S, Mildner A, Fellert S, Tennagels N, Petry S, Müller G, Jäckle H, Kühnlein RP.

Cell Metab. 2005 May;1(5):323-30.

40.

[Typical angina pectoris complaints without coronary macroangiopathy].

Grönke S, Schmidt M, Schwinger RH.

Dtsch Med Wochenschr. 2005 Apr 15;130(15):942-5. German.

PMID:
15812718
41.

Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions.

Carrera P, Moshkin YM, Gronke S, Sillje HH, Nigg EA, Jackle H, Karch F.

Genes Dev. 2003 Oct 15;17(20):2578-90.

42.

Control of fat storage by a Drosophila PAT domain protein.

Grönke S, Beller M, Fellert S, Ramakrishnan H, Jäckle H, Kühnlein RP.

Curr Biol. 2003 Apr 1;13(7):603-6.

43.

Mitochondrial and cytoplasmic thioredoxin reductase variants encoded by a single Drosophila gene are both essential for viability.

Missirlis F, Ulschmid JK, Hirosawa-Takamori M, Grönke S, Schäfer U, Becker K, Phillips JP, Jäckle H.

J Biol Chem. 2002 Mar 29;277(13):11521-6. Epub 2002 Jan 16.

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