Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 100

1.

An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.

Dai S, Horton JR, Wilkinson AW, Gozani O, Zhang X, Cheng X.

J Biol Chem. 2020 Jan 7. pii: jbc.RA119.012319. doi: 10.1074/jbc.RA119.012319. [Epub ahead of print]

2.

Cardioinformatics: the nexus of bioinformatics and precision cardiology.

Khomtchouk BB, Tran DT, Vand KA, Might M, Gozani O, Assimes TL.

Brief Bioinform. 2019 Dec 4. pii: bbz119. doi: 10.1093/bib/bbz119. [Epub ahead of print]

PMID:
31802103
3.

Histone lysine methyltransferases in biology and disease.

Husmann D, Gozani O.

Nat Struct Mol Biol. 2019 Oct;26(10):880-889. doi: 10.1038/s41594-019-0298-7. Epub 2019 Oct 3. Review.

PMID:
31582846
4.

Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules.

Li TM, Coan JP, Krajewski K, Zhang L, Elias JE, Strahl BD, Gozani O, Chua KF.

Sci Rep. 2019 Oct 2;9(1):14226. doi: 10.1038/s41598-019-50817-6.

5.

Enterovirus pathogenesis requires the host methyltransferase SETD3.

Diep J, Ooi YS, Wilkinson AW, Peters CE, Foy E, Johnson JR, Zengel J, Ding S, Weng KF, Laufman O, Jang G, Xu J, Young T, Verschueren E, Kobluk KJ, Elias JE, Sarnow P, Greenberg HB, Hüttenhain R, Nagamine CM, Andino R, Krogan NJ, Gozani O, Carette JE.

Nat Microbiol. 2019 Dec;4(12):2523-2537. doi: 10.1038/s41564-019-0551-1. Epub 2019 Sep 16.

PMID:
31527793
6.

Structural basis for the target specificity of actin histidine methyltransferase SETD3.

Dai S, Horton JR, Woodcock CB, Wilkinson AW, Zhang X, Gozani O, Cheng X.

Nat Commun. 2019 Aug 6;10(1):3541. doi: 10.1038/s41467-019-11554-6.

7.

HeartBioPortal.

Khomtchouk BB, Vand KA, Koehler WC, Tran DT, Middlebrook K, Sudhakaran S, Nelson CS, Gozani O, Assimes TL.

Circ Genom Precis Med. 2019 Apr;12(4):e002426. doi: 10.1161/CIRCGEN.118.002426. Epub 2019 Apr 16. No abstract available.

PMID:
31294639
8.

SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

Wilkinson AW, Diep J, Dai S, Liu S, Ooi YS, Song D, Li TM, Horton JR, Zhang X, Liu C, Trivedi DV, Ruppel KM, Vilches-Moure JG, Casey KM, Mak J, Cowan T, Elias JE, Nagamine CM, Spudich JA, Cheng X, Carette JE, Gozani O.

Nature. 2019 Jan;565(7739):372-376. doi: 10.1038/s41586-018-0821-8. Epub 2018 Dec 10.

9.

METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.

Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA Jr, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O.

Cell. 2019 Jan 24;176(3):491-504.e21. doi: 10.1016/j.cell.2018.11.038. Epub 2019 Jan 3.

PMID:
30612740
10.

Characterization of H3.3K36M as a tool to study H3K36 methylation in cancer cells.

Sankaran SM, Gozani O.

Epigenetics. 2017;12(11):917-922. doi: 10.1080/15592294.2017.1377870. Epub 2017 Dec 11.

11.

RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation.

Carlson SM, Soulette CM, Yang Z, Elias JE, Brooks AN, Gozani O.

J Biol Chem. 2017 Aug 11;292(32):13381-13390. doi: 10.1074/jbc.M117.784371. Epub 2017 Jun 27.

12.

Histone modifications for chromatin dynamics and cellular plasticity.

Kutateladze TG, Gozani O, Bienz M, Ostankovitch M.

J Mol Biol. 2017 Jun 30;429(13):1921-1923. doi: 10.1016/j.jmb.2017.06.001. No abstract available.

PMID:
28623961
13.

Cancer epigenetics: Reading the future of leukaemia.

Wilkinson AW, Gozani O.

Nature. 2017 Mar 9;543(7644):186-188. doi: 10.1038/nature21894. Epub 2017 Mar 1. No abstract available.

PMID:
28241142
14.

Nonhistone Lysine Methylation in the Regulation of Cancer Pathways.

Carlson SM, Gozani O.

Cold Spring Harb Perspect Med. 2016 Nov 1;6(11). pii: a026435. doi: 10.1101/cshperspect.a026435. Review.

15.

Systematic Analysis of Known and Candidate Lysine Demethylases in the Regulation of Myoblast Differentiation.

Munehira Y, Yang Z, Gozani O.

J Mol Biol. 2017 Jun 30;429(13):2055-2065. doi: 10.1016/j.jmb.2016.10.004. Epub 2016 Oct 11.

16.

Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome.

Huang WH, Guenthner CJ, Xu J, Nguyen T, Schwarz LA, Wilkinson AW, Gozani O, Chang HY, Shamloo M, Luo L.

Neuron. 2016 Oct 19;92(2):392-406. doi: 10.1016/j.neuron.2016.09.019. Epub 2016 Sep 29.

17.

Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase.

Mazur PK, Gozani O, Sage J, Reynoird N.

Transl Cancer Res. 2016 Jun;5(3):330-333. doi: 10.21037/tcr.2016.06.26. No abstract available.

18.

ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.

Zhu L, Li Q, Wong SH, Huang M, Klein BJ, Shen J, Ikenouye L, Onishi M, Schneidawind D, Buechele C, Hansen L, Duque-Afonso J, Zhu F, Martin GM, Gozani O, Majeti R, Kutateladze TG, Cleary ML.

Cancer Discov. 2016 Jul;6(7):770-83. doi: 10.1158/2159-8290.CD-16-0058. Epub 2016 May 6.

19.

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer.

Reynoird N, Mazur PK, Stellfeld T, Flores NM, Lofgren SM, Carlson SM, Brambilla E, Hainaut P, Kaznowska EB, Arrowsmith CH, Khatri P, Stresemann C, Gozani O, Sage J.

Genes Dev. 2016 Apr 1;30(7):772-85. doi: 10.1101/gad.275529.115. Epub 2016 Mar 17.

20.

A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.

Sankaran SM, Wilkinson AW, Elias JE, Gozani O.

J Biol Chem. 2016 Apr 15;291(16):8465-74. doi: 10.1074/jbc.M116.720748. Epub 2016 Feb 24.

21.

Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette.

Li S, Yang Z, Du X, Liu R, Wilkinson AW, Gozani O, Jacobsen SE, Patel DJ, Du J.

Structure. 2016 Mar 1;24(3):486-94. doi: 10.1016/j.str.2016.01.004. Epub 2016 Feb 11.

22.

Histone H4 Lysine 20 (H4K20) Methylation, Expanding the Signaling Potential of the Proteome One Methyl Moiety at a Time.

van Nuland R, Gozani O.

Mol Cell Proteomics. 2016 Mar;15(3):755-64. doi: 10.1074/mcp.R115.054742. Epub 2015 Nov 23. Review.

23.

The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.

Chen S, Yang Z, Wilkinson AW, Deshpande AJ, Sidoli S, Krajewski K, Strahl BD, Garcia BA, Armstrong SA, Patel DJ, Gozani O.

Mol Cell. 2015 Oct 15;60(2):319-27. doi: 10.1016/j.molcel.2015.08.019. Epub 2015 Oct 1.

24.

A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme.

Carlson SM, Moore KE, Sankaran SM, Reynoird N, Elias JE, Gozani O.

J Biol Chem. 2015 May 8;290(19):12040-7. doi: 10.1074/jbc.M115.641530. Epub 2015 Mar 20.

25.

A Meier-Gorlin syndrome mutation impairs the ORC1-nucleosome association.

Zhang W, Sankaran S, Gozani O, Song J.

ACS Chem Biol. 2015 May 15;10(5):1176-80. doi: 10.1021/cb5009684. Epub 2015 Feb 24.

26.

A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.

Cheng Z, Cheung P, Kuo AJ, Yukl ET, Wilmot CM, Gozani O, Patel DJ.

Genes Dev. 2014 Aug 15;28(16):1758-71. doi: 10.1101/gad.246561.114.

27.

Nuclear PI5P, Uhrf1, and the road not taken.

Reynoird N, Gozani O.

Mol Cell. 2014 Jun 19;54(6):901-3. doi: 10.1016/j.molcel.2014.06.012.

28.

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.

Mazur PK, Reynoird N, Khatri P, Jansen PW, Wilkinson AW, Liu S, Barbash O, Van Aller GS, Huddleston M, Dhanak D, Tummino PJ, Kruger RG, Garcia BA, Butte AJ, Vermeulen M, Sage J, Gozani O.

Nature. 2014 Jun 12;510(7504):283-7. doi: 10.1038/nature13320. Epub 2014 May 21.

29.

Emerging technologies to map the protein methylome.

Carlson SM, Gozani O.

J Mol Biol. 2014 Oct 9;426(20):3350-62. doi: 10.1016/j.jmb.2014.04.024. Epub 2014 May 5. Review.

30.

An unexpected journey: lysine methylation across the proteome.

Moore KE, Gozani O.

Biochim Biophys Acta. 2014 Dec;1839(12):1395-403. doi: 10.1016/j.bbagrm.2014.02.008. Epub 2014 Feb 20. Review.

31.

Histone-binding domains: strategies for discovery and characterization.

Wilkinson AW, Gozani O.

Biochim Biophys Acta. 2014 Aug;1839(8):669-75. doi: 10.1016/j.bbagrm.2014.01.007. Epub 2014 Feb 11. Review.

32.

Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons.

Martín GM, King DA, Green EM, Garcia-Nieto PE, Alexander R, Collins SR, Krogan NJ, Gozani OP, Morrison AJ.

Epigenetics. 2014 Apr;9(4):513-22. doi: 10.4161/epi.27645. Epub 2014 Jan 17.

33.

Proteome-wide enrichment of proteins modified by lysine methylation.

Carlson SM, Moore KE, Green EM, Martín GM, Gozani O.

Nat Protoc. 2014 Jan;9(1):37-50. doi: 10.1038/nprot.2013.164. Epub 2013 Dec 5.

34.
35.

A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation.

Moore KE, Carlson SM, Camp ND, Cheung P, James RG, Chua KF, Wolf-Yadlin A, Gozani O.

Mol Cell. 2013 May 9;50(3):444-56. doi: 10.1016/j.molcel.2013.03.005. Epub 2013 Apr 11.

36.

Everybody's welcome: The big tent approach to epigenetic drug discovery.

Green EM, Gozani O.

Drug Discov Today Ther Strateg. 2012 Fall;9(2-3):e75-e81. Epub 2011 Sep 20.

37.

Chd5 requires PHD-mediated histone 3 binding for tumor suppression.

Paul S, Kuo A, Schalch T, Vogel H, Joshua-Tor L, McCombie WR, Gozani O, Hammell M, Mills AA.

Cell Rep. 2013 Jan 31;3(1):92-102. doi: 10.1016/j.celrep.2012.12.009. Epub 2013 Jan 10.

38.

Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity.

Ballaré C, Lange M, Lapinaite A, Martin GM, Morey L, Pascual G, Liefke R, Simon B, Shi Y, Gozani O, Carlomagno T, Benitah SA, Di Croce L.

Nat Struct Mol Biol. 2012 Dec;19(12):1257-65. doi: 10.1038/nsmb.2434. Epub 2012 Oct 28.

39.

On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions.

Price JV, Tangsombatvisit S, Xu G, Yu J, Levy D, Baechler EC, Gozani O, Varma M, Utz PJ, Liu CL.

Nat Med. 2012 Sep;18(9):1434-40.

40.

Methylation by Set9 modulates FoxO3 stability and transcriptional activity.

Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A.

Aging (Albany NY). 2012 Jul;4(7):462-79.

41.

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.

Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF.

Nature. 2012 Jul 5;487(7405):114-8. doi: 10.1038/nature11043.

42.

New marks on the block: Set5 methylates H4 lysines 5, 8 and 12.

Green EM, Morrison AJ, Gozani O.

Nucleus. 2012 Jul 1;3(4):335-9. Epub 2012 Jun 12.

43.

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.

Van Aller GS, Reynoird N, Barbash O, Huddleston M, Liu S, Zmoos AF, McDevitt P, Sinnamon R, Le B, Mas G, Annan R, Sage J, Garcia BA, Tummino PJ, Gozani O, Kruger RG.

Epigenetics. 2012 Apr;7(4):340-3. doi: 10.4161/epi.19506. Epub 2012 Apr 1.

44.

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome.

Kuo AJ, Song J, Cheung P, Ishibe-Murakami S, Yamazoe S, Chen JK, Patel DJ, Gozani O.

Nature. 2012 Mar 7;484(7392):115-9. doi: 10.1038/nature10956.

45.

Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.

Green EM, Mas G, Young NL, Garcia BA, Gozani O.

Nat Struct Mol Biol. 2012 Feb 19;19(3):361-3. doi: 10.1038/nsmb.2252.

46.

Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies.

Liu CL, Tangsombatvisit S, Rosenberg JM, Mandelbaum G, Gillespie EC, Gozani OP, Alizadeh AA, Utz PJ.

Arthritis Res Ther. 2012 Feb 2;14(1):R25. doi: 10.1186/ar3707.

47.

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.

Kuo AJ, Cheung P, Chen K, Zee BM, Kioi M, Lauring J, Xi Y, Park BH, Shi X, Garcia BA, Li W, Gozani O.

Mol Cell. 2011 Nov 18;44(4):609-20. doi: 10.1016/j.molcel.2011.08.042.

48.

A proteomic approach for the identification of novel lysine methyltransferase substrates.

Levy D, Liu CL, Yang Z, Newman AM, Alizadeh AA, Utz PJ, Gozani O.

Epigenetics Chromatin. 2011 Oct 24;4:19. doi: 10.1186/1756-8935-4-19.

49.

Regulation of p53 function by lysine methylation.

West LE, Gozani O.

Epigenomics. 2011 Jun;3(3):361-9. doi: 10.2217/EPI.11.21.

50.

Hypoxia-induced methylation of a pontin chromatin remodeling factor.

Lee JS, Kim Y, Bhin J, Shin HJ, Nam HJ, Lee SH, Yoon JB, Binda O, Gozani O, Hwang D, Baek SH.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13510-5. doi: 10.1073/pnas.1106106108. Epub 2011 Aug 8.

Supplemental Content

Loading ...
Support Center