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Items: 13


Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression.

Gowans GJ, Bridgers JB, Zhang J, Dronamraju R, Burnetti A, King DA, Thiengmany AV, Shinsky SA, Bhanu NV, Garcia BA, Buchler NE, Strahl BD, Morrison AJ.

Mol Cell. 2019 Dec 19;76(6):909-921.e3. doi: 10.1016/j.molcel.2019.09.029. Epub 2019 Oct 29.


Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaM Sites to Activation.

Hawley SA, Fyffe FA, Russell FM, Gowans GJ, Grahame Hardie D.

Methods Mol Biol. 2018;1732:239-253. doi: 10.1007/978-1-4939-7598-3_16.


The INO80 chromatin remodeler sustains metabolic stability by promoting TOR signaling and regulating histone acetylation.

Beckwith SL, Schwartz EK, García-Nieto PE, King DA, Gowans GJ, Wong KM, Eckley TL, Paraschuk AP, Peltan EL, Lee LR, Yao W, Morrison AJ.

PLoS Genet. 2018 Feb 20;14(2):e1007216. doi: 10.1371/journal.pgen.1007216. eCollection 2018 Feb.


INO80 Chromatin Remodeling Coordinates Metabolic Homeostasis with Cell Division.

Gowans GJ, Schep AN, Wong KM, King DA, Greenleaf WJ, Morrison AJ.

Cell Rep. 2018 Jan 16;22(3):611-623. doi: 10.1016/j.celrep.2017.12.079.


Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib.

Ross FA, Hawley SA, Auciello FR, Gowans GJ, Atrih A, Lamont DJ, Hardie DG.

Cell Chem Biol. 2017 Jul 20;24(7):813-824.e4. doi: 10.1016/j.chembiol.2017.05.021. Epub 2017 Jun 15.


The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.

Hawley SA, Ford RJ, Smith BK, Gowans GJ, Mancini SJ, Pitt RD, Day EA, Salt IP, Steinberg GR, Hardie DG.

Diabetes. 2016 Sep;65(9):2784-94. doi: 10.2337/db16-0058. Epub 2016 Jul 5.


AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2.

Fogarty S, Ross FA, Vara Ciruelos D, Gray A, Gowans GJ, Hardie DG.

Mol Cancer Res. 2016 Aug;14(8):683-95. doi: 10.1158/1541-7786.MCR-15-0479. Epub 2016 May 2.


The INO80 Complex Requires the Arp5-Ies6 Subcomplex for Chromatin Remodeling and Metabolic Regulation.

Yao W, King DA, Beckwith SL, Gowans GJ, Yen K, Zhou C, Morrison AJ.

Mol Cell Biol. 2016 Jan 11;36(6):979-91. doi: 10.1128/MCB.00801-15.


PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain.

Jensen TE, Ross FA, Kleinert M, Sylow L, Knudsen JR, Gowans GJ, Hardie DG, Richter EA.

Biochem J. 2015 May 1;467(3):461-72. doi: 10.1042/BJ20141142.


Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α.

Rog-Zielinska EA, Craig MA, Manning JR, Richardson RV, Gowans GJ, Dunbar DR, Gharbi K, Kenyon CJ, Holmes MC, Hardie DG, Smith GL, Chapman KE.

Cell Death Differ. 2015 Jul;22(7):1106-16. doi: 10.1038/cdd.2014.181. Epub 2014 Oct 31.


Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

Hawley SA, Ross FA, Gowans GJ, Tibarewal P, Leslie NR, Hardie DG.

Biochem J. 2014 Apr 15;459(2):275-87. doi: 10.1042/BJ20131344.


AMPK: a cellular energy sensor primarily regulated by AMP.

Gowans GJ, Hardie DG.

Biochem Soc Trans. 2014 Feb;42(1):71-5. doi: 10.1042/BST20130244.


AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation.

Gowans GJ, Hawley SA, Ross FA, Hardie DG.

Cell Metab. 2013 Oct 1;18(4):556-66. doi: 10.1016/j.cmet.2013.08.019.

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