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Biomarker-Driven Staging-Are We There Yet?

Devarakonda S, Govindan R.

JAMA Netw Open. 2019 Dec 2;2(12):e1917052. doi: 10.1001/jamanetworkopen.2019.17052. No abstract available.


NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 1.2020.

Ettinger DS, Wood DE, Aggarwal C, Aisner DL, Akerley W, Bauman JR, Bharat A, Bruno DS, Chang JY, Chirieac LR, D'Amico TA, Dilling TJ, Dobelbower M, Gettinger S, Govindan R, Gubens MA, Hennon M, Horn L, Lackner RP, Lanuti M, Leal TA, Lin J, Loo BW Jr, Martins RG, Otterson GA, Patel SP, Reckamp KL, Riely GJ, Schild SE, Shapiro TA, Stevenson J, Swanson SJ, Tauer KW, Yang SC, Gregory K; OCN, Hughes M.

J Natl Compr Canc Netw. 2019 Dec;17(12):1464-1472. doi: 10.6004/jnccn.2019.0059.


Pooled overall survival and safety data from the pivotal phase II studies (NP28673 and NP28761) of alectinib in ALK-positive non-small-cell lung cancer.

Ou SI, Gadgeel SM, Barlesi F, Yang JC, De Petris L, Kim DW, Govindan R, Dingemans AM, Crino L, Léna H, Popat S, Ahn JS, Dansin E, Mitry E, Müller B, Bordogna W, Balas B, Morcos PN, Shaw AT.

Lung Cancer. 2019 Oct 14;139:22-27. doi: 10.1016/j.lungcan.2019.10.015. [Epub ahead of print]


The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.

Canon J, Rex K, Saiki AY, Mohr C, Cooke K, Bagal D, Gaida K, Holt T, Knutson CG, Koppada N, Lanman BA, Werner J, Rapaport AS, San Miguel T, Ortiz R, Osgood T, Sun JR, Zhu X, McCarter JD, Volak LP, Houk BE, Fakih MG, O'Neil BH, Price TJ, Falchook GS, Desai J, Kuo J, Govindan R, Hong DS, Ouyang W, Henary H, Arvedson T, Cee VJ, Lipford JR.

Nature. 2019 Nov;575(7781):217-223. doi: 10.1038/s41586-019-1694-1. Epub 2019 Oct 30.


Open-Sourced CIViC Annotation Pipeline to Identify and Annotate Clinically Relevant Variants Using Single-Molecule Molecular Inversion Probes.

Barnell EK, Waalkes A, Mosior MC, Penewit K, Cotto KC, Danos AM, Sheta LM, Campbell KM, Krysiak K, Rieke D, Spies NC, Skidmore ZL, Pritchard CC, Fehniger TA, Uppaluri R, Govindan R, Griffith M, Salipante SJ, Griffith OL.

JCO Clin Cancer Inform. 2019 Oct;3:1-12. doi: 10.1200/CCI.19.00077.


Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study.

Morgensztern D, Besse B, Greillier L, Santana-Davila R, Ready N, Hann CL, Glisson BS, Farago AF, Dowlati A, Rudin CM, Moulec Le S, Lally S, Yalamanchili S, Wolf J, Govindan R, Carbone DP.

Clin Cancer Res. 2019 Dec 1;25(23):6958-6966. doi: 10.1158/1078-0432.CCR-19-1133. Epub 2019 Sep 10.


Identifying an optimal epoch length for spectral analysis of heart rate of critically-ill infants.

Govindan RB, Massaro A, Vezina G, Chang T, du Plessis A.

Comput Biol Med. 2019 Oct;113:103391. doi: 10.1016/j.compbiomed.2019.103391. Epub 2019 Aug 16.


The effect of labor and delivery mode on electrocortical and brainstem autonomic function during neonatal transition.

Mulkey SB, Kota S, Govindan RB, Al-Shargabi T, Swisher CB, Eze A Jr, Hitchings L, Russo S, Herrera N, McCarter R, Maxwell GL, Baker R, du Plessis AJ.

Sci Rep. 2019 Jul 30;9(1):11020. doi: 10.1038/s41598-019-47306-1.


Circulating Tumor DNA Profiling in Small-Cell Lung Cancer Identifies Potentially Targetable Alterations.

Devarakonda S, Sankararaman S, Herzog BH, Gold KA, Waqar SN, Ward JP, Raymond VM, Lanman RB, Chaudhuri AA, Owonikoko TK, Li BT, Poirier JT, Rudin CM, Govindan R, Morgensztern D.

Clin Cancer Res. 2019 Oct 15;25(20):6119-6126. doi: 10.1158/1078-0432.CCR-19-0879. Epub 2019 Jul 12.


Untangling the evolutionary roots of lung cancer.

Devarakonda S, Govindan R.

Nat Commun. 2019 Jul 5;10(1):2979. doi: 10.1038/s41467-019-10879-6. No abstract available.


Phase I, Open-Label, Dose-Escalation Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of GSK2879552 in Relapsed/Refractory SCLC.

Bauer TM, Besse B, Martinez-Marti A, Trigo JM, Moreno V, Garrido P, Ferron-Brady G, Wu Y, Park J, Collingwood T, Kruger RG, Mohammad HP, Ballas MS, Dhar A, Govindan R.

J Thorac Oncol. 2019 Oct;14(10):1828-1838. doi: 10.1016/j.jtho.2019.06.021. Epub 2019 Jun 28.


Heart rate variability is depressed in the early transitional period for newborns with complex congenital heart disease.

Mulkey SB, Govindan R, Metzler M, Swisher CB, Hitchings L, Wang Y, Baker R, Larry Maxwell G, Krishnan A, du Plessis AJ.

Clin Auton Res. 2019 Jun 25. doi: 10.1007/s10286-019-00616-w. [Epub ahead of print]


Healthcare resource utilization and associated cost analysis of the PROCLAIM study in patients with stage III non-small-cell lung cancer.

Govindan R, Senan S, Dickgreber N, Provencio M, Wu YL, Syrigos K, Parente B, Wilson M, Ziemiecki R, Chouaki N, Hossain A, San Antonio B, Winfree K, Vokes EE.

Curr Med Res Opin. 2019 Oct;35(10):1761-1767. doi: 10.1080/03007995.2019.1623185. Epub 2019 Jul 5.


Multicenter Phase I Study of Erdafitinib (JNJ-42756493), Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors.

Bahleda R, Italiano A, Hierro C, Mita A, Cervantes A, Chan N, Awad M, Calvo E, Moreno V, Govindan R, Spira A, Gonzalez M, Zhong B, Santiago-Walker A, Poggesi I, Parekh T, Xie H, Infante J, Tabernero J.

Clin Cancer Res. 2019 Aug 15;25(16):4888-4897. doi: 10.1158/1078-0432.CCR-18-3334. Epub 2019 May 14.


Knowledge and perceptions of Indian primary care nurses towards mental illness.

Gandhi S, Poreddi V, Govindan R, G J, Anjanappa S, Sahu M, Narayanasamy P, N M, C N, Badamath S.

Invest Educ Enferm. 2019 Feb;37(1). doi: 10.17533/udea.iee.v37n1e06.


Comparison of Frequency- and Time-Domain Autoregulation and Vasoreactivity Indices in a Piglet Model of Hypoxia-Ischemia and Hypothermia.

Govindan RB, Brady KM, Massaro AN, Perin J, Jennings JM, DuPlessis AJ, Koehler RC, Lee JK.

Dev Neurosci. 2019 May 2:1-13. doi: 10.1159/000499425. [Epub ahead of print]


The effect of unilateral stroke on autonomic function in the term newborn.

Reich DA, Govindan RB, Whitehead MT, Wang J, Chang T, Kota S, du Plessis AJ.

Pediatr Res. 2019 May;85(6):830-834. doi: 10.1038/s41390-019-0320-0. Epub 2019 Feb 2.


Anodal tDCS modulates cortical activity and synchronization in Parkinson's disease depending on motor processing.

Schoellmann A, Scholten M, Wasserka B, Govindan RB, Krüger R, Gharabaghi A, Plewnia C, Weiss D.

Neuroimage Clin. 2019;22:101689. doi: 10.1016/j.nicl.2019.101689. Epub 2019 Jan 23.


Phase II Study of Roniciclib in Combination with Cisplatin/Etoposide or Carboplatin/Etoposide as First-Line Therapy in Patients with Extensive-Disease Small Cell Lung Cancer.

Reck M, Horn L, Novello S, Barlesi F, Albert I, Juhász E, Kowalski D, Robinet G, Cadranel J, Bidoli P, Chung J, Fritsch A, Drews U, Wagner A, Govindan R.

J Thorac Oncol. 2019 Apr;14(4):701-711. doi: 10.1016/j.jtho.2019.01.010. Epub 2019 Jan 21. Erratum in: J Thorac Oncol. 2019 Aug;14(8):1484.


Accounting for proximal variants improves neoantigen prediction.

Hundal J, Kiwala S, Feng YY, Liu CJ, Govindan R, Chapman WC, Uppaluri R, Swamidass SJ, Griffith OL, Mardis ER, Griffith M.

Nat Genet. 2019 Jan;51(1):175-179. doi: 10.1038/s41588-018-0283-9. Epub 2018 Dec 3.


SELECT: A Phase II Trial of Adjuvant Erlotinib in Patients With Resected Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer.

Pennell NA, Neal JW, Chaft JE, Azzoli CG, Jänne PA, Govindan R, Evans TL, Costa DB, Wakelee HA, Heist RS, Shapiro MA, Muzikansky A, Murthy S, Lanuti M, Rusch VW, Kris MG, Sequist LV.

J Clin Oncol. 2019 Jan 10;37(2):97-104. doi: 10.1200/JCO.18.00131. Epub 2018 Nov 16. Erratum in: J Clin Oncol. 2019 Mar 1;37(7):612.


A deep learning approach to automate refinement of somatic variant calling from cancer sequencing data.

Ainscough BJ, Barnell EK, Ronning P, Campbell KM, Wagner AH, Fehniger TA, Dunn GP, Uppaluri R, Govindan R, Rohan TE, Griffith M, Mardis ER, Swamidass SJ, Griffith OL.

Nat Genet. 2018 Dec;50(12):1735-1743. doi: 10.1038/s41588-018-0257-y. Epub 2018 Nov 5.


ABOUND.2L+: A randomized phase 2 study of nanoparticle albumin-bound paclitaxel with or without CC-486 as second-line treatment for advanced nonsquamous non-small cell lung cancer (NSCLC).

Morgensztern D, Cobo M, Ponce Aix S, Postmus PE, Lewanski CR, Bennouna J, Fischer JR, Juan-Vidal O, Stewart DJ, Fasola G, Ardizzoni A, Bhore R, Wolfsteiner M, Talbot DC, Jin Ong T, Govindan R, On Behalf Of The Abound L Investigators.

Cancer. 2018 Dec 15;124(24):4667-4675. doi: 10.1002/cncr.31779. Epub 2018 Nov 1.


Targeting Resistance to Targeted Therapies: Combating a Resilient Foe.

Devarakonda S, Govindan R.

Clin Cancer Res. 2018 Dec 15;24(24):6112-6114. doi: 10.1158/1078-0432.CCR-18-3178. Epub 2018 Oct 23.


Correlation of PD-L1 Expression with Tumor Mutation Burden and Gene Signatures for Prognosis in Early-Stage Squamous Cell Lung Carcinoma.

Yu H, Chen Z, Ballman KV, Watson MA, Govindan R, Lanc I, Beer DG, Bueno R, Chirieac LR, Chui MH, Chen G, Franklin WA, Gandara DR, Genova C, Brovsky KA, Joshi MM, Merrick DT, Richards WG, Rivard CJ, Harpole DH, Tsao MS, van Bokhoven A, Shepherd FA, Hirsch FR.

J Thorac Oncol. 2019 Jan;14(1):25-36. doi: 10.1016/j.jtho.2018.09.006. Epub 2018 Sep 22.


Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer.

Wagner AH, Devarakonda S, Skidmore ZL, Krysiak K, Ramu A, Trani L, Kunisaki J, Masood A, Waqar SN, Spies NC, Morgensztern D, Waligorski J, Ponce J, Fulton RS, Maggi LB Jr, Weber JD, Watson MA, O'Conor CJ, Ritter JH, Olsen RR, Cheng H, Mukhopadhyay A, Can I, Cessna MH, Oliver TG, Mardis ER, Wilson RK, Griffith M, Griffith OL, Govindan R.

Nat Commun. 2018 Sep 17;9(1):3787. doi: 10.1038/s41467-018-06162-9.


Ensuring signal quality of cerebral near infrared spectroscopy during continuous longterm monitoring.

Govindan RB, Massaro AN, du Plessis A.

J Neurosci Methods. 2018 Nov 1;309:147-152. doi: 10.1016/j.jneumeth.2018.09.003. Epub 2018 Sep 4.


Tumor Mutation Burden as a Biomarker in Resected Non-Small-Cell Lung Cancer.

Devarakonda S, Rotolo F, Tsao MS, Lanc I, Brambilla E, Masood A, Olaussen KA, Fulton R, Sakashita S, McLeer-Florin A, Ding K, Le Teuff G, Shepherd FA, Pignon JP, Graziano SL, Kratzke R, Soria JC, Seymour L, Govindan R, Michiels S.

J Clin Oncol. 2018 Oct 20;36(30):2995-3006. doi: 10.1200/JCO.2018.78.1963. Epub 2018 Aug 14.


Phase Ib/II study of the pan-cyclin-dependent kinase inhibitor roniciclib in combination with chemotherapy in patients with extensive-disease small-cell lung cancer.

Cho BC, Dy GK, Govindan R, Kim DW, Pennell NA, Zalcman G, Besse B, Kim JH, Koca G, Rajagopalan P, Langer S, Ocker M, Nogai H, Barlesi F.

Lung Cancer. 2018 Sep;123:14-21. doi: 10.1016/j.lungcan.2018.04.022. Epub 2018 Apr 27.


Autonomic nervous system depression at term in neurologically normal premature infants.

Mulkey SB, Kota S, Swisher CB, Hitchings L, Metzler M, Wang Y, Maxwell GL, Baker R, du Plessis AJ, Govindan R.

Early Hum Dev. 2018 Aug;123:11-16. doi: 10.1016/j.earlhumdev.2018.07.003. Epub 2018 Jul 17.


Proteogenomic Analysis of Surgically Resected Lung Adenocarcinoma.

Sharpnack MF, Ranbaduge N, Srivastava A, Cerciello F, Codreanu SG, Liebler DC, Mascaux C, Miles WO, Morris R, McDermott JE, Sharpnack JL, Amann J, Maher CA, Machiraju R, Wysocki VH, Govindan R, Mallick P, Coombes KR, Huang K, Carbone DP.

J Thorac Oncol. 2018 Oct;13(10):1519-1529. doi: 10.1016/j.jtho.2018.06.025. Epub 2018 Jul 11.


The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer (NSCLC).

Brahmer JR, Govindan R, Anders RA, Antonia SJ, Sagorsky S, Davies MJ, Dubinett SM, Ferris A, Gandhi L, Garon EB, Hellmann MD, Hirsch FR, Malik S, Neal JW, Papadimitrakopoulou VA, Rimm DL, Schwartz LH, Sepesi B, Yeap BY, Rizvi NA, Herbst RS.

J Immunother Cancer. 2018 Jul 17;6(1):75. doi: 10.1186/s40425-018-0382-2.


NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 5.2018.

Ettinger DS, Aisner DL, Wood DE, Akerley W, Bauman J, Chang JY, Chirieac LR, D'Amico TA, Dilling TJ, Dobelbower M, Govindan R, Gubens MA, Hennon M, Horn L, Lackner RP, Lanuti M, Leal TA, Lilenbaum R, Lin J, Loo BW, Martins R, Otterson GA, Patel SP, Reckamp K, Riely GJ, Schild SE, Shapiro TA, Stevenson J, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M.

J Natl Compr Canc Netw. 2018 Jul;16(7):807-821. doi: 10.6004/jnccn.2018.0062.


Direct Visualization of the Conformational Dynamics of Single Influenza Hemagglutinin Trimers.

Das DK, Govindan R, Nikić-Spiegel I, Krammer F, Lemke EA, Munro JB.

Cell. 2018 Aug 9;174(4):926-937.e12. doi: 10.1016/j.cell.2018.05.050. Epub 2018 Jun 28.


The Impact of Staging by Positron-Emission Tomography on Overall Survival and Progression-Free Survival in Patients With Locally Advanced NSCLC.

Vokes EE, Govindan R, Iscoe N, Hossain AM, San Antonio B, Chouaki N, Koczywas M, Senan S.

J Thorac Oncol. 2018 Aug;13(8):1183-1188. doi: 10.1016/j.jtho.2018.04.028. Epub 2018 May 5.


Four-mirror flat-field anastigmat aplanat telescopes with simple closed-form solutions.

Govindan R.

J Opt Soc Am A Opt Image Sci Vis. 2018 May 1;35(5):779-784. doi: 10.1364/JOSAA.35.000779.


Pathogenic Germline Variants in 10,389 Adult Cancers.

Huang KL, Mashl RJ, Wu Y, Ritter DI, Wang J, Oh C, Paczkowska M, Reynolds S, Wyczalkowski MA, Oak N, Scott AD, Krassowski M, Cherniack AD, Houlahan KE, Jayasinghe R, Wang LB, Zhou DC, Liu D, Cao S, Kim YW, Koire A, McMichael JF, Hucthagowder V, Kim TB, Hahn A, Wang C, McLellan MD, Al-Mulla F, Johnson KJ; Cancer Genome Atlas Research Network, Lichtarge O, Boutros PC, Raphael B, Lazar AJ, Zhang W, Wendl MC, Govindan R, Jain S, Wheeler D, Kulkarni S, Dipersio JF, Reimand J, Meric-Bernstam F, Chen K, Shmulevich I, Plon SE, Chen F, Ding L.

Cell. 2018 Apr 5;173(2):355-370.e14. doi: 10.1016/j.cell.2018.03.039.


Changes in Autonomic Tone in Premature Infants Developing Necrotizing Enterocolitis.

Al-Shargabi T, Reich D, Govindan RB, Shankar S, Metzler M, Cristante C, McCarter R, Sandler AD, Said M, Plessis AD.

Am J Perinatol. 2018 Sep;35(11):1079-1086. doi: 10.1055/s-0038-1639339. Epub 2018 Apr 2.


Non-small-cell Lung Cancer With Brain Metastasis at Presentation.

Waqar SN, Samson PP, Robinson CG, Bradley J, Devarakonda S, Du L, Govindan R, Gao F, Puri V, Morgensztern D.

Clin Lung Cancer. 2018 Jul;19(4):e373-e379. doi: 10.1016/j.cllc.2018.01.007. Epub 2018 Mar 9.


Autonomic Dysfunction in Neonates with Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia Impairs Physiological Responses to Routine Care Events.

Campbell H, Govindan RB, Kota S, Al-Shargabi T, Metzler M, Andescavage N, Chang T, Vezina G, du Plessis A, Massaro AN.

J Pediatr. 2018 May;196:38-44. doi: 10.1016/j.jpeds.2017.12.071. Epub 2018 Mar 6.


Early Mortality in Patients Undergoing Adjuvant Chemotherapy for Non-Small Cell Lung Cancer.

Morgensztern D, Samson PS, Waqar SN, Devarakonda S, Robinson CG, Govindan R, Puri V.

J Thorac Oncol. 2018 Apr;13(4):543-549. doi: 10.1016/j.jtho.2018.01.010. Epub 2018 Feb 2.


Genomic heterogeneity of ALK fusion breakpoints in non-small-cell lung cancer.

Rosenbaum JN, Bloom R, Forys JT, Hiken J, Armstrong JR, Branson J, McNulty S, Velu PD, Pepin K, Abel H, Cottrell CE, Pfeifer JD, Kulkarni S, Govindan R, Konnick EQ, Lockwood CM, Duncavage EJ.

Mod Pathol. 2018 May;31(5):791-808. doi: 10.1038/modpathol.2017.181. Epub 2018 Jan 12.


The impact of an add-on video assisted structured aerobic exercise module on mood and somatic symptoms among women with depressive disorders: Study from a tertiary care centre in India.

Roy A, Govindan R, Muralidharan K.

Asian J Psychiatr. 2018 Feb;32:118-122. doi: 10.1016/j.ajp.2017.12.004. Epub 2017 Dec 5.


Phase III Trial of Ipilimumab Combined With Paclitaxel and Carboplatin in Advanced Squamous Non-Small-Cell Lung Cancer.

Govindan R, Szczesna A, Ahn MJ, Schneider CP, Gonzalez Mella PF, Barlesi F, Han B, Ganea DE, Von Pawel J, Vladimirov V, Fadeeva N, Lee KH, Kurata T, Zhang L, Tamura T, Postmus PE, Jassem J, O'Byrne K, Kopit J, Li M, Tschaika M, Reck M.

J Clin Oncol. 2017 Oct 20;35(30):3449-3457. doi: 10.1200/JCO.2016.71.7629. Epub 2017 Aug 30.


Structural and Neuronal Integrity Measures of Fatigue Severity in Multiple Sclerosis.

Bernitsas E, Yarraguntla K, Bao F, Sood R, Santiago-Martinez C, Govindan R, Khan O, Seraji-Bozorgzad N.

Brain Sci. 2017 Aug 12;7(8). pii: E102. doi: 10.3390/brainsci7080102.


Evaluation of marginal and internal gaps of metal ceramic crowns obtained from conventional impressions and casting techniques with those obtained from digital techniques.

Rai R, Kumar SA, Prabhu R, Govindan RT, Tanveer FM.

Indian J Dent Res. 2017 May-Jun;28(3):291-297. doi: 10.4103/ijdr.IJDR_81_17.


Pooled Systemic Efficacy and Safety Data from the Pivotal Phase II Studies (NP28673 and NP28761) of Alectinib in ALK-positive Non-Small Cell Lung Cancer.

Yang JC, Ou SI, De Petris L, Gadgeel S, Gandhi L, Kim DW, Barlesi F, Govindan R, Dingemans AC, Crino L, Lena H, Popat S, Ahn JS, Dansin E, Golding S, Bordogna W, Balas B, Morcos PN, Zeaiter A, Shaw AT.

J Thorac Oncol. 2017 Oct;12(10):1552-1560. doi: 10.1016/j.jtho.2017.06.070. Epub 2017 Jul 6.


TRAC(ERx)-ing lung cancer evolution.

Devarakonda S, Govindan R.

Ann Oncol. 2017 Aug 1;28(8):1690-1692. doi: 10.1093/annonc/mdx313. No abstract available.


Neural activity during attentional conflict predicts reduction in tinnitus perception following rTMS.

James GA, Thostenson JD, Brown G, Carter G, Hayes H, Tripathi SP, Dobry DJ, Govindan RB, Dornhoffer JL, Williams DK, Kilts CD, Mennemeier MS.

Brain Stimul. 2017 Sep - Oct;10(5):934-943. doi: 10.1016/j.brs.2017.05.009. Epub 2017 Jun 2.


Identification of QRS complex in non-stationary electrocardiogram of sick infants.

Kota S, Swisher CB, Al-Shargabi T, Andescavage N, du Plessis A, Govindan RB.

Comput Biol Med. 2017 Aug 1;87:211-216. doi: 10.1016/j.compbiomed.2017.05.033. Epub 2017 Jun 2.


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