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In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A.

Akram AR, Chankeshwara SV, Scholefield E, Aslam T, McDonald N, Megia-Fernandez A, Marshall A, Mills B, Avlonitis N, Craven TH, Smyth AM, Collie DS, Gray C, Hirani N, Hill AT, Govan JR, Walsh T, Haslett C, Bradley M, Dhaliwal K.

Sci Transl Med. 2018 Oct 24;10(464). pii: eaal0033. doi: 10.1126/scitranslmed.aal0033.


Magnetically activated adhesives: towards on-demand magnetic triggering of selected polymerisation reactions.

Davies GL, Govan J, Tekoriute R, Serrano-García R, Nolan H, Farrell D, Hajatpour O, Gun'ko YK.

Chem Sci. 2017 Nov 1;8(11):7758-7764. doi: 10.1039/c7sc03474a. Epub 2017 Sep 26.


A Randomized Controlled Trial of Atorvastatin in Patients With Bronchiectasis Infected With Pseudomonas Aeruginosa: A Proof of Concept Study.

Bedi P, Chalmers JD, Graham C, Clarke A, Donaldson S, Doherty C, Govan JRW, Davidson DJ, Rossi AG, Hill AT.

Chest. 2017 Aug;152(2):368-378. doi: 10.1016/j.chest.2017.05.017. Epub 2017 May 26.


Molecular Recognition of Biomolecules by Chiral CdSe Quantum Dots.

Mukhina MV, Korsakov IV, Maslov VG, Purcell-Milton F, Govan J, Baranov AV, Fedorov AV, Gun'ko YK.

Sci Rep. 2016 Apr 11;6:24177. doi: 10.1038/srep24177.


Lung Microbiota Changes Associated with Chronic Pseudomonas aeruginosa Lung Infection and the Impact of Intravenous Colistimethate Sodium.

Collie D, Glendinning L, Govan J, Wright S, Thornton E, Tennant P, Doherty C, McLachlan G.

PLoS One. 2015 Nov 6;10(11):e0142097. doi: 10.1371/journal.pone.0142097. eCollection 2015.


Optically Triggered Immune Response through Photocaged Oligonucleotides.

Govan JM, Young DD, Lively MO, Deiters A.

Tetrahedron Lett. 2015 Jun 3;56(23):3639-3642.


Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure.

Gong L, Govan JM, Evans EB, Dai H, Wang E, Lee SW, Lin HK, Lazar AJ, Mills GB, Lin SY.

Cell Cycle. 2015;14(14):2323-32. doi: 10.1080/15384101.2015.1044174.


Intrinsic Chirality of CdSe/ZnS Quantum Dots and Quantum Rods.

Mukhina MV, Maslov VG, Baranov AV, Fedorov AV, Orlova AO, Purcell-Milton F, Govan J, Gun'ko YK.

Nano Lett. 2015 May 13;15(5):2844-51. doi: 10.1021/nl504439w. Epub 2015 Apr 27.


Preparation of chiral quantum dots.

Moloney MP, Govan J, Loudon A, Mukhina M, Gun'ko YK.

Nat Protoc. 2015 Apr;10(4):558-73. doi: 10.1038/nprot.2015.028. Epub 2015 Mar 5.


Garlic revisited: antimicrobial activity of allicin-containing garlic extracts against Burkholderia cepacia complex.

Wallock-Richards D, Doherty CJ, Doherty L, Clarke DJ, Place M, Govan JR, Campopiano DJ.

PLoS One. 2014 Dec 1;9(12):e112726. doi: 10.1371/journal.pone.0112726. eCollection 2014.


Cathelicidin host defence peptide augments clearance of pulmonary Pseudomonas aeruginosa infection by its influence on neutrophil function in vivo.

Beaumont PE, McHugh B, Gwyer Findlay E, Mackellar A, Mackenzie KJ, Gallo RL, Govan JR, Simpson AJ, Davidson DJ.

PLoS One. 2014 Jun 2;9(6):e99029. doi: 10.1371/journal.pone.0099029. eCollection 2014.


Site-specific promoter caging enables optochemical gene activation in cells and animals.

Hemphill J, Govan J, Uprety R, Tsang M, Deiters A.

J Am Chem Soc. 2014 May 14;136(19):7152-8. doi: 10.1021/ja500327g. Epub 2014 May 6.


Synthesis Characterization and Photocatalytic Studies of Cobalt Ferrite-Silica-Titania Nanocomposites.

Greene D, Serrano-Garcia R, Govan J, Gun'ko YK.

Nanomaterials (Basel). 2014 Apr 23;4(2):331-343. doi: 10.3390/nano4020331.


Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled trial.

Mandal P, Chalmers JD, Graham C, Harley C, Sidhu MK, Doherty C, Govan JW, Sethi T, Davidson DJ, Rossi AG, Hill AT.

Lancet Respir Med. 2014 Jun;2(6):455-63. doi: 10.1016/S2213-2600(14)70050-5. Epub 2014 Mar 24.


Recent Advances in the Application of Magnetic Nanoparticles as a Support for Homogeneous Catalysts.

Govan J, Gun'ko YK.

Nanomaterials (Basel). 2014 Apr 2;4(2):222-241. doi: 10.3390/nano4020222. Review.


Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis: a prospective study.

Chalmers JD, McHugh BJ, Doherty C, Smith MP, Govan JR, Kilpatrick DC, Hill AT.

Lancet Respir Med. 2013 May;1(3):224-32. doi: 10.1016/S2213-2600(13)70001-8. Epub 2013 Jan 28.


Draft Genome Sequence of a Stable Mucoid Strain of Pseudomonas aeruginosa PAO581 with a mucA25 Mutation.

Yin Y, Withers TR, Govan JR, Johnson SL, Yu HD.

Genome Announc. 2013 Oct 10;1(5). pii: e00834-13. doi: 10.1128/genomeA.00834-13.


Optochemical control of RNA interference in mammalian cells.

Govan JM, Young DD, Lusic H, Liu Q, Lively MO, Deiters A.

Nucleic Acids Res. 2013 Dec;41(22):10518-28. doi: 10.1093/nar/gkt806. Epub 2013 Sep 10.


Cellular delivery and photochemical activation of antisense agents through a nucleobase caging strategy.

Govan JM, Uprety R, Thomas M, Lusic H, Lively MO, Deiters A.

ACS Chem Biol. 2013 Oct 18;8(10):2272-82. doi: 10.1021/cb400293e. Epub 2013 Aug 19.


A lung segmental model of chronic Pseudomonas infection in sheep.

Collie D, Govan J, Wright S, Thornton E, Tennant P, Smith S, Doherty C, McLachlan G.

PLoS One. 2013 Jul 9;8(7):e67677. doi: 10.1371/journal.pone.0067677. Print 2013.


Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection.

Clancy JP, Dupont L, Konstan MW, Billings J, Fustik S, Goss CH, Lymp J, Minic P, Quittner AL, Rubenstein RC, Young KR, Saiman L, Burns JL, Govan JR, Ramsey B, Gupta R; Arikace Study Group.

Thorax. 2013 Sep;68(9):818-25. doi: 10.1136/thoraxjnl-2012-202230. Epub 2013 Jun 8.


Recovery of human DNA profiles from poached deer remains part 2: improved recovery protocol without the need for LCN analysis.

Tobe SS, Bailey S, Govan J, Welch LA.

Sci Justice. 2013 Mar;53(1):23-7. doi: 10.1016/j.scijus.2012.03.002. Epub 2012 Mar 31.


Vitamin-D deficiency is associated with chronic bacterial colonisation and disease severity in bronchiectasis.

Chalmers JD, McHugh BJ, Docherty C, Govan JR, Hill AT.

Thorax. 2013 Jan;68(1):39-47. doi: 10.1136/thoraxjnl-2012-202125. Epub 2012 Oct 16.


Antibiotic susceptibility testing in early and chronic respiratory infections with Pseudomonas aeruginosa.

Foweraker JE, Govan JR.

J Cyst Fibros. 2013 May;12(3):302. doi: 10.1016/j.jcf.2012.08.009. Epub 2012 Sep 5. No abstract available.


Hydrogen peroxide induced activation of gene expression in mammalian cells using boronate estrone derivatives.

Govan JM, McIver AL, Riggsbee C, Deiters A.

Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9066-70. doi: 10.1002/anie.201203222. Epub 2012 Jul 31.


Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis.

Chalmers JD, Smith MP, McHugh BJ, Doherty C, Govan JR, Hill AT.

Am J Respir Crit Care Med. 2012 Oct 1;186(7):657-65. doi: 10.1164/rccm.201203-0487OC. Epub 2012 Jun 28.


Regulation of transcription through light-activation and light-deactivation of triplex-forming oligonucleotides in mammalian cells.

Govan JM, Uprety R, Hemphill J, Lively MO, Deiters A.

ACS Chem Biol. 2012 Jul 20;7(7):1247-56. doi: 10.1021/cb300161r. Epub 2012 May 11.


Recovery of human DNA profiles from poached deer remains: a feasibility study.

Tobe SS, Govan J, Welch LA.

Sci Justice. 2011 Dec;51(4):190-5. doi: 10.1016/j.scijus.2011.06.002. Epub 2011 Jul 30.


Can transmissible strains of Pseudomonas aeruginosa be successfully eradicated?

Gilchrist FJ, France M, Bright-Thomas R, Doherty CJ, Govan JR, Webb AK, Jones AM.

Eur Respir J. 2011 Dec;38(6):1483-6. doi: 10.1183/09031936.00048611. No abstract available.


Stabilization and photochemical regulation of antisense agents through PEGylation.

Govan JM, McIver AL, Deiters A.

Bioconjug Chem. 2011 Oct 19;22(10):2136-42. doi: 10.1021/bc200411n. Epub 2011 Sep 30.


Why 5 is better than 4.

Gruener AM, Govan JA.

J Cataract Refract Surg. 2011 Aug;37(8):1560-1. doi: 10.1016/j.jcrs.2011.05.019. No abstract available.


Photochemical control of DNA decoy function enables precise regulation of nuclear factor κB activity.

Govan JM, Lively MO, Deiters A.

J Am Chem Soc. 2011 Aug 24;133(33):13176-82. doi: 10.1021/ja204980v. Epub 2011 Jul 29.


Pseudomonas aeruginosa bacteraemia in an adult with cystic fibrosis and acute appendicitis.

Gilchrist FJ, Doherty CJ, Govan JR, Webb AK, Jones AM.

J Cyst Fibros. 2011 Dec;10(6):477-8. doi: 10.1016/j.jcf.2011.06.009. Epub 2011 Jul 14.


Can early Burkholderia cepacia complex infection in cystic fibrosis be eradicated with antibiotic therapy?

Horsley A, Webb K, Bright-Thomas R, Govan J, Jones A.

Front Cell Infect Microbiol. 2011 Dec 21;1:18. doi: 10.3389/fcimb.2011.00018. eCollection 2011.


Photocaged morpholino oligomers for the light-regulation of gene function in zebrafish and Xenopus embryos.

Deiters A, Garner RA, Lusic H, Govan JM, Dush M, Nascone-Yoder NM, Yoder JA.

J Am Chem Soc. 2010 Nov 10;132(44):15644-50. doi: 10.1021/ja1053863.


A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis.

Murray MP, Govan JR, Doherty CJ, Simpson AJ, Wilkinson TS, Chalmers JD, Greening AP, Haslett C, Hill AT.

Am J Respir Crit Care Med. 2011 Feb 15;183(4):491-9. doi: 10.1164/rccm.201005-0756OC. Epub 2010 Sep 24.


Early Pseudomonas aeruginosa infection in individuals with cystic fibrosis: is susceptibility testing justified?

Macdonald D, Cuthbertson L, Doherty C, Campana S, Ravenni N, Taccetti G, Govan JR.

J Antimicrob Chemother. 2010 Nov;65(11):2373-5. doi: 10.1093/jac/dkq342. Epub 2010 Sep 13.


Chiral luminescent CdS nano-tetrapods.

Govan JE, Jan E, Querejeta A, Kotov NA, Gun'ko YK.

Chem Commun (Camb). 2010 Sep 7;46(33):6072-4. doi: 10.1039/c0cc00930j. Epub 2010 Jul 23.


Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex.

Bodewits K, Raetz CR, Govan JR, Campopiano DJ.

Antimicrob Agents Chemother. 2010 Aug;54(8):3531-3. doi: 10.1128/AAC.01600-09. Epub 2010 Jun 1. No abstract available.


Do processing time and storage of sputum influence quantitative bacteriology in bronchiectasis?

Murray MP, Doherty CJ, Govan JR, Hill AT.

J Med Microbiol. 2010 Jul;59(Pt 7):829-33. doi: 10.1099/jmm.0.016683-0. Epub 2010 Mar 25.


Peptide fragments of a beta-defensin derivative with potent bactericidal activity.

Reynolds NL, De Cecco M, Taylor K, Stanton C, Kilanowski F, Kalapothakis J, Seo E, Uhrin D, Campopiano D, Govan J, Macmillan D, Barran P, Dorin JR.

Antimicrob Agents Chemother. 2010 May;54(5):1922-9. doi: 10.1128/AAC.01568-09. Epub 2010 Feb 22.


The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium.

Barlow PG, Beaumont PE, Cosseau C, Mackellar A, Wilkinson TS, Hancock RE, Haslett C, Govan JR, Simpson AJ, Davidson DJ.

Am J Respir Cell Mol Biol. 2010 Dec;43(6):692-702. doi: 10.1165/rcmb.2009-0250OC. Epub 2010 Jan 22.


Clinical outcome for cystic fibrosis patients infected with transmissible pseudomonas aeruginosa: an 8-year prospective study.

Jones AM, Dodd ME, Morris J, Doherty C, Govan JR, Webb AK.

Chest. 2010 Jun;137(6):1405-9. doi: 10.1378/chest.09-2406. Epub 2010 Jan 15.


Subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins based on catalytic activity.

Clarke DJ, Ortega XP, Mackay CL, Valvano MA, Govan JR, Campopiano DJ, Langridge-Smith P, Brown AR.

Biochemistry. 2010 Feb 16;49(6):1319-30. doi: 10.1021/bi901703m.


Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia.

Conway Morris A, Kefala K, Wilkinson TS, Moncayo-Nieto OL, Dhaliwal K, Farrell L, Walsh TS, Mackenzie SJ, Swann DG, Andrews PJ, Anderson N, Govan JR, Laurenson IF, Reid H, Davidson DJ, Haslett C, Sallenave JM, Simpson AJ.

Thorax. 2010 Mar;65(3):201-7. doi: 10.1136/thx.2009.122291. Epub 2009 Oct 12. Erratum in: Thorax. 2010 Sep;65(9):844.


Photochemical regulation of restriction endonuclease activity.

Young DD, Govan JM, Lively MO, Deiters A.

Chembiochem. 2009 Jul 6;10(10):1612-6. doi: 10.1002/cbic.200900090.


Efficient production of human beta-defensin 2 (HBD2) in Escherichia coli.

Vargues T, Morrison GJ, Seo ES, Clarke DJ, Fielder HL, Bennani J, Pathania U, Kilanowski F, Dorin JR, Govan JR, Mackay CL, Uhrín D, Campopiano DJ.

Protein Pept Lett. 2009;16(6):668-76.


Contributions of two UDP-glucose dehydrogenases to viability and polymyxin B resistance of Burkholderia cenocepacia.

Loutet SA, Bartholdson SJ, Govan JR, Campopiano DJ, Valvano MA.

Microbiology. 2009 Jun;155(Pt 6):2029-39. doi: 10.1099/mic.0.027607-0. Epub 2009 Apr 21.


Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment.

Wilkinson TS, Dhaliwal K, Hamilton TW, Lipka AF, Farrell L, Davidson DJ, Duffin R, Morris AC, Haslett C, Govan JR, Gregory CD, Sallenave JM, Simpson AJ.

Am J Pathol. 2009 Apr;174(4):1338-46. doi: 10.2353/ajpath.2009.080746. Epub 2009 Mar 5.


The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.

Holden MT, Seth-Smith HM, Crossman LC, Sebaihia M, Bentley SD, Cerdeño-Tárraga AM, Thomson NR, Bason N, Quail MA, Sharp S, Cherevach I, Churcher C, Goodhead I, Hauser H, Holroyd N, Mungall K, Scott P, Walker D, White B, Rose H, Iversen P, Mil-Homens D, Rocha EP, Fialho AM, Baldwin A, Dowson C, Barrell BG, Govan JR, Vandamme P, Hart CA, Mahenthiralingam E, Parkhill J.

J Bacteriol. 2009 Jan;191(1):261-77. doi: 10.1128/JB.01230-08. Epub 2008 Oct 17. Erratum in: J Bacteriol. 2009 Apr;191(8):2907.

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