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Items: 1 to 50 of 431

1.

Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2-dependent transcription in cardiac myocytes.

Tóth AD, Schell R, Lévay M, Vettel C, Theis P, Haslinger C, Alban F, Werhahn S, Frischbier L, Krebs-Haupenthal J, Thomas D, Gröne HJ, Avkiran M, Katus HA, Wieland T, Backs J.

EMBO Mol Med. 2018 Jul;10(7). pii: e8536. doi: 10.15252/emmm.201708536.

2.

Intracapillary immune complexes recruit and activate slan-expressing CD16+ monocytes in human lupus nephritis.

Olaru F, Döbel T, Lonsdorf AS, Oehrl S, Maas M, Enk AH, Schmitz M, Gröne EF, Gröne HJ, Schäkel K.

JCI Insight. 2018 Jun 7;3(11). pii: 96492. doi: 10.1172/jci.insight.96492. [Epub ahead of print]

3.

[Progressive renal insufficiency in a 55-year-old man with psoriasis].

Herfurth K, Busch M, Gröne HJ, Wolf G.

Internist (Berl). 2018 Jun 5. doi: 10.1007/s00108-018-0446-x. [Epub ahead of print] German.

PMID:
29872889
4.

The atypical chemokine receptor 2 limits renal inflammation and fibrosis in murine progressive immune complex glomerulonephritis.

Bideak A, Blaut A, Hoppe JM, Müller MB, Federico G, Eltrich N, Gröne HJ, Locati M, Vielhauer V.

Kidney Int. 2018 Apr;93(4):826-841. doi: 10.1016/j.kint.2017.11.013. Epub 2018 Feb 1.

PMID:
29395335
5.

Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart.

Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A.

Circulation. 2018 Jun 12;137(24):2592-2608. doi: 10.1161/CIRCULATIONAHA.117.029733. Epub 2018 Jan 20.

PMID:
29353241
6.

Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis.

Jennemann R, Federico G, Mathow D, Rabionet M, Rampoldi F, Popovic ZV, Volz M, Hielscher T, Sandhoff R, Gröne HJ.

Oncotarget. 2017 Nov 24;8(65):109201-109216. doi: 10.18632/oncotarget.22648. eCollection 2017 Dec 12.

7.

A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.

Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J.

Nat Med. 2018 Jan;24(1):62-72. doi: 10.1038/nm.4452. Epub 2017 Dec 11.

PMID:
29227474
8.

The interplay of UV and cutaneous papillomavirus infection in skin cancer development.

Hasche D, Stephan S, Braspenning-Wesch I, Mikulec J, Niebler M, Gröne HJ, Flechtenmacher C, Akgül B, Rösl F, Vinzón SE.

PLoS Pathog. 2017 Nov 30;13(11):e1006723. doi: 10.1371/journal.ppat.1006723. eCollection 2017 Nov.

9.

α-Galactosidase A Genotype N215S Induces a Specific Cardiac Variant of Fabry Disease.

Oder D, Liu D, Hu K, Üçeyler N, Salinger T, Müntze J, Lorenz K, Kandolf R, Gröne HJ, Sommer C, Ertl G, Wanner C, Nordbeck P.

Circ Cardiovasc Genet. 2017 Oct;10(5). pii: e001691. doi: 10.1161/CIRCGENETICS.116.001691.

PMID:
29018006
10.

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).

Lu S, Liu S, Wietelmann A, Kojonazarov B, Atzberger A, Tang C, Schermuly RT, Gröne HJ, Offermanns S.

PLoS One. 2017 Aug 14;12(8):e0183166. doi: 10.1371/journal.pone.0183166. eCollection 2017.

11.

Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells.

Popovic ZV, Rabionet M, Jennemann R, Krunic D, Sandhoff R, Gröne HJ, Porubsky S.

Front Immunol. 2017 Jul 21;8:848. doi: 10.3389/fimmu.2017.00848. eCollection 2017.

12.

The hormetic functions of Wnt pathways in tubular injury.

Gröne EF, Federico G, Nelson PJ, Arnold B, Gröne HJ.

Pflugers Arch. 2017 Aug;469(7-8):899-906. doi: 10.1007/s00424-017-2018-7. Epub 2017 Jul 6. Review.

13.

Effects of CTGF Blockade on Attenuation and Reversal of Radiation-Induced Pulmonary Fibrosis.

Bickelhaupt S, Erbel C, Timke C, Wirkner U, Dadrich M, Flechsig P, Tietz A, Pföhler J, Gross W, Peschke P, Hoeltgen L, Katus HA, Gröne HJ, Nicolay NH, Saffrich R, Debus J, Sternlicht MD, Seeley TW, Lipson KE, Huber PE.

J Natl Cancer Inst. 2017 Aug 1;109(8). doi: 10.1093/jnci/djw339.

PMID:
28376190
14.

Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals.

von Gerichten J, Schlosser K, Lamprecht D, Morace I, Eckhardt M, Wachten D, Jennemann R, Gröne HJ, Mack M, Sandhoff R.

J Lipid Res. 2017 Jun;58(6):1247-1258. doi: 10.1194/jlr.D076190. Epub 2017 Apr 3.

15.

Hyperosmolarity impedes the cross-priming competence of dendritic cells in a TRIF-dependent manner.

Popovic ZV, Embgenbroich M, Chessa F, Nordström V, Bonrouhi M, Hielscher T, Gretz N, Wang S, Mathow D, Quast T, Schloetel JG, Kolanus W, Burgdorf S, Gröne HJ.

Sci Rep. 2017 Mar 22;7(1):311. doi: 10.1038/s41598-017-00434-y.

16.

ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy.

Sulaj A, Kopf S, Gröne E, Gröne HJ, Hoffmann S, Schleicher E, Häring HU, Schwenger V, Herzig S, Fleming T, Nawroth PP, von Bauer R.

J Diabetes Complications. 2017 Jun;31(6):1058-1065. doi: 10.1016/j.jdiacomp.2017.01.002. Epub 2017 Jan 21.

PMID:
28325697
17.

Accumulation of worn-out GBM material substantially contributes to mesangial matrix expansion in diabetic nephropathy.

Kriz W, Löwen J, Federico G, van den Born J, Gröne E, Gröne HJ.

Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F1101-F1111. doi: 10.1152/ajprenal.00020.2017. Epub 2017 Feb 22.

18.

Analysis of FOXP3+ regulatory T cell subpopulations in peripheral blood and tissue of patients with systemic lupus erythematosus.

Schmidt A, Rieger CC, Venigalla RK, Éliás S, Max R, Lorenz HM, Gröne HJ, Krammer PH, Kuhn A.

Immunol Res. 2017 Apr;65(2):551-563. doi: 10.1007/s12026-017-8904-4.

PMID:
28224362
19.

Ezetimibe reduces cholesterol content and NF-kappaB activation in liver but not in intestinal tissue in guinea pigs.

Fraunberger P, Gröne E, Gröne HJ, Drexel H, Walli AK.

J Inflamm (Lond). 2017 Feb 2;14:3. doi: 10.1186/s12950-017-0150-y. eCollection 2017.

20.

Circulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes.

Klemis V, Ghura H, Federico G, Würfel C, Bentmann A, Gretz N, Miyazaki T, Gröne HJ, Nakchbandi IA.

Kidney Int. 2017 Jun;91(6):1374-1385. doi: 10.1016/j.kint.2016.12.006. Epub 2017 Jan 31.

PMID:
28159318
21.

Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-γ-producing γδ T cells.

Rampoldi F, Brunk F, Bonrouhi M, Federico G, Krunic D, Porubsky S, Gröne HJ, Popovic ZV.

J Leukoc Biol. 2017 Apr;101(4):1005-1014. doi: 10.1189/jlb.1A0616-264R. Epub 2017 Jan 6.

PMID:
28062573
22.

Investigations of Glucocorticoid Action in GN.

Kuppe C, van Roeyen C, Leuchtle K, Kabgani N, Vogt M, Van Zandvoort M, Smeets B, Floege J, Gröne HJ, Moeller MJ.

J Am Soc Nephrol. 2017 May;28(5):1408-1420. doi: 10.1681/ASN.2016010060. Epub 2016 Nov 28.

23.

Correction: E6 and E7 from Beta Hpv38 Cooperate with Ultraviolet Light in the Development of Actinic Keratosis-Like Lesions and Squamous Cell Carcinoma in Mice.

Viarisio D, Mueller-Decker K, Kloz U, Aengeneyndt B, Kopp-Schneider A, Gröne HJ, Gheit T, Flechtenmacher C, Gissmann L, Tommasino M.

PLoS Pathog. 2016 Oct 28;12(10):e1006005. doi: 10.1371/journal.ppat.1006005. eCollection 2016 Oct.

24.

Rat kidney lipid composition addressed by mass spectrometry imaging.

Sandhoff R, Gröne HJ.

Kidney Int. 2016 Nov;90(5):1129-1130. doi: 10.1016/j.kint.2016.07.033. No abstract available.

PMID:
27742183
25.

Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis.

Federico G, Meister M, Mathow D, Heine GH, Moldenhauer G, Popovic ZV, Nordström V, Kopp-Schneider A, Hielscher T, Nelson PJ, Schaefer F, Porubsky S, Fliser D, Arnold B, Gröne HJ.

JCI Insight. 2016 Jan 21;1(1):e84916.

26.

Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure.

Kreusser MM, Lehmann LH, Wolf N, Keranov S, Jungmann A, Gröne HJ, Müller OJ, Katus HA, Backs J.

Basic Res Cardiol. 2016 Nov;111(6):65. Epub 2016 Sep 28.

PMID:
27683174
27.

Lipid microdomain modification sustains neuronal viability in models of Alzheimer's disease.

Herzer S, Meldner S, Rehder K, Gröne HJ, Nordström V.

Acta Neuropathol Commun. 2016 Sep 17;4(1):103. doi: 10.1186/s40478-016-0354-z.

28.

Preclinical evaluation of a diabody-based (177)Lu-radioimmunoconjugate for CD22-directed radioimmunotherapy in a non-Hodgkin lymphoma mouse model.

Weber T, Bötticher B, Arndt MA, Mier W, Sauter M, Exner E, Keller A, Krämer S, Leotta K, Wischnjow A, Grosse-Hovest L, Strumberg D, Jäger D, Gröne HJ, Haberkorn U, Brem G, Krauss J.

Cancer Lett. 2016 Oct 28;381(2):296-304. doi: 10.1016/j.canlet.2016.08.007. Epub 2016 Aug 11.

PMID:
27524505
29.

Atrasentan Reduces Albuminuria by Restoring the Glomerular Endothelial Glycocalyx Barrier in Diabetic Nephropathy.

Boels MG, Avramut MC, Koudijs A, Dane MJ, Lee DH, van der Vlag J, Koster AJ, van Zonneveld AJ, van Faassen E, Gröne HJ, van den Berg BM, Rabelink TJ.

Diabetes. 2016 Aug;65(8):2429-39. doi: 10.2337/db15-1413. Epub 2016 Mar 25.

30.

Transcriptional profiling of dendritic cells matured in different osmolarities.

Chessa F, Hielscher T, Mathow D, Gröne HJ, Popovic ZV.

Genom Data. 2015 Nov 26;7:64-6. doi: 10.1016/j.gdata.2015.11.016. eCollection 2016 Mar.

31.

Distinct roles of T-cell lymphopenia and the microbial flora for gastrointestinal and CNS autoimmunity.

Fischer HJ, Witte AK, Walter L, Gröne HJ, van den Brandt J, Reichardt HM.

FASEB J. 2016 May;30(5):1724-32. doi: 10.1096/fj.15-277384. Epub 2016 Jan 6.

PMID:
26740263
32.

Glomerulonephritis triggered by a chronically infected left ventricular assist device.

Saritas T, Brandenburg V, Federico G, Gröne HJ, Floege J, Moeller MJ, Moza A.

Lancet. 2015 Dec 5;386(10010):2363-4. doi: 10.1016/S0140-6736(15)00822-3. No abstract available.

PMID:
26681291
33.

Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB.

Oliver Metzig M, Fuchs D, Tagscherer KE, Gröne HJ, Schirmacher P, Roth W.

Oncogene. 2016 Jun 30;35(26):3399-409. doi: 10.1038/onc.2015.398. Epub 2015 Nov 2.

PMID:
26522725
34.

The renal microenvironment modifies dendritic cell phenotype.

Chessa F, Mathow D, Wang S, Hielscher T, Atzberger A, Porubsky S, Gretz N, Burgdorf S, Gröne HJ, Popovic ZV.

Kidney Int. 2016 Jan;89(1):82-94. doi: 10.1038/ki.2015.292. Epub 2016 Jan 4.

PMID:
26466317
35.

Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation.

Rampoldi F, Bonrouhi M, Boehm ME, Lehmann WD, Popovic ZV, Kaden S, Federico G, Brunk F, Gröne HJ, Porubsky S.

J Immunol. 2015 Nov 1;195(9):4228-43. doi: 10.4049/jimmunol.1500622. Epub 2015 Sep 30.

36.

Molecular and biochemical alterations in tubular epithelial cells of patients with isolated methylmalonic aciduria.

Ruppert T, Schumann A, Gröne HJ, Okun JG, Kölker S, Morath MA, Sauer SW.

Hum Mol Genet. 2015 Dec 15;24(24):7049-59. doi: 10.1093/hmg/ddv405. Epub 2015 Sep 29.

PMID:
26420839
37.

Advanced electron microscopic techniques provide a deeper insight into the peculiar features of podocytes.

Burghardt T, Hochapfel F, Salecker B, Meese C, Gröne HJ, Rachel R, Wanner G, Krahn MP, Witzgall R.

Am J Physiol Renal Physiol. 2015 Dec 15;309(12):F1082-9. doi: 10.1152/ajprenal.00338.2015. Epub 2015 Sep 23.

38.

Toxicity of teriflunomide in aryl hydrocarbon receptor deficient mice.

Redaelli C, Gaffarogullari EC, Brune M, Pilz C, Becker S, Sonner J, Jäschke A, Gröne HJ, Wick W, Platten M, Lanz TV.

Biochem Pharmacol. 2015 Dec 1;98(3):484-92. doi: 10.1016/j.bcp.2015.08.111. Epub 2015 Sep 2.

PMID:
26341389
39.

The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis.

Tuorto F, Herbst F, Alerasool N, Bender S, Popp O, Federico G, Reitter S, Liebers R, Stoecklin G, Gröne HJ, Dittmar G, Glimm H, Lyko F.

EMBO J. 2015 Sep 14;34(18):2350-62. doi: 10.15252/embj.201591382. Epub 2015 Aug 13.

40.

Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors.

Rabionet M, Bayerle A, Jennemann R, Heid H, Fuchser J, Marsching C, Porubsky S, Bolenz C, Guillou F, Gröne HJ, Gorgas K, Sandhoff R.

Hum Mol Genet. 2015 Sep 1;24(17):4792-808. doi: 10.1093/hmg/ddv204. Epub 2015 Jun 4.

PMID:
26045466
41.

Fasting-Induced Lipolysis and Hypothalamic Insulin Signaling Are Regulated by Neuronal Glucosylceramide Synthase.

Herzer S, Meldner S, Gröne HJ, Nordström V.

Diabetes. 2015 Oct;64(10):3363-76. doi: 10.2337/db14-1726. Epub 2015 Jun 2.

42.

Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protein-1 Ubiquitination.

Dong W, Wang H, Shahzad K, Bock F, Al-Dabet MM, Ranjan S, Wolter J, Kohli S, Hoffmann J, Dhople VM, Zhu C, Lindquist JA, Esmon CT, Gröne E, Gröne HJ, Madhusudhan T, Mertens PR, Schlüter D, Isermann B.

J Am Soc Nephrol. 2015 Nov;26(11):2789-99. doi: 10.1681/ASN.2014080846. Epub 2015 May 26.

43.

Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair.

Xia J, Swiercz JM, Bañón-Rodríguez I, Matković I, Federico G, Sun T, Franz T, Brakebusch CH, Kumanogoh A, Friedel RH, Martín-Belmonte F, Gröne HJ, Offermanns S, Worzfeld T.

Dev Cell. 2015 May 4;33(3):299-313. doi: 10.1016/j.devcel.2015.02.001. Epub 2015 Apr 16.

44.

Common histological patterns in glomerular epithelial cells in secondary focal segmental glomerulosclerosis.

Kuppe C, Gröne HJ, Ostendorf T, van Kuppevelt TH, Boor P, Floege J, Smeets B, Moeller MJ.

Kidney Int. 2015 Nov;88(5):990-8. doi: 10.1038/ki.2015.116. Epub 2015 Apr 8.

PMID:
25853334
45.

Dickkopf-3, a tissue-derived modulator of local T-cell responses.

Meister M, Papatriantafyllou M, Nordström V, Kumar V, Ludwig J, Lui KO, Boyd AS, Popovic ZV, Fleming TH, Moldenhauer G, Nawroth PP, Gröne HJ, Waldmann H, Oelert T, Arnold B.

Front Immunol. 2015 Feb 24;6:78. doi: 10.3389/fimmu.2015.00078. eCollection 2015.

46.

Dickkopf-3 acts as a modulator of B cell fate and function.

Ludwig J, Federico G, Prokosch S, Küblbeck G, Schmitt S, Klevenz A, Gröne HJ, Nitschke L, Arnold B.

J Immunol. 2015 Mar 15;194(6):2624-34. doi: 10.4049/jimmunol.1402160. Epub 2015 Feb 11.

47.

Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism.

Mathow D, Chessa F, Rabionet M, Kaden S, Jennemann R, Sandhoff R, Gröne HJ, Feuerborn A.

EMBO Rep. 2015 Mar;16(3):321-31. doi: 10.15252/embr.201439333. Epub 2015 Feb 2.

48.

Long-term kidney allograft survival in patients with transplant glomerulitis.

Nabokow A, Dobronravov VA, Khrabrova M, Gröne HJ, Gröne E, Hallensleben M, Kieneke D, Weithofer P, Smirnov AV, Kliem V.

Transplantation. 2015 Feb;99(2):331-9. doi: 10.1097/TP.0000000000000606.

PMID:
25594551
49.

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.

Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S.

Nat Med. 2015 Feb;21(2):173-7. doi: 10.1038/nm.3779. Epub 2015 Jan 12.

PMID:
25581519
50.

Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance.

Dong L, Pietsch S, Tan Z, Perner B, Sierig R, Kruspe D, Groth M, Witzgall R, Gröne HJ, Platzer M, Englert C.

J Am Soc Nephrol. 2015 Sep;26(9):2118-28. doi: 10.1681/ASN.2014080819. Epub 2015 Jan 2.

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