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Items: 12


Energy dissipation and noise correlations in biochemical sensing.

Govern CC, ten Wolde PR.

Phys Rev Lett. 2014 Dec 19;113(25):258102. Epub 2014 Dec 16.


Optimal resource allocation in cellular sensing systems.

Govern CC, Ten Wolde PR.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17486-91. doi: 10.1073/pnas.1411524111. Epub 2014 Nov 24.


Stochastic responses may allow genetically diverse cell populations to optimize performance with simpler signaling networks.

Govern CC, Chakraborty AK.

PLoS One. 2013 Aug 7;8(8):e65086. doi: 10.1371/journal.pone.0065086. eCollection 2013.


Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.

Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP.

Sci Signal. 2013 Mar 26;6(268):ra21. doi: 10.1126/scisignal.2003848.


Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection.

Vanguri V, Govern CC, Smith R, Huseby ES.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):288-93. doi: 10.1073/pnas.1208328110. Epub 2012 Dec 17.


Fundamental limits on sensing chemical concentrations with linear biochemical networks.

Govern CC, ten Wolde PR.

Phys Rev Lett. 2012 Nov 21;109(21):218103. Epub 2012 Nov 20.


Identifying dynamical bottlenecks of stochastic transitions in biochemical networks.

Govern CC, Yang M, Chakraborty AK.

Phys Rev Lett. 2012 Feb 3;108(5):058102. Epub 2012 Jan 30.


Fast on-rates allow short dwell time ligands to activate T cells.

Govern CC, Paczosa MK, Chakraborty AK, Huseby ES.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8724-9. doi: 10.1073/pnas.1000966107. Epub 2010 Apr 26.


For T cell receptors, some breakups might not last forever.

Govern CC, Chakraborty AK.

Immunity. 2010 Feb 26;32(2):141-2. doi: 10.1016/j.immuni.2010.02.005.


Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.

Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J.

Sci Signal. 2009 Apr 14;2(66):pt2. doi: 10.1126/scisignal.266pt2.


Signaling cascades modulate the speed of signal propagation through space.

Govern CC, Chakraborty AK.

PLoS One. 2009;4(2):e4639. doi: 10.1371/journal.pone.0004639. Epub 2009 Feb 27.


Digital signaling and hysteresis characterize ras activation in lymphoid cells.

Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP.

Cell. 2009 Jan 23;136(2):337-51. doi: 10.1016/j.cell.2008.11.051.

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