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Items: 33

1.

Correction: Mammalian DNA methyltransferases: new discoveries and open questions.

Gowher H, Jeltsch A.

Biochem Soc Trans. 2019 Jun 28;47(3):959. doi: 10.1042/BST-2017-0574C_COR. Epub 2019 Jun 24. No abstract available.

PMID:
31235548
2.

Effect of Disease-Associated Germline Mutations on Structure Function Relationship of DNA Methyltransferases.

Norvil AB, Saha D, Saleem Dar M, Gowher H.

Genes (Basel). 2019 May 14;10(5). pii: E369. doi: 10.3390/genes10050369. Review.

3.

Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity.

Elsebaei MM, Mohammad H, Samir A, Abutaleb NS, Norvil AB, Michie AR, Moustafa MM, Samy H, Gowher H, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2019 Aug 1;175:49-62. doi: 10.1016/j.ejmech.2019.04.063. Epub 2019 Apr 27.

PMID:
31075608
4.

DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells.

Veland N, Lu Y, Hardikar S, Gaddis S, Zeng Y, Liu B, Estecio MR, Takata Y, Lin K, Tomida MW, Shen J, Saha D, Gowher H, Zhao H, Chen T.

Nucleic Acids Res. 2019 Jan 10;47(1):152-167. doi: 10.1093/nar/gky947.

5.

Mammalian DNA methyltransferases: new discoveries and open questions.

Gowher H, Jeltsch A.

Biochem Soc Trans. 2018 Oct 19;46(5):1191-1202. doi: 10.1042/BST20170574. Epub 2018 Aug 28. Review. Erratum in: Biochem Soc Trans. 2019 Jun 28;47(3):959.

PMID:
30154093
6.

Characterization of Small Molecules Inhibiting the Pro-Angiogenic Activity of the Zinc Finger Transcription Factor Vezf1.

He M, Yang Q, Norvil AB, Sherris D, Gowher H.

Molecules. 2018 Jul 3;23(7). pii: E1615. doi: 10.3390/molecules23071615.

7.

The transcription factor Vezf1 represses the expression of the antiangiogenic factor Cited2 in endothelial cells.

AlAbdi L, He M, Yang Q, Norvil AB, Gowher H.

J Biol Chem. 2018 Jul 13;293(28):11109-11118. doi: 10.1074/jbc.RA118.002911. Epub 2018 May 24.

8.

A refined DNA methylation detection method using MspJI coupled quantitative PCR.

Petell CJ, Loiseau G, Gandy R, Pradhan S, Gowher H.

Anal Biochem. 2017 Sep 15;533:1-9. doi: 10.1016/j.ab.2017.06.006. Epub 2017 Jun 15.

9.

Dnmt3b Methylates DNA by a Noncooperative Mechanism, and Its Activity Is Unaffected by Manipulations at the Predicted Dimer Interface.

Norvil AB, Petell CJ, Alabdi L, Wu L, Rossie S, Gowher H.

Biochemistry. 2018 Jul 24;57(29):4312-4324. doi: 10.1021/acs.biochem.6b00964. Epub 2016 Nov 4.

10.

Extra-coding RNAs regulate neuronal DNA methylation dynamics.

Savell KE, Gallus NV, Simon RC, Brown JA, Revanna JS, Osborn MK, Song EY, O'Malley JJ, Stackhouse CT, Norvil A, Gowher H, Sweatt JD, Day JJ.

Nat Commun. 2016 Jul 7;7:12091. doi: 10.1038/ncomms12091.

11.

An epigenetic switch regulates de novo DNA methylation at a subset of pluripotency gene enhancers during embryonic stem cell differentiation.

Petell CJ, Alabdi L, He M, San Miguel P, Rose R, Gowher H.

Nucleic Acids Res. 2016 Sep 19;44(16):7605-17. doi: 10.1093/nar/gkw426. Epub 2016 May 13.

12.

Chromatin domains, insulators, and the regulation of gene expression.

Ghirlando R, Giles K, Gowher H, Xiao T, Xu Z, Yao H, Felsenfeld G.

Biochim Biophys Acta. 2012 Jul;1819(7):644-51. doi: 10.1016/j.bbagrm.2012.01.016. Epub 2012 Feb 2. Review.

13.

Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II.

Gowher H, Brick K, Camerini-Otero RD, Felsenfeld G.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2370-5. doi: 10.1073/pnas.1121538109. Epub 2012 Jan 30.

14.

Chromatin boundaries, insulators, and long-range interactions in the nucleus.

Giles KE, Gowher H, Ghirlando R, Jin C, Felsenfeld G.

Cold Spring Harb Symp Quant Biol. 2010;75:79-85. doi: 10.1101/sqb.2010.75.006. Epub 2010 Nov 3.

PMID:
21047907
15.

VEZF1 elements mediate protection from DNA methylation.

Dickson J, Gowher H, Strogantsev R, Gaszner M, Hair A, Felsenfeld G, West AG.

PLoS Genet. 2010 Jan;6(1):e1000804. doi: 10.1371/journal.pgen.1000804. Epub 2010 Jan 8.

16.

Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b.

Gowher H, Stuhlmann H, Felsenfeld G.

Genes Dev. 2008 Aug 1;22(15):2075-84. doi: 10.1101/gad.1658408.

17.

Phosphorylation of serine-515 activates the Mammalian maintenance methyltransferase Dnmt1.

Goyal R, Rathert P, Laser H, Gowher H, Jeltsch A.

Epigenetics. 2007 Sep;2(3):155-60. Epub 2007 Jul 20.

PMID:
17965600
18.

Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L.

Xie ZH, Huang YN, Chen ZX, Riggs AD, Ding JP, Gowher H, Jeltsch A, Sasaki H, Hata K, Xu GL.

Hum Mol Genet. 2006 May 1;15(9):1375-85. Epub 2006 Mar 16.

PMID:
16543361
19.

Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase.

Gowher H, Loutchanwoot P, Vorobjeva O, Handa V, Jurkowska RZ, Jurkowski TP, Jeltsch A.

J Mol Biol. 2006 Mar 31;357(3):928-41. Epub 2006 Jan 30.

PMID:
16472822
20.

De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases.

Gowher H, Stockdale CJ, Goyal R, Ferreira H, Owen-Hughes T, Jeltsch A.

Biochemistry. 2005 Jul 26;44(29):9899-904.

PMID:
16026162
21.

Avidin plate assay system for enzymatic characterization of a histone lysine methyltransferase.

Gowher H, Zhang X, Cheng X, Jeltsch A.

Anal Biochem. 2005 Jul 15;342(2):287-91.

22.

Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L.

Gowher H, Liebert K, Hermann A, Xu G, Jeltsch A.

J Biol Chem. 2005 Apr 8;280(14):13341-8. Epub 2005 Jan 24.

23.

Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy.

Gowher H, Jeltsch A.

Cancer Biol Ther. 2004 Nov;3(11):1062-8. Epub 2004 Nov 12. Review.

PMID:
15539938
24.

Biochemistry and biology of mammalian DNA methyltransferases.

Hermann A, Gowher H, Jeltsch A.

Cell Mol Life Sci. 2004 Oct;61(19-20):2571-87. Review.

PMID:
15526163
25.

Chromatin targeting of de novo DNA methyltransferases by the PWWP domain.

Ge YZ, Pu MT, Gowher H, Wu HP, Ding JP, Jeltsch A, Xu GL.

J Biol Chem. 2004 Jun 11;279(24):25447-54. Epub 2004 Mar 3.

27.

Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA.

Fatemi M, Hermann A, Gowher H, Jeltsch A.

Eur J Biochem. 2002 Oct;269(20):4981-4.

28.

The Escherichia coli dam DNA methyltransferase modifies DNA in a highly processive reaction.

Urig S, Gowher H, Hermann A, Beck C, Fatemi M, Humeny A, Jeltsch A.

J Mol Biol. 2002 Jun 21;319(5):1085-96.

PMID:
12079349
29.

Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases.

Gowher H, Jeltsch A.

J Biol Chem. 2002 Jun 7;277(23):20409-14. Epub 2002 Mar 27.

30.

DNA from Aspergillus flavus contains 5-methylcytosine.

Gowher H, Ehrlich KC, Jeltsch A.

FEMS Microbiol Lett. 2001 Nov 27;205(1):151-5.

31.
32.

DNA of Drosophila melanogaster contains 5-methylcytosine.

Gowher H, Leismann O, Jeltsch A.

EMBO J. 2000 Dec 15;19(24):6918-23.

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