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Items: 1 to 50 of 358

1.

Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association.

Vossen DM, Verhagen CVM, Grénman R, Kluin RJC, Verheij M, van den Brekel MWM, Wessels LFA, Vens C.

PLoS One. 2018 Nov 8;13(11):e0206632. doi: 10.1371/journal.pone.0206632. eCollection 2018.

2.

Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.

Jamieson SM, Tsai P, Kondratyev MK, Budhani P, Liu A, Senzer NN, Chiorean EG, Jalal SI, Nemunaitis JJ, Kee D, Shome A, Wong WW, Li D, Poonawala-Lohani N, Kakadia PM, Knowlton NS, Lynch CR, Hong CR, Lee TW, Grénman RA, Caporiccio L, McKee TD, Zaidi M, Butt S, Macann AM, McIvor NP, Chaplin JM, Hicks KO, Bohlander SK, Wouters BG, Hart CP, Print CG, Wilson WR, Curran MA, Hunter FW.

JCI Insight. 2018 Aug 23;3(16). pii: 122204. doi: 10.1172/jci.insight.122204. [Epub ahead of print]

3.

Downregulation of CEACAM6 gene expression in laryngeal squamous cell carcinoma is an effect of DNA hypermethylation and correlates with disease progression.

Bednarek K, Kostrzewska-Poczekaj M, Szaumkessel M, Kiwerska K, Paczkowska J, Byzia E, Ustaszewski A, Janiszewska J, Bartochowska A, Grenman R, Wierzbicka M, Szyfter K, Giefing M, Jarmuz-Szymczak M.

Am J Cancer Res. 2018 Jul 1;8(7):1249-1261. eCollection 2018.

4.

Small oral tongue cancers (≤ 4 cm in diameter) with clinically negative neck: from the 7th to the 8th edition of the American Joint Committee on Cancer.

Almangush A, Mäkitie AA, Mäkinen LK, Kauppila JH, Pukkila M, Hagström J, Laranne J, Soini Y, Kowalski LP, Grénman R, Haglund C, Coletta RD, Salo T, Leivo I.

Virchows Arch. 2018 Oct;473(4):481-487. doi: 10.1007/s00428-018-2417-y. Epub 2018 Jul 23.

PMID:
30039390
5.

Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton.

Pehkonen H, Lento M, von Nandelstadh P, Filippou A, Grénman R, Lehti K, Monni O.

Cell Commun Signal. 2018 Jul 13;16(1):41. doi: 10.1186/s12964-018-0253-y.

6.

Targeting CD44v6 for fluorescence-guided surgery in head and neck squamous cell carcinoma.

Odenthal J, Rijpkema M, Bos D, Wagena E, Croes H, Grenman R, Boerman O, Takes R, Friedl P.

Sci Rep. 2018 Jul 11;8(1):10467. doi: 10.1038/s41598-018-28059-9.

7.

Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy.

Lepikhova T, Karhemo PR, Louhimo R, Yadav B, Murumägi A, Kulesskiy E, Kivento M, Sihto H, Grénman R, Syrjänen SM, Kallioniemi O, Aittokallio T, Wennerberg K, Joensuu H, Monni O.

Mol Cancer Ther. 2018 Sep;17(9):2060-2071. doi: 10.1158/1535-7163.MCT-17-0733. Epub 2018 Jul 3.

PMID:
29970484
8.

Polyomaviruses detectable in head and neck carcinomas.

Poluschkin L, Rautava J, Turunen A, Wang Y, Hedman K, Syrjänen K, Grenman R, Syrjänen S.

Oncotarget. 2018 Apr 27;9(32):22642-22652. doi: 10.18632/oncotarget.25202. eCollection 2018 Apr 27.

9.

Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma.

Verhagen CVM, Vossen DM, Borgmann K, Hageman F, Grénman R, Verwijs-Janssen M, Mout L, Kluin RJC, Nieuwland M, Severson TM, Velds A, Kerkhoven R, O'Connor MJ, van der Heijden M, van Velthuysen ML, Verheij M, Wreesmann VB, Wessels LFA, van den Brekel MWM, Vens C.

Oncotarget. 2018 Apr 6;9(26):18198-18213. doi: 10.18632/oncotarget.24797. eCollection 2018 Apr 6.

10.

Single nucleotide polymorphism rs11614913 associated with CC genotype in miR-196a2 is overrepresented in laryngeal squamous cell carcinoma, but not salivary gland tumors in Polish population.

Skalski M, Ustaszewski A, Jaskiewicz K, Kiwerska K, Wierzbicka M, Klimza H, Grenman R, Giefing M.

J Appl Genet. 2018 Aug;59(3):301-304. doi: 10.1007/s13353-018-0445-6. Epub 2018 Apr 29.

11.

Recurrent transcriptional loss of the PCDH17 tumor suppressor in laryngeal squamous cell carcinoma is partially mediated by aberrant promoter DNA methylation.

Byzia E, Soloch N, Bodnar M, Szaumkessel M, Kiwerska K, Kostrzewska-Poczekaj M, Jarmuz-Szymczak M, Szylberg L, Wierzbicka M, Bartochowska A, Kalinowicz E, Grenman R, Szyfter K, Marszalek A, Giefing M.

Mol Carcinog. 2018 Jul;57(7):878-885. doi: 10.1002/mc.22808. Epub 2018 Apr 6.

PMID:
29566279
12.

Prognostic impact of tumour-stroma ratio in early-stage oral tongue cancers.

Almangush A, Heikkinen I, Bakhti N, Mäkinen LK, Kauppila JH, Pukkila M, Hagström J, Laranne J, Soini Y, Kowalski LP, Grénman R, Haglund C, Mäkitie AA, Coletta RD, Leivo I, Salo T.

Histopathology. 2018 Jun;72(7):1128-1135. doi: 10.1111/his.13481. Epub 2018 Mar 23.

PMID:
29427291
13.

Epidemiological and treatment-related factors contribute to improved outcome of oropharyngeal squamous cell carcinoma in Finland.

Jouhi L, Halme E, Irjala H, Saarilahti K, Koivunen P, Pukkila M, Hagström J, Haglund C, Lindholm P, Hirvikoski P, Vaittinen S, Ellonen A, Tikanto J, Blomster H, Laranne J, Grénman R, Mäkitie A, Atula T.

Acta Oncol. 2018 Apr;57(4):541-551. doi: 10.1080/0284186X.2017.1400688. Epub 2017 Nov 17.

PMID:
29145765
14.

PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression.

Liu Y, Mattila J, Ventelä S, Yadav L, Zhang W, Lamichane N, Sundström J, Kauko O, Grénman R, Varjosalo M, Westermarck J, Hietakangas V.

Dev Cell. 2017 Oct 23;43(2):240-252.e5. doi: 10.1016/j.devcel.2017.09.022.

15.

Functional analysis of ESM1 by siRNA knockdown in primary and metastatic head and neck cancer cells.

Bender O, Gunduz M, Cigdem S, Hatipoglu OF, Acar M, Kaya M, Grenman R, Gunduz E, Ugur KS.

J Oral Pathol Med. 2018 Jan;47(1):40-47. doi: 10.1111/jop.12648. Epub 2017 Oct 30.

PMID:
29024069
16.

Combined deletion and DNA methylation result in silencing of FAM107A gene in laryngeal tumors.

Kiwerska K, Szaumkessel M, Paczkowska J, Bodnar M, Byzia E, Kowal E, Kostrzewska-Poczekaj M, Janiszewska J, Bednarek K, Jarmuż-Szymczak M, Kalinowicz E, Wierzbicka M, Grenman R, Szyfter K, Marszałek A, Giefing M.

Sci Rep. 2017 Jul 14;7(1):5386. doi: 10.1038/s41598-017-05857-1.

17.

Outcome of nasopharyngeal carcinoma in Finland: A nationwide study.

Ruuskanen M, Grenman R, Leivo I, Vahlberg T, Mäkitie A, Saarilahti K, Wigren T, Korpela M, Voutilainen L, Koivunen P, Irjala H, Minn H.

Acta Oncol. 2018 Feb;57(2):251-256. doi: 10.1080/0284186X.2017.1346378. Epub 2017 Jul 7. Erratum in: Acta Oncol. 2018 Feb;57(2):304.

PMID:
28686479
18.

Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma.

Farshchian M, Nissinen L, Siljamäki E, Riihilä P, Piipponen M, Kivisaari A, Kallajoki M, Grénman R, Peltonen J, Peltonen S, Quint KD, Bavinck JNB, Kähäri VM.

Oncotarget. 2017 Jul 11;8(28):45825-45836. doi: 10.18632/oncotarget.17573.

19.

Improved outcomes with oral tongue squamous cell carcinoma in Finland.

Mroueh R, Haapaniemi A, Grénman R, Laranne J, Pukkila M, Almangush A, Salo T, Mäkitie A.

Head Neck. 2017 Jul;39(7):1306-1312. doi: 10.1002/hed.24744. Epub 2017 May 8.

PMID:
28481417
20.

Epstein-Barr virus (EBV)-encoded small RNAs (EBERs) associated with poor prognosis of head and neck carcinomas.

Turunen A, Rautava J, Grénman R, Syrjänen K, Syrjänen S.

Oncotarget. 2017 Apr 18;8(16):27328-27338. doi: 10.18632/oncotarget.16033.

21.

Recurrent epigenetic silencing of the PTPRD tumor suppressor in laryngeal squamous cell carcinoma.

Szaumkessel M, Wojciechowska S, Janiszewska J, Zemke N, Byzia E, Kiwerska K, Kostrzewska-Poczekaj M, Ustaszewski A, Jarmuz-Szymczak M, Grenman R, Wierzbicka M, Bartochowska A, Szyfter K, Giefing M.

Tumour Biol. 2017 Mar;39(3):1010428317691427. doi: 10.1177/1010428317691427.

PMID:
28345455
22.

Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma.

Riihilä P, Nissinen L, Farshchian M, Kallajoki M, Kivisaari A, Meri S, Grénman R, Peltonen S, Peltonen J, Pihlajaniemi T, Heljasvaara R, Kähäri VM.

Am J Pathol. 2017 May;187(5):1186-1197. doi: 10.1016/j.ajpath.2017.01.006. Epub 2017 Mar 17.

23.

The feasibility of NBI in patients with suspected upper airway lesions: A multicenter study.

Bäck LJJ, Rekola J, Raittinen L, Halme E, Pietarinen P, Keski-Säntti H, Aaltonen LM, Mäkitie AA, Raappana A, Tikanto J, Schrey A, Grenman R, Laranne J, Koivunen P, Irjala H.

Laryngoscope. 2017 Aug;127(8):1821-1825. doi: 10.1002/lary.26526. Epub 2017 Feb 22.

PMID:
28224618
24.

Hypoxia Induces a HIF-1-Dependent Transition from Collective-to-Amoeboid Dissemination in Epithelial Cancer Cells.

Lehmann S, Te Boekhorst V, Odenthal J, Bianchi R, van Helvert S, Ikenberg K, Ilina O, Stoma S, Xandry J, Jiang L, Grenman R, Rudin M, Friedl P.

Curr Biol. 2017 Feb 6;27(3):392-400. doi: 10.1016/j.cub.2016.11.057. Epub 2017 Jan 12.

25.

Interaction between hypoxia, AKT and HIF-1 signaling in HNSCC and NSCLC: implications for future treatment strategies.

Stegeman H, Span PN, Peeters WJ, Verheijen MM, Grénman R, Meijer TW, Kaanders JH, Bussink J.

Future Sci OA. 2016 Jan 29;2(1):FSO84. doi: 10.4155/fso.15.84. eCollection 2016 Mar.

26.

Investigation of the expression of RIF1 gene on head and neck, pancreatic and brain cancer and cancer stem cells.

GursesCila HE, Acar M, Barut FB, Gunduz M, Grenman R, Gunduz E.

Clin Invest Med. 2016 Dec 1;39(6):27500.

PMID:
27917791
27.

Prognostic significance of the methylation of Wnt pathway antagonists-CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling-ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas.

Paluszczak J, Wiśniewska D, Kostrzewska-Poczekaj M, Kiwerska K, Grénman R, Mielcarek-Kuchta D, Jarmuż-Szymczak M.

Clin Oral Investig. 2017 Jun;21(5):1777-1788. doi: 10.1007/s00784-016-1946-5. Epub 2016 Aug 23.

28.

Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription.

Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, Sihto H, Ventelä S, Elo L, Jokitalo E, Westermarck J, Kellokumpu-Lehtinen PL, Joensuu H, Grenman R, Ivaska J.

Nat Commun. 2016 Aug 4;7:12237. doi: 10.1038/ncomms12237.

29.

Dasatinib promotes apoptosis of cutaneous squamous carcinoma cells by regulating activation of ERK1/2.

Farshchian M, Nissinen L, Grénman R, Kähäri VM.

Exp Dermatol. 2017 Jan;26(1):89-92. doi: 10.1111/exd.13109. Epub 2016 Dec 20. No abstract available.

PMID:
27305645
30.

Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests.

Kriegs M, Kasten-Pisula U, Riepen B, Hoffer K, Struve N, Myllynen L, Braig F, Binder M, Rieckmann T, Grénman R, Petersen C, Dikomey E, Rothkamm K.

Oncotarget. 2016 Jul 19;7(29):45122-45133. doi: 10.18632/oncotarget.9161.

31.

Susceptibility of human tonsillar epithelial cells to enterovirus 71 with normal cytokine response.

Xie GC, Guo NJ, Grénman R, Wang H, Wang Y, Vuorenmma M, Zhang Q, Zhang S, Li HY, Pang LL, Li DD, Jin M, Sun XM, Kong XY, Duan ZJ.

Virology. 2016 Jul;494:108-18. doi: 10.1016/j.virol.2016.04.016. Epub 2016 Apr 20.

32.

Liprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery.

Pehkonen H, von Nandelstadh P, Karhemo PR, Lepikhova T, Grenman R, Lehti K, Monni O.

Sci Rep. 2016 Apr 14;6:24486. doi: 10.1038/srep24486.

33.

Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells.

Möckelmann N, Rieckmann T, Busch CJ, Becker B, Gleißner L, Hoffer K, Omniczynski M, Steinmeister L, Laban S, Grénman R, Petersen C, Rothkamm K, Dikomey E, Knecht R, Kriegs M.

Oncotarget. 2016 Apr 26;7(17):23542-51. doi: 10.18632/oncotarget.8275.

34.

Proteomic profiling identifies the inorganic pyrophosphatase (PPA1) protein as a potential biomarker of metastasis in laryngeal squamous cell carcinoma.

Bodnar M, Luczak M, Bednarek K, Szylberg L, Marszalek A, Grenman R, Szyfter K, Jarmuz-Szymczak M, Giefing M.

Amino Acids. 2016 Jun;48(6):1469-76. doi: 10.1007/s00726-016-2201-8. Epub 2016 Mar 7.

35.

Recurrent CDK1 overexpression in laryngeal squamous cell carcinoma.

Bednarek K, Kiwerska K, Szaumkessel M, Bodnar M, Kostrzewska-Poczekaj M, Marszalek A, Janiszewska J, Bartochowska A, Jackowska J, Wierzbicka M, Grenman R, Szyfter K, Giefing M, Jarmuz-Szymczak M.

Tumour Biol. 2016 Aug;37(8):11115-26. doi: 10.1007/s13277-016-4991-4. Epub 2016 Feb 24.

36.

Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma.

Janiszewska J, Szaumkessel M, Kostrzewska-Poczekaj M, Bednarek K, Paczkowska J, Jackowska J, Grenman R, Szyfter K, Wierzbicka M, Giefing M, Jarmuz-Szymczak M.

PLoS One. 2015 Dec 22;10(12):e0144924. doi: 10.1371/journal.pone.0144924. eCollection 2015.

37.

Copy number increase of oncoprotein CIP2A is associated with poor patient survival in human head and neck squamous cell carcinoma.

Routila J, Bilgen T, Saramäki O, Grénman R, Visakorpi T, Westermarck J, Ventelä S.

J Oral Pathol Med. 2016 May;45(5):329-37. doi: 10.1111/jop.12372. Epub 2015 Oct 5.

PMID:
26436875
38.

MicroRNA expression profiles of cancer stem cells in head and neck squamous cell carcinoma.

Yata K, Beder LB, Tamagawa S, Hotomi M, Hirohashi Y, Grenman R, Yamanaka N.

Int J Oncol. 2015 Oct;47(4):1249-56. doi: 10.3892/ijo.2015.3145. Epub 2015 Aug 31.

39.

Pretreatment microRNA Expression Impacting on Epithelial-to-Mesenchymal Transition Predicts Intrinsic Radiosensitivity in Head and Neck Cancer Cell Lines and Patients.

de Jong MC, Ten Hoeve JJ, Grénman R, Wessels LF, Kerkhoven R, Te Riele H, van den Brekel MW, Verheij M, Begg AC.

Clin Cancer Res. 2015 Dec 15;21(24):5630-8. doi: 10.1158/1078-0432.CCR-15-0454. Epub 2015 Aug 11. Erratum in: Clin Cancer Res. 2016 Jun 15;22(12):3118.

40.

[Laryngeal cancer in Finland].

Grénman R, Koivunen P, Minn H.

Duodecim. 2015;131(4):331-7. Finnish.

PMID:
26237923
41.

Expression of toll-like receptors in HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma--an in vivo and in vitro study.

Jouhi L, Datta N, Renkonen S, Atula T, Mäkitie A, Haglund C, Ahmed A, Syrjänen S, Grénman R, Auvinen E, Lehtonen S, Hagström J.

Tumour Biol. 2015 Sep;36(10):7755-64. doi: 10.1007/s13277-015-3494-z. Epub 2015 May 5.

PMID:
25941114
42.

For early-stage oral tongue cancer, depth of invasion and worst pattern of invasion are the strongest pathological predictors for locoregional recurrence and mortality.

Almangush A, Bello IO, Coletta RD, Mäkitie AA, Mäkinen LK, Kauppila JH, Pukkila M, Hagström J, Laranne J, Soini Y, Kosma VM, Koivunen P, Kelner N, Kowalski LP, Grénman R, Leivo I, Läärä E, Salo T.

Virchows Arch. 2015 Jul;467(1):39-46. doi: 10.1007/s00428-015-1758-z. Epub 2015 Apr 3.

PMID:
25838076
43.

EphB2 Promotes Progression of Cutaneous Squamous Cell Carcinoma.

Farshchian M, Nissinen L, Siljamäki E, Riihilä P, Toriseva M, Kivisaari A, Ala-Aho R, Kallajoki M, Veräjänkorva E, Honkanen HK, Heljasvaara R, Pihlajaniemi T, Grénman R, Peltonen J, Peltonen S, Kähäri VM.

J Invest Dermatol. 2015 Jul;135(7):1882-1892. doi: 10.1038/jid.2015.104. Epub 2015 Mar 19.

44.

The negative regulators of Wnt pathway-DACH1, DKK1, and WIF1 are methylated in oral and oropharyngeal cancer and WIF1 methylation predicts shorter survival.

Paluszczak J, Sarbak J, Kostrzewska-Poczekaj M, Kiwerska K, Jarmuż-Szymczak M, Grenman R, Mielcarek-Kuchta D, Baer-Dubowska W.

Tumour Biol. 2015 Apr;36(4):2855-61. doi: 10.1007/s13277-014-2913-x. Epub 2014 Dec 7.

45.

CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance.

Ventelä S, Sittig E, Mannermaa L, Mäkelä JA, Kulmala J, Löyttyniemi E, Strauss L, Cárpen O, Toppari J, Grénman R, Westermarck J.

Oncotarget. 2015 Jan 1;6(1):144-58.

46.

A simple novel prognostic model for early stage oral tongue cancer.

Almangush A, Coletta RD, Bello IO, Bitu C, Keski-Säntti H, Mäkinen LK, Kauppila JH, Pukkila M, Hagström J, Laranne J, Tommola S, Soini Y, Kosma VM, Koivunen P, Kowalski LP, Nieminen P, Grénman R, Leivo I, Salo T.

Int J Oral Maxillofac Surg. 2015 Feb;44(2):143-50. doi: 10.1016/j.ijom.2014.10.004. Epub 2014 Nov 11.

PMID:
25457829
47.

Hypoxia, blood flow and metabolism in squamous-cell carcinoma of the head and neck: correlations between multiple immunohistochemical parameters and PET.

Grönroos TJ, Lehtiö K, Söderström KO, Kronqvist P, Laine J, Eskola O, Viljanen T, Grénman R, Solin O, Minn H.

BMC Cancer. 2014 Nov 24;14:876. doi: 10.1186/1471-2407-14-876.

48.

Ecto-5'-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature.

Yegutkin GG, Auvinen K, Rantakari P, Hollmén M, Karikoski M, Grénman R, Elima K, Jalkanen S, Salmi M.

Eur J Immunol. 2015 Feb;45(2):562-73. doi: 10.1002/eji.201444856. Epub 2014 Dec 15.

49.

Voice quality after treatment of early vocal cord cancer: a randomized trial comparing laser surgery with radiation therapy.

Aaltonen LM, Rautiainen N, Sellman J, Saarilahti K, Mäkitie A, Rihkanen H, Laranne J, Kleemola L, Wigren T, Sala E, Lindholm P, Grenman R, Joensuu H.

Int J Radiat Oncol Biol Phys. 2014 Oct 1;90(2):255-60. doi: 10.1016/j.ijrobp.2014.06.032.

PMID:
25304787
50.

Diversified expression of aryl hydrocarbon receptor dependent genes in human laryngeal squamous cell carcinoma cell lines treated with β-naphthoflavone.

Brauze D, Fijalkiewicz K, Szaumkessel M, Kiwerska K, Bednarek K, Rydzanicz M, Richter J, Grenman R, Jarmuz-Szymczak M.

Toxicol Lett. 2014 Nov 18;231(1):99-107. doi: 10.1016/j.toxlet.2014.09.005. Epub 2014 Sep 8.

PMID:
25218365

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