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Items: 1 to 50 of 129

1.

Timing of enterostomy closure for neonatal isolated intestinal perforation.

Bonasso PC, Dassinger MS, Mehl SC, Gokun Y, Gowen MS, Burford JM, Smith SD.

J Pediatr Surg. 2020 Jan 7. pii: S0022-3468(19)30874-7. doi: 10.1016/j.jpedsurg.2019.12.001. [Epub ahead of print]

PMID:
31954555
2.

In-hospital Pediatric Endoscopic Retrograde Cholangiopancreatography Is Associated With Shorter Hospitalization for Children With Choledocholithiasis.

Bonasso PC, Gurien LA, Staszak J, Gowen ME, Troendle DM, Odiase E, Lazar L, Ruan W, Barth BA, Williams RF, Dassinger MS.

J Pediatr Gastroenterol Nutr. 2019 Jan;68(1):64-67. doi: 10.1097/MPG.0000000000002102.

PMID:
30044307
3.

24-hour and 30-day perioperative mortality in pediatric surgery.

Bonasso PC, Dassinger MS, Ryan ML, Gowen MS, Burford JM, Smith SD.

J Pediatr Surg. 2019 Apr;54(4):628-630. doi: 10.1016/j.jpedsurg.2018.06.026. Epub 2018 Jun 25.

PMID:
30017066
4.

Resource utilization and indications for helicopter transport of head-injured children.

Elswick CM, Wyrick D, Gurien LA, Rettiganti M, Gowen M, Pownall A, Bahgat D, Maxson RT, Öcal E, Albert GW.

J Pediatr Surg. 2018 Sep;53(9):1795-1799. doi: 10.1016/j.jpedsurg.2018.04.032. Epub 2018 May 1.

PMID:
29792280
5.

Barriers to Breastfeeding in Female Physicians.

Cantu RM, Gowen MS, Tang X, Mitchell K.

Breastfeed Med. 2018 Jun;13(5):341-345. doi: 10.1089/bfm.2018.0022. Epub 2018 May 9.

PMID:
29741914
6.

Pediatric Perioperative Cardiac Arrest, Death in the Off Hours: A Report From Wake Up Safe, The Pediatric Quality Improvement Initiative.

Christensen RE, Lee AC, Gowen MS, Rettiganti MR, Deshpande JK, Morray JP.

Anesth Analg. 2018 Aug;127(2):472-477. doi: 10.1213/ANE.0000000000003398.

PMID:
29677059
7.

Characteristics of deposits and pump exchange in the Berlin Heart EXCOR ventricular assist device: Experience with 67 cases.

Maeda K, Almond C, Hollander SA, Rosenthal DN, Kaufman B, Gowen MM, Murray J, Shuttleworth P, Reinhartz O.

Pediatr Transplant. 2018 Jun;22(4):e13181. doi: 10.1111/petr.13181. Epub 2018 Apr 10.

PMID:
29635728
8.

Baseline antibody profiles predict toxicity in melanoma patients treated with immune checkpoint inhibitors.

Gowen MF, Giles KM, Simpson D, Tchack J, Zhou H, Moran U, Dawood Z, Pavlick AC, Hu S, Wilson MA, Zhong H, Krogsgaard M, Kirchhoff T, Osman I.

J Transl Med. 2018 Apr 2;16(1):82. doi: 10.1186/s12967-018-1452-4.

9.

Pediatric vascular trauma practice patterns and resource availability: A survey of American College of Surgeon-designated pediatric trauma centers.

Bonasso PC, Gurien LA, Smith SD, Gowen ME, Dassinger MS.

J Trauma Acute Care Surg. 2018 May;84(5):758-761. doi: 10.1097/TA.0000000000001799.

PMID:
29334567
10.

Temporary Circulatory Support in U.S. Children Awaiting Heart Transplantation.

Yarlagadda VV, Maeda K, Zhang Y, Chen S, Dykes JC, Gowen MA, Shuttleworth P, Murray JM, Shin AY, Reinhartz O, Rosenthal DN, McElhinney DB, Almond CS.

J Am Coll Cardiol. 2017 Oct 31;70(18):2250-2260. doi: 10.1016/j.jacc.2017.08.072.

11.

Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells.

Vitiello M, Tuccoli A, D'Aurizio R, Sarti S, Giannecchini L, Lubrano S, Marranci A, Evangelista M, Peppicelli S, Ippolito C, Barravecchia I, Guzzolino E, Montagnani V, Gowen M, Mercoledi E, Mercatanti A, Comelli L, Gurrieri S, Wu LW, Ope O, Flaherty K, Boland GM, Hammond MR, Kwong L, Chiariello M, Stecca B, Zhang G, Salvetti A, Angeloni D, Pitto L, Calorini L, Chiorino G, Pellegrini M, Herlyn M, Osman I, Poliseno L.

Oncotarget. 2017 Apr 11;8(15):25395-25417. doi: 10.18632/oncotarget.15915.

12.

US immigration order strikes against biotech.

Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forrester R, Francois C, Franklin H, Freeman MW, Furst H, Gage LP, Galakatos N, Gallagher BM, Geraghty JA, Gill S, Goeddel DV, Goldsmith MA, Gowen M, Goyal V, Graney T, Grayzel D, Greene B, Grint P, Gutierrez-Ramos JC, Haney B, Ha-Ngoc T, Harris T, Hasnain F, Hata YS, Hecht P, Henshaw L, Heyman R, Hoppenot H, Horvitz HR, Hughes TE, Hutton WS, Isaacs ST, Jenkins A, Jonker J, Kaplan J, Karsen P, Keiper J, Kim J, Kindler J, King R, King V, Kjellson N, Koenig S, Koenig G, Kolchinsky P, Laikind P, Langer RB, Lee JJ, Leff JS, Leicher BA, Leschly N, Levin A, Levin M, Levine AJ, Levy A, Liu DR, Lodish HF, Lopatin U, Love TW, Macdonald G, Maderis GJ, Mahadevia A, Mahanthappa NK, Martin JF, Martin A, Martucci WE, McArthur JG, McCann CM, McCarthy SA, McDonough CG, Mendlein J, Miller L, Miralles D, Moch KI, More B, Myers AG, Narachi MA, Nashat A, Nelson W, Newell WJ, Olle B, Osborn JE, Owens JC, Pande A, Papadopoulos S, Parker HS, Parmar KM, Patterson MR, Paul SM, Perez R, Perry M, Pfeffer CG, Powell M, Pruzanski M, Purcell DJ, Rakhit A, Ramamoorthi K, Rastetter W, Rawcliffe AA, Reid LE, Renaud RC, Rhodes JP, Rieflin WJ, Robins C, Rocklage SM, Rosenblatt M, Rosin JG, Rutter WJ, Saha S, Samuels C, Sato VL, Scangos G, Scarlett JA, Schenkein D, Schreiber SL, Schwab A, Sekhri P, Shah R, Shenk T, Siegall CB, Simon NJ, Simonian N, Stein J, Su M, Szela MT, Taglietti M, Tandon N, Termeer H, Thornberry NA, Tolar M, Ulevitch R, Vaishnaw AK, VanLent A, Varsavsky M, Vlasuk GP, Vounatsos M, Waksal SG, Warma N, Watts RJ, Werber Y, Westphal C, Wierenga W, Williams DE, Williams LR, Xanthopoulos KG, Zohar D, Zweifach SS.

Nat Biotechnol. 2017 Mar 7;35(3):204-206. doi: 10.1038/nbt.3824. No abstract available.

PMID:
28267733
13.

Long-Term Pediatric Ventricular Assist Device Therapy: A Case Report of 2100+ Days of Support.

Purkey NJ, Lin A, Murray JM, Gowen M, Shuttleworth P, Maeda K, Almond CS, Rosenthal DN, Chen S.

ASAIO J. 2018 Jan/Feb;64(1):e1-e2. doi: 10.1097/MAT.0000000000000546.

PMID:
28195883
14.

Collateralization of projections from the rostral ventrolateral medulla to the rostral and caudal thoracic spinal cord in felines.

Gowen MF, Ogburn SW, Suzuki T, Sugiyama Y, Cotter LA, Yates BJ.

Exp Brain Res. 2012 Jul;220(2):121-33. doi: 10.1007/s00221-012-3122-8. Epub 2012 May 24.

15.

The relationship between basal cisterns on CT and time-linked intracranial pressure in paediatric head injury.

Kouvarellis AJ, Rohlwink UK, Sood V, Van Breda D, Gowen MJ, Figaji AA.

Childs Nerv Syst. 2011 Jul;27(7):1139-44. doi: 10.1007/s00381-011-1464-3. Epub 2011 May 3.

PMID:
21538131
16.

Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance.

Violin JD, DeWire SM, Yamashita D, Rominger DH, Nguyen L, Schiller K, Whalen EJ, Gowen M, Lark MW.

J Pharmacol Exp Ther. 2010 Dec;335(3):572-9. doi: 10.1124/jpet.110.173005. Epub 2010 Aug 26.

PMID:
20801892
17.

Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues.

Marquis RW, Lago AM, Callahan JF, Rahman A, Dong X, Stroup GB, Hoffman S, Gowen M, DelMar EG, Van Wagenen BC, Logan S, Shimizu S, Fox J, Nemeth EF, Roethke T, Smith BR, Ward KW, Bhatnagar P.

J Med Chem. 2009 Nov 12;52(21):6599-605. doi: 10.1021/jm900563e.

PMID:
19821575
18.

An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation.

Kumar S, Matheny CJ, Hoffman SJ, Marquis RW, Schultz M, Liang X, Vasko JA, Stroup GB, Vaden VR, Haley H, Fox J, DelMar EG, Nemeth EF, Lago AM, Callahan JF, Bhatnagar P, Huffman WF, Gowen M, Yi B, Danoff TM, Fitzpatrick LA.

Bone. 2010 Feb;46(2):534-42. doi: 10.1016/j.bone.2009.09.028. Epub 2009 Sep 26.

PMID:
19786130
19.

Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.

Marquis RW, Lago AM, Callahan JF, Trout RE, Gowen M, DelMar EG, Van Wagenen BC, Logan S, Shimizu S, Fox J, Nemeth EF, Yang Z, Roethke T, Smith BR, Ward KW, Lee J, Keenan RM, Bhatnagar P.

J Med Chem. 2009 Jul 9;52(13):3982-93. doi: 10.1021/jm900364m.

PMID:
19492813
20.

Method for quantitative protein-ligand affinity measurements in compound mixtures.

Annis DA, Shipps GW Jr, Deng Y, Popovici-Müller J, Siddiqui MA, Curran PJ, Gowen M, Windsor WT.

Anal Chem. 2007 Jun 15;79(12):4538-42. Epub 2007 May 15.

PMID:
17500537
21.

A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.

Kumar S, Dare L, Vasko-Moser JA, James IE, Blake SM, Rickard DJ, Hwang SM, Tomaszek T, Yamashita DS, Marquis RW, Oh H, Jeong JU, Veber DF, Gowen M, Lark MW, Stroup G.

Bone. 2007 Jan;40(1):122-31. Epub 2006 Sep 7.

PMID:
16962401
22.

Dentists and self-administered retirement trusts.

Gowen M.

J Ir Dent Assoc. 2005 Autumn;51(3):140. No abstract available.

PMID:
16167625
23.

Personal pensions.

Gowen M.

J Ir Dent Assoc. 2005 Autumn;51(3):138. No abstract available.

PMID:
16167624
24.

Inhibition of cathepsin K--a novel approach to antiresorptive therapy.

Gowen M.

Expert Opin Investig Drugs. 1997 Sep;6(9):1199-202.

PMID:
15991895
25.

An azepanone-based inhibitor of human cathepsin K with improved oral bioavailability in the rat and the monkey.

Marquis RW, Ward KW, Roethke T, Smith BR, Ru Y, Yamashita DS, Tomaszek TA, Gorycki PD, Cheng HY, James IE, Stroup GB, Lark MW, Gowen M, Veber DF.

Mol Pharm. 2004 Jan 12;1(1):97-100. No abstract available.

PMID:
15832505
26.

Rapid inhibition of thyroxine-induced bone resorption in the rat by an orally active vitronectin receptor antagonist.

Hoffman SJ, Vasko-Moser J, Miller WH, Lark MW, Gowen M, Stroup G.

J Pharmacol Exp Ther. 2002 Jul;302(1):205-11.

PMID:
12065718
27.

A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat.

Lark MW, Stroup GB, James IE, Dodds RA, Hwang SM, Blake SM, Lechowska BA, Hoffman SJ, Smith BR, Kapadia R, Liang X, Erhard K, Ru Y, Dong X, Marquis RW, Veber D, Gowen M.

Bone. 2002 May;30(5):746-53.

PMID:
11996914
28.

Clusterin expression in adult human normal and osteoarthritic articular cartilage.

Connor JR, Kumar S, Sathe G, Mooney J, O'Brien SP, Mui P, Murdock PR, Gowen M, Lark MW.

Osteoarthritis Cartilage. 2001 Nov;9(8):727-37.

29.

Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.

Kumar S, Connor JR, Dodds RA, Halsey W, Van Horn M, Mao J, Sathe G, Mui P, Agarwal P, Badger AM, Lee JC, Gowen M, Lark MW.

Osteoarthritis Cartilage. 2001 Oct;9(7):641-53.

30.

Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate.

Stroup GB, Lark MW, Veber DF, Bhattacharyya A, Blake S, Dare LC, Erhard KF, Hoffman SJ, James IE, Marquis RW, Ru Y, Vasko-Moser JA, Smith BR, Tomaszek T, Gowen M.

J Bone Miner Res. 2001 Oct;16(10):1739-46.

31.

Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone.

Nemeth EF, Delmar EG, Heaton WL, Miller MA, Lambert LD, Conklin RL, Gowen M, Gleason JG, Bhatnagar PK, Fox J.

J Pharmacol Exp Ther. 2001 Oct;299(1):323-31.

PMID:
11561095
32.

Emerging therapies in osteoporosis.

MacDonald BR, Gowen M.

Best Pract Res Clin Rheumatol. 2001 Jul;15(3):483-96. Review.

PMID:
11485342
33.

Antagonism of oestrogen action in human breast and endometrial cells in vitro: potential novel antitumour agents.

Nuttall ME, Pendrak I, Emery JG, Nadeau DP, Fisher PW, Nicholson TA, Zhu Y, Suva LJ, Kingsbury WD, Gowen M.

Cancer Chemother Pharmacol. 2001 May;47(5):437-43.

PMID:
11391860
34.

Novel bone antiresorptive agents that selectively inhibit the osteoclast V-H+-ATPase.

Farina C, Gagliardi S, Nadler G, Morvan M, Parini C, Belfiore P, Visentin L, Gowen M.

Farmaco. 2001 Jan-Feb;56(1-2):113-6. Review.

PMID:
11347950
35.
36.

IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase.

Kumar S, Votta BJ, Rieman DJ, Badger AM, Gowen M, Lee JC.

J Cell Physiol. 2001 Jun;187(3):294-303.

PMID:
11319753
37.

Azepanone-based inhibitors of human and rat cathepsin K.

Marquis RW, Ru Y, LoCastro SM, Zeng J, Yamashita DS, Oh HJ, Erhard KF, Davis LD, Tomaszek TA, Tew D, Salyers K, Proksch J, Ward K, Smith B, Levy M, Cummings MD, Haltiwanger RC, Trescher G, Wang B, Hemling ME, Quinn CJ, Cheng HY, Lin F, Smith WW, Janson CA, Zhao B, McQueney MS, D'Alessio K, Lee CP, Marzulli A, Dodds RA, Blake S, Hwang SM, James IE, Gress CJ, Bradley BR, Lark MW, Gowen M, Veber DF.

J Med Chem. 2001 Apr 26;44(9):1380-95.

PMID:
11311061
38.

Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption.

Dodds RA, James IE, Rieman D, Ahern R, Hwang SM, Connor JR, Thompson SD, Veber DF, Drake FH, Holmes S, Lark MW, Gowen M.

J Bone Miner Res. 2001 Mar;16(3):478-86.

39.

Biosynthesis and processing of cathepsin K in cultured human osteoclasts.

Rieman DJ, McClung HA, Dodds RA, Hwang SM, Holmes MW, James IE, Drake FH, Gowen M.

Bone. 2001 Mar;28(3):282-9.

PMID:
11248658
40.

Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis.

Badger AM, Blake S, Kapadia R, Sarkar S, Levin J, Swift BA, Hoffman SJ, Stroup GB, Miller WH, Gowen M, Lark MW.

Arthritis Rheum. 2001 Jan;44(1):128-37.

41.

Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat.

Lark MW, Stroup GB, Dodds RA, Kapadia R, Hoffman SJ, Hwang SM, James IE, Lechowska B, Liang X, Rieman DJ, Salyers KL, Ward K, Smith BR, Miller WH, Huffman WF, Gowen M.

J Bone Miner Res. 2001 Feb;16(2):319-27.

42.

Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro.

James IE, Marquis RW, Blake SM, Hwang SM, Gress CJ, Ru Y, Zembryki D, Yamashita DS, McQueney MS, Tomaszek TA, Oh HJ, Gowen M, Veber DF, Lark MW.

J Biol Chem. 2001 Apr 13;276(15):11507-11. Epub 2001 Jan 8. Erratum in: J Biol Chem. 2003 Aug 22;278(34):32484.

43.

FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis.

James IE, Kumar S, Barnes MR, Gress CJ, Hand AT, Dodds RA, Connor JR, Bradley BR, Campbell DA, Grabill SE, Williams K, Blake SM, Gowen M, Lark MW.

Osteoarthritis Cartilage. 2000 Nov;8(6):452-63.

44.

Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures.

Badger AM, Roshak AK, Cook MN, Newman-Tarr TM, Swift BA, Carlson K, Connor JR, Lee JC, Gowen M, Lark MW, Kumar S.

Osteoarthritis Cartilage. 2000 Nov;8(6):434-43.

46.

Distinct mechanisms of action of selective estrogen receptor modulators in breast and osteoblastic cells.

Nuttall ME, Stroup GB, Fisher PW, Nadeau DP, Gowen M, Suva LJ.

Am J Physiol Cell Physiol. 2000 Nov;279(5):C1550-7.

47.

Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro.

Nuttall ME, Nadeau DP, Fisher PW, Wang F, Keller PM, DeWolf WE Jr, Goldring MB, Badger AM, Lee D, Levy MA, Gowen M, Lark MW.

J Orthop Res. 2000 May;18(3):356-63.

PMID:
10937621
48.

A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats.

Visentin L, Dodds RA, Valente M, Misiano P, Bradbeer JN, Oneta S, Liang X, Gowen M, Farina C.

J Clin Invest. 2000 Jul;106(2):309-18.

49.

Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats.

Gowen M, Stroup GB, Dodds RA, James IE, Votta BJ, Smith BR, Bhatnagar PK, Lago AM, Callahan JF, DelMar EG, Miller MA, Nemeth EF, Fox J.

J Clin Invest. 2000 Jun;105(11):1595-604.

50.

Amphibian Melanophore Technology as a Functional Screen for Antagonists of G-Protein Coupled 7-Transmembrane Receptors.

Nuttall ME, Lee JC, Murdock PR, Badger AM, Wang FL, Laydon JT, Hofmann GA, Pettman GR, Lee JA, Parihar A, Van Wagenen BC, Fox J, Gowen M, Johnson RK, Mattern MR.

J Biomol Screen. 1999;4(5):269-278.

PMID:
10838447

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