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Items: 22

1.

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.

Vandekeere S, Dubois C, Kalucka J, Sullivan MR, García-Caballero M, Goveia J, Chen R, Diehl FF, Bar-Lev L, Souffreau J, Pircher A, Kumar S, Vinckier S, Hirabayashi Y, Furuya S, Schoonjans L, Eelen G, Ghesquière B, Keshet E, Li X, Vander Heiden MG, Dewerchin M, Carmeliet P.

Cell Metab. 2018 Jul 6. pii: S1550-4131(18)30391-7. doi: 10.1016/j.cmet.2018.06.009. [Epub ahead of print]

PMID:
30017355
2.

Role of glutamine and interlinked asparagine metabolism in vessel formation.

Huang H, Vandekeere S, Kalucka J, Bierhansl L, Zecchin A, Brüning U, Visnagri A, Yuldasheva N, Goveia J, Cruys B, Brepoels K, Wyns S, Rayport S, Ghesquière B, Vinckier S, Schoonjans L, Cubbon R, Dewerchin M, Eelen G, Carmeliet P.

EMBO J. 2017 Aug 15;36(16):2334-2352. doi: 10.15252/embj.201695518. Epub 2017 Jun 28.

3.

Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.

4.

The role of fatty acid β-oxidation in lymphangiogenesis.

Wong BW, Wang X, Zecchin A, Thienpont B, Cornelissen I, Kalucka J, García-Caballero M, Missiaen R, Huang H, Brüning U, Blacher S, Vinckier S, Goveia J, Knobloch M, Zhao H, Dierkes C, Shi C, Hägerling R, Moral-Dardé V, Wyns S, Lippens M, Jessberger S, Fendt SM, Luttun A, Noel A, Kiefer F, Ghesquière B, Moons L, Schoonjans L, Dewerchin M, Eelen G, Lambrechts D, Carmeliet P.

Nature. 2017 Feb 2;542(7639):49-54. doi: 10.1038/nature21028. Epub 2016 Dec 26.

PMID:
28024299
5.

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.

Cantelmo AR, Conradi LC, Brajic A, Goveia J, Kalucka J, Pircher A, Chaturvedi P, Hol J, Thienpont B, Teuwen LA, Schoors S, Boeckx B, Vriens J, Kuchnio A, Veys K, Cruys B, Finotto L, Treps L, Stav-Noraas TE, Bifari F, Stapor P, Decimo I, Kampen K, De Bock K, Haraldsen G, Schoonjans L, Rabelink T, Eelen G, Ghesquière B, Rehman J, Lambrechts D, Malik AB, Dewerchin M, Carmeliet P.

Cancer Cell. 2016 Dec 12;30(6):968-985. doi: 10.1016/j.ccell.2016.10.006. Epub 2016 Nov 17.

6.

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis.

Wenes M, Shang M, Di Matteo M, Goveia J, Martín-Pérez R, Serneels J, Prenen H, Ghesquière B, Carmeliet P, Mazzone M.

Cell Metab. 2016 Nov 8;24(5):701-715. doi: 10.1016/j.cmet.2016.09.008. Epub 2016 Oct 20.

7.

Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities.

Goveia J, Pircher A, Conradi LC, Kalucka J, Lagani V, Dewerchin M, Eelen G, DeBerardinis RJ, Wilson ID, Carmeliet P.

EMBO Mol Med. 2016 Oct 4;8(10):1134-1142. doi: 10.15252/emmm.201606798. Print 2016 Oct.

8.

Adequate hypoxia inducible factor 1α signaling is indispensable for bone regeneration.

Stegen S, Deprez S, Eelen G, Torrekens S, Van Looveren R, Goveia J, Ghesquière B, Carmeliet P, Carmeliet G.

Bone. 2016 Jun;87:176-86. doi: 10.1016/j.bone.2016.03.014. Epub 2016 Apr 4.

PMID:
27058876
9.

Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.

Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, Batista A, Muzikansky A, Leow CC, Xu L, Batchelor TT, Duda DG, Fukumura D, Jain RK.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4470-5. doi: 10.1073/pnas.1525349113. Epub 2016 Apr 4.

10.

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival.

Stegen S, van Gastel N, Eelen G, Ghesquière B, D'Anna F, Thienpont B, Goveia J, Torrekens S, Van Looveren R, Luyten FP, Maxwell PH, Wielockx B, Lambrechts D, Fendt SM, Carmeliet P, Carmeliet G.

Cell Metab. 2016 Feb 9;23(2):265-79. doi: 10.1016/j.cmet.2016.01.002.

11.

Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells.

Schoors S, Bruning U, Missiaen R, Queiroz KC, Borgers G, Elia I, Zecchin A, Cantelmo AR, Christen S, Goveia J, Heggermont W, Goddë L, Vinckier S, Van Veldhoven PP, Eelen G, Schoonjans L, Gerhardt H, Dewerchin M, Baes M, De Bock K, Ghesquière B, Lunt SY, Fendt SM, Carmeliet P.

Nature. 2015 Oct 1;526(7571):144. doi: 10.1038/nature14624. Epub 2015 Aug 5. No abstract available.

PMID:
26245368
12.

Fatty acid carbon is essential for dNTP synthesis in endothelial cells.

Schoors S, Bruning U, Missiaen R, Queiroz KC, Borgers G, Elia I, Zecchin A, Cantelmo AR, Christen S, Goveia J, Heggermont W, Goddé L, Vinckier S, Van Veldhoven PP, Eelen G, Schoonjans L, Gerhardt H, Dewerchin M, Baes M, De Bock K, Ghesquière B, Lunt SY, Fendt SM, Carmeliet P.

Nature. 2015 Apr 9;520(7546):192-197. doi: 10.1038/nature14362. Epub 2015 Apr 1. Erratum in: Nature. 2015 Oct 1;526(7571):144.

13.

Metabolic pathway compartmentalization: an underappreciated opportunity?

Zecchin A, Stapor PC, Goveia J, Carmeliet P.

Curr Opin Biotechnol. 2015 Aug;34:73-81. doi: 10.1016/j.copbio.2014.11.022. Epub 2014 Dec 11. Review.

PMID:
25499800
14.

Angiogenesis revisited - role and therapeutic potential of targeting endothelial metabolism.

Stapor P, Wang X, Goveia J, Moens S, Carmeliet P.

J Cell Sci. 2014 Oct 15;127(Pt 20):4331-41. doi: 10.1242/jcs.153908. Epub 2014 Sep 1. Review.

15.

The multifaceted activity of VEGF in angiogenesis - Implications for therapy responses.

Moens S, Goveia J, Stapor PC, Cantelmo AR, Carmeliet P.

Cytokine Growth Factor Rev. 2014 Aug;25(4):473-82. doi: 10.1016/j.cytogfr.2014.07.009. Epub 2014 Jul 23. Review.

PMID:
25169850
16.

Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease.

Goveia J, Stapor P, Carmeliet P.

EMBO Mol Med. 2014 Sep;6(9):1105-20. doi: 10.15252/emmm.201404156. Review.

17.

Endothelial cell differentiation by SOX17: promoting the tip cell or stalking its neighbor instead?

Goveia J, Zecchin A, Rodriguez FM, Moens S, Stapor P, Carmeliet P.

Circ Res. 2014 Jul 7;115(2):205-7. doi: 10.1161/CIRCRESAHA.114.304234. No abstract available.

PMID:
24989487
18.

Analytical characterization of an assay designed to detect and identify diverse agents of disseminated viral infection.

Metzgar D, Lovari R, Ray K, Baynes D, Drapp D, Frinder M, Vijesurier R, Stemler M, Ofsaiof R, Carolan H, Welk J, Toleno D, Ranken R, Hall TA, Massire C, Sampath R, Blyn LB, Goveia J, Schneider G.

J Clin Virol. 2014 Mar;59(3):177-83. doi: 10.1016/j.jcv.2013.12.005. Epub 2013 Dec 29.

PMID:
24440177
19.

Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.

Schoors S, De Bock K, Cantelmo AR, Georgiadou M, Ghesquière B, Cauwenberghs S, Kuchnio A, Wong BW, Quaegebeur A, Goveia J, Bifari F, Wang X, Blanco R, Tembuyser B, Cornelissen I, Bouché A, Vinckier S, Diaz-Moralli S, Gerhardt H, Telang S, Cascante M, Chesney J, Dewerchin M, Carmeliet P.

Cell Metab. 2014 Jan 7;19(1):37-48. doi: 10.1016/j.cmet.2013.11.008. Epub 2013 Dec 12.

20.

Educational interventions to improve the meaningful use of Electronic Health Records: a review of the literature: BEME Guide No. 29.

Goveia J, Van Stiphout F, Cheung Z, Kamta B, Keijsers C, Valk G, Ter Braak E.

Med Teach. 2013 Nov;35(11):e1551-60. doi: 10.3109/0142159X.2013.806984. Epub 2013 Jul 12. Review.

PMID:
23848402
21.

Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma.

Lu-Emerson C, Snuderl M, Kirkpatrick ND, Goveia J, Davidson C, Huang Y, Riedemann L, Taylor J, Ivy P, Duda DG, Ancukiewicz M, Plotkin SR, Chi AS, Gerstner ER, Eichler AF, Dietrich J, Stemmer-Rachamimov AO, Batchelor TT, Jain RK.

Neuro Oncol. 2013 Aug;15(8):1079-87. doi: 10.1093/neuonc/not082. Epub 2013 Jul 4.

22.

Severe soft tissue infections of the extremities in patients admitted to an intensive care unit.

Zahar JR, Goveia J, Lesprit P, Brun-Buisson C.

Clin Microbiol Infect. 2005 Jan;11(1):79-82.

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