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Items: 41


Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation.

Norman TA Jr, Gower AC, Chen F, Fine A.

PLoS One. 2019 May 13;14(5):e0216795. doi: 10.1371/journal.pone.0216795. eCollection 2019.


Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder.

Abdolmaleky HM, Gower AC, Wong CK, Cox JW, Zhang X, Thiagalingam A, Shafa R, Sivaraman V, Zhou JR, Thiagalingam S.

Am J Med Genet B Neuropsychiatr Genet. 2019 Mar;180(2):138-149. doi: 10.1002/ajmg.b.32691. Epub 2018 Nov 23.


NKX2-1-AS1 negatively regulates CD274/PD-L1, cell-cell interaction genes, and limits human lung carcinoma cell migration.

Kathuria H, Millien G, McNally L, Gower AC, Tagne JB, Cao Y, Ramirez MI.

Sci Rep. 2018 Sep 26;8(1):14418. doi: 10.1038/s41598-018-32793-5.


Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm.

Noguchi T, Hussein AI, Horowitz N, Carroll D, Gower AC, Demissie S, Gerstenfeld LC.

Sci Rep. 2018 Sep 13;8(1):13756. doi: 10.1038/s41598-018-31830-7.


Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases.

Francis IP, Islam EA, Gower AC, Shaik-Dasthagirisaheb YB, Gray-Owen SD, Wetzler LM.

BMC Genomics. 2018 Aug 22;19(1):627. doi: 10.1186/s12864-018-5000-7.


Summarizing performance for genome scale measurement of miRNA: reference samples and metrics.

Pine PS, Lund SP, Parsons JR, Vang LK, Mahabal AA, Cinquini L, Kelly SC, Kincaid H, Crichton DJ, Spira A, Liu G, Gower AC, Pass HI, Goparaju C, Dubinett SM, Krysan K, Stass SA, Kukuruga D, Van Keuren-Jensen K, Courtright-Lim A, Thompson KL, Rosenzweig BA, Sorbara L, Srivastava S, Salit ML.

BMC Genomics. 2018 Mar 6;19(1):180. doi: 10.1186/s12864-018-4496-1.


The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.

Kozlowski E, Wasserman GA, Morgan M, O'Carroll D, Ramirez NP, Gummuluru S, Rah JY, Gower AC, Ieong M, Quinton LJ, Mizgerd JP, Jones MR.

PLoS One. 2017 Jun 30;12(6):e0179797. doi: 10.1371/journal.pone.0179797. eCollection 2017.


miRNA profiling of primary lung and head and neck squamous cell carcinomas: Addressing a diagnostic dilemma.

Muñoz-Largacha JA, Gower AC, Sridhar P, Deshpande A, O'Hara CJ, Yamada E, Godfrey TE, Fernando HC, Litle VR.

J Thorac Cardiovasc Surg. 2017 Aug;154(2):714-727. doi: 10.1016/j.jtcvs.2017.02.071. Epub 2017 Apr 12.


The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland.

Szymaniak AD, Mi R, McCarthy SE, Gower AC, Reynolds TL, Mingueneau M, Kukuruzinska M, Varelas X.

Elife. 2017 May 11;6. pii: e23499. doi: 10.7554/eLife.23499.


Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression in the Cerebral Cortex of an Alzheimer's Disease Mouse Model.

Wang E, Zhu H, Wang X, Gower AC, Wallack M, Blusztajn JK, Kowall N, Qiu WQ.

J Alzheimers Dis. 2017;56(1):47-61. doi: 10.3233/JAD-160677.


Changes in gene expression profiles in patients with pulmonary arterial hypertension associated with scleroderma treated with tadalafil.

Cheong FY, Gower AC, Farber HW.

Semin Arthritis Rheum. 2017 Feb;46(4):465-472. doi: 10.1016/j.semarthrit.2016.05.015. Epub 2016 Jun 7.


Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia.

Kamata H, Yamamoto K, Wasserman GA, Zabinski MC, Yuen CK, Lung WY, Gower AC, Belkina AC, Ramirez MI, Deng JC, Quinton LJ, Jones MR, Mizgerd JP.

Am J Respir Cell Mol Biol. 2016 Sep;55(3):407-18. doi: 10.1165/rcmb.2015-0261OC.


TLR3 Signaling Promotes the Induction of Unique Human BDCA-3 Dendritic Cell Populations.

Colletti NJ, Liu H, Gower AC, Alekseyev YO, Arendt CW, Shaw MH.

Front Immunol. 2016 Mar 14;7:88. doi: 10.3389/fimmu.2016.00088. eCollection 2016.


Microbial Diversity in the Early In Vivo-Formed Dental Biofilm.

Heller D, Helmerhorst EJ, Gower AC, Siqueira WL, Paster BJ, Oppenheim FG.

Appl Environ Microbiol. 2016 Jan 8;82(6):1881-8. doi: 10.1128/AEM.03984-15.


Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells.

Lambert AW, Wong CK, Ozturk S, Papageorgis P, Raghunathan R, Alekseyev Y, Gower AC, Reinhard BM, Abdolmaleky HM, Thiagalingam S.

Mol Cancer Res. 2016 Jan;14(1):103-13. doi: 10.1158/1541-7786.MCR-15-0079. Epub 2015 Oct 27.


Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy.

Whitney DH, Elashoff MR, Porta-Smith K, Gower AC, Vachani A, Ferguson JS, Silvestri GA, Brody JS, Lenburg ME, Spira A.

BMC Med Genomics. 2015 May 6;8:18. doi: 10.1186/s12920-015-0091-3.


Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells.

Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN.

Stem Cell Reports. 2015 May 12;4(5):873-85. doi: 10.1016/j.stemcr.2015.02.021. Epub 2015 Apr 2.


The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL.

Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344. Epub 2015 Apr 22.


Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet.

Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC 3rd, Freedman JE, Ingalls RR, Genco CA.

BMC Genomics. 2014 Dec 24;15:1176. doi: 10.1186/1471-2164-15-1176.


Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis.

Ooi AT, Gower AC, Zhang KX, Vick JL, Hong L, Nagao B, Wallace WD, Elashoff DA, Walser TC, Dubinett SM, Pellegrini M, Lenburg ME, Spira A, Gomperts BN.

Cancer Prev Res (Phila). 2014 May;7(5):487-95. doi: 10.1158/1940-6207.CAPR-13-0372. Epub 2014 Mar 11.


Analysis of Notch signaling-dependent gene expression in developing airways reveals diversity of Clara cells.

Guha A, Vasconcelos M, Zhao R, Gower AC, Rajagopal J, Cardoso WV.

PLoS One. 2014 Feb 21;9(2):e88848. doi: 10.1371/journal.pone.0088848. eCollection 2014.


Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer.

Kadara H, Fujimoto J, Yoo SY, Maki Y, Gower AC, Kabbout M, Garcia MM, Chow CW, Chu Z, Mendoza G, Shen L, Kalhor N, Hong WK, Moran C, Wang J, Spira A, Coombes KR, Wistuba II.

J Natl Cancer Inst. 2014 Mar;106(3):dju004. doi: 10.1093/jnci/dju004. Epub 2014 Feb 22.


MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis.

Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18946-51. doi: 10.1073/pnas.1220319110. Epub 2013 Oct 24.


Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors.

Tagne JB, Gupta S, Gower AC, Shen SS, Varma S, Lakshminarayanan M, Cao Y, Spira A, Volkert TL, Ramirez MI.

PLoS One. 2012;7(1):e29907. doi: 10.1371/journal.pone.0029907. Epub 2012 Jan 5.


LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages.

Bushell KN, Leeman SE, Gillespie E, Gower AC, Reed KL, Stucchi AF, Becker JM, Amar S.

PLoS One. 2011;6(9):e25849. doi: 10.1371/journal.pone.0025849. Epub 2011 Sep 30.


Discovering biological connections between experimental conditions based on common patterns of differential gene expression.

Gower AC, Spira A, Lenburg ME.

BMC Bioinformatics. 2011 Sep 27;12:381. doi: 10.1186/1471-2105-12-381.


Transcriptomic studies of the airway field of injury associated with smoking-related lung disease.

Gower AC, Steiling K, Brothers JF 2nd, Lenburg ME, Spira A.

Proc Am Thorac Soc. 2011 May;8(2):173-9. doi: 10.1513/pats.201011-066MS.


Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer.

Ooi AT, Mah V, Nickerson DW, Gilbert JL, Ha VL, Hegab AE, Horvath S, Alavi M, Maresh EL, Chia D, Gower AC, Lenburg ME, Spira A, Solis LM, Wistuba II, Walser TC, Wallace WD, Dubinett SM, Goodglick L, Gomperts BN.

Cancer Res. 2010 Aug 15;70(16):6639-48. doi: 10.1158/0008-5472.CAN-10-0455.


Open adhesiolysis is more effective in reducing adhesion reformation than laparoscopic adhesiolysis in an experimental model.

Prushik SG, Stucchi AF, Matteotti R, Aarons CB, Reed KL, Gower AC, Becker JM.

Br J Surg. 2010 Mar;97(3):420-7. doi: 10.1002/bjs.6899.


Stasis predisposes ileal pouch inflammation in a rat model of ileal pouch-anal anastomosis.

Stucchi AF, Shebani KO, Reed KL, Gower AC, Alapatt MF, Crivello KM, McClung JP, Becker JM.

J Surg Res. 2010 Nov;164(1):75-83. doi: 10.1016/j.jss.2009.03.049. Epub 2009 May 3.


Practical limitations of bioresorbable membranes in the prevention of intra-abdominal adhesions.

Lim R, Morrill JM, Lynch RC, Reed KL, Gower AC, Leeman SE, Stucchi AF, Becker JM.

J Gastrointest Surg. 2009 Jan;13(1):35-41; discussion 41-2. doi: 10.1007/s11605-008-0724-3. Epub 2008 Oct 15.


An FDA approved neurokinin-1 receptor antagonist is effective in reducing intraabdominal adhesions when administered intraperitoneally, but not orally.

Lim R, Morrill JM, Prushik SG, Reed KL, Gower AC, Leeman SE, Stucchi AF, Becker JM.

J Gastrointest Surg. 2008 Oct;12(10):1754-61. doi: 10.1007/s11605-008-0634-4. Epub 2008 Aug 16. Erratum in: J Gastrointest Surg. 2009 Jan;13(1):43.


A neurokinin-1 receptor antagonist that reduces intraabdominal adhesion formation increases peritoneal matrix metalloproteinase activity.

Cohen PA, Gower AC, Stucchi AF, Leeman SE, Becker JM, Reed KL.

Wound Repair Regen. 2007 Nov-Dec;15(6):800-8.


Intraperitoneal administration of methylene blue attenuates oxidative stress, increases peritoneal fibrinolysis, and inhibits intraabdominal adhesion formation.

Heydrick SJ, Reed KL, Cohen PA, Aarons CB, Gower AC, Becker JM, Stucchi AF.

J Surg Res. 2007 Dec;143(2):311-9. Epub 2007 Sep 10.


A neurokinin-1 receptor antagonist that reduces intra-abdominal adhesion formation decreases oxidative stress in the peritoneum.

Reed KL, Heydrick SJ, Aarons CB, Prushik S, Gower AC, Stucchi AF, Becker JM.

Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G544-51. Epub 2007 Jul 12.


A neurokinin 1 receptor antagonist decreases adhesion reformation after laparoscopic lysis of adhesions in a rat model of adhesion formation.

Prushik SG, Aarons CB, Matteotti R, Reed KL, Gower AC, Leeman SE, Stucchi AF, Becker JM.

Surg Endosc. 2007 Oct;21(10):1790-5. Epub 2007 Mar 14.


The effectiveness of a single intraperitoneal infusion of a neurokinin-1 receptor antagonist in reducing postoperative adhesion formation is time dependent.

Cohen PA, Aarons CB, Gower AC, Stucchi AF, Leeman SE, Becker JM, Reed KL.

Surgery. 2007 Mar;141(3):368-75. Epub 2007 Feb 6.


NF-kappaB activation precedes increases in mRNA encoding neurokinin-1 receptor, proinflammatory cytokines, and adhesion molecules in dextran sulfate sodium-induced colitis in rats.

Reed KL, Fruin AB, Gower AC, Gonzales KD, Stucchi AF, Andry CD, O'Brien M, Becker JM.

Dig Dis Sci. 2005 Dec;50(12):2366-78.


A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity.

Reed KL, Fruin AB, Gower AC, Stucchi AF, Leeman SE, Becker JM.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9115-20. Epub 2004 Jun 8.


A neurokinin 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the response to a subsequent inflammatory stimulus.

Stucchi AF, Shebani KO, Leeman SE, Wang CC, Reed KL, Fruin AB, Gower AC, McClung JP, Andry CD, O'Brien MJ, Pothoulakis C, Becker JM.

Am J Physiol Gastrointest Liver Physiol. 2003 Dec;285(6):G1259-67. Epub 2003 Jul 31.


Neurokinin-1 receptor and substance P messenger RNA levels increase during intraabdominal adhesion formation.

Reed KL, Fruin AB, Bishop-Bartolomei KK, Gower AC, Nicolaou M, Stucchi AF, Leeman SE, Becker JM.

J Surg Res. 2002 Nov;108(1):165-72.


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